• The Plant Pathology Journal
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• v.26 no.2
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• pp.101-109
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• 2010

Protein phosphorylation is one of the major mechanisms for controlling many cellular processes in all living organisms. Mitogen-activated protein kinase (MAPK) cascades are known to transducer extracellular stimuli to several cellular processes, including cell division, differentiation as well as responses to various stresses. In plants, several studies have revealed that MAPK cascade pathways play an important role in responses against biotic and abiotic stresses, including wounding, pathogen infection, temperature, drought, salinity and plant hormones. It is also known that MAPK cascades-mediated signaling is an essential process in the resistance step to pathogens by regulating the activity of transcription factors. Here, the insights into the functions of MAPK cascade pathways in plant defense response signaling from Arabidopsis, tobacco and rice are described.

• Interdisciplinary Bio Central
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• v.5 no.3
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• pp.6.1-6.7
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• 2013

Many insects such as mosquitoes cause life-threatening diseases such as malaria, yellow fever and West Nile virus. Malaria alone infects 500 million people annually and causes 1-3 million death per year. Volatile insect repellents, which are detected through the sense of smell, have long been used to protect humans against insect pests. Antifeed-ants are non-volatile aversive compounds that are detected through the sense of taste and prevent insects from feeding on plants. The molecular targets and signaling path-ways required for sensing insect repellents and antifeedants are poorly understood. Transient Receptor Potential (TRP) Ca2+-permeable cation channels exist in organisms ranging from C. elegans to D. melanogaster and Homo sapiens. Drosophila has 13 family members, which mainly function in sensory physiology such as vision, thermotaxis and chemotaxis. G protein-coupled receptors (GPCRs) initiate olfactory signaling cascades in mammals and in nematodes C.elegans. However, the mechanisms of G protein signaling cascades in insect chemosensation are controversial. In this review, I will discuss the putative roles of G protein-coupled receptors (GPCRs) and Transient Receptor Potential (TRP) channels as targets for insect repellents.

• BMB Reports
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• v.45 no.12
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• pp.700-706
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• 2012

Obesity is a worldwide epidemic as well as being a major risk factor for diabetes, cardiovascular diseases and several types of cancers. Obesity is mainly due to the overgrowth of adipose tissue arising from an imbalance between energy intake and energy expenditure. Adipose tissue, primarily composed of adipocytes, plays a key role in maintaining whole body energy homeostasis. In view of the treatment of obesity and obesity-related diseases, it is critical to understand the detailed signal transduction mechanisms of adipogenic differentiation. Adipogenic differentiation is tightly regulated by many key signal cascades, including insulin signaling. These signal cascades generally transfer or amplify the signal by using serial tyrosine phosphorylations. Thus, protein tyrosine kinases and protein tyrosine phosphatases are closely related to adipogenic differentiation. Compared to protein tyrosine kinases, protein tyrosine phosphatases have received little attention in adipogenic differentiation. This review aims to highlight the involvement of protein tyrosine phosphatases in adipogenic differentiation and the possibility of protein tyrosine phosphatases as drugs to target obesity.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.12
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• pp.3917-3925
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• 1996

A numerical analysis on three dimensional turbulent incompressible flows through linear cascades of turbine rotor blades with high turning angles has been performed by using a generalized k-.epsilon. model which is a high Reynolds number form and derived by RNG(renormalized group) method to account for the variation of the rate of strain. A second order upwind scheme is used to suppress numerical diffusion in approximating the convective terms. Body-fitted coordinates are adopted to represent the complex blade geometry accurately. For the case without tip clearance, velocity vectors and static pressure contours are shown to be in good agreement with previous experimental results. For the case with tip clearance, the effects of the passage vortex and tip clearance flow on the total pressure loss as well as their interactions are discussed.

• 연구논문집
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• s.25
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• pp.67-76
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• 1995

A grid generation algorithm associated with turbomachinery cascade flow fields has been developed. The present grid generation system consists of four separate modules. The system input is made of the results of the preliminary design, i.e., flow-path, aerodynamic conditions along the spanwise direction, and the blade profile data. The grid generation method generates a series of two-dimensional grids in the blade-to-blade passage to build up the three-¬dimensional grid, The numerical algorithm adopts the combination of the algebraic and elliptic method to create the internal grids efficiently and quickly. The resultant grids generated from each module of the system are used as the preprocessor for the performance prediction of the turbomachinery blade using Naveir-Stokes method in addition to the blade surface modelling for CAD data. For purposes of illustration, the grid generation system is applied to several complex geometries inculding a turbine rotor with and without a tip flow grid. Application to the blade design of the LP compressor was demonstrated to be very reliable and practical in support of design activities. This customized system are coupled strongly with the design procedure and reduces the man-hours required to predict the aerodynamic performance of the turbomachinery cascades using the CFD technique.

• 한국전산유체공학회:학술대회논문집
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• 2002.05a
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• pp.102-108
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• 2002

Numerical analysis has been conducted in order to simulate the flow characteristics by tip clearance of turbine cascades. A 3-D Navier-Stokes CFD code based on body-fitted coordinate system, pressure-correction and finite volume method has been used along with a commercial CFD code. The present results have showed that the development and generation of leakage vortex, vortex within tip clearance, etc. are clearly simulated, consistent with the generally known tendency. The leakage vortex occurs mainly by a separation of leakage flow that arises due to a pressure difference between two surfaces of the blade at the tip.

• Nuclear Engineering and Technology
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• v.52 no.12
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• pp.2867-2873
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• 2020

In reprocessed uranium, derived from an impoverished fuel of light-water moderated reactors, there are isotopes of ^{232, 234, 236}U, which make its recycling remarkably difficult. A method of concentration of ²³⁵U target isotope in cascade's additional product was proposed to recover the isotopic composition of reprocessed uranium. A general calculation procedure is presented and a parameters' optimization of multi-flow cascades with additional products. For the first time a numeric model of a cascade that uses the cuts of partial flows of stages with relatively high separation factors was applied in this procedure. A novel computing experiment is carried out on separation of reprocessed uranium hexafluoride with providing a high concentration of ²³⁵U in cascade's additional product with subsequent dilution. The parameters of cascades' stages are determined so as to allow reducing the ^{232, 234, 236}U isotope content up to the acceptable. It was demonstrated that the dilution of selected products by the natural waste makes it possible to receive a low enriched uranium hexafluoride that meets the ASTM C996-15 specification for commercial grade.

• Transactions of the Korean Society of Mechanical Engineers
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• v.14 no.5
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• pp.1311-1319
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• 1990

For the purpose of preventing the flow undulation in the cascade of steam turbine, the blades are made into a constant expansion rate in static pressure. And the flow in those cascades is transonic or supersonic in the range of 0.7-2.0 in Mach number. As a consequence, an oblique shock wave, known as inner or outer edge shock wave, arises in the flow of cascades. Especially when the steam in cascades is in a state of high wetness, nonequilibrium condensation and condensation shock wave occur, and they give rise to an interference with oblique shock wave. In the present study the case of expansion of moist air through a supersonic nozzle of constant expansion rate, which behaves similar to that of wet steam, was adopted. The effect of nonequilibrium condensation on the oblique shock wave generated by placing the wedge into the supersonic part of the nozzle was investigated. Furthermore, the relationship between nonequilibrium condensation zone and incident point of the oblique shock wave, oblique shock wave angle, the variations of angles of incident and reflected shock waves due to the variation of initial stagnation supersaturation and the relationship between the height of Mach stem and initial stagnation supersaturation are discussed.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2008.03a
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• pp.195-201
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• 2008

In the jet engines on the aircrafts cruising at high altitude over 20 km and subsonic speed, the Reynolds number in terms of the compressor blades becomes very low. In such an operating condition with low Reynolds number, it is widely reported that total pressure loss of the air flow through the compressor cascades increases dramatically due to separation of the boundary layer and the secondary-flow. But the detail of flow mechanisms causes the total pressure loss has not been fully understood yet. In the present study, two series of numerical investigations were conducted to study the effects of Reynolds number on the aerodynamic characteristics of compressor cascades. At first, the incompressible flow fields in the two-dimensional compressor cascade composed of C4 airfoils were numerically simulated with various values of Reynolds number. Compared with the corresponding experimental data, the numerically estimated trend of total pressure loss as a function of Reynolds number showed good agreement with that of experiment. From the visualized numerical results, the thickness of boundary layer and wake were found to increase with the decrease of Reynolds number. Especially at very low Reynolds number, the separation of boundary layer and vortex shedding were observed. The other series, as the preparatory investigation, the flow fields in the transonic compressor, NASA Rotor 37, were simulated under the several conditions, which corresponded to the operation at sea level static and at 10 km of altitude with low density and temperature. It was found that, in the case of operation at high altitude, the separation region on the blade surface became lager, and that the radial and reverse flow around the trailing edge become stronger than those under sea level static condition.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.05a
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• pp.94-94
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• 2002