• Journal of Ginseng Research
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• 제20권2호
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• pp.154-158
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• 1996

To investigate the protective effect of Korean red ginseng (RG) against oxidative damage, rats were intoxicated by carbon tetrachloride and liver tissues and blood were taken and analyzed histopathologically and biochemically. Light microscopy of the liver showed that RG prevented the necrosis of hepatocytes remarkably and reduced the change of fat. RG increased the capability for serum to suppress oxygen radical in the generating system. It is suggested that RG enhanced the antioxidative potential of the body against $CCl_4$, which would prevent the necrosis of hepatocytes in vivo.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.175.1-175.1
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• 2003

The protective effects of acteoside, a phenylethanoid glycoside, on carbon tetrachloride-induced hepatotoxicity and the possible mechanisms involved in this protection were investigated in mice. Pretreatment with acteoside prior to the administration of carbon tetrachloride significantly prevented the increased serum enzymatic activities of alanine and aspartate aminotransferase in a dose-dependent manner. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.290.2-290.2
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• 2002

The protective effects of a Platycodi Radix (Changkil: CK), the root of Platycodon grandiflorum A. DC (Campanulaceae). on carbon tetrachloride-induced hepatotoxicity and the possible mechanisms involved in this protection were investigated in mice. Pretreatment with CK prior to the administration of carbon tetrachloride significantly prevented the increased serum enzymatic activities of alanine and aspartate aminotransferase in a dose-dependent manner. (omitted)

• Toxicological Research
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• 제14권3호
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• pp.321-328
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• 1998

This study was performed to evaluate the effect of liver damage on toluene metabolism in rats pretreated with carbon tetachloride. Liver damage in rats was induced by administration of 0.1ml of carbon tetrachloride per 100g of body wight intraperitoneally every day for four weeks except the last day before sacrifice. One day before sacrifice, toluene was administered to the animals instead of carbon tetrachloride. Rats were sacrificed at the 1st, the 2nd, the 3rd and the 4th week after the first administration of carbon tetachloride. Based on the histopathological findings, liver weight and serum alanine aminotransferase, the $CCl_4$-preteated group was found to have gradual severe liver damage. Especially the degree of liver injury became increasingly severe throughout the whole course of the experiment. The contnts of hippuric acid in urine lower in the all groups pretreated with $CCl_4$than that of the control. The contents of hepatic cytochrome P450(CYP), benzylalcohol dehydrogenase and benzaldehyde dehydrogenase activities were decreased in $CCl_4$-pretreated rats than those of the control. The $CCl_4$treated animals showed the gradual decreased activities of these enzyme as injection times elapsed. Km values of the benzylalcohol dehydrogenase in pooled liver samples from $CCl_4$-pretreated or control groups were similar. On the other hand, Vmax values of the $CCl_4$-pretreated group was lower than of the control. Therefore, it can be concluded that reduction of the toluene metabolism in damaged rat liver induced with $CCl_4$was due to the inhibition of CYP content, bezylalcohol and benzaldehyde dehydrogenase activities which related with toluene metabolic enzyme system.

• 대한화학회지
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• 제24권1호
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• pp.44-52
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• 1980

동적 핵자기공명법에 대하여 toluene-$d_8$ 및 carbon tetrachloride 용매속에서의 $\alpha$-chlorobenzyl ethyl ether의 이온해리속도를 측정하였다. 먼저, 동적NMR spectra를 얻고 $J_{AB}, T_2,{\Delta}_{vAB}$ 값 등을 이용하여 computer simulation에 의한 이론spectra를 얻었는데 실측spectra와 매우 잘 일치하였으며, 이로부터 해리속도정수 k를 얻고 이 k의 Eyring plot에 의하여 기울기와 절편의 길이를 알고 이로부터 동력학적 parameter를 얻었다. 이온 해리의 난역도는 용매의 극성에 의존하였으며 활성화 enthalpy는 toluene-$d_8$ 용매중에서 4.7kcal/mole 이었고 carbon tetrachloride 용매중에서 10.7kcal/mole 이었다. 활성화 entropy는 toluene-$d_8$ 용매중에서 -35.8 e.u. 이었고 carbon tetrachloride 용매중에서 -14.4 e.u. 이었다. $S_N$ mechanism의 초기단계로 볼 수 있는 이 이온 해리는 ${\Delta}H^{neq}$ 값이 작아도 비극성 비양자성용매중에서 이온해리가 용역함을 알았으며 작은 ${\Delta}H^{neq}$에 비하여 ${\Delta}S^{neq}$는 음의 큰 값을 가졌음은 주목할 필요가 있다.

• 동국한의학연구소논문집
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• 제8권2호
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• pp.97-113
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• 2000

본 연구는 보원탕(保元湯)이 $CCl_4$로 유도된 간중독 mouse에 미치는 효과를 조사하였다. 실험동물은 3개의 군(정상군, 대조군, 약물투여군)으로 나누었다. 정상군은 마우스용 고형사료와 물을 제한 없이 공급하였으며, 대조군은 7일간 마우스용 고형 사료와 물을 제한 없이 공급한 후 carbon tetrachloride($CCl_4$)를 실험 동물의 체중 kg당 0.6ml을 1일간 복강 주사하여 마우스용 고형사료와 물을 2주간 제한없이 공급하였으며 약물투여군은 7일간 마우스용 고형 사료와 물을 제한 없이 공급한 후 carbon tetrachloride($CCl_4$)를 실험 동물의 체중 kg당 0.6ml을 1일간 복강 주사하여 마우스용 고형사료와 보원탕(保元湯) 추출물을 kg당 900mg씩 2주간 음용시켰다. 보원탕(保元湯) 추출물은 지질과산화 반응에 주요원인이 되는 자유기에 대한 직접적인 소거능을 나타내었고 혈청중 GPT, GOT, ALP 및 LPO는 대조군에 비해 약물투여군이 유의성 있는 감소를 나타내었으며 GSH 함량 및 catalase 활성은 약물투여군이 대조군에 비해 유의성 있게 증가하였다. 이 결과들로 보아 $CCl_4$로 유도된 mouse의 간손상에 보원탕(保元湯)이 유효한 것으로 확인되었으며 앞으로 이에 대한 심도 있는 연구가 계속되어야 할 것으로 사료된다.

• 대한수의사회지
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• 제19권10호
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• pp.29-36
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• 1983

The sedative action of xylazine hydrochloride and effects of doxapram hydrochloride on the sedative action of xylazine hydrochloride were investigated in goats with carbon tetrachloride induced liver damage. The results obtained were as follows. 1. Sedati

• Archives of Pharmacal Research
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• 제14권1호
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• pp.93-95
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• 1991

Alcoholic extract of the leaves of Andrographis paniculata Ness (=AAP) was obtained by cold maceration. A dose of 300 mg/kg $(1/6of\;LD_{50})$ of the extract was selected to study hepatoprotective action against carbon tetrachloride-induced liver damage. The extract was found to be effective in preventing liver damage which was evident by morphological, biochemical and functional parameters.

• Natural Product Sciences
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• 제13권1호
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• pp.23-26
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• 2007

Hepatoprotective activity of different extracts of Citrullus colocynthis L. sch. (roots) (cucurbitaceae) was investigated in albino rats by inducing hepatotoxicity with carbon tetrachloride. The alcoholic extract of Citrullus colocynthis sch. 100 mg/kg b.w. has been shown to posses significant hepatoprotective effect by lowering the serum level of transaminases (GPT & GOT), alkaline phosphate (ALP) and bilirubin (P < 0.05 to P < 0.001).

• 한국식품위생안전성학회지
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• 제9권2호
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• pp.75-80
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• 1994

The effects of ursodeoxycholic acid (UDCA) were studied on the hepatotoxicity induced by several hepatotoxicants such as carbonte trachloride, thioacetamide and 1-naphthylisothiocyanate in ICR male mice. UDCA (50 mg/kg, 100 mg/kg) decreased the elevated serum bilirubin in carbon tetrachloride intoxicated mice, the elevated serum AST, alkaline phosphatase in thioacetamide intoxicated mice, the elevated serum AST and bilirubin in 1-naphthylisothiocyanate intoxicated mice.