• Title/Summary/Keyword: Calcium phosphate

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Sphingosine 1-phosphate mediated suppression of leptin secretion in rat adipocytes.

  • Jun, Dong-Jae;Kim, Kyong-Tai
    • Proceedings of the Korean Biophysical Society Conference
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    • 2001.06a
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    • pp.49-49
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    • 2001

  • Sphingosine 1-phosphate is a metabolite of complex sphingolipids that acts as both a second messenger and as a high-affinity ligand for cell surface receptor. Since the possible involvement of sphingosine 1-phosphate has not been investigated in adipocyte, we examined the response of intracellular calcium ([Ca$^{2＋}$]$_{i}$) and intracellular cAMP ([cAMP]$_{i}$ and the effect of sphingosine 1-phosphate on adipocyte function using rat primary adipocyte.(omitted)ted)

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Neuromedin B modulates phosphate-induced vascular calcification

  • Park, Hyun-Joo;Kim, Mi-Kyoung;Kim, Yeon;Kim, Hyung Joon;Bae, Soo-Kyung;Bae, Moon-Kyoung
    • BMB Reports
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    • v.54 no.11
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    • pp.569-574
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    • 2021

  • Vascular calcification is the heterotopic accumulation of calcium phosphate salts in the vascular tissue and is highly correlated with increased cardiovascular morbidity and mortality. In this study, we found that the expression of neuromedin B (NMB) and NMB receptor is upregulated in phosphate-induced calcification of vascular smooth muscle cells (VSMCs). Silencing of NMB or treatment with NMB receptor antagonist, PD168368, inhibited the phosphate-induced osteogenic differentiation of VSMCs by inhibiting Wnt/β-catenin signaling and VSMC apoptosis. PD168368 also attenuated the arterial calcification in cultured aortic rings and in a rat model of chronic kidney disease. The results of this study suggest that NMB-NMB receptor axis may have potential therapeutic value in the diagnosis and treatment of vascular calcification.

  • https://doi.org/10.5483/BMBRep.2021.54.11.089 인용 PDF KSCI