• 대한핵의학회지
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• 제26권1호
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• pp.40-48
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• 1992

Gated blood pool scan is frequently used for evaluating the change in cardiac function in various cardiac diseases. But resting gated blood pool scan using only LVEF as a cardiac index has been consitently shown to have a low sensitivity, which is about 50%, in detecting coronary artery disease. So it is recommended to compare exercise gated blood pool scan to resting gated blood pool scan. Exercise tests, however, are not always possible, especially in patients with musculoskeletal diseases, recent myocardial infarction and in elderly persons. We studied the usefulness of resting gated blood pool scan using multiple indices in evaluating the patients with coronary artery disease. Studied cases were 185 patients with coronary artery disease (angina pectoris 31, myocardial infarction 154) and 25 normals with low likelihood of coronary artery disease. We used $^{99m}Tc-labeled$ RBC, 740 MBq labeled by in vivo method. The data were evaluated by Micro DELTA computer program. The results were as following: 1) The ejection rates (PER, AER) and filling rates (PFR, AFR) were different in normls and patients with angina pectoris or myocardial infarction. 2) Mean phase angle, ejection rates and filling rates could separate normals from coronary artery disease patients with normal LVEF. 3) Regional ejection fraction was decreased at the site of the infarct in patients with myocardial infarction. 4) Peak filling rate was the the most detectable index in evaluation of cardiac function in patients with coronary artery disease. 5) The threshold at 1.5 standard deviation of normal range was considered as the most reliable cut-off value from ROC analysis. These data suggest that the resting gated blood pool scan has an important role in the evaluation of cardiac functional changes using various cardiac indices in patients with coronary artery disease.

• 한국방사선학회논문지
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• 제13권5호
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• pp.683-689
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• 2019

소아의 선천적 심장질환 진단을 위해 High Pitch Mode를 사용하여 획득한 소아 심장 CT 영상과 Wide Coverage Volume Axial Mode를 사용하여 획득한 소아 심장 CT 영상으로부터 환자의 피폭선량과 각 영상의 화질을 비교 및 분석하여 Wide Coverage Volume Axial Mode의 유용성을 평가해보고자 한다. 소아 심장 CT 검사 시 High Pitch Mode와 Wide Coverage Volume Axial Mode를 각각 50명 총 100명의 환자를 대상으로 시행하였으며, 각 프로토콜로부터 얻은 영상을 이용하여 환자의 피폭선량을 비교하였다. 각 영상에 ROI를 설정해 SNR과 CNR을 산출하여 영상의 화질을 비교하였다. High Pitch Mode에 비해 Wide Coverage Volume Axial Mode를 사용하여 검사하였을 때 환자의 피폭선량이 13.07% 감소하였고, SNR과 CNR이 향상되었다. Wide Coverage Volume Axial Mode는 고속 회전 스캐너를 이용하여 조사시간을 줄이고, 저선량 기술인 ASi R-V를 통해 High Pitch Mode를 사용했을 때보다 환자의 피폭선량이 감소하고 영상의 화질 또한 향상되는 유용한 검사라 할 수 있다.

• 대한전자공학회논문지
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• 제26권2호
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• pp.132-139
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• 1989

본 연구에서는 심장의 박동영상을 방사선 투시법으로 관찰하여 심장질환을 진단하기 위한 실시간 처리 심장 디지탈 감산 조영 영상기법(cardiac digital subtraction angiography)을 개발하여 임상실험을 시행하였다. 평균 1초에 1번의 심장박동에 따른 주변부위의 운동에 의한 오차의 영향을 감소하면서, 좌심실 박동상을 32프레임까지 실시간으로 감산 처리하는 고속기억(512X512 해상도와 256 gray level) 및 고속 데이타링크 시스템과 프로세서를 개발하였다. 기억된 영상을 컴퓨터에 입력하고, 심장의 경계면을 Dynamic Programming을 사용하여 검출하고, 부피를 구하여 심장의 박동에 따른 최대부피(ESV)와 박동후 최소부피(ESV), 최대와 최소부피의 비율(EF)로서 표시되는 심박출계수 등 심장의 좌심실기능을 나타내는 생리계수를 영상으로 부터 구하는 알고리듬을 개발해서 임상실험을 시행하였다.

• 대한한의학방제학회지
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• 제31권3호
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• pp.157-169
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• 2023

Gracilaria Verrucosa (GV), a seaweed used in traditional Korean medicine, was studied for its effects on MI-induced heart failure in rats. MI is caused by a blocked coronary artery, leading to severe cardiac dysfunction. The study used a rat model to assess cardiac changes over time and evaluate the impact of GV on heart failure. Ischemia was induced through LAD ligation surgery, and the extent of ischemic area was measured as a prognostic factor. GV extract administration significantly improved cardiac morphology and reduced cardiac weight compared to the MI group. GV treatment also improved cardiac function, as evidenced by positive effects on chamber dilation during MI-induced heart failure. Parameters such as ejection fraction (EF) and fractional shortening (FS) were measured. The MI group showed decreased EF and FS compared to the sham group, while these parameters improved in the GV group. GV treatment also reduced levels of LDH, CPK, and CK-MB in the serum, indicating reduced myocardial damage. Histological analysis revealed that GV treatment attenuated cardiac hypertrophy and fibrosis, with reduced collagen deposition in the myocardium. Immunohistochemistry analysis showed suppressed expression of TGF-β1 and collagen 1, involved in fibrosis. In conclusion, GV showed potential in improving cardiac function in a rat model of MI-induced heart failure. It alleviated myocardial damage, attenuated cardiac hypertrophy and fibrosis, and suppressed fibrotic markers. Further studies are needed to explore its clinical efficacy and underlying mechanisms in cardiac diseases beyond animal models.

• Genomics & Informatics
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• 제19권2호
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• pp.13.1-13.8
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• 2021

Ranked in the topmost position among the deadliest diseases in the world, cardiovascular diseases (CVDs) are a global burden with alterations in heart and blood vessels. Early diagnostics and prognostics could be the best possible solution in CVD management. OMICS (genomics, proteomics, transcriptomics, and metabolomics) approaches could be able to tackle the challenges against CVDs. Genome-wide association studies along with next-generation sequencing with various computational biology tools could lead a new sight in early detection and possible therapeutics of CVDs. Human cardiac proteins are also characterized by mass spectrophotometry which could open the scope of proteomics approaches in CVD. Besides this, regulation of gene expression by transcriptomics approaches exhibits a new insight while metabolomics is the endpoint on the downstream of multi-omics approaches to confront CVDs from the early onset. Although a lot of challenges needed to overcome in CVD management, OMICS approaches are certainly a new prospect.

• Tuberculosis and Respiratory Diseases
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• 제42권4호
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• pp.610-617
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• 1995

저자들은 활동성 선단거대증과 이로 인하여 생긴 확장형 성근병증에 의한 울혈성 심부전과 중증의 심실성 부정맥이 있는 환자에 동반된 폐쇄성 수면 무호흡증후군을 치료하기 위하여 4개월간 지속적 영양공급치료를 시행한 예를 경험하였기에 문헌고찰과 함께 보고한다.

• Journal of Chest Surgery
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• 제27권9호
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• pp.738-745
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• 1994

In order to evaluate the myocardial injury in cardiac valvular and coronary surgery, variables of creatine kinase[CK], myocardial band of CK[CK-MB], lactate dehydrogenase[LDH], aspartate aminotrasferase[AST] were measured in the preoperative[Preop], the operation day[POD0], and the first[POD1], third[POD3], fifth[POD5], seventh[POD7], ninth[POD9] day after operation in 29 patients. The subjects were divided into two groups according to the diseases: group V [valvular disease, n=16] and group C[coronary artery disease, n=13]. Each group was subdivided into two subgroups according to the duration of aortic crossclamping time[ACT]; group VI[ACT 120min, n=7] and group VII[ACT>120min, n=9]; group CI[ACT 120min, n=6] and group CII[ACT>120min, n=7]. The results were as followed 1. The values of CK between group V and group C had no significant difference. The values of CK in group CII were significantly greater than those in group CI and the values of CK in group VII were significantly greater than those in group VI. 2. Percentages of CK-MB between groups had no significant difference. 3. The serum levels of LDH in group V were significantly greater than those in group C. The serum levels of LDH in group VII were significantly greater than those in group VI. 4. The serum levels of AST in group VII were significantly greater than that in group VI. We were concluded that myocardial injury was more related with the duration of aortic cross clamping time rather than the type of diseases.

• Tuberculosis and Respiratory Diseases
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• 제42권5호
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• pp.787-792
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• 1995

저자 등은 우측 늑막삼출과 간암을 동반하고 드물게 보이는 심막 횡격 정맥의 측부 순환을 동반한 신정맥 상부에서 하대정맥 폐쇄 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 약학회지
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• 제37권1호
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• pp.84-88
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• 1993

Brovincamine is a selective cerebral vasodilator that was apparently produced via a slow calcium blockade. Brovincamine has been shown to increase ATP production and glucose and oxygen consumption in brain, improving energy metabolism. Also brovincamine inhibited platelet aggregation induced by ADP and collagen in vivo and in vitro via an increase of cAMP concentration, promoting therapeutic effects on cerebral circulatory disorders. So we investigated and represented the clinical effects and safety of brovincamine in patients with cerebral stroke. Thirty patients of cerebral stroke that was older than 2 months, who were 22 cases of cerebral infarction, 6 of cerebral embolism that originated from carebral infarction, 6 of cerebral embolism that originated from cardiac diseases, and 2 of cerebral embolism that originated from cardiac diseases, and 2 of cerebral hemorrhage, were administered of 20 mg of oral brovincamine three times daily for 8 weeks. Improvement rates of each symptom after 8 week administration were 30.8% for subjective symptoms, 76% for psychiatric symptoms and 65.6% for neurologic symptoms. In final global improvement rates, much improvement was 10%, improvement was 23.3% slight improvement is 36.7%, and no change was 30%. So global improvement rate including slight improvement was 70%. As for side effects, there were 3 cases of mild gastrointestinal symptoms, but there were no other subjective side effects and significant fluctuation in laboratory examination. Conclusively throughout the present study, brovincamine is judged to be well tolerated and effective in patients with cerebral stroke.

• Clinical and Experimental Pediatrics
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• 제58권10호
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• pp.392-397
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• 2015

Purpose: Alagille syndrome is a complex hereditary disorder that is associated with cardiac, hepatic, skeletal, ocular, and facial abnormalities. Mutations in the Notch signaling pathway, such as in JAG1 and NOTCH2, play a key role in embryonic development. A cardiac or hepatic presentation is a critical factor for determining the prognosis. Methods: We conducted a retrospective study of 41 patients with Alagille syndrome or a JAG1 mutation between 1983 and 2013. Results: The first presentations were jaundice, murmur, cyanosis, and small bowel obstruction at a median age of 1.0 months (range, 0-24 months). The JAG1 mutation was found in 27 of the 28 genetically-tested patients. Cardiovascular anomalies were identified in 36 patients, chronic cholestasis was identified in 34, and liver transplantation was performed in 9. There was no significant correlation between the severity of the liver and cardiac diseases. The most common cardiovascular anomaly was peripheral pulmonary stenosis (83.3%), with 13 patients having significant hemodynamic derangement and 12 undergoing surgical repair. A total bilirubin level of >15 mg/dL with a complex surgical procedure increased the surgical mortality (P=0.022). Eight patients died after a median period of 2.67 years (range, 0.33-15 years). The groups with fetal presentation and with combined severe liver and heart disease had the poorest survival (P<0.001). Conclusion: The group with combined severe liver and heart disease had the poorest survival, and a multidisciplinary approach is necessary to improve the outcome.