• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2000년도 추계학술대회 및 정기총회
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• pp.62-63
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• 2000

• ETRI Journal
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• 제27권3호
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• pp.312-318
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• 2005

Mid-span spectral inversion (MSSI) has to utilize high optical pump power, for its operation principle is based on a nonlinear optical wavelength conversion. In this paper, a low pump-power operation of MSSI-based chromatic dispersion compensation (CDC) has been achieved successfully, for the first time to our knowledge, by introducing a noise pre-reduction scheme in cascaded wavelength conversions with periodically poled $LiNbO_3$ waveguides at a relatively low operation temperature. As preliminary studies, phase-matching properties and operation-temperature dependence of the wavelength converter (WC) were characterized. The WC pumped at 1549 nm exhibited a wide conversion bandwidth of 59 nm covering the entire C-band and a conversion efficiency of -23.6 dB at 11 dBm pump power. CDC experiments were implemented with 2.5 and 10 Gb/s transmission systems over 100 km single-mode fiber. Although it is well-known that the signal distortion due to chromatic dispersion is not critical at a 2.5 Gb/s transmission, the clear recovery of eye patterns was identified. At 10 Gb/s transmission experiments, eye patterns were retrieved distinctly from seriously distorted ones, and notable improvements in bit-error rates were acquired at a low pump power of 14 dBm.

• Journal of Power Electronics
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• 제18권2호
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• pp.395-406
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• 2018

Marine controlled-source electromagnetic transmitters (MCSETs) are important in marine electromagnetic exploration systems. They play a crucial role in the exploration of solid mineral resources, marine oil, and gas and in marine engineering evaluation. A DC-DC controlled-source circuit is typically used in traditional MCSETs, but using this circuit in MCSETs causes several problems, such as large voltage ringing of the high-frequency diode, heating of the insulated-gate bipolar transistor (IGBT) module, high temperature of the high-frequency transformer, loss of the duty cycle, and low transmission efficiency of the controlled-source circuit. This paper presents a clamping-diode circuit for MCSET (CDC-MCSET). Clamping diodes are added to the controlled-source circuit to reduce the loss of the duty ratio and the voltage peak of the high-frequency diode. The temperature of the high-frequency diode, IGBT module, and transformer is decreased, and the service life of these devices is prolonged. The power transmission efficiency of the controlled-source circuit is also improved. Saber simulation and a 20 KW MCSET are used to verify the correctness and effectiveness of the proposed CDC-MCSET.

• 대한화학회지
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• 제26권4호
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• pp.205-209
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• 1982

순수 액체상태의 $CDCl_3$의 비등방성 회전운동을 라만 스펙트럼의 ${\nu}_1$- band를 분석하여 조사하였다. 이로부터 분자의 $C_3$-대칭축에 수직한 축 주위로의 회전운동에 관계되는 확산상수($D_{II}$)는 위에서 얻은 $D_{\perp}$와$^35C$l의 NQR이완시간으로 부터 구하였다. 이렇게 구한 확산상수들은 $^2H$와 $^35C$l의 NQR 이완시간으로 부터 구한 값들과 실험오차 범위내에서 잘 일치하였다. 또한 두 확산상수들의 값들로부터 순수한 CDC$l_3$의 재배치 운동이 상당히 비등방적인 것을 알게 되었다.

• 한국분무공학회지
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• 제26권2호
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• pp.57-66
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• 2021

The reactivity controlled compression ignition (RCCI) is the technology that provides two different types of fuel to the combustion chamber with the advantage of significantly reducing particulate matter and nitrogen oxides emissions. However, due to the characteristics of lean combustion, combustion efficiency is worsened. The conventional type of pistons for conventional diesel combustion (CDC) has mostly been used in the researches on RCCI. Because the pistons for CDC are optimized to enhance flow and target spray, the pistons are unsuitable for RCCI. In this study, a piston that is suitable for RCCI is designed to improve combustion efficiency. The new piston was designed by considering the factors such as squish geometry, bowl depth, and surface area. The experiment was carried out by fixing the energy supply to 0.9kJ/cycle and 1.5kJ/cycle respectively. The two pistons were quantitatively compared in terms of thermal efficiency and combustion efficiency.

• 대한영상의학회지
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• 제85권1호
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• pp.222-229
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• 2024

신장의 동시성 악성종양은 드물게 발견되며, 신장 수술 후 진단된다. 신세포암과 요로상피세포암이 함께 동반되는 경우가 가장 많이 보고 되었다. 대부분의 경우 신세포암의 아형은 투명세포형 신세포암이지만, 동시성 집합관세포암종과 요로상피세포암이 동반되는 경우에 대한 보고는 매우 드물다. 동측 신장에서 발생한 동시성 집합관세포함종과 요로상피세포암의 2건의 증례를 보고한다.

• 한국간담췌외과학회지
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• 제27권4호
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• pp.433-436
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• 2023

Forty-five adults with type IV-A choledochal cysts (CDC) who underwent extrahepatic cyst excision from January 2013 to December 2021 were followed up for a median interval of 25 months (range, 2 to 10 years) to observe the long-term complications in the remaining intrahepatic cyst. Late complications in varying combinations were seen in 10 patients, which included cholangitis and/or intrahepatic stones in 9 patients, intrahepatic bile duct stenosis with stones in 2 patients, anastomotic stricture in 6 patients, and left lobar atrophy with intrahepatic stones in 3 patients. Out of 6 patients who required re-do hepaticojejunostomy (HJ), three patients had left lobe atrophy with patent HJ anastomosis and a recurrent attack of cholangitis on follow-up at 3, 8, and 10 years. Complications occur frequently after extrahepatic cyst excision for type IV-A CDC and require a long-term follow-up.

• IMMUNE NETWORK
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• 제12권1호
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• pp.33-39
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• 2012

Background: Therapeutic approaches using monoclonal antibodies (mAbs) against complement regulatory proteins (CRPs:i.e.,CD46,CD55 and CD59) have been reported for adjuvant cancer therapy. In this study, we generated a recombinant 1E8 single-chain anti-CD59 antibody (scFv-Fc) and tested anti-cancer effect.by using complement dependent cytotoxicity (CDC). Methods: We isolated mRNA from 1E8 hybridoma cells and amplified the variable regions of the heavy chain (VH) and light chain (VL) genes using reversetranscriptase polymerase chain reaction (RT-PCR). Using a linker, the amplified sequences for the heavy and light chains were each connected to the sequence for a single polypeptide chain that was designed to be expressed. The VL and VH fragments were cloned into the pOptiVEC-TOPO vector that contained the human CH2-CH3 fragment. Then, 293T cells were transfected with the 1E8 single-chain Fv-Fc (scFv-Fc) constructs. CD59 expression was evaluated in the prostate cancer cell lines using flow cytometry. The enhancement of CDC effect by mouse 1E8 and 1E8 scFv-Fc were evaluated using a cytotoxicity assay. Results: The scFv-Fc constructs were expressed by the transfected 293T cells and secreted into the culture medium. The immunoreactivity of the secreted scFv-Fc construct was similar to that of the mouse 1E8 for CCRF-CEM cells. The molecular masses of 1E8 scFv-Fc were about 120 kDa and 55 kDa under reducing and non-reducing conditions, respectively. The DNA sequence of 1E8 scFv-Fc was obtained and presented. CD59 was highly expressed by the prostate cancer cell line. The recombinant 1E8 scFv-Fc mAb revealed significantly enhanced CDC effect similar with mouse 1E8 for prostate cancer cells. Conclusion: A 1E8 scFv-Fc construct for adjuvant cancer therapy was developed.

• Journal of Nutrition and Health
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• 제32권8호
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• pp.887-896
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• 1999

The purpose of this research is to assess hematological and biochemical status and the prevalence of iron deficiency of pregnant women by gestational age to provide the primary data about iron nutritional status of pregnant women. Pregnant women visiting public health centers in Ulsan participated in study and were divided into 3 trimester by last menstrual period(LMP). Hemoglobin (Hgb), hematocrit(Hct)and mean corpuscular volume(MCV) among iron status indices were not statistically different from normal distribution, however total iron binding capacity(TIBC) and serum ferritin were skewed to left and serum iron and transferrin saturation(TS) were skewed to right. Hgb was positively correlated with Hct(r=0.93, p<0.001) but TIBC was negatively correlated with all indices. Serum ferritin was also correlated with all indices, especially in 3rd trimester but not reached to 1st trimester level. Mean corpuscular hemoglobin(MCH), mean corpuscular hemoglobin concentration(MCHC), Red cell distribution width(RDW), serum iron and TS were not significantly different by trimester, however when serum serum iron was adjusted with hematocrit to correct the hemodilution, it significantly decreased in 2nd trimester. MCV increased in 2nd trimester and was maintained until late pregnancy, TIBC continued to increase throughout the trimester. The prevalence of anemic by CDC(Centers for Disease Control) Hgb criteria(Hgb <11.0g/dl in 1st and 3nd trimester, Hgb<10.5g/dl in 2nd trimester) was 2.8% in 1st trimester, 22.5% in 2nd trimester, 27.1% in 3rd trimester and was similar with prevalence by CDC Hct criteria(Hct < 33% in 1st and 3rd, Hct < 32% in 2nd). The prevalence of anemic of total subjects was 32.7% by WHO criteria(Hgb < 11.0g/dl). Although almost iron status indices increased in 3rd trimester, the prevalence of anemia by different criteria of all indices increased throughout the trimester, so iron nutritional status was considered as serious during late pregnancy. However, since factors other than iron deficiency, such as infection, infection, inflammation, other nutrient deficiency may also play a significant role, to differentiate the anemia due to mainly iron deficiency from the anemia due to other factors, serum ferritin is among the more useful indices in distinguishing the two conditions because it is depressed only in iron deficiency. Hgb<11.0g/dl and serum ferritin<12.0ug/L as the criteria of iron deficiency was suggested by CDC. 17.8% of all subjects were classified as iron deficient anemia, 14.9% as anemic from other reasons, 21.2% as iron deficiency any only 46.2% were in normal iron status.

• Journal of Microbiology and Biotechnology
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• 제14권5호
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• pp.978-984
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• 2004

In the course of screening for a novel inhibitor of CDC2, HY558-1 was isolated from a culture broth of Penicillium minioluteum F558. Moreover, it was found that HY558-1 had an effect on both the cell cycle regulation and apoptosis of human cervical adenocarcinoma HeLa cells. A flow cytometric analysis of HeLa cells revealed appreciable cell cycle arrest at the G1 and G2/M phases following treatment with HY558-1. Furthermore, DNA fragmentation due to apoptosis was observed in HeLa cells treated with HY558-1. To obtain further information on the cell cycle arrest and apoptotic induction induced by HY558-1, the expression of certain cell cycle and apoptosis-associated proteins was examined using a Western blot analysis. The results revealed that HY558-1 inhibited the phosphorylation of pRb and decreased the expression levels of CDK2, CDC2, and cyclin A in the cell cycle progression. It was also shown that the level of $p21^{WAF1/CIP1}$ was increased in HeLa cells treated with 0.52 mM of HY558-1. Accordingly, HY558-1 was found to inhibit the proliferation of HeLa cells through the induction of G1 phase arrest by inhibiting pRb phosphorylation via an upregulation of $p21^{WAF1/CIP1}$, and G2/M phase arrest by directly inhibiting CDC2 and cyclin A. Moreover, HeLa cells treated with 0.52 mM of HY558-1 exhibited apoptotic induction associated with the cleavage of Bid and release of cytochrome c from mitochondria into the cytosol. Subsequent investigation of the activation of caspase-3 and cleavage of poly (ADP-ribose) polymerase (PARP) suggested that the mitochondrial pathway was primarily involved in the HY558-1-induced apoptosis in HeLa cells.