• Journal of Chest Surgery
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• v.19 no.3
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• pp.433-437
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• 1986

Authors experienced a case of typical carcinoid in a patient of 46 year-old female who has been suffered from hemoptysis intermittently for 13 years. Exploratory thoracotomy and middle and lower lobectomy was carried out. The tumor was located in the right intermediate bronchus. Tissue pathology shows a glandular tumor with focal proliferation of Kulchitzky cells in the bronchial epithelium by H&E stain and membrane-bounded neurosecretory granules in the cytoplasm by electron microscope. Authors report the case with a literature reviews.

• Journal of Chest Surgery
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• v.53 no.5
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• pp.317-320
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• 2020

Pulmonary carcinoids are relatively rare tumors with low metastatic potential. Pleural carcinomatosis of a bronchial carcinoid has only been reported in 4 cases. Due to the rarity of this condition, there are no guidelines for its treatment or management. We report a case of atypical carcinoid with local recurrence and pleural metastases treated by video-assisted thoracoscopic surgery lobectomy and total pleurectomy with photodynamic therapy after non-radical wedge resection.

• Journal of Chest Surgery
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• v.44 no.6
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• pp.444-447
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• 2011

We report a rare case of a 38-year-old woman with a bronchial carcinoid tumor arising from an intralobar bronchopulmonary sequestration. The vascular supply to the sequestered left lower lobe originated from the descending thoracic aorta. A left lower lobe lobectomy was performed. The findings of the pathological examination revealed an atypical carcinoid tumor that was immunopositive for chromogranin and synaptophysin. At the 3-year follow-up examination, the patient was healthy.

• Journal of Chest Surgery
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• v.25 no.11
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• pp.1236-1239
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• 1992

Carcinoid tumors arising in the thymus are rare. Since Rosai and Higa in 1972 distinguished these neoplasms from thymomas, fewer than 100 cases have been reported in the world literature. The pathologic diagnosis of thymic carcinoids is been on findings from light microscopy, histochemical studies, and electron microscopy. About 50% of thymic carcinoids are seen with endocrinopathies. Recurrence and extrathoracic metastasis are characteristic of thymic carcinoids. Surgical extirpation of the tumor initially and of the subseguent recurrences in the most effective treatment today The role of adjuvant radiotherapy and chemotherapy is still uncertain. Herein we report a case of thymic carcinoid tumor in a 36-year old male with brief review of literatures.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2579-2581
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• 2016

Background: Neuroendocrine tumors represent 20% of primary lung neoplasms in some registries. According to the WHO classification of 2004, reconsidered for 2015, these lung tumors are divided into 4 groups: typical and atypical carcinoid, small cell and large cell neuroendocrine carcinomas. We report in this paper, for the first time in Lebanon, the distribution and the population characteristics of these tumors. Materials and Methods: This descriptive retrospective study concerned all the pulmonary neuroendocrine tumors (NET) with their characteristics diagnosed in $H\hat{o}tel$ Dieu de France in Beirut, Lebanon from 2001 to 2012, with attention to features like age, gender and subgroup. Results: Of 194 patients with pulmonary NET, 12.4% were typical carcinoid tumors, 3.6% atypical carcinoid, 66.5% small cell lung cancer, 7.7% combined small cell carcinomas and 9.8% large cell neuroendocrine tumors. The mean ages of patients were respectively 51.2 years in typical carcinoid, 64 years in atypical carcinoid, 64.2 years in small cell lung cancers, 67.2 in combined small cell lung cancer and 66.9 in large cells neuroendocrine tumors. The M/F sex ratios were respectively 0.3, 1.3, 1.4, 2.7 and 2.2. Conclusions: The characteristics of lung neuroendocrine tumors in our Lebanese institution are comparable to those reported in the literature.

• Tuberculosis and Respiratory Diseases
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• v.38 no.1
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• pp.74-82
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• 1991

Bronchial carcinoid is one of the unusual tumors of the lung, accounting for 1 percent of all lung tumors. Carcinoids, like small cell carcinomas, are generally considered to be derived from a neurosecretary type of cell of the respiratory epithelium, the Kulchtsky's cell. So, they are no longer classified as bronchial adenoma, and are recently grouped into the neuroendocrine group of tumors, the so-called APUD (Amine Precursor Uptake Decarboxylase) group of tumors. Although usually characterized by a slow growth pattern and a low incidence of metastatic disease, bronchial carcinoids should no longer be considered as beingn, and a much higher malignant behavior has been described with a special destignation of 'atypical carcinoid'. Bronchial carcinoids are histologically confirmed by the azurophil staining and the presence of the characteristic neurosecretary granule on electron microscopy. Recently we experienced two cases of bronchial carcinoid, the first case, being peripheral-located and histologically proven as atypical carcinoid, and the second, being central-located and hitologically typical. So we report these cases with a review of the literature.

• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.1
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• pp.72-78
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• 2015

This study aims to report a case of rectosigmoid neuroendocrine tumor patient with liver metastasis whose outstanding carcinoid symptom was mucosal diarrhea for more than 10 times a day. Three different herbal decoctions were administered orally for the treatment of diarrhea which was among carcinoid symptoms from diffuse metastatic liver lesion. The herbal decoctions given were modified Lijung-tang, modified Sambaek-tang and modified Jeokseokjiuyeoryang-tang. The administration period was 5, 14 and 9 days respectively. Frequency of patient's mucosal diarrhea had increased consistently during hospitalization. It had almost doubled compared to pre-hospitalization up to 27 times/24 hrs. But during the period of modified Sambaek-tang administration, frequency of diarrhea was maintained between 9 to 15 times/24hrs. There was no difference of liver tumors between Nov 16th 2013 and Dec 9th 2013 in computed tomography images. Three conventional established herbal prescriptions administered in this case didn't show any favorable effect on improving mucosal diarrhea induced by carcinoid symptoms of a rectosigmoid neuroendocrine tumor with liver metastasis. Even if modified Sambaek-tang showed partial effect on frequency of diarrhea, we concluded that it was not sufficient to be a therapeutic method of the diarrhea as carcinoid symptom. Furthermore, it is necessary to conduct additional studies about the diarrhea of neuroendocrine tumor with liver metastasis.

• Journal of Chest Surgery
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• v.35 no.8
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• pp.634-637
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• 2002

Thymic carcinoid or neuroendocrine tumor of thymus is a very rare disease and has poor prognosis due to frequent recurrence and distant metastasis. A 43-year-old man was refered to our hospital because of Rt. chest pain and tightness. Chest X-ray revealed $7{\times}8$cm sized mass on Rt. anterior mediastinum. Surgical excision was performed and light microscopic, immunohistochemical and electron microscopic findings were confirmed as atypical thymic carcinoid tumor with thymic cyst. The patient has been followed up without recurrence or distant metastasis postoperatively for 3 months to now. We report a case of atypical thymic carcinoid with thymic cysts.

• The Korean Journal of Cytopathology
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• v.16 no.1
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• pp.41-46
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• 2005

Carcinoid tumors of the thymus are vanishingly rare, and the characteristic cytologic findings of this condition have never before been reported in Korea. Recently, we encountered a 58-year-old woman who had been suffering from general weakness and weight loss for several months. Radiological imaging revealed a large anterior mediastinal mass. A fine needle aspiration biopsy (FNAB) of the mass showed predominantly scattered single cells, as well as some loose clusters of small cells with scanty cytoplasm. Some of these small cells exhibited plasmacytoid features, with moderately granular cytoplasm. We also discuss the cytological differential diagnosis between thymic carcinoid and other mediastinal tumors.

• Journal of Chest Surgery
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• v.52 no.6
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• pp.420-424
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• 2019

Atypical thymic carcinoid is an extremely rare tumor with a poor prognosis. In addition to its known association with multiple endocrine neoplasia type 1, its hallmark characteristics include local invasion and early distant metastasis. In this report, we share our experience treating atypical thymic carcinoid in a patient with Zollinger-Ellison syndrome.