• Management & Information Systems Review
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• v.32 no.5
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• pp.101-117
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• 2013

This study compares the relative effectiveness of affective factor(Ad attitude) and cognitive factor(candidate cognition) on candidate attitude among three ad types - direct comparative, indirect comparative, and noncomparative ads. The results showed that in direct comparative advertising context the candidate cognition is dominant in determining candidate attitude. In indirect comparative advertising context candidate cognition is also dominant in determining candidate attitude, but the difference is less than direct comparative advertising. In noncomparative advertising context the ads attitude is dominant in determining candidate attitude. According to research outcomes, it could be said that direct comparative advertising is more effective than indirect comparative advertising in political advertising area.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.3
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• pp.193-200
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• 2018

In a formal speech, the speaker's voice has a variety of effects on the listener. Depending on the voice characteristics, the effectiveness and efficiency of the speech change as well. In the presidential election, the candidate's voice characteristics will affect the cognition of voters. Thus, we need to understand about the a more effective voice of candidate. This study proves whether voters will change their cognition if the candidate changes owe voice. If the cognition of voters can be changed according to the changed voice characteristics of the candidate, we will be able to explain what voices are needed for the candidate. We will also be able to suggest the necessary voice change strategies for effective speech. We describe cognition change of the voters according to the change of the voices of the presidential candidates by the dimension of the sori-engineering and the cognitive dimension. Hence, this study explains the voice characteristics and change strategies needed for candidates for effective speech.

• Proceedings of the Korea Society of Design Studies Conference
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• 2001.10a
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• pp.54.1-54
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• 2001

• Journal of the Korean Institute of Landscape Architecture
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• v.38 no.3
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• pp.1-14
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• 2010

Areas with negative images in cities can degrade the image of the city as a whole and slow the city's efforts to improve its image. The identification of such areas and the development of a city contour that charts the images of various areas in advance can help urban planners establish relevant strategies to ameliorate detrimental images of the city. This study intends to draw a contour of Seongnam City according to citizen's cognition levels of and preference for city area images and aim to shift the strategy of urban image planning from being results-oriented to being process-oriented. The results of this study are as follows: First, an analysis of the level of cognition of and preferences for Seongnam City's landmarks shows that the degree of cognition varies in different areas, whereas that of preferences remains similar; Second, the cognition and preference contour makes it easy to assess and diagnose city images; Third, the image management map, which merges the cognition contour with the preference contour, divides the city into four different areas. In order to manage city images, it follows that those areas with a high degree of cognition but low preference need to be classified and dealt with first. Further, this study shows that those areas with high cognition are the most populated and visited. Areas with high preference can become a strong candidate for being a landscape control point of a city, which adds to the usefulness of this study. The contour of Seongnam will contribute to networking sightseeing areas for visitors centered upon those places of high preference. It would appear that this type of networking will inspire a better image for the city.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.3
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• pp.1477-1491
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• 2017

Inspired by the multi-scale nature of hippocampal place cells, a biologically inspired model based on a multi-scale spatial representation for goal-directed navigation is proposed in order to achieve robotic spatial cognition and autonomous navigation. First, a map of the place cells is constructed in different scales, which is used for encoding the spatial environment. Then, the firing rate of the place cells in each layer is calculated by the Gaussian function as the input of the Q-learning process. The robot decides on its next direction for movement through several candidate actions according to the rules of action selection. After several training trials, the robot can accumulate experiential knowledge and thus learn an appropriate navigation policy to find its goal. The results in simulation show that, in contrast to the other two methods(G-Q, S-Q), the multi-scale model presented in this paper is not only in line with the multi-scale nature of place cells, but also has a faster learning potential to find the optimized path to the goal. Additionally, this method also has a good ability to complete the goal-directed navigation task in large space and in the environments with obstacles.

• Journal of Ginseng Research
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• v.48 no.3
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• pp.245-252
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• 2024

Ginseng is a traditional herbal medicine used for prevention and treatment of various diseases as a tonic. Recent scientific cohort studies on life prolongation with ginseng consumption support this record, as those who consumed ginseng for more than 5 years had reduced mortality and cognitive decline compared to those who did not. Clinical studies have also shown that acute or long-term intake of ginseng total extract improves acute working memory performance or cognitive function in healthy individuals and those with subjective memory impairment (SMI), mild cognitive impairment (MCI), or early Alzheimer's disease (AD) dementia who are taking AD medication(s). Ginseng contains various components ranging from classical ginsenosides and polysaccharides to more recently described gintonin. However, it is unclear which ginseng component(s) might be the main candidate that contribute to memory or cognitive improvements or prevent cognitive decline in older individuals. This review describes recent clinical contributors to ginseng components in clinical tests and introduces emerging evidence that ginseng components could be novel candidates for cognitive improvement in older individuals, as ginseng components improve SMI cognition and exhibits add-on effects when coadministered with early AD dementia drugs. The mechanism behind the beneficial effects of ginseng components and how it improves cognition are presented. Additionally, this review shows how ginseng components can contribute to SMI, MCI, or early AD dementia when used as a supplementary food and/or medicine, and proposes a novel combination therapy of current AD medicines with ginseng component(s).

• Toxicological Research
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• v.32 no.2
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• pp.123-132
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• 2016

The impact of mobile phone (MP) radiation on the brain is of specific interest to the scientific community and warrants investigations, as MP is held close to the head. Studies on humans and rodents revealed hazards MP radiation associated such as brain tumors, impairment in cognition, hearing etc. Melatonin (MT) is an important modulator of CNS functioning and is a neural antioxidant hormone. Zebrafish has emerged as a popular model organism for CNS studies. Herein, we evaluated the impact of GSM900MP (GSM900MP) radiation exposure daily for 1 hr for 14 days with the SAR of 1.34W/Kg on neurobehavioral and oxidative stress parameters in zebrafish. Our study revealed that, GSM900MP radiation exposure, significantly decreased time spent near social stimulus zone and increased total distance travelled, in social interaction test. In the novel tank dive test, the GSM900MP radiation exposure elicited anxiety as revealed by significantly increased time spent in bottom half; freezing bouts and duration and decreased distance travelled, average velocity, and number of entries to upper half of the tank. Exposed zebrafish spent less time in the novel arm of the Y-Maze, corroborating significant impairment in learning as compared to the control group. Exposure decreased superoxide dismutase (SOD), catalase (CAT) activities whereas, increased levels of reduced glutathione (GSH) and lipid peroxidation (LPO) was encountered showing compromised antioxidant defense. Treatment with MT significantly reversed the above neurobehavioral and oxidative derangements induced by GSM900MP radiation exposure. This study traced GSM900MP radiation exposure induced neurobehavioral aberrations and alterations in brain oxidative status. Furthermore, MT proved to be a promising therapeutic candidate in ameliorating such outcomes in zebrafish.

• The Journal of the Korea Contents Association
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• v.18 no.11
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• pp.306-316
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• 2018

This research studies voter's value and attitude reflected by the politician's overall image and scrutinizes the separate structures of the voters' subjectivity on the matter. Objective of the research is to explain the influence that exercises on voters' political actions through this procedure. On this research, there were 32 Q samples that are selected, and they were categorized by a pool of 20 people. Result showed total of 3 different categories of cognition patterns towards Gyeonggi-do Governor Lee Jae Myeong. Of the 3 categories, category 1 (N=4) was a reformer with apparent principles and initiatives, category 2 (N=12) was an efficient tactician with executive ability, and the last category 3 (N=4) was a populist that strives to achieve his political ambition. Opinion of the samples in the first category was that Governor Lee is the right guy for demolishing the barrier between vested class and the non-vesting in the society. Voters in the second category showed expectation for Governor Lee's executive policies that satisfy the voters, given his abilities proven while he was in mayor's office for Seongnam city. People in the pool of category 3 worried that Governor Lee is busy increasing his approval rating and popularity by asserting unrealistic opinions and impractical policies.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.1
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• pp.11-17
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• 2022

In this study, we investigated the effects of Ginseng Radix (G), Rehmanniae Radix (R), and Fermented red-ginseng extracts (FRG) on cognitive function in scopolamine-induced memory-impaired mice. We measured the effects of G, R, and FRG on the improvement of memory and cognition via behavior analysis. In addition, we measured the acetylcholinesterase (AChE) activity in the hippocampus of each group of mice. The expression of β-amyloid, Tau, and BDNF in the brain tissues were observed through immunohistochemical staining. Ginseng Radix (G) and Fermented red-ginseng (FRG) have effectively improved cognitive function in the water maze test. Ginseng Radix (G), Rehmanniae Radix (R), and Fermented red-ginseng (FRG) have improved the willingness of mice to explore the new environment, as confirmed by Y maze test. In addition, immunohistochemical staining revealed that Ginseng Radix (G) decreased the expression of β-amyloid and Tau in the hippocampus. In addition, fermented red-ginseng (FRG) increased the expression of BDNF. Ginseng Radix (G), Rehmanniae Radix (R), and Fermented red-ginseng (FRG) have decreased the concentration of acetylcholinesterase in the hippocampus as compared with the control group of mice. In conclusion, Ginseng Radix (G), Rehmanniae Radix (R), and Fermented red-ginseng (FRG) are considered to have the potential for development as candidate drugs to control the progression of Alzheimer's disease (AD).

• Journal of Ginseng Research
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• v.45 no.2
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• pp.264-272
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• 2021

Background: Gintonin is a ginseng-derived exogenous G-protein-coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors. A recent study demonstrated that systemic treatment with gintonin enhances paracellular permeability of the blood-brain barrier (BBB) through the LPA1/3 receptor. However, little is known about whether gintonin can enhance brain delivery of donepezil (DPZ) (Aricept), which is a representative cognition-improving drug used in AD clinics. In the present study, we examined whether systemic administration of gintonin can stimulate brain delivery of DPZ. Methods: We administered gintonin and DPZ alone or coadministered gintonin with DPZ intravenously or orally to rats. Then we collected the cerebral spinal fluid (CSF) and serum and determined the DPZ concentration through liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Results: Intravenous, but not oral, coadministration of gintonin with DPZ increased the CSF concentration of DPZ in a concentration- and time-dependent manner. Gintonin-mediated enhancement of brain delivery of DPZ was blocked by Ki16425, a LPA1/3 receptor antagonist. Coadministration of vascular endothelial growth factor (VEGF) + gintonin with DPZ similarly increased CSF DPZ concentration. However, gintonin-mediated enhancement of brain delivery of DPZ was blocked by axitinip, a VEGF receptor antagonist. Mannitol, a BBB disrupting agent that increases the BBB permeability, enhanced gintonin-mediated enhancement of brain delivery of DPZ. Conclusions: We found that intravenous, but not oral, coadministration of gintonin facilitates brain delivery of DPZ from plasma via LPA1/3 and VEGF receptors. Gintonin is a potential candidate as a ginseng-derived novel agent for the brain delivery of DPZ for treatment of patients with AD.