• Journal of Environmental Impact Assessment
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• v.4 no.2
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• pp.105-121
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• 1995

Nitrate contamination problems from groundwater supplies have been documented throughout many countries in the world, including Korea. Nitrate salts can induce methemoglobinemia and possibly human gastric cancer. In farmed areas. intensive agricultural activities have caused a major increase in nitrate loading to groundwater. To determine whether decision makers must take farm-management actions to control the increase of groundwater nitrate concentration and to decide the timing of such actions, it is important to predict groundwater Nitrate levels that would result over time from various farm-management practices. However, the input values such as soil, fertilizer and crop data) used to examine the effects of various farm-management practices on groundwater nitrate level are usually uncertain due to a lack of available information. In this paper. the ease of a community with a nitrate water quality problem is illustrated to examine the effects of various farm-management practices and to show bow to perform, with uncertain information. a time-series analysis on groundwater nitrate levels that would result. from each farm-management practice.

• Journal of the Korean Association of Geographic Information Studies
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• v.17 no.1
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• pp.61-69
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• 2014

In this study spatial analysis of PM10 was performed to Particulate Materials(PM) less than $10{\mu}m$ in diameter in Seoul city. Because PM10 are responsible for the increasing mortality rate of lung cancer and cardiovascular diseases, spatial distribution of PM10 are special interest in air pollution of Seoul. In this study, spatial analysis of Particulate Materials were monitored by monthly averaged PM10 concentration of 2010, 2011. The monthly spatial patterns of PM10 showed the west area of Seoul(Youngdungpo) higher PM10 concentration than northern part of Seoul in early spring and winter seasons. In the comparison of PM10 concentration distribution patterns in 2010 and 2011, the PM10 concentration of 2011 at Gangnam and Songpa-gu were more increased than yearly averaged patterns of 2010. The distribution patterns of PM10 in Seoul city showed the high concentration PM10 of several areas with Youngdungpo-gu, Gangnam-gu and Cheongnyangni. Therefore we need to establish PM10 management strategy for these area.

• Journal of the Korean Data and Information Science Society
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• v.20 no.4
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• pp.673-684
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• 2009

Lower Prices are offered through sales by telemarketing. This is to serve our customers by the fastest and most appropriate referral product that is most important to attract insurance. Therefore, Considering the time the customer's preferred products and preferred customer for screening and targeting, depending on what is the difference between the premiums. This study of the logistic regression model using datamining techniques, the life insurance companies in outbound telemarketing to support sales of the effect you want to validate. To join existing life insurance companies for the customer response and sales strategy based on the L segment and by age group, family-love insurance, accident insurance, and cancer insurance were in progress for the modeling. Set model based on the progress of the campaign to existing customers marketing methods and how to extract and run the model results has proven the superiority of the model. In addition, over time, depending on the aging model is set to a decline in operating profit to maximize the profits th update the model which was derived.

• 대한예방의학회:학술대회논문집
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• 1994.02a
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• pp.431-438
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• 1994

As currently conducted, standard rodent bioassays do not provide sufficient information to assess carcinogenic risk to humans at doses thousands of times below the maximum tolerated dose. Recent analyses indicate that measures of carcinogenic potency from these tests are restricted to a narrow range about the maximum tolerated dose and that information on shape of the dose-response is limited in experiments with only two doses and a control. Extrapolation from high to low doses should be based on an understanding of the mechanisms of carcinogenesis. We have postulated that administration of the maximum tolerated dose can increase mitogenesis which, in turn. increases rates of mutagenesis and, thus, carcinogenesis. The animal data are consistent with this mechanism, because about half of all chemicals tested are indeed rodent carcinogens, and about 40% of the positives are not detectably mutagenic. Thus, at low doses where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than commonly assumed. In contrast, for high-dose exposures in the workplace, assessment of hazard requires comparatively little extrapolation. Nevertheless. permitted workplace exposures are sometimes close to the tumorigenic dose-rate in animal tests. Regulatory policy to prevent human cancer has primarily addressed synthetic chemicals, yet similar proportions of natural chemicals and synthetic chemicals test positive in rodent studies as expected from an understanding of toxicological defenses, and the vast proportion of human exposures are to natural chemicals. Thus, human exposures to rodent carcinogens are common. The natural chemicals are the control to evaluate regulatory strategies, and the possible hazards from synthetic chemicals should be compared to the possible hazards from natural chemicals. Qualitative extrapolation of the carcinogenic response between species has been investigated by comparing two closely related species: rats and mice. Overall predictive values provide moderate confidence in interspecies extrapolation; however, knowing that a chemical is positive at any site in one species gives only about a 50% chance that it will be positive at the same site in the other species.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.24 no.4
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• pp.281-299
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• 2013

The purpose of this study is to suggest improvements of pharmacy field in the KDC 6th edition. To achieve this purpose, first, this study reviewed academic area and system of pharmacy. Second, we analyzed headings of pharmacy field from first edition to 6th edition. Third, we analyzed change process of classification items in pharmacy field. Forth, we investigated general problems concerning pharmacy field in the KDC 6th edition based on the comparative analysis with DDC, NLMC, and Research Field Code by Korean Research Foundation. As a result, pharmacy field of KDC has never changed since its 4th edition. And then, this study was added new subjects related to sections and subsections of pharmacy and suggested modern terminology. Also newly assigned pharmaceutics industry, cancer treatment and biological pharmaceutics fields under 518.7-.8 which do not use in pharmacy field for efficient classification.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.9
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• pp.2032-2037
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• 2011

Marker genes are defined as genes in which the expression level characterizes a specific experimental condition. Such genes in which the expression levels differ significantly between different groups are highly informative relevant to the studied phenomenon. In this paper, first the system can detect marker genes that are selected by ranking genes according to statistics after normalizing data with methods that are the most widely used among several normalization methods proposed the while, And it compare and analyze a performance of each of normalization methods with mult-perceptron neural network layer. The Result that apply Multi-Layer perceptron algorithm at Microarray data set including eight of marker gene that are selected using ANOVA method after Lowess normalization represent the highest classification accuracy of 99.32% and the lowest prediction error estimate.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.8
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• pp.1699-1704
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• 2009

If detected early enough, cervical cantor may have a good survival rate due to its preneoplastic state. However, the process is so time consuming that a medical expert can handle only a small amount of such examinations. In this paper, we propose a new nucleus extraction algorithm for uterine cervical pap smears in order to mitigate such burdens of medical experts. In the preneoplastic state cytodiagnosis images, it is important to differentiate three main areas - background, cytoplasm and nucleus. Thus, we apply lighting compensation and $3{\times}3$ mask of B channel in order to restore damaged image and remove noises respectively. The cell object is obtained from those clean binarized images with Grossfire algorithm. When there are clusters of cells, the target nucleus can be obtained with repetitive binarization of R channel brightness. In our experiment of using uterine cervical pap smears of 400 magnifications that is common in the diagnostic cytology, our method is able to extract 40 nucleus out of 45 population successfully.

• Journal of Preventive Medicine and Public Health
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• v.39 no.3
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• pp.205-212
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• 2006

Objectives: In spite of the recent increased concern for Asian dust storms, there are few studies concerning how dangerous the general public recognizes these dust storms to be. This study examined the public's perceptions of the risk of the Asian dust storms and also the source of the information concerning the risk. Methods: A telephone interview survey using a standardized questionnaire was done for the adults living in Seoul and its metropolitan area from May 15th, 2003 to May 16th, 2003. The contents of the questionnaire were the sociodemographic characteristics, the perceptions of risk to the Asian dust storms, and the coping strategy of the study participants. Results: The study participants get their information on Asian dust storms mainly from TV newscasts and they have a good knowledge of them. They regard it as one of the most dangerous health risks, along with dioxin. They think that it is associated with allergic rhinitis, conjunctivitis and bronchial asthma, etc. Of the 500 study participants, 201 (40.2%) persons suffered bodily discomforts during the Asian dust storm period. Conclusions: Although there are uncertainties about the health risks of Asian dust storms, the public thinks these dust storms are very dangerous to health in many ways This negative perception will not disappear easily. To fill the gap of the public's perceptions of the risk and the objective evidence of its health effects, more studies about its health effects and the methods to reduce exposure are required.

• Journal of the Korean Society of Radiology
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• v.12 no.3
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• pp.367-372
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• 2018

The supply of medical services using high-priced medical equipment is increasing due to the medicalization of medical science. The level of medical knowledge of medical consumers and the ability to select medical institutions are required to provide high quality medical services because of the popularization of medical information. As the attitudes of medical consumers toward medical institutions change, medical institutions also need to change their perception to improve customer satisfaction. The purpose of this study is to analyze the difference of medical service satisfaction according to the medical knowledge about the utility of PET / CT in order to change the consciousness structure of medical service. The results of this study showed that both medical satisfaction and environmental satisfaction were high in those who had medical knowledge about their own illness and the usefulness of PET / CT. Therefore, medical institutions will need a practical medical service countermeasures to provide medical information by noticing the changes in perception of the medical knowledge of medical consumers, rather than providing formal medical services.

• Journal of Microbiology and Biotechnology
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• v.15 no.5
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• pp.1060-1066
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• 2005

Under environmental stress, such as strong irradiance or nitrogen deficiency, unicellular green algae of the genus Haematococcus accumulate secondary carotenoids, i.e. astaxanthin, in the cytosol. The induction and regulation of astaxanthin biosynthesis in microalgae has recently received considerable attention owing to the increasing use of secondary carotenoids as a source of pigmentation for fish aquacultures, and as a potential drug in cancer prevention as a free-radical quencher. Accordingly, this study generated expressed sequence tags (ESTs) from a library constructed from astaxanthin-induced Haematococcus pluvialis. Partial sequences were obtained from the 5' ends of 1,858 individual cDNAs, and then grouped into 1,025 non-overlapping sequences, among which 708 sequences were singletons, while the remainder fell into 317 clusters. Approximately $63\%$ of the EST sequences showed similarity to previously described sequences in public databases. H. pluvialis was found to consist of a relatively high percentage of genes involved in genetic information processing ($15\%$) and metabolism ($11\%$), whereas a relatively low percentage of sequences was involved in the signal transduction ($3\%$), structure ($2\%$), and environmental information process ($3\%$). In addition, a relatively large fraction of H. pluvialis sequences was classified as genes involved in photosynthesis ($9\%$) and cellular process ($9\%$). Based on this EST analysis, the full-length cDNA sequence for superoxide dismutase (SOD) of H. pluvialis was cloned, and the expression of this gene was investigated. The abundance of SOD changed substantially in response to different culture conditions, indicating the possible regulation of this gene in H. pluvialis.