• Preventive Nutrition and Food Science
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• v.6 no.1
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• pp.73-78
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• 2001

The elevation of total plasmahomocysteine is now an established risk factor for cardiovascular disease. Plasma folate and vitamin {TEX}$B_{12}${/TEX} influence Hcy metabolism as cofactors. In this study, we studied the relationship of major risk factors for cardovascular disease, including advanced age, male gender, obesity, hypertension, hyperglycemia, and dislipidemia and plasma homocyteine, folate and vitamin {TEX}$B_{12}${/TEX} levels in Koreans. A total of 195 adult Koreans participated. The subjects were divided into three groups according to how many major conventional risk factors of cardiovascular disease they had: no risk, low risk (1~3 risk factors) and high risk (>3 risk factors) groups. As the number of risk factors increased, the plasma homocysteine levels significantly increase, while the plasma folate levels significantly decreased. The plasma homocysteine levels re higher in males than in females. The subjects with hyperglycemia had higher plasma homocysteine levels than the subjects without the risk factor. Also the subjects with dislipidemia had higher plasma homocysteine levels than the subjects without the risk factor. The plasma folate and vitamin {TEX}$B_{12}${/TEX} levels were significantly lower in males tan females. However, there were no significant differences in plasma folate and vitamin {TEX}$B_{12}${/TEX} levels between the subjects with or without other risk factors. These results indicate that plasma homocysteine levels were positively related with risk factors for cardiovascular disease and plasma folate levels were negatively related with the risk factors for cardiovascular disease. Also, we conclude that plasmahomocysteine levels might be related to the combination of risk factors, rather than an individual risk factor.

• Archives of Pharmacal Research
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• v.10 no.4
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• pp.245-249
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• 1987

Cardiovascular disease is at present the leading cause of deth in the United States and other in dustrilized countries. A major contributing factor of cardiovascular disease is essential hypertension. Untreated, essential hypertension is considered a risk factor for sudden death due to myocardial infarctions, as well as a risk factor for cerebral vascular disease, renal failure and congestive heart failure. During the last decade, significant progress has been made in the basic knowledge of the pathogenesis of hypertension as well as in the development of new antihypertensive drugs.

• The Journal of Internal Korean Medicine
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• v.31 no.4
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• pp.870-879
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• 2010

Objective : This study is about stroke risk factors which may differ between countries. Methods : We recruited 1725 ischemic stroke patients from multiple-centers. We analyzed stroke risk factors: hypertension, diabetes mellitus, dyslipidemia, depression, cardiac source, smoking, waist-to hip ratio, alcohol intake, physical activity, and psychosocial stress. We then compared risk factor results from other countries (the INTERSTROKE study) with this study. Results : 10 risk factors are related to stroke incidence. They were somewhat different between this study and the INTERSTROKE study. Conclusions : Hypertension is the most important risk factor of stroke, and other 9 risk factors also should be managed to prevent stroke incidence. Frequency of risk factors were different from the INTERSTROKE study. I think it could be partly due to differences of ethnicity and age. More studies are needed to describe characteristics of risk factors of Koreans.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.2
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• pp.97-107
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• 2016

Purpose : Cardiovascular disease is major factor of mortality in worldwide. Previous studies shown that the socioeconomic factors, nutrition factors, health behavior factors, biological factors and co-morbidity are increasing a prevalence of cardiovascular disease. Method : This study examined the risk factors for cardiovascular disease among adults aged 30 years and older using the data from the 2012 to 2014 Korean National Health and Nutrition Examination Survey (KNHANES). The study participants were 7,555 Cardiovascular disease includes hypertension, stroke, angina pactoris, and myocardial infarction. Descriptive statistic and multivariates logistic regression were calculated. Result : The overall prevalence of cardiovascular disease was 31.16% in the participants. Cardiovascular disease was significantly associated with gender, age, income, education, marital status as socioeconomic factors in unadjusted model. After adjusting socioeconomic status variables, past smoker (OR 1.27, 95% CI 1.05-1.55), obesity (OR 7.14, 95% CI 4.21-12.11), skipping a meal (OR 2.79, 95% CI 2.46-3.16), HDL-C (OR 0.99, 95% CI 0.98-0.99) and WC (OR 1.06, 95% CI 1.05-1.07) were associated with cardiovascular disease. Conclusion : The results marked the importance of finding high risk groups and an early management of cardiovascular disease.

• Research in Community and Public Health Nursing
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• v.26 no.2
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• pp.150-159
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• 2015

Purpose: This study was performed in order to identify the relationships among self-care behavior, health conservation, and cardiovascular risk factors and to examine the influence of self-care behavior and health conservation on cardiovascular risk factors among Korean elders with diabetes mellitus. Methods: The participants were 105 elders with diabetes mellitus using senior welfare centers and elderly leisure houses in Daegu. Data were collected through interviews during the period from April to May in 2014. Self-care behavior was measured with Kim's (1997) Self-care Behavior Scale, health conservation with Sung's (2005) Health Conservation Scale, and cardiovascular risk factors with the Arizona Heart Institute Cardiovascular Risk Factor Questionnaire. Collected data were analyzed through one-way ANOVA, independent t-test, Pearson's correlation, and stepwise multiple regression using the SPSS/WIN 19.0 program. Results: A negative correlation was found between self-care behavior and cardiovascular risk factors, and between health conservation and cardiovascular risk factors. Self-care behavior explained 6% and health conservation did 49% of variance in elderly diabetes mellitus patients' cardiovascular risk. Conclusion: The results indicate that, in order to reduce cardiovascular risk factors among Korean elders with diabetes mellitus, we need nursing interventions for increasing health conservation and self-care behavior.

• Korean Journal of Occupational Health Nursing
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• v.13 no.1
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• pp.59-69
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• 2004

Purpose: The purpose of this study is to investigate cardiovascular risk factors, their interaction, degree of cardiovascular risk and to analyze the effects of related fcators in women workers. Method: A Survey was conducted in 529 employed women in 36 workplaces from October 25, 2002 to December 12, 2002. The survey was distributed and collected by occupational health nurses working at work sites. Result: The result were as followings; The female workers had about 2 cardiovascular risk factors. 82.1% were not exercising more than 3 times a week, 45.9% reported noise-exposure, 38.2% had higher perceived stress, 25.4% were shift-workers, 10.4% were long-time workers(over 60hour/week), 4.4% were frequent drinker, 3.9% were current smokers. The rate of obesity in measured as BMI greater than 25 was 4.0%. Many cardiovascular risk factors were correlated. Job-related and health behavior-related cardiovascular risk factors were correlated statistically. Expose to noise, reported perceived stress were powerful predictors in their degree of cardiovascular risk. Conclusion; Based on the results of this study, cardiovascular prevention programs for women in workplace should be designed as a multifactorial approach, which include stress management and job-related risk factor management as essential components to be effective in addressing the needs of the population.

• Research in Community and Public Health Nursing
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• v.17 no.2
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• pp.153-165
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• 2006

Purpose: The purpose of this study was to develop and test a structural model on cardiovascular disease risk factors among male manufacturing workers. Methods: Data were collected through questionnaires and health exams from 201 workers in a local electronic company during September 2004. Data analysis was done with SAS 9.1 for descriptive statistics and PC-LISREL 8.54 for covariance structural analysis Results: The overall fit of the hypothetical model to the data was moderate, it was modified by deleting five paths. The modified model had a better fit to the data($x^2=504.23$(p<001, df: 180), $x^2/df=2.80$, GFI=.95, RMR=.07, NFI=.90, PGFI=.64). Health behaviors and psychosocial distress were found to have significant direct effects on the cardiovascular disease risk factors. Self-concept had direct effect on psychosocial distress or health behaviors. Self-concept, work environment, and work condition had direct effect on social support. Work environment had indirect effect on psychosocial distress. Social support had indirect effect on health behaviors. But work environment and work condition were found to have little direct effect on health behaviors, psychosocial distress or cardiovascular disease risk factors. Conclusion: A cardiovascular health promotion program should therefore include psycho-social factors as well as health behavioral determinants in worksites.

• Journal of Korean Medicine for Obesity Research
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• v.4 no.1
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• pp.33-43
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• 2004

Background: Recently obesity has become a social problem in all over the world including Korea. It is known that obesity is closely related with cardiovascular disease. Many studies are carrying out in the relation between several obesity indices, such as body mass index(BMI), waist-circumference(WC), body fat percent and risk factors of cardiovascular disease. Objective: This study was done in order to investigate correlation of obesity and cardiovascular risk factors. Method: We gathered totally 138 subjects who have taken health screening test in university hospital. With the exception of 40 abnormal cases on current illness and laboratory study, 98 healthy cases were analysed. We divided the groups as normal, overweight, obese group according to body mass index $(22.9kg/m^2\;and\;below\;/\;23{\sim}24.9kg/m^2\;/\;25kg/m^2\;and\;above)$and investigated the relationship between obesity based on body mass index(BMI) and cardiovascular risk factors. And investigated the relationship between each cardiovascular risk factor and body mass index, waist-hip ratio, body fat percent. Results: With the exception of blood pressure, other lab data such as total cholesterol, triglycerid, glucose were significantly different between the three groups divided by body mass index$(22.9kg/m^2\;and\;below\;/\;23{\sim}24.9kg/m^2\;/\;25kg/m^2\;and\;above)$. And Correlation coefficient of cardiovascular risk factors with body mass index, waist-hip ratio, body fat precent were acquired. Conclusion: We have concluded that the body mass index and waist-hip ratio body fat precent were predictive factors cardiovascular disease.

• Journal of Preventive Medicine and Public Health
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• v.38 no.3
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• pp.366-372
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• 2005

Objectives : This study was conducted to assess the distribution of cardiovascular risk factors (serum lipid profiles, BMI, blood pressure, fasting blood sugar) and evaluate the risk profile of CVD by the clustering of the cardiovascular risk factors in school-aged children in the Kyoung-Gi area. Methods : The study sample consists of 208 11 year-old children (51.4% boys, 48.6% girls) who participated in a cross-sectional screening of cardiovascular risk factors. We surveyed their socio-demographic characteristics, measured the anthropometric variables and analyzed the biochemical markers. Results : Of the cardiovascular risk factors, the percentage risk of the BMI, dyslipidememia and hypertension were highest. The prevalence rates of total cholesterol and LDL-cholesterol in girls was higher than in boys. Also, the associations of the BMI, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, systolic and diastolic blood pressures were highly significant. In addition, the proportion of subjects with 1, 2, 3 and 4 or more risk factors were 29.3, 12.5, 2.9 and 1.9%, respectively; therefore, a total of 97 subjects (46.6%) had at least one more risk factor. Conclusions : From these findings, we concluded that the rates of hypercholesterolemia, cardiovascular risk groups and obesity prevalence of these groups were relatively high. These data provide further evidence that the early intervention for cardiovascular health prevention and promotion in school-aged children is necessary at the population level.

• Biomolecules & Therapeutics
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• v.31 no.6
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• pp.583-598
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• 2023

Dementia is a clinical syndrome characterized by progressive impairment of cognitive and functional abilities. As currently applied treatments for dementia can only delay the progression of dementia and cannot fundamentally cure it, much attention is being paid to reducing its incidence by preventing the associated risk factors. Cardiovascular and metabolic diseases are well-known risk factors for dementia, and many studies have attempted to prevent dementia by treating these risk factors. Growing evidence suggests that sex-based factors may play an important role in the pathogenesis of dementia. Therefore, a deeper understanding of the differences in the effects of drugs based on sex may help improve their effectiveness. In this study, we reviewed sex differences in the impact of therapeutics targeting risk factors for dementia, such as cardiovascular and metabolic diseases, to prevent the incidence and/or progression of dementia.