• 한국포장학회지
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• 제22권1호
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• pp.15-23
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• 2016

Gelatin soft capsules, manufactured by the press through package(PTP) process, are widely used in the production of multivitamin dietary supplements and other health functional foods. Gelatin capsules can prevent light and air from having a direct contact with the contents in the capsule, and the nutrients inside the capsules are preserved without any loss. In the present study, on the basis of the results on the safety of gelatin capsules. The parameters investigated included degradation of the capsules before their shelf life, capsule deformation, and changes in specific nutrients. Moisture and heat in the production and storage environments of the capsules caused the gelatin to swell and attach some of the inorganic salts in the vitamin contents. Nutritional component analysis showed that B1, B5, B9, and B12 contents were decreased, while mineral elemental analysis shown calcium, chloride, and zinc compound were found to be infused into the gelatin of the capsule shell.

• 대한수의학회지
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• 제35권2호
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• pp.391-398
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• 1995

This study was carried to investigate the usefulness of the radiopaque material as the GI transition and disintegration test of enteric coated capsules radiologically. The obtained results were as follows; 1. The GI transition times that the enteric coated capsules pass through the pylorus were that the time of the first capsule was 210 minutes and the time of the last capsules was more than 300 minutes. Therefore, the GI transition times largely differ from each animal and each enteric coated capsule. 2. The disintegration times of enteric coated capsules were similar in vitro test and in vivo test. 3. The GI transition and disintegration test of enteric coated capsules using barium sulfate, radiopaque material for the gastrointestinal track, was useful to investigate the times that the capsules passed through the pylorus and disintegrated in intestinal track.

• 한국임상수의학회지
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• 제11권1호
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• pp.377-381
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• 1994

This study was performed to investigate the usefulness of the radiopaque material as a disintegration test of enteric coated capsules radiologically. The results obtained were as follows; 1. The times that the enteric coated capsules passed the pylorus(GI transition times) were the first 150 minute and the last 390 minutes. Therefore, the GI transition times largely differ from each animal and each enteric coated capsule. 2. The disintegration times of enteric coated capsules were similar in vitro test and in vitro test. 3. The disintegration test of enteric coated capsules using Barium sulfate, radiopaque material for the gastrointestinal track, was useful to check the time pass through the pylorus and the time enteric coated capsules were disintegration.

• 한국수산과학회지
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• 제48권5호
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• pp.589-595
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• 2015

Alginates are used to encapsulate various materials, including food, cosmetics, and pharmaceuticals. This study examined the properties and oxidation stability of fish oil capsules manufactured with calcium alginate gels. The fish oil capsules were manufactured by dropping sodium alginate solution and fish oil into a calcium chloride solution through nozzles. The membrane thickness, sphericity, rupture strength and deformation depth of the fish oil capsules were determined. The peroxide value of the fish oil was assayed to determine the oxidation stability of the capsules. The capsules measured approximately 3 mm with a membrane thickness of 90 μm independent of the amount of fish oil added. As the amount of fish oil encapsulated increased, the sphericity, rupture strength and deformation depth of the capsules decreased. The encapsulation efficiency increased until the amount of fish oil was 30%. The oxidation stability of fish oil in capsules was dependent on the type of nozzle, e.g., the oxidation stability of fish oil in capsules made using a double nozzle was greater than with a single nozzle. These results should lead to industrial application of fish oils including eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, as nutraceuticals.

• Journal of Pharmaceutical Investigation
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• 제2권1호
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• pp.40-51
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• 1972

Water vapor sorption of corn starch in various protective film coated capsules in 100% RH chamber for 14 days were as follows: The percent of water vapor sorption were 28.63% in uncoated capsule, 25.16% in hydroxy propylcellulose(HPC) coated capsule, 15.59% in 2-methyl-5-vinyl pyridine-methyl acrylated-methacrylic acid (MPM) coated capsule and 15.50% in polyvinyl acetal diethyl amino acetate(AEA) coated capsule. 2. Water vapor sorotion of magnesium trisilicate in various protective film coated capsules in 100% RH chamber for 14 days were as follows. The percent of water vapor sorption were 13.91% in uncoated capsule, 13.30% in HPC-coated capsule, 10.87% in MPM-caated capsule and 9.9% in AEA-coated capsule. 3. Water vapor sorption of magnesium carbonate in various protective film coated capsules in 100% RH chamber for 14 days were as follows: The percent of water vapor sorption were 12.48% in uncoated capsule, 10.72% in HPC-coated capsule, 8.10% in MPM coated capsule and 7.8% in AEA-coated capsule. 4. MPM-coated capsules and AEA-canted capsules were mere effective to protect water vapor sorption than HPC-coated capsules.

• Journal of Pharmaceutical Investigation
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• 제3권3호
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• pp.16-19
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• 1973

Stability is impaired in capsules in which there is a transfer of water vapor from capsule to the contents of the capsules. The water vapor transfer between AEA-coated capsules and corn starch, magnesium trisilicate in the closed container was examined. Experimental eguilibrium relative humidity after water vapor transfer and estimated values calculated from a formula of these substances were in close agreement with each other.

• 한국농업기계학회:학술대회논문집
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• 한국농업기계학회 2017년도 춘계공동학술대회
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• pp.27-27
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• 2017

Biocompatible capsules have recently been highlighted as novel delivery platforms of any "materials" (e.g., drug, food, agriculture pesticide) to address current problems of living systems such as humans, animals, and plats in academia and industry for agriculture, biological, biomedical, environmental, food applications. For example, biocompatible alginate capsules were proposed as a delivery platform of biocontrol agents (e.g., bacterial antagonists) for an alternative to antibiotics, which will be a potential strategy in future agriculture. Here, we proposed a new platform based on biocompatible alginate capsules that can control the movements as an active target delivery strategy for various applications including agriculture and biological engineering. We designed and fabricated large scale biocompatible capsules using alginates and custom-made nozzles as well as gelling solutions. To develop the active target delivery platforms, we incorporated the iron oxide nanoparticles in the large scale alginate capsules. It was found that the sizes of large scale alginate capsules could be controlled via various working conditions such as concentrations of alginate solutions and iron oxide nanoparticles. As a proof of concept work, we showed that the iron oxide particles-incorporated large scale alginate capsules could be moved actively by the magnetic fields, which would be a strategy as active target delivery platforms for agriculture and biological engineering (e.g., controlled delivery of agriculture pesticides and biocontrol agents).

• Journal of Biosystems Engineering
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• 제42권4호
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• pp.323-329
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• 2017

Purpose: Biocompatible capsules have recently been highlighted as a novel platform for delivering various components, such as drug, food, and agriculture pesticides, to overcome the current limitations of living systems, such as those in agriculture, biology, the environment, and foods. However, few active targeting systems using biocompatible capsules and physical forces simultaneously have been developed in the agricultural engineering field. Methods: Here, we developed an active targeting delivery platform that uses biocompatible alginate capsules and controls movements by magnetic forces for agricultural and biological engineering applications. We designed and fabricated large-scale biocompatible capsules, using custom-made nozzles ejecting alginate solutions for encapsulation. Results: To develop the active target delivery platforms, we incorporated iron oxide nanoparticles in the large-scale alginate capsules. The sizes of alginate capsules were controlled by regulating the working conditions, such as concentrations of alginate solutions and iron oxide nanoparticles. Conclusions: We confirmed that the iron oxide particle-incorporated large-scale alginate capsules moved actively in response to magnetic fields, which will be a good strategy for active targeted delivery platforms for agriculture and biological engineering applications, such as for the controlled delivery of agriculture pesticides and biocontrol agents.

• 한국건설순환자원학회논문집
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• 제10권3호
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• pp.335-342
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• 2022

본 연구에서는 무기재료를 코어재료로 사용한 자기치유 고상캡슐 및 자기치유 마이크로캡슐을 혼합하여 자기치유 하이브리드 캡슐을 제조하였다. 자기치유 하이브리드캡슐을 시멘트 질량 기준으로 3:7, 5:5 및 7:3의 조성비에 따라 3 % 혼합하여 자기치유 시멘트 복합재료 배합을 진행하였으며, 정수위 투수시험 및 표면균열 모니터링을 통해 균열 자기치유 하이브리드캡슐의 치유 특성을 평가하였다. 실험 결과, 자기치유 고상캡슐 및 자기치유 마이크로캡슐의 조성비가 7:3으로 제조된 자기치유 하이브리드 캡슐을 혼합함에 따라 균열 자기치유 성능을 향상시키는 효과가 큰 것으로 나타났다.

• Journal of Pharmaceutical Investigation
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• 제24권1호
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• pp.25-28
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• 1994

The previous vitamin assays in soft capsules have been performed only with capsule contents. Since some vitamins, however, could migrate into gelatin layer of the soft capsules, each vitamin of multivitamin soft capsules in the market was analyzed simultaneously in both capsule content and gelatin layer. The results showed that migrations of nicotinamide and pyridoxine hydrochloride into gelatin layer were pronounced, while those of other vitamins were negligible.