• Smart Structures and Systems
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• 제11권3호
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• pp.283-297
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• 2013

An innovative cage for spinal fusion surgery is presented within this work. The cage utilizes shape memory alloy for its hinge actuation. Because of the use of SMA, a smaller incision is needed which makes the cage deployment minimally invasive. In the development of the cage, a model for predicting the torsional behavior of SMAs was developed and verified experimentally. The prototype design of the cage was developed and manufactured. The prototype was subjected to static tests per ASTM specifications. The cage survived all of the tests, alluding to its safety within the body.

• Molecules and Cells
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• 제21권3호
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• pp.367-375
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• 2006

We previously identified a novel cancer/testis antigen gene CAGE by screening cDNA expression libraries of human testis and gastric cancer cell lines with sera of gastric cancer patients. CAGE is expressed in many cancers and cancer cell lines, but not in normal tissues apart from the testis. In the present study, we investigated its role in the motility of cells of two human cancer cell lines: HeLa and the human hepatic cancer cell line, SNU387. Induction of CAGE by tetracycline or transient transfection enhanced the migration and invasiveness of HeLa cells, but not the adhesiveness of either cell line. Overexpression of CAGE led to activation of ERK and p38 MAPK but not Akt, and inhibition of ERK by PD98059 or p38 MAPK by SB203580 counteracted the CAGE-promoted increase in motility in both cell lines. Overexpression of CAGE also resulted in a reduction of ROS and an increase of ROS scavenging, associated with induction of catalase activity. Inhibition of ERK and p38 MAPK increased ROS levels in cells transfected with CAGE, suggesting that ROS reduce the motility of both cell lines. Inhibition of ERK and p38 MAPK reduced the induction of catalase activity resulting from overexpression of CAGE, and inhibition of catalase reduced CAGE-promoted motility. We conclude that CAGE enhances the motility of cancer cells by activating ERK and p38 MAPK, inducing catalase activity, and reducing ROS levels.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 1995년도 추계학술대회 논문집
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• pp.30-36
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• 1995

This paper proposed on the effective cutting conditions of cage motor rotor by turning. If you want to introduce automatic manufacturing system into the cutting process of cage motor rotor, the selections of effective cutting conditions are necessary. The cutting process of cage motor rotor requires the precision and the out of roundness of cage motor rotor. The surface roughness of cutting face. it is very important factor with effect on the magnetic flux density of cage motor rotor. The purpose of this study is to find out the effects of cutting condition. upon adapting this results, we will improve the production rate in the cutting process of cage motor rotor. As a result, the selection of cutting conditions are important factors to production rate. And these are chosen by the investigations of cutting characters and surface roughness. The experimental result, showed that the increase of cutting speed caused the decrease of cutting force and the high surface integrity. The increase of feed rate and increase of depth of cut caused the increase of cutting force and surface roughness. Thus, the effective cutting conditions of cage motor rotor by turing are cutting speed 291m/min, feed rate 0.10mm/rev, depth of cut 0.05mm.

• 대한의용생체공학회:의공학회지
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• 제25권6호
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• pp.525-530
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• 2004

Cage와 나사를 이용하여 유합된 추체의 3차원 유한 요소 모델을 제작하여, 골밀도의 변화에 따른 골다공증과 cage의 위치 변화에 대해, Von-Mites 최대 응력과 최대 변형량을 살펴보았다. 그 결과 해면골의 강도가 증가함에 따라서, 피질골의 응력은 감소하고, 해면골에서의 응력은 증가하였다. 또한 cage의 위치의 변화에 따라서 추체의 응력 분포의 양상이 달라짐을 알 수 있었으며, 이를 통해 수술의 성공도를 높이고자 한다.

• 대한의용생체공학회:의공학회지
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• 제25권5호
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• pp.361-367
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• 2004

척추체간 유합케이지의 성능평가에 있어서 압축강도와 상대적인 3차원적 안정성 그리고 골유도를 촉진시킬 수 있는 형상은 성공적인 골유합의 정도를 판가름 할 수 있는 중요한 척도이다. 새로 고안된 박스형 유합케이지 스파이크의 형상변화에 따른 척추체의 골단판에 미치는 응력분포 양상과 케이지의 안정성을 비교하기 위하여 압축하중 작용 초기에 스파이크 끝딘과 골단판이 접촉하는 경우와 스파이크가 골단판에 삽입되었을 경우를 구분하여 스파이크의 높이, 폭 및 각도를 변화시켜 가면서 유한요소 해석을 실시하여 고찰하였다. 유합케이지 2개가 척추체간에 삽입되어 있는 상태에서 수직하중 1700N이 가해질 때 척추체 골단판에 전달되는 응력분포를 조사하였으며, 전, 후방향으로 케이지 하나에 100N의 pull out하중을 부과하여 케이지의 스파이크 형상변화에 따른 미세이동 정도를 비교 평가하였다. 그 결과, 척추체 골단판의 응력 집중 정도에 가장 큰 영향을 미치는 요인은 케이지스파이크 끝단 폭의 크기이며, 케이지 스파이크의 높이 및 각도의 변화는 스파이크 끝단과 접촉하는 척추체 골단판에 미치는 응력 정도에 큰 영향을 미치지 않았다. 스파이크 경사면 각도조절 및 양방향혼합형의 대칭 배열을 통하여 전후방향 pull-out하중에 대한 변위량을 저감시킬 수 있었다. 본 연구의 결과를 통하여 척추체에서의 응력집중을 피할 수 있고 케이지의 초기 접촉시 골단판의 파괴를 방지하고 골유합에 유리한 케이지 스파이크 형상을 설계하였고, 케이지 치환술 후 운동시 전후방향으로 이동을 최소화하여 기계적 안정성을 높일 수 있는 새로운 척추체간 유합 케이지의 최적 형상을 제안하였다.

• 수산해양기술연구
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• 제48권1호
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• pp.40-50
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• 2012

This study aims to analyze the performance of a submersible fish cage which was designed for developing an economical cage system can be applied in korean aquaculture environment easily. To analyze the performance of the designed cage a model test was carried out. In the test, inclination changes of the upper frame and mooring tensions of model cage were measured during the submerging and surfacing motion in still water and wave condition (period: 2s, wave height: 0.1, 0.2, 0.3m). As a result, in the still water condition the model cage kept horizontal balance and inclination degree of the upper frame was about $1^{\circ}$. In the wave condition, the model cage showed bilateral symmetric up-and-down motion but the average inclination degree of the upper frame was about $0^{\circ}$. When the model cage reached at a depth of 1m, the up-and-down motion of the cage was decreased by 12% compared with that of at the surface (period 2s, height 0.3m). In the same wave condition, the maximum and average line tension under the bottom position were about 8% and 11% respectively compared with that of at surface.

• Journal of Korean Neurosurgical Society
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• 제54권2호
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• pp.128-131
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• 2013

Transforaminal lumbar interbody fusion (TLIF) is commonly used procedure for spinal fusion. However, there are no reports describing anterior cage dislodgement after surgery. This report is a rare case of anterior dislodgement of fusion cage after TLIF for the treatment of isthmic spondylolisthesis with lumbosacral transitional vertebra (LSTV). A 51-year-old man underwent TLIF at L4-5 with posterior instrumentation for the treatment of grade 1 isthmic spondylolisthesis with LSTV. At 7 weeks postoperatively, imaging studies demonstrated that banana-shaped cage migrated anteriorly and anterolisthesis recurred at the index level with pseudoarthrosis. The cage was removed and exchanged by new cage through anterior approach, and screws were replaced with larger size ones and cement augmentation was added. At postoperative 2 days of revision surgery, computed tomography (CT) showed fracture on lateral pedicle and body wall of L5 vertebra. He underwent surgery again for paraspinal decompression at L4-5 and extension of instrumentation to S1 vertebra. His back and leg pains improved significantly after final revision surgery and symptom relief was maintained during follow-up period. At 6 months follow-up, CT images showed solid fusion at L4-5 level. Careful cage selection for TLIF must be done for treatment of spondylolisthesis accompanied with deformed LSTV, especially when reduction will be attempted. Banana-shaped cage should be positioned anteriorly, but anterior dislodgement of cage and reduction failure may occur in case of a highly unstable spine. Revision surgery for the treatment of an anteriorly dislodged cage may be effectively performed using an anterior approach.

• Clinics in Shoulder and Elbow
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• 제22권1호
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• pp.24-28
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• 2019

Background: Glenoid baseplate location is important to good clinical outcomes of reverse total shoulder arthroplasty (RTSA). The glenoid vault is the determining factor for glenoid baseplate location, but, to date, there are no reports on the effect of central cage location within the glenoid vault on RTSA outcomes when using the $Exactech^{(R)}$ $Equinoxe^{(R)}$ Reverse System. The purpose of this study was to determine the appropriate cage location in relation to the glenoid vault and monitor for vault and/or cortex penetration by the cage. Methods: Data were retrospectively collected from the Samsung Medical Center (SMC) and Seoul National University Bundang Hospital (SNUBH). Patients who underwent RTSA between November 2016 and February 2018 were enrolled. Glenoid vault depth, central cage location within the vault were examined. Inferior glenoid rim-center distance, inferior glenoid rim-cage distance, and center-cage center distances were collected. Results: Twenty-two patients were enrolled. Three SNUBH patients had inappropriate central cage fixation (33.3%) versus 4 SMC patients (30.8%). All cage exposures were superior and posterior to the glenoid vault. Mean center-cage distance was 5.0 mm in the SNUBH group and 5.21 mm in the SMC group. Center-prosthesis distance was significantly longer in the inappropriate fixation group than in the appropriate fixation group (p<0.024). Conclusions: To ensure appropriate glenoid baseplate fixation within the glenoid vault, especially in a small glenoid, the surgeon should place the cage lower than usually targeted, and it should overhang the inferior glenoid rim.

• Journal of Microbiology and Biotechnology
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• 제18권3호
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• pp.600-610
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• 2008

A cancer-associated antigen gene (CAGE) was identified by serological analysis of a recombinant cDNA expression library (SEREX). The gene was identified by screening cDNA expression libraries of human testis and gastric cancer cell lines with sera from patients with gastric cancer. CAGE was found to contain a D-E-A-D box domain and encodes a putative protein of 630 amino acids with possible helicase activity. The CAGE gene is widely expressed in various cancer tissues and cancer cell lines. Demethylation plays a role in the activation of CAGE in certain cancer cell lines where the gene is not expressed. The functional roles of CAGE in tumorigenesis, the molecular mechanisms of CAGE expression, and cell motility are also discussed.

• Journal of Advanced Marine Engineering and Technology
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• 제35권5호
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• pp.690-699
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• 2011

A numerical model analysis was performed to analyze the stability of the mooring lines of an automatic submersible fish cage system in waves and currents. The fish cage system consisted of a 12-angled rigid frame, net cage, cover net, 12 upper floats, 12 tanks(for fixed and variable ballast), mooring lines, anchors, and a control station. Simulations were performed with the cage at the surface of the water and at a depth of 20 m. A Morison equation type model was used for simulations of the system in two configurations. The force parameters described both regular and random waves, with and without currents, and their values were input to the model. Mooring tension calculations were conducted on the mooring lines, grid lines and lower bridle lines of the cage. The stability of the mooring lines was checked under both static and dynamic conditions.