• 대한화학회지
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• 제37권12호
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• pp.1035-1046
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• 1993

몇 가지 iron(III)porphyrin 착화합물을 합성하고, 이들에 대하여 역상 액체 크로마토그래피에서의 최적 분리조건 및 용리거동을 조사하였다. 분리관, 흐름속도, 용리액의 조성 등을 변화시킨 실험에서 분리관은 NOVA-PAK $C_{18}$, 용리액은 methanol/water의 이성분 혼합용매를 적당히 조절하였을 때 용량인자가 최적 분리조건인 $0{\leq}logk'{\leq}1$ 범위를 만족시켰다. 용리거동에 관련된 인자들로는 용리액의 세기, 분포비$(D_c)$ 및 분리관의 온도변화에 따른 엔탈피(${\Delta}H^{\circ}$), 엔트로피(${\Delta}S^{\circ}$), 보정온도($\beta$)를 조사하여 분리 메카니즘을 규명하였다. 이성분 용매계에서 용리 세기 및 물의 부피분율과 용량인자(logk')와의 관계를 조사한 결과 이들간에는 직선성이 잘 성립되었으며, 부피비와 용량인자와의 관계에서도 비교적 직선성을 잘 나타내었다. 이러한 결과로부터 시료의 용리 메카니즘이 소용매성 효과에 기인하고 있음을 확인할 수 있었다. 또한 열역학적인 방법으로 용리거동을 조사하기 위하여, van't Hoff plot으로부터 엔탈피, 엔트로피를 구하였다. 엔탈피와 용량인자와의 상관관계를 조사한 결과 iron(III)porphyrin 착화합물과 정지상과의 상호작용은 온도변화에 과계없이 일정함을 알 수 있었고, 정지상과의 소용매성 결합 과정은 등평형 거동을 나타내었다.

• Geomechanics and Engineering
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• 제27권5호
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• pp.497-509
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• 2021

A large deformation FEM (Finite Element Method) based numerical analysis has been performed to study the behaviour of the bell-shaped anchor embedded in undrained saturated (cohesive) soil with the help of finite element based software ABAQUS. A typical model anchor with bell-diameter of 0.125 m, embedded in undrained saturated soil with varying cohesive strength (from 5 kN/m² to 200 kN/m²) has been chosen for studying the characteristic behaviour of the bell-shaped anchor installed in cohesive soil. Breakout factors have been evaluated for each case and verified with the results of experimental model tests for three different types of soil samples. The maximum value of breakout factor was found as about 8.5 within a range of critical embedment ratio of 2.5 to 3. An explicit model has been developed to estimate the breakout factor (F_c) for uplift capacity of bell-shaped anchor within clay mass in terms of H/D ratio (embedment ratio). It was also found that, the ultimate uplift capacity of the anchor increases with the increase of the value of cohesive strength of the soil and H/D ratio. The empirical equation developed in the present investigation is usable within the range of cohesion value and H/D ratio from 5 kN/m² to 200 kN /m² and 0.5 to 3.0 respectively. The proposed model has been validated against data obtained from a series of model tests carried out in the present investigation. From the stress-profile analysis of the soil mass surrounding the anchor, occurrence of stress concentration is found to be generated at the joint of anchor shaft and bell. It was also found that the vertical and horizontal stresses surrounding the anchor diminish at about a distance of 0.3 m and 0.15 m respectively.

• Structural Engineering and Mechanics
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• 제17권2호
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• pp.167-186
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• 2004

The design load-carrying capacities of wooden shores depend on factors, such as the wood species and properties, and construction methods. This paper focuses on the construction methods, including an upright single shore, group of upright shores, group of inclined shores, butt connections and lap connections. This paper reports experiments to obtain critical loads and then developed an empirical equation based on Euler' formula for the critical loads and design load-carrying capacities. The test results show that the critical loads for an upright single wooden shore are greater than the average values for a group of upright shores, and the latter are greater than the average values for a group of inclined shores. Test results also show that the critical loads become smaller when butt or lap connections are used, butt connections possessing greater critical loads than lap connections. Groups of inclined shores are very popular at work sites because they have some practical advantages even though they actually possess inferior critical loads. This paper presents an improved setup for constructing groups of inclined shores. With this method, the inclined shores have larger critical loads than upright shores. The design load-carrying capacities were obtained by multiplying the average critical loads by a resistance factor (or strength reduction factor, ${\phi}$) that were all smaller than 1. This article preliminarily suggests ${\phi}$ factors based on the test results for the reference of engineers or specification committees.

• Structural Engineering and Mechanics
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• 제12권6호
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• pp.615-632
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• 2001

Ductility of open piled wharves under reversed cyclic loads has been investigated. Experimental testing of five wharf models having a scale of about 1:4 was conducted under the application of horizontal reversed cyclic loading. The experiments were designed to focus on the horizontal ultimate load, ductility and failure mode of the considered wharf models. Nonlinear numerical analyses using the finite element method were also performed on numerical models representing the experimentally tested wharves. The results of the experimental tests showed that open piled wharves possessed favourable ductile behaviour and that their load bearing capacity did not depreciate until a ductility factor of 3 to 4 was reached. The numerical analysis showed that the relative rotation that took place at the joints between the steel piles and the R.C. beam was responsible for a considerable portion of the total horizontal deformation of the wharves. Therefore, it was concluded that introducing the joint stiffness in calculating the deformations of open piled wharves was important to achieve reasonable accuracy.

• 한국토양비료학회지
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• 제6권1호
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• pp.29-31
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• 1973

Upon the assumption that the available components in the soil evaluated by present analytical procedures, are as effective as the components applied to the soil as fertilizer, some formulas for the calculation of fertilizer requirements (F. R) for crops are suggested. Basically, the formulas are derived by combining the country average values of soil test data(${\overline{ST}}$) and of the optimum rate of fertilizers (ORF) for crops obtained from N.P.K. trials in farmer's field, as following. $$F.R(kg/10a)={\overline{ST}}(kg/10a)+ORFkg/10a-ST(kg/10a)$$ where, ST denotes the available components tested in the soil under question. Although this formula can be used both for P and K fertilizers, considering the significance of the potassium saturation rate of the soil for the availability of K, for the calculation of K fertilizer requirement, following formula is suggested. $$F.R(kg/10a)=(C.E.C.{\times}B.S.R.K.-KST(me/100g){\times}CF$$ where, B. S. R. K. is the basic potassium saturation rate of the soil and CF is conversion factor for the conversion of K me/100g into $K_2O$ kg/10a. The B. S. R. K. for different crops are obtained from the country average values of soil exchangeable K (${\overline{KST}}$), cation exchange capacity (CEC) and the optimum rates of K fertilizers for crops (ORF $K_2O$). $$B.S.R.K.=\frac{{\overline{KST}}{\times}CF+ORF(K_2O)}{CEC{\times}CF}$$ Using these formulas, equations for P and K fertilizer requirements for rice, barley, wheat, corn, italian millet, soy bean, sweet potato, potato and rape are derived.

• 공업화학
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• 제22권1호
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• pp.114-118
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• 2011

미네랄 오일을 결합재로 사용하는 탄소반죽전극은 효소의 특성 연구 분야에서 효과적으로 활용되고 있으나 전극이 기계적 경도가 없으므로 실용화의 가능성은 없다. 본 실험실에서는 톨루엔에 녹인 고무 용액이 탄소가루의 결합재로 사용될 때 탄소반죽의 기계적 물성이 얻어지는 것을 확인하였다. 클로로프렌 고무 용액을 이용하여 만든 전극이 정량적인 전기화학적 행동을 보이는지 확인하기 위하여 여러 가지 속도론적 파라메터 즉 대칭인자($\alpha$, 0.28), 교환전류밀도 ($i_0$, $4.06{\mu}A/cm^2$), 이중층의 축전용량($C_d$, $2.11{\times}10^{-3}F$), Michaelis 상수($K_M$, $2.45{\times}10^{-3}M$), 시간상수(${\tau}_B$, 0.077 sec) 등을 구하였다. 이 실험적 사실들은 클로로프렌 고무가 탄소반죽전극의 실용화에 전망 좋은 결합재임을 입증하였다.

• 한국지진공학회논문집
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• 제16권4호
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• pp.1-8
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• 2012

국내 철골모멘트골조를 이전 KBC2005 및 현 KBC2009 기준에 따라 설계한 후 비선형동적해석을 이용하여 FEMA355F의 내진성능평가 절차에 따라 성능을 평가하였다. 그 결과 비선형정적 Push-over 해석을 이용한 역량스펙트럼법과 차이가 있었다. 특히 국내 철골모멘트골조는 약패널존을 가지기 때문에 비선형동적해석을 통해서만 보다 정확한 거동을 예측할 수 있었다. 국내 철골모멘트골조는 지반 조건 SB 또는 SC에 위치한다면 층수 및 R값에 관계없이 성능목표를 만족하는 것으로 나타났다. 하지만 지반 조건 SD 또는 SE에 위치한다면 성능목표 만족 여부는 명확하지 않았다. 따라서 KBC2005나 KBC2009 어떤 기준을 사용하더라도 지반 조건이 상대적으로 좋다면 국내 철골모멘트골조는 내진성능을 충분히 확보하고 있다고 볼 수 있다.

• Nutrition Research and Practice
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• 제10권5호
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• pp.494-500
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• 2016

BACKGROUND/OBJECTIVES: Evidence indicates that berry anthocyanins are anti-atherogenic, antioxidant, and anti-inflammatory. However, berries differ vastly in their anthocyanin composition and thus potentially in their biological and metabolic effects. The present study compared hypolipidemic, antioxidant, and anti-inflammatory properties of blueberry (BB), blackberry (BK), and blackcurrant (BC) in a diet-induced obesity (DIO) mouse model. MATERIALS/METHODS: Male C57BL/6J mice were fed a high fat (HF; 35% fat, w/w) control diet or a HF diet supplemented with freeze-dried 5% BB, 6.3% BK or 5.7% BC for 12 weeks (10 mice/group) to achieve the same total anthocyanin content in each diet. Plasma lipids, antioxidant status and pro-inflammatory cytokines were measured. The expression of genes involved in antioxidant defense, inflammation, and lipid metabolism was determined in the liver, epididymal adipose tissue, proximal intestine, and skeletal muscle. Histological analysis was performed to identify crown-like structure (CLS) in epididymal fat pads to determine macrophage infiltration. RESULTS: No differences were noted between the control and any berry-fed groups in plasma levels of liver enzymes, insulin, glucose, ferric reducing antioxidant power, superoxide dismutase, and tumor necrosis factor ${\alpha}$. However, BK significantly lowered plasma triglyceride compared with the HF control and other berries, whereas BC significantly reduced F4/80 mRNA and the number of CLS in the epididymal fat pad, indicative of less macrophage infiltration. CONCLUSIONS: The present study provides evidence that BB, BK and BC with varying anthocyanin composition differentially affect plasma lipids and adipose macrophage infiltration in DIO mice, but with no differences in their antioxidant capacity and anti-inflammatory potential.

• 한국지반환경공학회 논문집
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• 제15권4호
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• pp.43-51
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• 2014

시험 설계된 초장대 사장교의 고주탑을 지지하는 대수심 대형 복합기초의 지중 대구경 현장타설말뚝을 허용응력 설계법으로 설계하고, 지지력에 대한 신뢰성 해석을 통해 파괴확률을 평가하였다. 말뚝의 지지력에 대한 허용응력 설계 결과를 신뢰성 해석으로 분석하였으며 파괴확률은 CFEM의 경우 0.12 %, 한국도로공사기준 방법의 경우 0.0002 %, 구조물기초설계기준의 경우 0.003 %였다. 허용응력 설계에서는 안전율 3을 적용하여 대구경 현장타설말뚝의 허용지지력을 구하였으며, 그 결과에 대한 신뢰성 해석을 실시하였다. AASHTO(2007)에서 제시하고 있는 파괴확률($P_f$) 0.02 %일 때 CFEM 방법에서는 근입 깊이가 25 % 만큼 증가하였으며 한국도로공사기준(KHCC)에서는 근입깊이를 60 %, 구조물기초설계기준(SFDC)에서는 근입 깊이를 89 % 만큼 감소시킬 수 있었다.

• Journal of Veterinary Science
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• 제24권3호
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• pp.44.1-44.17
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• 2023

Background: Antibiotic resistance is a significant public health concern around the globe. Antimicrobial peptides exhibit broad-spectrum and efficient antibacterial activity with an added advantage of low drug resistance. The higher water content and 3D network structure of the hydrogels are beneficial for maintaining antimicrobial peptide activity and help to prevent degradation. The antimicrobial peptide released from hydrogels also hasten the local wound healing by promoting epithelial tissue regeneration and granulation tissue formation. Objective: This study aimed at developing sodium alginate based hydrogel loaded with a novel antimicrobial peptide Chol-37(F34-R) and to investigate the characteristics in vitro and in vivo as an alternative antibacterial wound dressing to treat infectious wounds. Methods: Hydrogels were developed and optimized by varying the concentrations of crosslinkers and subjected to various characterization tests like cross-sectional morphology, swelling index, percent water contents, water retention ratio, drug release and antibacterial activity in vitro, and Pseudomonas aeruginosa infected wound mice model in vivo. Results: The results indicated that the hydrogel C proved superior in terms of cross-sectional morphology having uniformly sized interconnected pores, a good swelling index, with the capacity to retain a higher quantity of water. Furthermore, the optimized hydrogel has been found to exert a significant antimicrobial activity against bacteria and was also found to prevent bacterial infiltration into the wound site due to forming an impermeable barrier between the wound bed and external environment. The optimized hydrogel was found to significantly hasten skin regeneration in animal models when compared to other treatments in addition to strong inhibitory effect on the release of pro-inflammatory cytokines (interleukin-1β and tumor necrosis factor-α). Conclusions: Our results suggest that sodium alginate -based hydrogels loaded with Chol-37(F34-R) hold the potential to be used as an alternative to conventional antibiotics in treating infectious skin wounds.