• 한국산학기술학회논문지
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• 제17권3호
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• pp.332-337
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• 2016

오버레이 멀티캐스트를 이용하는 응용에서는 노드들의 잦은 탈퇴로 인하여 발생하는 전송 경로의 빠른 재구성이 필요하다. 이를 위해 많은 연구들이 진행되어 왔지만 빠른 경로 복구를 위한 연구는 지속적으로 요구된다. 본 논문에서는 오버레이 멀티캐스트에서 부모노드의 탈퇴로 발생하는 전송 경로 재구성 시간을 개선하고 안정적인 경로를 유지하기 위하여 새로운 빠른 경로 복구 방법을 제안한다. 제안 방법에서는 빠른 경로 복구를 위하여 가상 전송 경로와 후보 부모 노드를 이용한다. 모든 노드들은 전송 경로 상 자신과 비슷한 깊이에 존재하는 노드 및 인접한 노드와 주기적으로 RTT(Round Trip Time)정보를 교환한다. 모든 노드들은 후보 부모 노드 리스트를 가지고 있고 각 노드는 이 교환된 RTT 정보를 리스트에 저장한다. 각 노드들은 경로 복구 시간을 줄이기 위하여 저장된 RTT 정보 순으로 후보 부모 노드들을 결정하고 가상 전송 경로를 구성한다. 구성된 가상 전송 경로를 이용하여 부모 노드의 탈퇴 시 빠르게 전송 경로를 복구할 수 있다. 시뮬레이션 결과는 제안 방법의 복구 시간이 일반적인 방법보다 평균 30%로 더 빨랐음을 보여준다.

• Journal of Preventive Medicine and Public Health
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• 제42권1호
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• pp.1-4
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• 2009

Objectives : Isolated cleft lip with or without cleft palate(CL/P) is among the most common human birth defects, with a prevalence of approximately 1 in 700 live births. The B-Cell Leukemia/lymphoma 3(BCL3) gene has been suggested as a candidate gene for CL/P based on association and linkage studies in some populations. This study tests for an association between markers in BCL3 and isolated, non-syndromic CL/P using a case-parent trio design, while considering parent-of-origin effects. Methods : Forty case-parent trios were genotyped for two single nucleotide polymorphisms(SNPs) in the BCL3 gene. We performed a transmission disequilibrium test(TDT) on individual SNPs, and the FAMHAP package was used to estimate haplotype frequencies and to test for excess transmission of multi-SNP haplotypes. Results : The odds ratio for transmission of the minor allele, OR(transmission), was significant for SNP rs8100239(OR=3.50, p=0.004) and rs2965169(OR=2.08, p=0.027) when parent-of-origin was not considered. Parentspecific TDT revealed that SNP rs8100239 showed excess maternal transmission. Analysis of haplotypes of rs2965169 and rs8100239 also suggested excess maternal transmission. Conclusions : BCL3 appears to influence risk of CL/P through a parent-of-origin effect with excess maternal transmission.

• Plant Biotechnology Reports
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• 제5권4호
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• pp.301-308
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• 2011

This study tested the relative and combined efficacy of ShPx2 and ShPAL transgenes by comparing Nicotiana tabacum hybrids with enhanced levels of $_L$-phenylalanine ammonia lyase (PAL) activity and cationic peroxidase (Prx) activity with transgenic parental lines that overexpress either transgene. The PAL/Prx hybrids expressed both transgenes driven by the 35S CaMV promoter, and leaf PAL and Prx enzyme activities were similar to those of the relevant transgenic parent and seven- to tenfold higher than nontransgenic controls. Lignin levels in the PAL/Prx hybrids were higher than the PAL parent and nontransgenic controls, but not significantly higher than the Prx parent. All transgenic plants showed increased resistance to the necrotrophs Phytophthora parasitica pv. nicotianae and Cercospora nicotianae compared to nontransgenic controls, with a preponderance of smaller lesion categories produced in Prx-expressing lines. However, the PAL/Prx hybrids showed no significant increase in resistance to either pathogen relative to the Prx parental line. These data indicate that, in tobacco, the PAL and Prx transgenes do not act additively in disease resistance. Stacking with Prx did not prevent a visible growth inhibition from PAL overexpression. Practical use of ShPAL will likely require more sophisticated developmental control, and we conclude that ShPx2 is a preferred candidate for development as a resistance transgene.

• 한국컴퓨터정보학회논문지
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• 제14권10호
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• pp.11-22
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• 2009

동적이고 자원 제한적인 무선 애드혹 네트워크 환경에서, 발행/구독을 위한 이벤트 라우팅 알고리즘은 네트워크의 성능을 결정하는 중요한 역할을 한다. 지금까지는 노드간의 거리 정보를 이용하여 네트워크 오버헤드를 최소화하려는 이벤트 라우팅 알고리즘이 대표적으로 사용되어 왔다. 본 논문에서는 네트워크 오버헤드 중심의 이벤트 라우팅 알고리즘을 기반으로, 구독되는 주제의 유사도를 추가적으로 고려하여 발행/구독 트리에서의 노드 부모를 결정하는 새로운 알고리즘, TopSim을 제안한다. 본 제안 알고리즘은 기반이 되는 ShopParent 알고리즘을 이용하여 네트워크 오버헤드를 계산하고, 이를 기반으로 부모 후보 집합을 만든 후 새로 가입하는 노드와 부모 후보 노드들의 구독주제의 유사도를 계산하여 이를 기반으로 부모를 결정한다. 그럼으로써 노드들이 다수의 구독 주제를 가지는 경우에 보다 효과적으로 네트워크 오버헤드를 줄이도록 하였다. 성능평가를 통해 기존의 네트워크 오버헤드기반의 알고리즘에 비해 제안 알고리즘이 네트워크 성능을 향상시키는 것을 확인하였다.

• 산업융합연구
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• 제21권9호
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• pp.57-66
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• 2023

본 연구는 한부모가정 자녀의 주관적 계층인식이 자살 충동에 어떠한 영향을 미치는지 살펴보고, 우울과 주관적 건강인식의 매개효과를 검증하고자 한다. 이를 위해 분석자료는 한국청소년정책연구원에서 실시한 2020년 한국아동·청소년 인권실태조사를 활용하였고, 조사에 응답한 한부모가정 자녀 618명을 연구대상자로 선정하여 분석하였다. 분석결과, 첫째, 주관적 계층인식이 높을수록 자살충동은 낮아지는 것으로 나타났다. 둘째, 주관적 계층인식과 자살충동의 관계에서 우울은 완전매개하는 것으로 나타났다. 셋째, 주관적 계층인식과 자살충동의 관계에서 주관적 건강인식은 완전매개하는 것으로 나타났다. 이러한 연구결과에 기반하여 한부모가정 자녀들이 인식하는 주관적 계층인식에 따른 자살충동을 줄이기 위한 정책적, 실천적 방안을 제안했다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.116-116
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• 2017

Low-temperature is one of the environmental stress factors that affect plant growth and development and consequently limit crop productivity. The control of seed germination under low-temperature is organized by many genes which are called quantitative trait loci (QTLs). High germination rate for low-temperature is an important factor of growing rice. Previously, we identified a major QTL controlling low-temperature germinability in rice using 96 introgression lines (ILs) derived from a cross between Oryza rufipogon (Rufi) and the Korean japonica cultivar, 'Hwaseongbyeo (HS)'. A $BC_3F_7$ line (TR5) showed better low-temperature germinability than its recurrent parent. TR5 was crossed with HS to develop a segregating F2:3 populations for the target QTL. Six SSR markers polymorphic between HS and Rufi were used to screen and fine map the qLTG1. The qLTG1 on chromosome 1, which accounted for 55.5% of the total phenotypic variation, confirmed that Rufi allele enhanced the low-temperature germinability. Intervals between markers CRM16 and CRM15, four candidate genes were identified. The identified candidate genes, which are encoded by a protein of unknown function, showed their direct involvement on seed germination at low-temperature. To identify genes targeted by qLTG1, we investigated the expression profiles of these candidate genes and germination behavior of qLTG1 under different stress conditions and compared to HS, Rufi, and TR5 at $13{\pm}2^{\circ}C$ for 3 days after incubation. Furthermore, transgenic rice plants will also be developed to conduct a detailed investigation on low-temperature germinability. Hence, the QTL for low-temperature germinability would be useful in rice breeding programs especially in the development of lines possessing low-temperature germinability.

• Asian-Australasian Journal of Animal Sciences
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• 제23권4호
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• pp.425-429
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• 2010

To develop an efficient DNA typing system for Chinese Holstein cattle, 17 microsatellites, which were amplified in four fluorescent multiplex reactions and genotyped by two capillary electrophoresis injections, were evaluated for parentage verification and identity test. These markers were highly polymorphic with a mean of 8.35 alleles per locus and an average expected heterozygosity of 0.711 in 371 individuals. Parentage exclusion probability with only one sampled parent was approximately 0.999. Parentage exclusion probability when another parent' genotype was known was over 0.99999. Overall probability of identity, i.e. the probability that two animals share a common genotype by chance, was $1.52{\times}10^{-16}$. In a test case of parentage assignment, the 17 loci assigned 31 out of 33 cows to the pedigree sires with 95% confidence, while 2 cows were excluded from the paternity relationship with candidate sires. The results demonstrated the high efficacy of the 17 markers in parentage analysis and individual identification for Chinese Holstein cattle.

• 원예과학기술지
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• 제34권3호
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• pp.453-460
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• 2016

The parentage of the horticulturally important pear cultivar 'Niitaka' was confirmed by determining its S-genotypes based on the S-RNase and $PpSFBB^{-{\gamma}}$ genes, and genotyping using simple sequence repeat (SSR) markers. Previous reports suggested that the cultivars 'Amanogawa' and 'Imamuraaki' were the parents of 'Niitaka', although the cultivars 'Chojuro' and 'Shinchu' were also examined as candidate parents, along with two other cultivars. In the present study, the S-genotype of 'Niitaka' was determined to be $S^3S^9$. The $S^9$-RNase of 'Niitaka' was found to be likely inherited from the parent 'Amanogawa' ($S^1S^9$) and the $S^3$-RNase from 'Chojuro' ($S^3S^5$) or 'Shinchu' ($S^3S^5$). Based on the S-genotypes, the cultivar 'Imamuraaki' ($S^1S^6$) had no contribution to the parentage of 'Niitaka' ($S^3S^9$). A total of 67 polymorphic SSR markers were used to further confirm the parentage of 'Niitaka'. Discrepancies were found at several SSR loci between 'Niitaka' and the cultivars 'Imamuraaki' and 'Shinchu', whereas 'Niitaka' inherited alleles from 'Amanogawa' and 'Chojuro' at all SSR loci. Therefore, our findings established that 'Amanogawa' and 'Chojuro' are the parents of pear cultivar 'Niitaka', and not 'Imamuraaki' as previously reported.

• Asian-Australasian Journal of Animal Sciences
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• 제22권6호
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• pp.893-899
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• 2009

Few studies have reported the existence of imprinted genes in cattle compared to the human and mouse. Genomic imprinting is expressed in monoallelic form and it depends on a single parent-specific form of the allele. Comparative analysis of mammals other than the human is a valuable tool for explaining the genomic basis of imprinted genes. In this study, we investigated 34 common imprinted genes in the human and mouse as well as 35 known non-imprinted genes in the human. We found short interspersed nuclear elements (SINEs), long interspersed nuclear elements (LINEs), and long terminal repeats (LTRs) in imprinted (human and mouse) and control (cattle) genes. Pair-wise comparisons for the three species were conducted using SINEs, LINEs, and LTRs. We also calculated 95% confidence intervals of frequencies of repetitive sequences for the three species. As a result, most genes had a similar interval between species. We found 11 genes with conserved SINEs, LINEs, and LTRs in the human, mouse, and cattle. In conclusion, eleven genes (CALCR, Grb10, HTR2A, KCNK9, Kcnq1, MEST, OSBPL5, PPP1R9A, Sgce, SLC22A18, and UBE3A) were identified as candidate imprinted genes in cattle.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권4호
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• pp.225-232
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• 2013

Children with abnormal liver function can often be seen in outpatient clinics or inpatients wards. Most of them have respiratory disease, or gastroenteritis by virus infection, accompanying fever. Occasionally, hepatitis by the viruses causing systemic infection may occur, and screening tests are required. In patients with jaundice, the tests for differential diagnosis and appropriate treatment are important. In the case of a child with hepatitis B virus infection vertically from a hepatitis B surface antigen positive mother, the importance of the recognition of immune clearance can't be overstressed, for the decision of time to begin treatment. Early diagnosis changes the fate of a child with Wilson disease. So, screening test for the disease should not be omitted. Non-alcoholic fatty liver disease, which is mainly discovered in obese children, is a new strong candidate triggering abnormal liver function. Muscular dystrophy is a representative disease mimicking liver dysfunction. Although muscular dystrophy is a progressive disorder, and early diagnosis can't change the fate of patients, it will be better to avoid parent's blame for delayed diagnosis.