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http://dx.doi.org/10.17480/psk.2016.60.2.73

Swelling of Commercial Matrix Tablets Based on Carboxymethyl Cellulose Sodium and Alginic Acid  

Kim, Ki Taek (College of Pharmacy, Seoul National University)
Kim, Ji Su (College of Pharmacy, Seoul National University)
Park, Ju-Hwan (College of Pharmacy, Seoul National University)
Lee, Jae-Young (College of Pharmacy, Seoul National University)
Jo, Yeong Woo (Daehwa Pharmaceutical Co., Ltd.)
Yang, Jae-Gwon (Daehwa Pharmaceutical Co., Ltd.)
Jang, Jun Hee (Daehwa Pharmaceutical Co., Ltd.)
Choi, Eun-Sun (Daehwa Pharmaceutical Co., Ltd.)
Kim, Dae-Duk (College of Pharmacy, Seoul National University)
Publication Information
YAKHAK HOEJI / v.60, no.2, 2016 , pp. 73-77 More about this Journal
Abstract
Alginic acid and carboxymethyl cellulose sodium are dietary fibers from plants. They have a swelling property and delay the gastric emptying time, thereby resulting in feeling satiated after oral administration, which may eventually contribute to loss of body weight. The goal of this study was to compare swelling property of three commercial matrix tablets based on alginic acid and carboxymethyl cellulose sodium. When the swelling was determined by the Korean Ministry of Food and Drug Safety (MFDS) guideline, the tablet prepared by direct compression method with highly viscous swelling agent showed the highest swelling in acidic conditions. Water uptake of these tablets was rapid and completed within 30 min. Moreover, when the pH was changed from 2.5 to 6.8 buffer, the water uptake was not significantly changed in all tablets.
Keywords
alginic acid; carboxymethyl cellulose sodium; tablet; swelling; water uptake;
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