• Clinical and Experimental Pediatrics
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• 제46권2호
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• pp.203-206
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• 2003

저자는 우연히 발견된 무통성 종괴로 내원한 환아에서 소아과 영역에서 드문 Castleman 씨 병 2례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. 림프절 종창으로 추정되는 무통성의 종괴를 보이는 환아에서는 Castleman 씨 병을 감별 진단으로 반드시 고려해 보아야 할 것이다.

• 대한두경부종양학회지
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• 제20권2호
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• pp.194-197
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• 2004

Castleman's disease was first described from Benjamin Castleman in 1956. The disease today is enumerated among lymphoproliferative disorders and has unknown etiology. Although the mediastinum is a their most common location, they also occurs in other areas of the body, usually where lymph nodes are normally found. Castleman's disease of the neck is very rare. We describe a case of Castleman's disease of the neck in a middle aged man, and discuss the clinical presentation, radiological findings, and pathological features.

• Clinical and Experimental Pediatrics
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• 제48권4호
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• pp.443-447
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• 2005

저자들은 지속되는 발열, 빈혈, 혈소판 감소증, 흉수, 복수 및 간비종대 등의 비특이적인 전신증상을 주소로 내원한 13세 남아를 경부 림프절 조직 검사에서 혼합형의 Castleman병으로 진단한 후 스테로이드와 면역글로불린을 투여하여 호전된 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한두경부종양학회지
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• 제21권1호
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• pp.48-52
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• 2005

Objectives: Castleman's disease(CD) is a lymphoproliferative disorder of unknown etiology. To elucidate the clinicopathologic characteristics of CD, we retrospectively reviewed our experience. Methods: Fifteen patients with CD of the neck and mediastinum were identified. Patients were divided into two groups: group I had an unicentric CD and group II had multicentric CD. The histology of CD was divided into 3 subtypes: hyaline-vascular(HV), plasma cell(PC), and mixed. Results: The study included 12 cases of group I, 3 cases of group II in the clinical aspect and 10 cases with HV, 3 cases with PC, 2 cases with mixed type in the histologic aspect. Of group I patients who underwent complete surgical excision, all are currently free of disease. The clinical course of group II patients was variable. Of two patients with multicentric plasma cell CD who were treated, one remain free from disease and the other had a local recurrence in the neck. One patient with multicentric mixed CD died of disease after 30 months of presentation. Conclusion: Surgical resection is recommend for patients with the unicentric CD, regardless of histologic subtype. Patients with multicentric disease do not benefit from surgical resection and should be candidates for multimodality therapy.

• Tuberculosis and Respiratory Diseases
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• 제44권3호
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• pp.669-676
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• 1997

Castleman's disease is uncommon lymphoproliferative disorder as giant lymph node hyperplasia and angiofollicular lymph node hyperplasia. Multicentric variant of Castleman's disease, plasma cell type has been described that has more generalized lymph node involvement as well as involvement of other organ systems than localized type. Multicentric plasma cell type is frequently accompanied by systemic manifestations, such as weight loss, lowgrade fever and weakness. But the reported cases of pulmonary parenchymal involvement are rare and have almost consisted of hyalinized granuloma adjacent to a bronchus. We report a patient with Castleman's disease of the lung, pathologically proven interstitial pulmonary involvement.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제27권5호
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• pp.468-473
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• 2001

본 교실에서는 우측 악하부와 우측 안와 하부의 종창으로 내원한 53세 여자 환자에서 Fine Needle Aspiration Biopsy로 림프절의 반응성 과증식으로 진단되어 다시 절제 생검을 시행하여 multi-centric Castleman's disease로 진단하였다. 조직 검사상 유리질 혈관형과 형질세포형이 공존하는 복합형으로 나타났으며 병소의 적출술만을 시행한 후 1년이 지난 지금까지는 별다른 소견없이 좋은 경과를 나타내고 있으며 앞으로도 계속 주의깊은 관찰이 필요로 한다.

• 대한두경부종양학회지
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• 제31권1호
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• pp.14-17
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• 2015

Castleman's disease is an uncommon lymphoproliferative disorder. The disorder can be classified based on histological subtype, such as hyaline vascular type, plasma cell type, and mixed type, and can also be clinically divided into either unicentric or multicentric type. Its exact pathophysiology is not clearly identified. The unicentric type is able to be treated by surgical resection. However, there is no standard treatment modlity for the multicentric type. Treatment of multicentric type includes anti-cancer chemotherapy and radiation therapy. Recently, authors have experienced a rare case of unicentric type of Castleman's disease accompanying a mucoepidermoid carcinoma of parotid gland and report a case which is discussed with references.