• Molecules and Cells
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• v.43 no.2
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• pp.99-106
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• 2020

Cells are constantly exposed to endogenous and exogenous stresses that can result in DNA damage. In response, they have evolved complex pathways to maintain genomic integrity. RUNX family transcription factors (RUNX1, RUNX2, and RUNX3 in mammals) are master regulators of development and differentiation, and are frequently dysregulated in cancer. A growing body of research also implicates RUNX proteins as regulators of the DNA damage response, often acting in conjunction with the p53 and Fanconi anemia pathways. In this review, we discuss the functional role and mechanisms involved in RUNX factor mediated response to DNA damage and other cellular stresses. We highlight the impact of these new findings on our understanding of cancer predisposition associated with RUNX factor dysregulation and their implications for designing novel approaches to prevent cancer formation in affected individuals.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.09a
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• pp.790-799
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• 2010

The Upper Devonian Grossmont Formation in Alberta, Canada reserves an estimated 50 billion cubic meters of bitumen and possess about 1/6 of the total bitumen resources in northern Alberta. However, unlike the overlying Athabasca oil sands, non conventional bitumen resources has not been developed as yet. The carbonate rocks of Grosmont Formation have been subject to various stages of diagenesis, including dolomatization and karstification with a strong effect on the distribution of porosity and permeability, which resulted in highly heterogeneous reservoirs. An extensive fracture logging and mapping was performed on total of six boreholes located in the study area to explore the characteristics of fracture geometry system and the subsurface structures of carbonates reservoir that holds bitumen. Fractal dimension was used as a measure of the statistical homogeneity of the fractured rock masses. The applicability of random Cantor dust, Dc, as a fractal parameter was examined systematically. The statistical homogeneity of fractured carbonates rock masses was investigated in the study area. The structural domains of the rock masses were delineated depthwise according to estimated Dc. The major fracture orientation was dominated by horizontal beddings having dip of $0-20^{\circ}$. Also, fractures having high dip angles existed with relatively low frequency. Three dimensional fracture network modeling for each structural domain has been performed based on fracture orientation and intensity, and some representative conceptual models for carbonates reservoir in the study area has been proposed. The developed subsurface conceptual models will be used to capture the geomechanical characteristics of the carbonates reservoir.

• Journal for History of Mathematics
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• v.23 no.3
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• pp.57-73
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• 2010

Transcendental numbers are important in the history of mathematics because their study provided that circle squaring, one of the geometric problems of antiquity that had baffled mathematicians for more than 2000 years was insoluble. Liouville established in 1844 that transcendental numbers exist. In 1874, Cantor published his first proof of the existence of transcendentals in article [10]. Louville's theorem basically can be used to prove the existence of Transcendental number as well as produce a class of transcendental numbers. The number e was proved to be transcendental by Hermite in 1873, and $\pi$ by Lindemann in 1882. In 1934, Gelfond published a complete solution to the entire seventh problem of Hilbert. Within six weeks, Schneider found another independent solution. In 1966, A. Baker established the generalization of the Gelfond-Schneider theorem. He proved that any non-vanishing linear combination of logarithms of algebraic numbers with algebraic coefficients is transcendental. This study aims to examine the concept and development of transcendental numbers and to present students with its open problems promoting a research on it any further.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.8
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• pp.1699-1704
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• 2009

If detected early enough, cervical cantor may have a good survival rate due to its preneoplastic state. However, the process is so time consuming that a medical expert can handle only a small amount of such examinations. In this paper, we propose a new nucleus extraction algorithm for uterine cervical pap smears in order to mitigate such burdens of medical experts. In the preneoplastic state cytodiagnosis images, it is important to differentiate three main areas - background, cytoplasm and nucleus. Thus, we apply lighting compensation and $3{\times}3$ mask of B channel in order to restore damaged image and remove noises respectively. The cell object is obtained from those clean binarized images with Grossfire algorithm. When there are clusters of cells, the target nucleus can be obtained with repetitive binarization of R channel brightness. In our experiment of using uterine cervical pap smears of 400 magnifications that is common in the diagnostic cytology, our method is able to extract 40 nucleus out of 45 population successfully.

• Animal Systematics, Evolution and Diversity
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• v.28 no.3
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• pp.215-219
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• 2012

To examine genetic divergences of two endemic Sorex caecutiens subspecies from Korea (S. c. hallamontanus in Korean Jeju Island and S. c. annexus in the mainland Korean Peninsula), we obtained partial cytochrome oxidase I (COI) sequences (429 bp) and complete cytochrome b sequences (1,140 bp) from the two Korean subspecies, and we compared these sequences to the corresponding sequences of S. caecutiens, obtained from GenBank. We found that Jeju S. c. hallamontanus is one of three clades within S. caecutiens, with an average Jukes-Cantor distance of 1.57% in the COI sequences and the distance of 2.07% and 11 fixed site differences in the cytochrome b sequences, indicating that Jeju S. c. hallamontanus is one endemic subspecies with concordant genetic distinctness, although further analyses with nuclear DNA sequences are necessary to confirm these findings. However, S. c. annexus from the mainland Korean Peninsula was not divergent from S. c. macropygmaeus from northeastern China and adjacent Russia, indicating that S. c. annexus from the mainland Korean Peninsula is another endemic subspecies with only morphological differences, although it is necessary to reexamine the subspecies status of S. c. annexus.

• Journal of Gifted/Talented Education
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• v.5 no.2
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• pp.37-54
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• 1995

The radical development of modern mathematics is due to the appearance of Collection Theory by George Cantor. The Set Theory is independent as an area and also closely interrelated with other areas. So its content becomes a common sense and a basic part across the whole area of modern mathematics. Accordingly, the basic element of modern mathematics is helping young children get familiar with set as early as possible. The thinking of set by which children can categorize, make partial sets and correspondences, understand the general characteristic, and conceptualize the discovered relationships is very important for young children. At this point where the Math education for young children is emphasized under the influence of the modernization movement of Math education, the systematic education for building up the set concept as the basic background of number concept during the early childhood is required. On current mathematics education for young children, graphs, the foundation of geometry, time, and patterns have been included in the traditional and practical content related to numbers. However, the education on collection which is the foundation of number concept is insufficient. A study shows that the level of young children's understanding on set is quite high, but the set concept isn't reflected in current Math curriculum for young children. And basic activities neccesary on building up the set concept, such as categorization, comparison, etc. are conducted in kindergardens but unsatisfactory because of those kindergarden teachers' premature understanding on the set concept. In conclusion, the curriculum for young children should be reorganized based on the set concept as the kernel concept. Also, the reappraisal of the training curriculum and the supplementary efucation for kindergarden teachers are urgent for raising the teaching ability of those kindergarden teachers.

• Journal of Pharmacopuncture
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• v.4 no.2
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• pp.35-47
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• 2001

Objectives : Through the literatures on the effets of Bufonis Venenum, we are finding out the clinical possibility and revealing the more effective to intractable diseases. Methods : We investigated the literatures of Oriental Medicine and experimental reports about Bufonis Venenum. Results : 1. Bufonis Venenum is made of bufonidae bufo bufo gargarizans cantor or bufo melanostictus schneider of white serum which secreted from parotid gland or dermato gland, and it is dried for using. 2. In oriental medicine, Bufonis Venenum has been mainly used on the tumors, cacanthrax and dermatic disease, and then it has been clinically used on infantile athrepsia, tetanus, sore throat, toothache, and so on. 3. The pharmacological effects of Bufonis Venenum are cardiotonic, respiration stimulation, depressor or vasopressor, topical anesthcsia, hallucination, striped muscle stimulation, antiasthmatic, antibacterial, antiinflammatory, anticancer, diuretic, immuno effects, etc. 4. Bufonis Venenum is largely divided in ether binding steroid compound, hydroxyl steroid compound, carboxyl or aldehyde steroid compound, indole compound, and adrenaline, cholesterole, etc. 5. Symptoms of Bufonis Venenum poisoning in digestive system are vommitig, abdominal pain, diarrhea, dehydration, in circulatory system are palpitation, shock, bradycardia, in nervous system are vertigo, somnolentia, muscle-tendon reflex weakness, and critical conditions to tissue necrosis and heart attack. 6. Ways to treat Bufonis Venenum poisoning include gastric irrigation with $0.2~0.5\%$ potassium permanganate fluid and atropine $0.5{\sim}1.0mg$ subcutaneous injection. From the chinese book of Bon Cho Gang Moke(本草綱目), if white serum of Bufonis Venenum enter the eyes, it happens the edema and pain. And then washed the eyes by juice of Lithospermi Radix(紫草) that the edema is removed. Conclusions and Discussion : The results from above literary studies show that prescriptions and Aqua-acupuncture of Bufonis Venenum could be clinically used to sedative, anticonvulsant, antibacterial, antiinflammatory, anticancer and topical ataralgesia. However it is expected that pharmacological and side effects of Bufonis Venenum are further studied.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.16 no.7
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• pp.680-695
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• 1991

In this paper, the conditions on the number of required copies of a self-routing network with and without extra stages in back-to-back manner are presented respectively for a nonblocking $Multi-Log_2N$ multiconnection network. Actually the obained results hold regardless of connection patterns, i.e., whether a network deploys on-to-one connections or multiconnections. Thus open problems on the nonblocking condition for a multi $Multi-Log_2N$ multiconnection network are solved. Interestingly some of the given formulas comprise the Benes network and the Canto network as a special case repectively. A novel switching system architecture deploying a distributed calls-distribution algorithm is provided to design a nonblocking $Multi-Log_2N$ photonic switching network using a directional coupler. And a directional couplex based call holding demultiplexer is introduced to hold a call until blocking disappears in a switching network and let it enter to a network, provided that the number of switching networks is less than that of required switching networks for a nonblocking $Multi-Log_2N$ network.

• Korean Journal of Agricultural Science
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• v.46 no.1
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• pp.113-124
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• 2019

Insect-resistant transgenic (Bt-9) rice was generated by inserting mCry1Ac1, a modified gene from the soil bacterium Bacillus thuringiensis, into the genome of a conventional variety of rice (Ilmi). With regard to potential problems such as safety, an evaluation of non-target organisms is necessary as an essential element of an environmental risk assessment of genetically modified (GM) crops. We studied the effects of the Bt-9 rice on the survival of cantor Daphnia magna, a commonly used model organism in ecotoxicological studies. D. magna fed on the Bt-transgenic rice (Bt-9) and its near non-GM counterparts (Ilmi) grown in the same environment (a 100% ground rice suspension). The Bt-9 rice was confirmed to have the inserted T-DNA and protein expression evident by the PCR and ELISA analyses. The feeding study showed a similar cumulative immobility and abnormal response of the Daphnia magna between the Bt-9 rice and Ilmi. Additionally, the 48 h-EC50 values of the Bt-9 and Ilmi rice were 4,400 mg/L (95% confidence limits: 3861.01 - 5015.01 mg/L) and 5,564 mg/L (95% confidence limits: 4780.03 - 6476.93 mg/L), respectively. The rice NOEC (No observed effect concentration) value for D. magna was suggested to be 1,620 mg/L. We conclude that the tested Bt-9 and Ilmi have a similar cumulative immobility for D. magna, a widely used model organism, and the growth of Bt-9 did not affect non-target insects.

• Hip & pelvis
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• v.35 no.1
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• pp.6-14
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• 2023

Purpose: The aim of this study was to determine correlation between the spinopelvic parameters in sitting and standing positions (sacral slope [SS], lumbar lordosis [LL], spinopelvic tilt [SPT], pelvic incidence [PI], and pelvic femoral angle [PFA]), with hip function assessed using the modified Harris hip scores (mHHs) in patients with symptomatic femoroacetabular impingement (FAI) at diagnosis. Materials and Methods: A retrospective study of 52 patients diagnosed with symptomatic FAI was conducted. Evaluation of the spinopelvic complex in terms of SS, LL, SPT, PI and PFA was performed using lateral radiographs of the pelvis and lumbosacral spine in standing and sitting positions. Assessment of hip function at diagnosis was performed using the mHHs. Calculation of spinopelvic mobility was based on the difference (Δ) between measurements performed in standing and sitting position. Results: The median time of pain evolution was 11 months (interquartile range [IQR], 5-24 months) with a median mHHs of 66.0 points (IQR, 46.0-73.0) at diagnosis. The mean change of LL, SS, SPT, and PFA was 20.9±11.2°, 14.2±8.6°, 15.5±9.0°, and 70.7±9.5°, respectively. No statistically significant correlation was observed between spinopelvic parameters and the mHHs (P>0.05). Conclusion: Radiological parameters of the spinopelvic complex did not show correlation with hip function at the time of diagnosis in patients with symptomatic FAI. Conduct of further studies will be required in the effort to understand the effect of the spinopelvic complex and its compensatory mechanics, primarily between the hip and spine, in patients with FAI before and after hip arthroscopy.