• Journal of Animal Science and Technology
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• 제62권6호
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• pp.765-776
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• 2020

The retinal degenerative disease, progressive retinal atrophy (PRA) is a major reason of vision impairment in canine population. Canine PRA signifies an inherently dissimilar category of retinal dystrophies which has solid resemblances to human retinis pigmentosa. Even though much is known about the biology of PRA, the knowledge about the intricate connection among genetic loci, genes and pathways associated to this disease in dogs are still remain unknown. Therefore, we have performed a genome wide association study (GWAS) to identify susceptibility single nucleotide polymorphisms (SNPs) of PRA. The GWAS was performed using a case-control based association analysis method on PRA dataset of 129 dogs and 135,553 markers. Further, the gene-set and pathway analysis were conducted in this study. A total of 1,114 markers associations with PRA trait at p < 0.01 were extracted and mapped to 640 unique genes, and then selected significant (p < 0.05) enriched 35 gene ontology (GO) terms and 5 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways contain these genes. In particular, apoptosis process, homophilic cell adhesion, calcium ion binding, and endoplasmic reticulum GO terms as well as pathways related to focal adhesion, cyclic guanosine monophosphate)-protein kinase G signaling, and axon guidance were more likely associated to the PRA disease in dogs. These data could provide new insight for further research on identification of potential genes and causative pathways for PRA in dogs.

• 한국임상수의학회지
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• 제29권6호
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• pp.498-501
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• 2012

10개월의 수컷 말티즈견 (1.6 kg)이 간헐적인 기침과 지속성 심잡음을 주증으로 내원 하였다. 환축은 경흉부심초음파 검사와 혈관 조영검사를 통하여 좌우단락의 동맥관개존증 (PDA)으로 진단되었다. 혈관조영 검사를 통하여 동맥관의 형태 및 크기에 대해 평가한 뒤, 대퇴동맥으로 $Amplatz^{(R)}$ Canine Duct Occluder (ACDO) 장치를 삽입하는 투시 유도하 동맥관 폐쇄술이 시도되었다. 동맥관의 폐쇄직후 지속성 심잡음이 사라졌으며, 시술 후 실시된 혈관조영검사를 통하여 잔류혈류가 관찰되지 않았다. 투시 유도하에서 ACDO 장착 및 성공적인 동맥관의 완전폐쇄가 확인되었다. 환자는 시술 1일 뒤 퇴원하였으며, 임상증상 관찰 및 심장검사가 정기적으로 이루어 졌다. 시술 후 합병증은 발생하지 않았다. 결론적으로 본 증례의 경우 대퇴동맥내로 ACDO를 적용한 성공적인 동맥관개존증 폐쇄술에 대한 국내 첫 증례보고이다.

• Journal of Oral Medicine and Pain
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• 제24권1호
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• pp.37-47
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• 1999

This study was performed to investigate the factors related to vibration of temporomandibular joint during mandibular opening movement. For this study, 144 patients with temporomandibular disorders were randomly selected. Angle's classification, lateral guidance pattern, range of maximal mouth opening, preferred chewing side, and affected side were investigated clinically. Mandibular torque rotational movement during opening was recorded with $BioEGN^{(R)}$ and vibration of temporomandibular joint during opening was recorded with $Sonopak^{(R)}$. After clinical diagnosis was made, visual analogue scale(VAS) was used for evaluation of clinical progress of the subject's chief complaints. The author calculated VAS treatment index(VAS Ti) from the record of VAS. The more VAS Ti was, the less remission of subjective symptom was, The data were analyzed with SAS/Stat program and the results of this study were as follows: 1. There were no significant difference in all the variables of joint vibration by age and sex. 2. Integral and peak amplitude in patients of Angle's class I were higher than those of class II or III patients. Integral in patients of group function was higher than that in patients of canine guidance or other types of lateral excursion. 3. As to Angle's classification or lateral guidance type, there were almost not significant difference between subgroup of same class or type and subgroup of different class or type on both sides. And there were also almost not difference between one side and the other side related to preferred chewing side or affected side. 4. Patients with disk displacement with reduction showed higher value of integral and peak amplitude than any other patients. 5. Joint vibration variables significantly correlated with VAS Ti of pain. with clinical range of mouth opening, and with ingredients of mandibular torque rotational movement.

• Journal of Oral Medicine and Pain
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• 제22권1호
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• pp.167-181
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• 1997

The aim of this study was to investigate the relationship between velocity and factors which could affect the velocity of mandibular movement. For this study, 30 dental students without any masticatory signs and symptoms and 90 patients with temporomandibular disorders(TMD) were selected as the control group and the patients group, respectively. After determining Angle's classification and lateral guidance pattern of occlusion, clinical examination for TMD was perfomed. Velocity and distance of mandibular movements were recorded with BioEGN, reproducibility index of lateral excursions was evaluated by Pantronic(PRI) and BioEGN (BERI) activity in masticatory and cervical muscles were measured with BioEMG, and occlusal contact time and cross-arch unbalance(Total left-right statistics, TLR) on clenching were recorded with T-scan, respectively. The results of this study were as follows : 1. Velocity in the patients was faster than that in the controls in most mandibular movements, but on wide opening and closing movement, result was reverse. 2. Velocity on closing movements were faster than that on opening movements in the control group and a similar tendency was also shown in the patients group. 3. Patients with muscle disorders showed a tendency to have the highest value of velocity of all diagnostic subgroups, while patients with degenerative joint diseases showed a tendency to have the lowest value. 4. Patients with canine guidance showed a tendency to have the highest value of velocity in three subgroups by lateral guidance pattern, while patients with group function showed a tendency to have the lowest value. 5. BERI had a positive correlation with opening velocity on lateral excursion, while TLR had a negative correlation with opening velocity on swallowing. 6. EMG activity on clenching in masticatory muscles had negative correlation with opening velocity on border movements, and on swollowing, while the activity in rest correlated positively with opening velocity on border movements. 7. There were positive correlation between the velocity and the distance in long components of mandibular trajectory.

• 대한치과보철학회지
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• 제53권2호
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• pp.128-137
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• 2015

목적: 교합접촉 분석에 대한 연구는 외국인을 대상으로 이루어져왔다. 이번 연구에서는 T-Scan을 이용하여 하악 측방운동시 교합접촉 분석을 통해 한국인의 교합 양상을 파악해보고자 한다. 재료 및 방법: 87명을 대상으로 T-Scan을 이용하여 하악 측방운동시 교합접촉을 분석하였다. 최대교두감합위에서 측방으로 3 mm범위까지 교합접촉을 측정하였으며, 최대교두감합위, 우측방운동, 좌측방운동을 각각 3회씩 측정하였다. 교합접촉은 thin metal foil을 이용하여 재확인하였다. 결과는 균형측 교합접촉 고려하지 않은 경우와 고려한 경우로 나누어 정리하였다. 결과: 하악 측방운동시 균형측 접촉 고려 유무에 따라 결과에서 많은 차이가 관찰되었으며, 두가지 분류 모두에서 군기능유도가 가장 우세하게 나타났다. 작업측에서는 견치에서 가장 많은 접촉빈도가 관찰되었으며, 견치에서 구치부로 멀어질수록 접촉빈도는 감소하는 양상을 보였다. 균형측에서는 제 2대구치에서 압도적으로 많은 빈도로 관찰되었다. 성별에 따른 균형측 접촉 빈도는 여성에서 더 높은 균형측 교합접촉이 관찰되었으며 이는 통계적으로 유의성이 있었다(${\alpha}$=.05). 결론: 전방유도의 양상 중 군기능유도가 가장 우세하게 나타났다. 작업측에서는 견치에서 가장 높은 접촉빈도가 관찰되었으며, 균형측에서는 제 2 대구치에서 가장 높은 접촉빈도가 관찰되었다.

• 대한수의학회지
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• 제44권2호
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• pp.317-322
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• 2004

This study was performed to evaluate echocardiographic parameters in dogs with experimental mitral regurgitation subjected to dobutamine stress testing. In 8 beagle dogs, a 4-prong grasping forceps was inserted into the left ventricle through the carotid artery with fluoroscopic guidance. The disruption of chordae or mitral valve leaflet was performed. Echocardiographic protocols included quantitative Doppler echocardiography and M-mode measurement for evaluating left ventricle function. After all measurement was obtained at rest, dobutamine was infused incrementally. In stress testing, all measurement also was performed at rest as the same method. In stress Doppler echocardiography, regurgitant fraction and aortic stroke volume was increased significantly (P<0.001). Effective regurgitant orifice and regurgitant volume was not changed. In M-mode examination, fractional shortening was increased significantly at stress test (P<0.001). From the results obtained in this study, it could be suggested that dobutamine stress echocardiography increase left ventricle performance in non-functional mitral regurgitation and quantitative Doppler echocardiography is non-invasive, accurate method in valvular regurgitation.

• 대한치과교정학회지
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• 제21권3호
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• pp.711-722
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• 1991

The first patient of this case was 13 year and 8 month old girl who had the Angle's class I malocclusion with uneruption of upper left central incisor and left canine. The second patient was 12 year old boy who had the Angle's class I malocclusion with uneruption of right central incisor. After surgical exposure of impacted teeth of those patients and bonding of attachment on exposed crown, those teeth were orthodontically pulled with removable appliances. The results were obtained as follow. 1. The functionally proper occlusion was established by guidance of the impacted teeth into the normal position in the arch. 2. Establishment of esthetic and balanced arch form was achieved. 3. The possibility of restorative prosthetic treatment induced by extraction of impacted teeth was eliminated. 4. The psychologic relief of pubertal patient who was very sensitive to facial esthetics was gained.

• 대한소아치과학회지
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• 제26권1호
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• pp.38-43
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• 1999

치아전위는 비교적 드문 발육장애이다. 적절하게 차단치료된다면 예방이 가능할 뿐 아니라 이후의 교정과 수복과정이 보다 용이할 수 있다. 이를 위한 8-9세 경의 조기 임상검사가 이러한 발육장애의 인지를 위해 추천된다. 일단 전위가 일어난 경우에는, 부정교합을 교정하고 최상의 기능적, 심미적 결과를 얻기 위해 주의깊은 교정적 평가가 요구된다. 이상적인 결과를 얻기 위하여 두 치아를 원래의 위치로 환원시키는 치료가 요구되나, 완전전위되어 두 치아가 맹출되었다면 전위된 상태로 치아를 배열하여도 비교적 양호한 결과를 얻을 수 있었다.

• Journal of Periodontal and Implant Science
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• 제34권1호
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• pp.19-28
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• 2004

Tooth is the most important element in esthetic consideration on facial area. Tooth alignment which is in harmony with gingiva, lips, and face is also key element. The purpose of this study was to give a clinical discipline for restoration of gingival contour, which contains a ratio of maxillary 6 anterior teeth, research for gingival contour etc., in case of rehabilitation of maxillary anterior teeth. 300 Dankook university dental school students ,who is their twenties and free from periodontitis, participate in this study. The result was from each 70 males and females who had normal occlusion and tooth alignment. Length, width and length/width ratio of maxillary 6 anterior teeth were 0.74-0.81 in male, 0.81-0.84 in female. There was significant difference between male and female. The most deepest position of gingiva in maxillary central incisor and canine was located in distal part of teeth and maxillary lateral incisor was middle portion. In maxillary central incisors, gingival line of the most deepest point appeared significant difference between male and female (p<0.01) whereas there was no difference in lateral incisors and canines. Distance between interdental papilla apex and the most deepest portion appeared significant difference between male and female. Distance of the deepest position of gingiva is statistically significant except maxillary central incisors and lateral incisors. Standard deviation and mean of the width of labio-lingual were measured in cervical area and there was a significant difference both male and female.(p<0.01) From this result, we could get the mean of maxillary anterior gingival line and these results have great value in clinical guidance in studying maxillary anterior teeth.

• 대한소아치과학회지
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• 제34권3호
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• pp.481-489
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• 2007

상악 견치의 매복은 임상에서 종종 관찰되며 인접치의 치근을 흡수하거나 낭종을 형성하는 등 여러 문제점을 유발한다. 매복 치아의 치료는 치근단의 완성 정도, 치아 매복의 방향과 위치, 맹출 공간의 존재 여부, 매복치 주변의 과잉치, 치아종, 낭종 등의 존재 여부 등에 따라 발치, 교정적 견인, 외과적 자가이식 등의 술식이 결정된다. 자가이식은 치아의 위치가 교정력을 가할 수 없는 위치에 존재하거나 치아 이동이 제한을 받게 되어 통상적인 치료가 불가능할 경우에 발거에 앞서 고려할 수 있으며, 자가이식의 예후는 치주인대의 보존, 치근의 완성도, 외과적 술식, 환자 연령, 근관치료 시기, 치아고정 기간 및 형태와 구강외 저장 용액 등에 의해 결정된다. 본 증례들은 영구 치열기 말기에 상악 견치 매복으로 내원하였고 그 매복 위치가 자발적인 맹출 유도나 교정적 견인 및 배열이 어렵다고 판단되었다. 따라서 자가이식과 근관치료를 시행하고 주기적인 관찰 중이다.