• Journal of Microbiology and Biotechnology
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• 제7권5호
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• pp.305-309
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• 1997

Bacillus stearothermophilus No. 236, an effective xylanolytic bacterium, produced an extracellular carboxymethyl cellulase when the strain was grown on xylan. The carboxymethyl cellulase was purified to homogeneity as judged by SDS-PAGE and zymogram, The carboxymethyl cellulase had a pI of 4.0, and a molecular mass of 95 kDa. The highest level of enzyme activity was observed at pH 6.5 and $60^{\circ}C$. The $K_m$, and $V_{max}$ values of the enzyme to carboxymethyl cellulose were 20.8 mg/ml and $0.63 {\mu}mole$/min/mg protein, respectively, The enzyme was found to act also on filter paper and xylan as well as carboxymethyl cellulose. Therefore, it is expected that this xylanolytic strain isolated from soil could be efficiently used for xylan biodegradation.

• Journal of Chest Surgery
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• 제33권7호
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• pp.541-546
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• 2000

배경; 심막유착은 심장을 재수술하는 경우 큰 문제가 된다. 이 연구의 목적은 실험적 심막유착에서 sodium carboxymethyl cellulose의 효과를 관찰한 것이다. 대상 및 방법; 24마리의 토끼들을 12마리씩 2군으로 나누어 심막에 찰과상을 가하여 심막중피에 손상을 주었다. A군은 링거액을 주었고 B군은 3% sodium carboxymethyl cellulose액을 주었다. 수술 3주후에 A군과 B군의 유착정도를 비교하였다. 결과; 심막유착의 정도를 점도와 형태로 평가하였다. 점도에 따른 점수는 3이상일 경우 임상적으로 유착이 있다고 판단하였다. 대조군인 A군에서는 100%유착을 보였으나 연구군인 B군에서는 25% 의 심막유착을 나타냈다. (p<0.0001). 형태에 따른 점수도 두군사이에 유의성을 나타냈다. 결론; 3% sodium carboxymethyl celluosedor을 심막내로 주임하는 것은 동물실험에서 심막유착의 빈도를 감소시켰다.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 2011년도 추계학술발표회 논문집
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• pp.133-141
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• 2011

• 약학회지
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• 제60권2호
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• pp.73-77
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• 2016

Alginic acid and carboxymethyl cellulose sodium are dietary fibers from plants. They have a swelling property and delay the gastric emptying time, thereby resulting in feeling satiated after oral administration, which may eventually contribute to loss of body weight. The goal of this study was to compare swelling property of three commercial matrix tablets based on alginic acid and carboxymethyl cellulose sodium. When the swelling was determined by the Korean Ministry of Food and Drug Safety (MFDS) guideline, the tablet prepared by direct compression method with highly viscous swelling agent showed the highest swelling in acidic conditions. Water uptake of these tablets was rapid and completed within 30 min. Moreover, when the pH was changed from 2.5 to 6.8 buffer, the water uptake was not significantly changed in all tablets.

• Journal of the Korean Wood Science and Technology
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• 제20권2호
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• pp.81-90
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• 1992

The effect of acid treatment of cellulose on the substitution charateristics of carboxymethylation was studied in this paper. Five samples of hydrocellulose(HC), all prepared from ${\alpha}$-cellulose by hydrolysis with five reaction times and determined on average molecular weight and polydispersity, were carboxymethylated to carboxymethyl cellulose (CMC). The CMCs from HCs were examined upon degree of substitution(DS), distribution of carboxymethyl groups in anhydroglucose units of the cellulose, and unsubstituted anhydroglucose(USAG) content. The DS of CMCs increased with increasing the hydrolysis time except CMC from HC at 1 hour hydrolysis time. In carboxymethylation the availability of hydroxyl groups on anhydroglucose units in HCs was the highest on OH(2), and the relative availability of OH(6) increased with the increasing of the hydrolysis time. The USAG contents were more deviated than that calculated based on Spurlin's model, and had a strong tendency of decreasing with increasing the hydrolysis time. The reactivity of HC was lower than that of ${\alpha}$-cellulose and the relative availability of OH(6) in HC increased with the hydrolysis time.

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 1992년도 제2차 학술발표초록집
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• pp.46-46
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• 1992

• 한국식품과학회지
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• 제21권1호
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• pp.63-67
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• 1989

식이섬유가 중금속인 납의 흡수억제 효과를 가지고 있는지를 알아보기 위하여 반투막을 이용한 in vitro법으로 흡수실험을 실시하였다. 식이섬유중 cellulose는 억제효과를 거의 기대할 수 없었고 guar gum과 carboxymethyl cellulose는 약간 나타났으며 citrus pectin과 sodium alginate는 매우 크게 나타났다. 섬유질 식품중 쌀겨, 밀기울, 배추, 무우, 미역은 납의 흡수억제 효과가 컸으며, 귤, 사과, 김은 효과가 다소 적었다.

• 한국응용과학기술학회지
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• 제32권3호
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• pp.377-385
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• 2015

가식성 코팅물질의 하나인 carboxymethyl cellulose(CMC)을 주원료로 하여 CMC 혼합 코팅용액(Carboxymethyl cellulose + sodium benzoate + citric acid + lecithin)을 제조한 후 저장 기간에 따른 박피 마늘의 품질변화를 분석하였다. 각 농도에 따른 CMC 코팅 처리구의 경우 사용된 CMC의 농도가 높을수록 중량변화가 적게 나타났다. 저장기간에 따른 박피마늘의 색도 및 갈변화 현상은 CMC혼합 코팅처리구의 경우 L값의 변화는 대조구와는 큰 차이가 나타나지 않았으나 b값의 변화는 저장기간이 길어질수록 대조구와는 뚜렷한 차이를 나타내었고, 이러한 결과는 대조구가 저장기간 1주 이후부터는 급격한 갈변화 현상을 통해 상품적 가치를 손실되고 있는 결과와 일치하는 것을 알 수 있었다. 혼합 코팅용액에 의해 처리된 박피 마늘의 경도는 저장기간 4주까지 초기 박피마늘의 경도 측정값에 비해 최대 26.4 %, 최소11.7 %의 감소치를 보였으며, 저장기간에 따른 박피마늘의 부패율은 혼합 코팅용액으로 처리한 박피 마늘의 경우 큰 변화 없이 4주까지 20%내외의 부패율을 나타냈다.

• 대한족부족관절학회지
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• 제13권1호
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• pp.7-13
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• 2009

Purpose: The purpose of this study was to evaluate the effect of Sodium hyaluronate-Sodium carboxymethyl cellulose (HA-CMC) on tissue adhesion after tenorrhapy in tenotomized Achilles tendon of the Sprague-Dawley rat. Materials and Methods: Twenty-eight legs of 14 Sprague-Dawley rat were used in study. After tenotomy of the Achilles tendons, tenorrhaphies were performed. Simple tenorrhaphy without any other procedures were performed on the left Achilles tendons (control group), and additional HA-CMC injections were done prior to the tenorrhaphy on the right Achilles tendons (HA-CMC group). Gross and histological examinations were made to identify differences between the two groups, 1, 2, 6, 8, 10, 12 and 14 weeks respectively. Results: Distinct decrease in granulation tissues and adhesions were seen in the HA-CMC group during gross inspection at 6 and 8 week after the operation. On histological analysis of the HA-CMC group, although increased infiltrations of inflammation cells were observed during 1 week, less adhesion were seen at 6, 8 and 10 weeks after the operation. In HA-CMC group, superior healing processes were seen at 6, 8 and 10 weeks and less fibrotic changes, compared to control group, were seen at 2 and 6 weeks. Conclusion: Prevention of adjacent tissue adhesion was made possible through decrease in collagen deposition and fibrosis by injecting HA-CMC before tenorrhaphy of Achilles tendon. Also, histologically faster healing process of the collagen fibers within the Achilles tendon was observed.

• 농업과학연구
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• 제24권2호
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• pp.275-282
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• 1997

섬유소분해세균 Cellulomonas sp. CS1-1을 미소결정성 섬유소(sigmacell)에서 배양하면서 생육 및 1,4-${\beta}$-glucanase의 생산량을 조사하였다. 생균수는 배양 1일만에 최대이었지만 1,4-${\beta}$-glucanase의 활성도는 CMC 당화력으로 280 units/mL, 점도저하력으로 $3{\times}10^3units/mL$으로서 배양 5일째 최대이었으며, 이것은 가용성기질에 비하여 약 3배 높은 수준이었다. 또한 배양여액으로 부터 황산암모늄침전, Ultro-gel Ac54 겔여과, DEAE-Sephadex A50 이온교환크로마토그래피, 그리고 Con A-Sepharose 4B 친화성크로마토그래피의 방법으로 CMCase의 한분획을 순수정제하였다, 정제한 CMCase는 8.2%의 탄수화물을 함유하는 당단백질이었으며 그 정제도는 배양여액에 비해 CMC 당화력으로 22배 증가한 것이었다. 분자량은 54,000 그리고 둥전점은 pI 5.4 이었으며, 작용최적 pH 및 온도는 각각 pH 6.0 과 $45^{\circ}C$ 이었다. 정제효소의 CMC에 대한 Michaelis 상수 및 최대반응속도는 10 mg/mL, $6.25{\mu}mol/min$, 그리고 sigmacell에 대해서는 각각 30.3 mg/mL, $2.85{\mu}mol/min$으로 계산되었다 효소의 활성도는 $Ag^+$, $Zn^{+{+}}$, $Fe^{+{+}}$ 그리고 EDTA에 의해 부분적으로 저해되었고, 1mM의 $Cd^{+{+}}$와 $Hg^{+{+}}$ 이온에 의해서는 완전히 저해되었다.