Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Sphingosine 1-phosphate mediated suppression of leptin secretion in rat adipocytes.

  • Jun, Dong-Jae (Dept of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology) ;
  • Kim, Kyong-Tai (Dept of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology)
  • Published : 2001.06.01
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Abstract

Sphingosine 1-phosphate is a metabolite of complex sphingolipids that acts as both a second messenger and as a high-affinity ligand for cell surface receptor. Since the possible involvement of sphingosine 1-phosphate has not been investigated in adipocyte, we examined the response of intracellular calcium ([Ca$^{2＋}$]$_{i}$) and intracellular cAMP ([cAMP]$_{i}$ and the effect of sphingosine 1-phosphate on adipocyte function using rat primary adipocyte.(omitted)ted)

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