• Tuberculosis and Respiratory Diseases
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• v.74 no.6
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• pp.256-263
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• 2013

Background: Health status measure is not only important for clinical research studies but also for clinical practices of chronic obstructive pulmonary disease (COPD) patients. The objective of this study is to evaluate the validity of the Korean Version of COPD Assessment Test (CAT) in primary care clinics as well as in referral hospitals. Methods: Smokers or ex-smokers, aged 40 years or older, with a smoking history of >10 pack-years; and a COPD diagnosis in the past 6 months or more, were recruited from 4 primary care clinics and 2 referral hospitals. Demographic, medical, and spirometry data was collected from patients who completed the CAT and St. George Respiratory Questionnaire (SGRQ), and had their dyspnea been assessed. The primary endpoint was the correlation between of the Korean version of CAT with SGRQ in patients with COPD. Results: A total 100 patients were enrolled. The mean age and smoking amounts were $69.2{\pm}8.4$ years and $40.6{\pm}22.3$ pack-years, respectively. Sixty-seven percent of the patients reported at least one exacerbation in the past year. The mean CAT score was $16.9{\pm}8.0$. The internal consistency assessed by Cronbach's alpha was 0.85. The CAT score was positively correlated with the SGRQ score (r=0.76, p<0.0001) and each component of SGRQ: symptoms, activity and impacts; r=0.68, r=0.61, and r=0.72, respectively (all p<0.0001). These positive correlations were preserved in the different groups (r=0.86, p<0.0001 in primary care clinic group; r=0.69, p<0.0001 in hospital group). The CAT score was also positively correlated to the Medical Research Council dyspnoea scale (r=0.46, p<0.0001). Conclusion: The Korean version of CAT had good internal consistency and showed good correlations with SGRQ. It can be used for assessing the impacts of COPD on the patient's health including primary care setting.

• Journal of Navigation and Port Research
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• v.46 no.6
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• pp.509-516
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• 2022

Recently, ships have begun using the Asterix CAT 240 format as a method for transmitting radar image data to other devices. However, the Asterix format has a flexible structure that can be defined by the user, and a format structure defined as unsuitable for ship radar operation may undesirably increase navigational equipment network traffic or reduce stability. Therefore, to reduce the traffic of the navigation network and enhance the stability, a method of defining the optimized Asterix CAT 240 format with an appropriate setting value according to the performance of the radar scanner and display device was studied.

• Journal of Microbiology and Biotechnology
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• v.31 no.2
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• pp.259-271
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• 2021

Many bacteria metabolize aromatic compounds via catechol as a catabolic intermediate, and possess multiple genes or clusters encoding catechol-cleavage enzymes. The presence of multiple isozyme-encoding genes is a widespread phenomenon that seems to give the carrying strains a selective advantage in the natural environment over those with only a single copy. In the naphthalene-degrading strain Pseudomonas putida ND6, catechol can be converted into intermediates of the tricarboxylic acid cycle via either the ortho- or meta-cleavage pathways. In this study, we demonstrated that the catechol ortho-cleavage pathway genes (catBICIAI and catBIICIIAII) on the chromosome play an important role. The catI and catII operons are co-transcribed, whereas catAI and catAII are under independent transcriptional regulation. We examined the binding of regulatory proteins to promoters. In the presence of cis-cis-muconate, a well-studied inducer of the cat gene cluster, CatRI and CatRII occupy an additional downstream site, designated as the activation binding site. Notably, CatRI binds to both the catI and catII promoters with high affinity, while CatRII binds weakly. This is likely caused by a T to G mutation in the G/T-N11-A motif. Specifically, we found that CatRI and CatRII regulate catBICIAI and catBIICIIAII in a cooperative manner, which provides new insights into naphthalene degradation.

• Tuberculosis and Respiratory Diseases
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• v.71 no.4
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• pp.271-277
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• 2011

Background: A chronic obstructive pulmonary disease (COPD) assessment test (CAT) has recently been developed as a short and simple method for assessing the quality of life in COPD patients. The object of this study was to assess the usefulness of the Korean version of the CAT for assessing COPD patients in an outpatient clinic. Methods: The study included 60 COPD patients in a stable state from an outpatient clinic. The authors investigated the frequency of acute exacerbation during aprevious year through reviewing medical records. We evaluated the spirometry test, a 6-min walk distance test, and obtained the MMRC dyspnea scale, the Korean version of the CAT, and the BODE index at the time of visit. To assess the usefulness of the CAT, correlations between the CAT and other methods were evaluated. Results: The mean age of patients was $68.3{\pm}8.6$ years and 95% of patients were male. There was a significant correlation between the CAT score and $FEV_1%$ (r=-0.323, p=0.012), the frequency of acute exacerbation (r=0.292, p=0.024), the MMRC dyspnea scale (r=0.554, p<0.001), the BODE index (r=0.380, p=0.003), and 6 MWD (r=-0.372, p=0.004). The mean CAT score increased according to the GOLD stage (stage 1, $10.7{\pm}4.5$; stage 2, $13.1{\pm}7.9$; stage 3, $16.3{\pm}6.2$; stage 4, $16.5{\pm}14.8$; p=0.746). Conclusion: The CAT was shown to be useful for the assessment of COPD severity. Therefore, the CAT is an easily applied and simple method for assessing COPD severity in an outpatient clinic.

• Parasites, Hosts and Diseases
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• v.62 no.3
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• pp.330-341
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• 2024

The Trichinella spiralis novel cystatin (TsCstN) inhibits cathepsin L (CatL) activity and inflammation of macrophages during lipopolysaccharide (LPS) induction. To identify the protease inhibitory region, this study applied an in silico modeling approach to simulate truncation sites of TsCstN (Ts01), which created four truncated forms, including TsCstN^∆1-39 (Ts02), TsCstN^∆1-71 (Ts03), TsCstN^{∆1-20, ∆73-117} (Ts04), and TsCstN^{∆1-20, ∆42-117} (Ts05). The superimposition of these truncates modeled with AlphaFold Colab indicated that their structures were more akin to Ts01 than those modeled with I-TASSER. Moreover, Ts04 exhibited the closest resemblance to the structure of Ts01. The recombinant Ts01 (rTs01) and truncated proteins (rTs02, rTs03, and rTs04) were successfully expressed in a prokaryotic expression system while Ts05 was synthesized, with sizes of approximately 14, 12, 8, 10, and 2.5 kDa, respectively. When determining the inhibition of CatL activity, both rTs01 and rTs04 effectively reduced CatL activity in vitro. Thus, the combination of the α1 and L1 regions may be sufficient to inhibit CatL. This study provides comprehensive insights into TsCstN, particularly regarding its protein function and inhibitory domains against CatL.

• Bulletin of the Korean Mathematical Society
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• v.36 no.4
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• pp.671-682
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• 1999

Using a base-point free version of the infinite symmetric product we define a fibrewise infinite symmetric product for any fibration $E\;\longrightarrow\;B$. The construction works for any commutative ring R with unit and is denoted by $R_f(E)\;l\ongrightarrow\;B$. For any pointed space B let $G_I(B)\;\longrightarrow\;B$ be the i-th Ganea fibration. Defining $M_R-cat(B):= inf{i\midR_f(G_i(B))\longrihghtarrow\;B$ admits a section} we obtain an approximation to the Lusternik-Schnirelmann category of B which satisfies .g.a product formula. In particular, if B is a 1-connected rational space of finite rational type, then $M_Q$-cat(B) coincides with the well-known (purely algebraically defined) M-category of B which in fact is equal to cat (B) by a result of K.Hess. All the constructions more generally apply to the Ganea category of maps.

• YAKHAK HOEJI
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• v.39 no.6
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• pp.676-680
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• 1995

The nucleotide sequence of Xbal-Mbol fragment of pKH7, a chloramphenicol-resistant($Cm^{r}$) plasmid isolated from multidrug-resistant S. aureus SA2, has been determined. Xbal-Mbol fragment of pKH7 was found to contain two ORFs. One ORF encoded Rap and the other encoded CAT protein. The deduced amino acid sequences of Rep and CAT of pKH7 were compared to those of pUB112 and pC221. Comparisons revealed that there was one amino acid difference in CAT between pKH7 and pUB112. CAT of pKH7 exhibited 98.6% amino acid identity to that of pC221. In case of Rep proteins, a slightly lower homology of 96.4% and 86.7% in amino acid sequences was observed between pKH7 and pUB112 and between pKH7 and pC221, respectively.

• Tuberculosis and Respiratory Diseases
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• v.72 no.6
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• pp.467-474
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• 2012

Background: The objective of this study was to assess the validity and reliability of the Korean version of chronic obstructive pulmonary disease assessment test (CAT) and Dyspnea-12 Questionnaire for patients with bronchiectasis or tuberculous destroyed lung. Methods: For 62 bronchiectasis patients and 37 tuberculous destroyed lung patients, 3 questionnaires including St. George's Respiratory Questionnaires (SGRQ), CAT, and Dyspnea-12 were obtained, in addition to spirometric measurements. To assess the validity of CAT and Dyspnea-12, correlation with SGRQ was evaluated. To assess the reliability of CAT and Dyspnea-12, Cronbach's ${\alpha}$ coefficient was calculated. Results: The mean ages of the patients were $60.7{\pm}8.3$ years in bronchiectasis and $64.4{\pm}9.3$ years in tuberculous destroyed lung. 46.8% and 54.1% were male, respectively. The SGRQ score was correlated with the score of the Korean version of CAT (r=0.72, p<0.0001) and Dyspnea-12 (r=0.67, p<0.0001) in bronchiectasis patients. The SGRQ score was correlated with the score of CAT (r=0.86, p<0.0001) and Dyspnea-12 (r=0.80, p<0.0001) in tuberculous destroyed lung patients. The Cronbach's ${\alpha}$ coefficient for the CAT and Dyspnea-12 were 0.84 and 0.90 in bronchiectasis, and 0.88 and 0.94 in tuberculous destroyed lung, respectively. Conclusion: We found that Korean version of CAT and Dyspnea-12 are valid and reliable in patients with tuberculous destroyed lung and bronchiectasis.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.186-186
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• 2018

본 연구에서는 매개변수 자동 보정기법인 PEST(Model-Independent Parameter Estimation and Uncertainty Analysis)를 CAT 모형에 연계하여 유출특성 분석을 실시하였다. CAT-PEST 연계모형은 CAT 모형의 모의유출량을 이용하며 PEST의 반복계산을 통하여 최적 매개변수를 추정한다. 침투방법은 CAT에서 제공하는 Rainfall Excess 방법, Green and Ampt 방법 및 Horton 방법을 이용하였으며 각 침투방법에 따른 유출 특성을 비교 및 분석하였다. 연구대상유역은 보령 댐 유역으로 유역면적은 $163.7km^2$이며 전체면적의 약 80%가 산지로 구성되어 있고, 유로연장은 22.3km, 유역평균경사는 40.19%이다. 또한 보령댐 유역의 월평년값 평균기온은 -0.8에서 $25.5^{\circ}C$로 계절변동이 매우 큰 것을 알 수 있다. 최근 몇 년간 심각한 가뭄 피해를 입은 보령댐 유역은 2016년에 도수관로를 완공하여 이를 통해 금강으로부터 물을 끌어다 쓰고 있는 실정이며, CAT 모형에서는 금강도수유입량을 외부유입 처리하여 유출량을 산정하였다. 모의기간은 1999년부터 2017년까지이며 전체기간에 대한 보정 후 연도별 보정을 실시하였다. 통계적 평가수단은 $R^2$, RMSE 및 NSE를 사용하여 유역 최종출구점에서의 유출량과 비교하였으며 전체기간에 대한 보정결과 NSE와 $R^2$가 0.75 이상으로 나타나 대체적으로 모의 유출수문곡선이 관측 수문곡선과 유사한 양상을 보였다.

• Korean Journal of Veterinary Research
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• v.56 no.2
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• pp.121-123
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• 2016

A 7-year-old castrated male domestic short-hair cat presented with anorexia, constipation, depression, and voice alteration. Physical and neurological examinations revealed hyperthermia ($40.5^{\circ}C$), ventroflexion of the neck, reduced responses to external stimuli, generalized muscle weakness, and exercise intolerance. Thoracic radiographs revealed the presence of a cranial mediastinal mass. The history, clinical signs, and other examination results were compatible with acquired myasthenia gravis (MG). Acetylcholine receptor (AChR) antibody titers were determined to confirm MG and the serum AChR antibody concentration was 1.24 nmol/L (reference interval, < 0.3 nmol/L). This is the first diagnosis of acquired MG in a cat in Korea.