• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2023년도 학술발표회
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• pp.163-163
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• 2023

Flooding has become an increasing event which is one of the major natural disasters responsible for direct economic damage in South Korea. Driven by climate change, precipitation extremes play significant role on the flood damage and its further increase is expected to exacerbate the socioeconomic impact in the country. However, the empirical evidence associating changes in precipitation extremes to the historical flood damage is limited. Thus, there is a need to assess the causal relationship between changes in precipitation extremes and flood damage, especially in agricultural region like Chungcheong region in South Korea. The spatial and temporal changes of precipitation extremes from 10 synoptic stations based on daily precipitation data were analyzed using the ClimPACT2 tool and Mann-Kendall test. The four precipitation extreme indices consisting of consecutive wet days (CWD), number of very heavy precipitation wet days (R30 mm), maximum 1-day precipitation amount (Rx1day), and simple daily precipitation intensity (SDII), which represent changes in intensity, frequency, and duration, respectively, and the time series data on flooded area and flood damage from 1985 to 2020 were used to investigate the causal relationship in the ARDL-ECM framework and pairwise Granger causality analysis. The trend results showed that majority of the precipitation indices indicated positive trends, however, CWD showed no significant changes. ARDL-ECM framework showed that there was a long-run relationship among the variables. Further analysis on the empirical results showed that flooded area and Rx1day have significant positive impacts on the flood damage in both short and long-runs while R30 mm only indicated significant positive impact in the short-run, both in the current period, which implies that an increase in flooded area, Rx1day, and R30 mm will cause an increase in the flood damage. The pairwise Granger analysis showed unidirectional causality from the flooded area, R30 mm, Rx1day, and SDII to flood damage. Thus, these precipitation indices could be useful as indicators of pluvial flood damage in Chungcheong region of South Korea.

• 한방비만학회지
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• 제23권2호
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• pp.78-85
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• 2023

Objectives: Weight gain is one of the symptoms of hypothyroidism and it could deteriorate thyroid function. Our objectives are to evaluate weight changes and analyze adverse events in overweight and obese women with hypothyroidism who were prescribed Gamitaeeumjowee-tang. Methods: A retrospective chart review was conducted using medical records of patients with hypothyroidism, who had body mass indexes (BMI) above 23 and were prescribed Gamitaeeumjowee-tang for 12 weeks between August 2017 and November 2022. Reported adverse events (AEs) were assessed by severity, causality and system-organ classes. Results: Thirty patients were included (mean±standard deviation, age 46.10±9.94 years, weight 70.52±11.18 kg, BMI 28.30±3.80 kg/m²). The mean total weight loss of hypothyroidism patients was 5.45±2.77 kg, while the mean weight loss rate and mean BMI change were 7.66±3.41% and 2.18±1.07 kg/m², respectively. Among evaluated causality of adverse events, 'Unlikely' was predominant (80.8%) and severity assessment showed most of the symptoms were mild (91.7%). Conclusions: Gamitaeeumjowee-tang could be an option for hypothyroidism patients, who are overweight or obese, to lose weight and no serious adverse events occurred. Further well-designed clinical studies are recommended.

• Journal of Yeungnam Medical Science
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• 제37권1호
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• pp.2-12
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• 2020

Drug-induced liver injury (DILI), including herbal and dietary supplement hepatotoxicity, is often passed lightly; however, it can lead to the requirement of a liver transplant or may even cause death because of liver failure. Recently, the American College of Gastroenterology, Chinese Society of Hepatology and European Association for the Study of the Liver guidelines for the diagnosis and treatment of DILI have been established, and they will be helpful for guiding clinical treatment decisions. Roussel Uclaf Causality Assessment Method scoring is the most commonly used method to diagnose DILI; however, it has some limitations, such as poor validity and reproducibility. Recently, studies on new biomarkers have been actively carried out, which will help diagnose DILI and predict the prognosis of DILI. It is expected that the development of new therapies such as autophagy inducers and various other technologies of the fourth industrial revolution will be applicable to DILI research.

• The Korean journal of internal medicine
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• 제33권6호
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• pp.1203-1209
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• 2018

Background/Aims: Adverse drug reaction (ADR) is an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product. The present study was conducted in order to monitor the frequency and severity of ADR during antimicrobial therapy of septicemia. Methods: A prospective, observational, and noncomparative study was conducted over a period of 6 months on patients of septicemia admitted at a university hospital. Naranjo algorithm scale was used for causality assessment. Severity assessment was done by Hartwig severity scale. Results: ADRs in selected hospitalized patients of septicemia was found to be in 26.5% of the study population. During the study period, 12 ADRs were confirmed occurring in 9, out of 34 admitted patients. Pediatric patients experienced maximum ADRs, 44.4%. Females experienced a significantly higher incidence of ADRs, 66.7%. According to Naranjo's probability scale, 8.3% of ADRs were found to be definite, 58.3% as probable, and 33.3% as possible. A higher proportion of these ADRs, 66.7% were preventable in nature. Severity assessment showed that more than half of ADRs were moderate. Teicoplanin was found to be the commonest antimicrobial agent associated with ADRs, followed by gemifloxacin and ofloxacin. Conclusions: The incidence and severity of ADRs observed in the present study was substantially high indicating the need of extra vigilant during the antimicrobial therapy of septicemia.

• 수면정신생리
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• 제24권2호
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• pp.86-96
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• 2017

목 적 : 본 연구는 폐쇄성 수면무호흡증 환자에서 수면무호흡지수, 수면관련척도, 기분관련척도, 그리고 인지기능간의 연관성을 보고자 하였다. 방 법 : 폐쇄성 수면무호흡증후군을 보이는 105명의 환자를 선정하였다. 수면무호흡지수로 RDI, AHI가 사용되었고, 수면관련척도로는 PSG에서 측정되는 TST, Duration N1, Duration N2, Duration N3, Duration R, Arousal Index, PLM Index, Snoring Index, Mean SpO2, Minimum SpO2와 설문지로 측정되는 PSQI, ESS, SIS (snoring index by scale)를 사용하였으며 기분관련척도로는 BDI, 인지기능관련 척도로는 Moca-K, MMSE-K, CDR을 사용하였다. 이를 이용하여 수면무호흡증 환자에서 수면무호흡지수, 수면 및 기분관련척도와 인지기능간의 상관관계를 분석하였으며 수면무호흡증 환자에서 보이는 인지기능장애의 기전을 밝히고자 우울증의 매개효과를 분석하였다. 결 과 : Duration N1가 증가할수록 그리고 TST가 감소할수록 MOCA-K에 부적 인과관계를 나타내었다(p < 0.01). BDI와 Supine RDI가 증가할수록 MOCA-K에 부적 인과관계를 보였다(p < 0.01). PSQI가 증가할수록(p < 0.001) 그리고 MMSE-K가 감소할수록(p < 0.01) 또한 SIS가 증가할수록(p < 0.01) BDI에 정적 인과관계를 보였다. 폐쇄성수면무호흡증 환자에서 나이가 MOCA-K에 미치는 영향에 BDI가 부분 매개하는 것으로 확인되었다. 결 론 : 수면무호흡증 환자에서 Duration N1, TST, BDI, Supine RDI가 인지기능과 연관성이 있었으며, 특히 BDI로 측정되는 우울증상이 수면무호흡증 환자의 인지기능저하에 부분적으로 매개 하였다.

• 치위생과학회지
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• 제19권2호
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• pp.86-95
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• 2019

The modern era of microbial genome analysis began in earnest in the 2000s with the generalization of metagenomics and gene sequencing techniques. Studying complex microbial community such as oral cavity and colon by a pure culture is considerably ineffective in terms of cost and time. Therefore, various techniques for genomic analysis have been developed to overcome the limitation of the culture method and to explore microbial communities existing in the natural environment at the gene level. Among these, DNA fingerprinting analysis and microarray chip have been used extensively; however, the most recent method of analysis is metagenomics. The study summarily examined the overview of metagenomics analysis techniques, as well as domestic and foreign studies on disease genomics and cluster analysis related to oral metagenome. The composition of oral bacteria also varies across different individuals, and it would become possible to analyze what change occurs in the human body depending on the activity of bacteria living in the oral cavity and what causality it has with diseases. Identification, isolation, metabolism, and presence of functional genes of microorganisms are being identified for correlation analysis based on oral microbial genome sequencing. For precise diagnosis and treatment of diseases based on microbiome, greater effort is needed for finding not only the causative microorganisms, but also indicators at gene level. Up to now, oral microbial studies have mostly involved metagenomics, but if metatranscriptomic, metaproteomic, and metabolomic approaches can be taken together for assessment of microbial genes and proteins that are expressed under specific conditions, then doing so can be more helpful for gaining comprehensive understanding.

• 대한한방내과학회지
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• 제30권1호
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• pp.181-190
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• 2009

It is important to establish the safety of herbal medicine because of its frequent and widespread use in Korea. Several studies on the safety of herbal medicine have been performed and there have been rare serious adverse drug reactions from those reports in Korea. However, the results are not strongly supported because of not adopting appropriate enough research methodology as to make the safety issue clear. For improving the quality of the safety research on herbal medicine. including investigations of drug induced liver injury (DILl). the aim of this study was to suggest herbal medicine-induced liver injury investigation forms for performing reasonable safety research. After a systematic review of the preceding studies regarding herbal safety in Korea was performed in 2008, we assessed the quality and the limitations of the primary studies. Two investigation forms for herbal safety research were made as a following step. one a basic investigation form for herbal safety research and the other an advanced investigation form for suspected DILl cases, Those forms include the essential informations and data needed to make an appropriate assessment of whether DILl occurred during or after the use of herbal medicine. Guidelines for using those forms and other recommendations were also suggested. More rigorous studies are required for answering the safety issue of herbal medicine as well as the efficacy issue. We hope for wide use and improvement of those investigation forms in the study of herbal safety by many researchers for establishing better evidences in Korea.

• 대한토목학회논문집
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• 제41권2호
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• pp.113-121
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• 2021

폭염의 발생 메커니즘은 대부분 종관 규모적 관점에서 연구가 이루어지고 있으나, 폭염발생 이전의 또 다른 자연재해로 인한 연쇄적인 영향을 해석하기 위한 연구도 중요하다. 본 연구에서는 폭염 발생 이전에 나타나는 가뭄과의 인과관계 및 영향을 평가하기 위해 부분최소제곱 구조방정식 모형(PLS-SEM)을 이용하였다. 1974년부터 약 46년간 발생한 여름철 폭염에 미치는 계절별 가뭄의 영향정도는, 겨울철 서울(경기)지역은 37%, 강원지역은 21 %, 충청지역은 17 %이며, 봄철 서울(경기)지역은 29 %, 강원지역은 18 %, 충청지역은 8 %이며, 여름철 서울(경기)지역은 22 %, 강원지역은 29 %, 충청지역 38 %로 확인되었다. 이는 지역별로 나타나는 폭염과 계절별 가뭄이 미치는 영향의 정도가 다르기 때문에 따라 나타나는 결과로 해석된다. 여름철 가뭄-폭염 간의 영향이 크게 나타난 강원, 충청 지역은 서울(경기)지역에 비해 가뭄-폭염으로 인한 피해양상이 복합적으로 나타날 가능성이 있다.

• 한국해안·해양공학회논문집
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• 제33권6호
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• pp.246-256
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• 2021

연안을 중심으로 시행되는 각종 개발사업은 표사수지 불균형, 연안표사 이동상 및 횡단표사 이동상 변화를 야기하며, 이로 인한 해빈의 완충구간 축소로 연안재해 위험성을 크게 증대시킬 뿐 아니라 회복 불가능한 장기적 해안침식 문제를 초래하게 된다. 연안개발을 위해 건설된 각종 구조물의 영향으로 발생되는 장기적·지속적인 해안침식 현상은 표사수지 및 연안표사와 횡단표사 변화량 평가를 통해 직접적인 원인 규명이 가능하다. 즉, 표사수지 변화, 연안표사 이동, 횡단표사 이동 구분되는 이들 개별적인 원인에 기인한 침식지역과 복합적인 작용에 의한 침식지역의 분류를 통해 연안개발과 해안침식 현상의 인과성 평가가 가능할 것이다. 본 연구에서는 연안개발에 따른 침식 문제가 지속적으로 제기되고 있는 동해안(강원도, 경상북도) 일대 해안을 대상으로 연안 구조물 건설 및 육역 개발 등 주요 개발현황과 연안침식 실태조사 결과를 기반으로 장기적·지속적 침식원인을 분석하였다. 아울러 인공구조물 건설에 따른 침식의 정도를 평가하고자 침식 영향도 개념을 정립하고, 침식 영향도 평가를 위한 세 가지 방법론을 제안하였다. 연안침식 실태조사에서 검토된 해빈 영상분석 자료를 활용하여 하저항을 대상으로 침식 영향도를 평가하였으며, 평가결과 하저항 개발은 93.4%, 호안도로 건설은 6.6%로 침식에 영향을 미친것으로 평가되었다.

• 대한한의학회지
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• 제30권2호
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• pp.30-45
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• 2009

Background: The safety of herbal products is an important issue in Korea. It is more complicated because of the concomitant use of conventional western drugs and herbal medicine, including prescribed medicine, folk herbs and food supplements. Although both western and traditional Korean medical doctors have studied on the safety of HMP, their results did not show relevant or consistent conclusions because of the poor quality of studies, including bias. Objectives: The aim of this study was to review the studies in Korea related to drug induced liver injury (DILI) systematically. We tried to estimate the proportion of causative materials of DILI and evaluate the clinical difference of DILIs from different materials. Methods: Systematic searches were performed on MedRIC and MEDLIS in Korea. The extraction of data as well as selective screening of the studies was carried out independently by two of the authors. There were no restrictions on the types of publication, including grey literature. Results: Twenty-one articles were included. Of them only 7 adapted prospective design and only 6 were published in peer-reviewed journals. The proportion of conventional drugs associated with hepatotoxic injuries in all DILI ranged from 15.8% to 83.3% and that of herbal medicine was from 28.9% to 44.7%. However, the criteria for herbal medicine were not clearly defined and concomitant medications were not fully investigated in most studies. There were limited objective data in the clinical differences of liver injuries from different materials and their results were conflicting. Conclusions: The causality assessments regarding DILI of herbal medicine were not performed properly and causative materials were misclassified in most of the studies published in Korea. These make the safety issue still ambiguous because of the limitations and lack of objectivity of the studies. More rigorous studies are required for clearly addressing these conflicting issues with cooperative investigation between traditional Korean and western medicine.