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A Case of Systemic Castleman's Disease in a Child and Successful Treatment with Oral Prednisolone  

Koo, So Eun (Department of Pediatrics, University of Ulsan College of Medicine)
Lee, Mee Jeong (Department of Pediatrics, College of Medicine, Dankook University)
Kim, Jeong Eun (Department of Pediatrics, College of Medicine, Konkuk University)
Huh, Joo Ryung (Department of Pathology, University of Ulsan College of Medicine)
Ghim, Taed (Department of Pediatrics, University of Ulsan College of Medicine)
Publication Information
Clinical and Experimental Pediatrics / v.48, no.4, 2005 , pp. 443-447 More about this Journal
Abstract
Castleman's disease is a rare non-neoplastic lymphoproliferative disorder of unknown etiology. It is divided into three histologic subtypes; hyaline-vascular(HV), plasma cell(PC) type and mixed type (HV-PC). It has two clinical expressions. The localized form, which presents as a slow growing mass, has a relatively benign clinical course. The multicentric form is multilocated and holds significant morbidity. The mainstay of treatment of the localized form is surgical resection. The multicentric form requires medical treatment comprising prednisolone and other immunosuppressor drugs. The disease in children seems to have a more favorable course than in adults. We report a 13-year-old boy with Castleman's disease of multicentric form who was successfully treated with prednisolone and intravenous immunoglobulin.
Keywords
Castleman's disease; Child; Prednisolone; Immunoglobulin;
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