• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.324.2-325
• /
• 2002

Recent studies suggest that inflammatory events are implicated in a variety of human diseases including cancer and neurodegenerative diseases. and non-steroidal anti-inflammatory drugs have beneficial effects in treatment or prevention of these disorders. It has been reported that expression of cyclooxygenase (COX)-2 and nitric oxide synthase and subsequent production of prostaglandin (PG) and nitric oxide (NO). respectively are elevated in many inflammatory disorders. (omitted)

• Proceedings of the KSRS Conference
• /
• 2004.10a
• /
• pp.47-52
• /
• 2004

Interferometric synthetic aperture radar (InSAR) is a remote sensing technique capable of measuring ground surface deformation with sub-centimeter precision and spatial resolution in tens-of-meters over a large region. This paper highlights our on-going investigations of Aleutian volcanoes with SAR images acquired from European ERS-1 and ERS-2, Canadian Radarsat-l, and Japanese JERS-l satellites.

• 한국전산유체공학회:학술대회논문집
• /
• 2003.10a
• /
• pp.181-182
• /
• 2003

A preconditioned numerical method for gas-liquid to-phase flow is applied to solve cavitating flow. The present method employs a density based finite-difference method of dual time-stepping integration procedure and Roe's flux difference splitting approximation with MUSCL-TVD scheme. A homogeneous equilibrium cavitation model is used. The method permits simple treatment of the whole gas-liquid two-phase flow field including wave propagation, large density changes and incompressible flow characteristics at low Mach number. By this method, two-dimensional internal flows through a venturi tuve and decelerating cascades are computed and discussed.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2002.05a
• /
• pp.94-94
• /
• 2002

Oxidative stress induced by reactive oxygen and/or nitrogen species has been considered as a major cause of cellular injuries in a variety of neurodegenerative disorders including Alzheimer's disease (AD). Inflammatory as well as oxidative tissue damage has been implicated in pathophysiology of AD, and non-steroidal anti-inflammatory drugs have been reported to have beneficial effects in the treatment or prevention of AD.(omitted)

• Proceedings of the Optical Society of Korea Conference
• /
• 2008.02a
• /
• pp.283-284
• /
• 2008

In this paper, we report a broadband circular polarization reflectors and color separators realized as cascades of helical films with different pitch thickness. These helical films were prepared by glancing angle deposition technique.

• Korean Journal of Remote Sensing
• /
• v.21 no.1
• /
• pp.59-72
• /
• 2005

Interferometric synthetic aperture radar (InSAR) is a remote sensing technique capable of measuring ground surface deformation with sub-centimeter precision and spatial resolution in tens-of­meters over a large region. This paper describes basics of InSAR and highlights our studies of Alaskan volcanoes with InSAR images acquired from European ERS-l and ERS-2, Canadian Radarsat-l, and Japanese JERS-l satellites.

• Molecules and Cells
• /
• v.26 no.5
• /
• pp.503-513
• /
• 2008

The vomeronasal organ (VNO) is a sensory organ that influences social and/or reproductive behavior and, in many cases, the survival of an organism. The VNO is believed to mediate responses to pheromones; however, many mechanisms of signal transduction in the VNO remain elusive. Here, we examined the expression of proteins involved in signal transduction that are found in the main olfactory system in the VNO. The localization of many signaling molecules in the VNO is quite different from those in the main olfactory system, suggesting differences in signal transduction mechanisms between these two chemosensory organs. Various signaling molecules are expressed in distinct areas of VNO sensory epithelium. Interestingly, we found the expressions of groups of these signaling molecules in glandular tissues adjacent to VNO, supporting the physiological significance of these glandular tissues. Our finding of high expression of signaling proteins in glandular tissues suggests that neurohumoral factors influence glandular tissues to modulate signaling cascades that in turn alter the responses of the VNO to hormonal status.

• BMB Reports
• /
• v.47 no.6
• /
• pp.318-323
• /
• 2014

We isolated the phenolic glucoside salicortin from a Populus euramericana bark extract, and examined its ability to suppress inflammatory responses as well as the molecular mechanisms underlying these abilities, using lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Salicortin inhibited iNOS expression and the subsequent production of NO in a dose-dependent manner in the LPS-stimulated RAW 264.7 cells. Salicortin significantly suppressed LPS-induced signal cascades of NF-${\kappa}B$ activation, such as IKK activation, $I{\kappa}B{\alpha}$ phosphorylation and p65 phosphorylation in RAW 264.7 cells. In addition, salicortin inhibited the LPS-induced activation of JNK, but not ERK or p38 MAPK. Furthermore, salicortin significantly inhibited production of pro-inflammatory cytokines, such as TNF-${\alpha}$, IL-$1{\beta}$ and IL-6 in the LPS-stimulated RAW 264.7 cells. These findings suggest that salicortin may show its anti-inflammatory activity by suppressing the LPS-induced expression of pro-inflammatory mediators through inhibition of NF-${\kappa}B$ and JNK MAPK signaling cascades in macrophages.

• The Korean Journal of Physiology and Pharmacology
• /
• v.18 no.6
• /
• pp.517-524
• /
• 2014

Phasic and tonic ${\gamma}$-aminobutyric acidA ($GABA_A$) receptor-mediated inhibition critically regulate neuronal information processing. As these two inhibitory modalities have distinctive features in their receptor composition, subcellular localization of receptors, and the timing of receptor activation, it has been thought that they might exert distinct roles, if not completely separable, in the regulation of neuronal function. Inhibition should be maintained and regulated depending on changes in network activity, since maintenance of excitation-inhibition balance is essential for proper functioning of the nervous system. In the present study, we investigated how phasic and tonic inhibition are maintained and regulated by different signaling cascades. Inhibitory postsynaptic currents were measured as either electrically evoked events or spontaneous events to investigate regulation of phasic inhibition in layer 2/3 pyramidal neurons of the rat visual cortex. Tonic inhibition was assessed as changes in holding currents by the application of the $GABA_A$ receptor blocker bicuculline. Basal tone of phasic inhibition was maintained by intracellular $Ca^{2+}$ and $Ca^{2+}$/calmodulin-dependent protein kinase II (CaMKII). However, maintenance of tonic inhibition relied on protein kinase A activity. Depolarization of membrane potential (5 min of 0 mV holding) potentiated phasic inhibition via $Ca^{2+}$ and CaMKII but tonic inhibition was not affected. Thus, phasic and tonic inhibition seem to be independently maintained and regulated by different signaling cascades in the same cell. These results suggest that neuromodulatory signals might differentially regulate phasic and tonic inhibition in response to changes in brain states.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.8
• /
• pp.3293-3299
• /
• 2015

Background: Arm protein lost in epithelial cancers, on chromosome X (ALEX) is a novel subgroup within the armadillo (ARM) family, which has one or two ARM repeat domains as opposed to more than six-thirteen repeats in the classical Armadillo family members. Materials and Methods: In the study, we explore the biological functions of ALEX1 in breast cancer cells. Overexpression of ALEX1 and silencing of ALEX1 were performed with SK-BR3 and MCF-7 cell lines. Cell proliferation and colony formation assays, along with flow cytometry, were carried out to evaluate the roles of ALEX1. Results: ALEX1 overexpression in SK-BR3 breast cancer cells inhibited proliferation and induced apoptosis. Furthermore, depletion of ALEX1 in MCF-7 breast cancer cells increased proliferation and inhibited apoptosis. Additional analyses demonstrated that the overexpression of ALEX1 activated the intrinsic apoptosis cascades through up-regulating the expression of Bax, cytosol cytochrome c, active caspase-9 and active caspase-3 and down-regulating the levels of Bcl-2 and mitochondria cytochrome c. Simultaneouly, silencing of ALEX1 inhibited intrinsic apoptosis cascades through down-regulating the expression of Bax, cytosol cytochrome c, active caspase-9, and active caspase-3 and up-regulating the level of Bcl-2 and mitochondria cytochrome c. Conclusions: Our data suggest that ALEX1 as a crucial tumor suppressor gene has been involved in cell proliferation and apoptosis in breast cancer, which may serve as a novel candidate therapeutic target.