• Title/Summary/Keyword: Castor Oil

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Evaluation of antidiarrhoeal activity of Cardamom (Elettaria cardamomum) on mice models

  • Rahman, Tasmina;Rahman, Khandaker Ashfaqur;Rajia, Sultana;Alamgir, Mahiuddin;Khan, Mahmud Tareq Hassan;Choudhuri, M Shahabuddin Kabir
    • Advances in Traditional Medicine
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    • v.8 no.2
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    • pp.130-134
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    • 2008
  • Diarrhoea is a major health care problem in developing countries. Elettaria cardamomum Maton fruits, commonly known as cardamom are widely used for flavoring purposes in food. In this study we evaluated the antidiarrhoeal activity of hot water extract of cardamom against experimental diarrhoeal models on mice. Cardamom extract showed significant antidiarrhoeal activity against castor oil and magnesium sulphate induced models. Whereas, the gastrointestinal motility was slightly increased.

Pharmacological findings of an Indian traditional Ayurvedic herbalformulation Amritaristo

  • Masuma, Runa;Choudhuri, MSK;Rajia, Sultana;Alamgir, Mahiuddin
    • Advances in Traditional Medicine
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    • v.8 no.3
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    • pp.215-221
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    • 2008
  • In this present study Indian traditional Ayurvedic herbal formulation Amritaristo has been studied to assess the general pharmacological effect on mice. The drug showed no significant activity on the neuropharmacological test models experimented. The increased pentobarbital sleeping time was considered related with hepatic metabolism of pentobarbital. The formulation exhibited a non-significant reduction of gastrointestinal motility, and devoid of any acute diuretic activity. The tested drug revealed antidiarrhoeal activity on castor oil-induced model, whereas on magnesium sulphate-induced model no effect was observed.

Antidiarrheal Evaluation of Ficus racemosa Linn. Leaf Extract

  • Mandal, Subhash C.;Mukherjee, Pulok K.;Saha, Kakali;Pal, M.;Saha, B.P.
    • Natural Product Sciences
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    • v.3 no.2
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    • pp.100-103
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    • 1997
  • A study was undertaken to evaluate the effect of petroleum ether extract of leaves of Ficus racemosa Linn. for its antidiarrheal potential against several experimental models of diarrhea in rats. Ficus racemosa leaves extract (FRLE) treated animals showed significant inhibitory activity against castor oil induced diarrhea and inhibited significantly $PGE_2$ induced enteropooling in rats. It also showed significant reduction in gastrointestinal motility following charcoal meal in rats. The results obtained establish the efficacy of FRLE as an antidiarrheal agent.

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THE ACUTE TOXICITY TEST OF A NOVEL MICELLAR SOLUBILIZER FOR USE WITH INJECTABLE ANTICANCER AGENTS

  • Kim, Y.W.;Min, K.N.;Pan, S.R.;Ok, K.E.;Lee, M.J.;Kim, J.J.;Sheen, Y.Y.
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.130-130
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    • 2001
  • The commercially available paclitaxel product, Taxol$\circledR$ is currently formulated in a vehicle containing approximately a 1:1 v/v mixture of polyoxyethylated castor oil (Cremophor EL) and ethanol. Cremophor EL, a commonly used surfactant for lipophilic compounds, has been associated with many issues, such as adverse effects particularly following rapid administration, stability with the possibility for drug precipitation upon dilution, and filtering requirements.(omitted)

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Histological effects of ricin on liver, spleen, thymus, lung and heart of mouse (Ricin의 독성이 생쥐의 간. 비장, 흉성, 폐 및 심장에 미치는 영향에 관한 조직학적 연구)

  • 유명희;김지혜;김재호
    • Journal of Life Science
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    • v.11 no.2
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    • pp.111-120
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    • 2001
  • The pathological aspects of purified ricin from the seeds of the castor oil plant, Ricinus communis, were examined, using light and transmission electron microscopy. ICR mice were exposed to ricin by peritoneal injection with 100 ng/1 $m\ell$ PBS(pH 7.0) mouse and histological observations on the liver, spleen, thymus, lung and heart were carried out at intervals up to 48 h after exposures. All the organs examined were damaged by ricin. Among the organs, the spleen and thymus; immune organs were the most sensitive to ricin, whereas the effect delayed in the liver, lung and heart. Furthermore, the immune cells in each organ were the most sensitive to ricin. Accordingly, the effect of ricin on the organs seems to be affected by the immune cells existed in each organ, In each organ, the immune cells showed apoptotic changes, while the capillary endothelial and parenchymal cells showed necrotic changes.

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Preliminary pharmacological evaluation of an Ayurvedic formulation Dasamularista

  • Rajia Sultana;Choudhuri M Shahabuddin Kabir;Sattar Mafruhi;Shahriar Masum
    • Advances in Traditional Medicine
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    • v.6 no.3
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    • pp.208-214
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    • 2006
  • In this study the Ayurvedic formulation Dasamularista was studied for its preliminary pharmacological properties using laboratory mice. Dasamularista showed a decrease in food intake and stool formation, while the water content of stool and water intake was higher and the volume of the urine was less. Dasamularista in a slight extent reduced the intestinal motility. This constipating effect was further supported by the significant anti-diarrhoeal property of the formulation in castor oil induced dairrhoea. The tested formulation markedly increased the latent period of diarrhoea and reduced the purging index value. Dasamularista did not alter the acetic acid induced abdominal writhing. Significant reduction on the onset of sleeping time and increased duration of sleep was observed in pentobarbital induced sleeping time test.

Synthesis of Durable Softner for Cotton Fabrics and Its Characterization (면직물용 내구성유연제의 합성과 그의 특성화)

  • Lee, Ki-Chang;Park, Hong-Soo
    • Journal of the Korean Applied Science and Technology
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    • v.7 no.1
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    • pp.87-91
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    • 1990
  • 1,3-Di(2-octadecanoyl)-2,7-dioxy-l,3,6,8-tetra aza cyclodecane [DDTC] was synthesized by reacting octadecanoic acid, 2,2'-di-aminodiethyl amine with urea. O/W type softner (STA) was prepared by blending DDTC and pentaerithritol monostearate with polyoxysthylene (20) oleyl ether, polyoxyethylene (10) castor oil, and PEG #1000-lauric acid ester. Treating STA to all cotton fabrics, the physical properties, such as tear strength, crease recovery, flexing abrasion resistance, and so on were measured. Resulting the measurements, STA was found to be durable softner with softness.

Antinociceptive and antidiarrhoeal activities of Sonneratia caseolaris

  • Ahmed, F;Baksi, B;Sadhu, SK;Shahid, IZ
    • Advances in Traditional Medicine
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    • v.7 no.3
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    • pp.274-279
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    • 2007
  • The crude ethanol extract of leaves of Sonneratia caseolaris Linn. (Sonneratiaceae) was screened for its antinociceptive and antidiarrhoeal activities. The extract produced significant writhing inhibition in acetic acid induced writhing in mice at dose of 250 and 500 mg/kg body weight (P<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. When tested for its antidiarrhoeal effects on castor oil induced diarrhea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 500 mg/kg body weight (P < 0.05) comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. The overall results tend to suggest the antinociceptive and antidiarrhoeal activities of the extract.

Antinociceptive and antidiarrhoeal activities of Bruguiera gymnorrhiza

  • Ahmed, F;Shahid, IZ;Gain, NC;Reza, MSH;Sadhu, SK
    • Advances in Traditional Medicine
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    • v.7 no.3
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    • pp.280-285
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    • 2007
  • The methanol extract of leaves of Bruguiera gymnorrhiza (L.) Lam. (Rhizophoraceae) was screened for its antinociceptive and antidiarrhoeal activities. The extract produced significant inhibition in acetic acid-induced writhing in mice at dose of 250 and 500 mg/kg body weight (P < 0.001), comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight (P < 0.001). When tested for its antidiarrhoeal effects on castor oil-induced diarrhea in mice, it increased mean latent period (P < 0.02) and decreased the frequency of defecation (P < 0.01) significantly at the dose of 500 mg/kg body weight, comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. The overall results tend to suggest the antinociceptive and antidiarrhoeal activities of the extract.

Synthesis and Properties of Ahcovel Type Durable Softner for Cotton Fabrics (Ahcovel계 면직물용 내구성 유연제의 합성과 물성연구)

  • Hong, Eui-Suk;Jeon, Young-Je;Ko, Jae-Yong;Park, Hong-Soo
    • Journal of the Korean Applied Science and Technology
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    • v.12 no.2
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    • pp.75-83
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    • 1995
  • 1, 3-Di(2-dodecanoylaminoethyl)-2, 7-dioxy-1, 3, 6, 8-tetraazacyclodecane[DDTD] and sorbitan monostearate(SMS) were synthesized as a main component for softner. O/W type softner(DSA) was prepared by blending of DSA, SMS, polyoxyethylene(10) castor oil, glyceryl monooleate, and polyoxyethylene(7) stearyl ether. After treatment of DSA to all cotton fabrics, the physical properties such as tear strength, crease recovery, and flexing abrasion resistance were measured. As a result of the measurement, DSA was found to be durable softner with good softness.