• Proceedings of the IEEK Conference
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• 1998.10a
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• pp.237-240
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• 1998

BISDN 망 구축을 위한 ATM 교환기는 고속의 스위치 망을 통해 사용자들의 고속 정보를 교환 할 수 있는 경로를 제공하고 있으며, 기존 통신망들과의 연동을 통해 다양한 서비스를 제공하기 위하여 여러 가지 가입자 정합장치의 수용이 요구되고 있다. 현재 국내에서 개발되어 시험중인 HANbit ACE ATM 교환기는 DS-1, DS-1E, DS-3 및 STM-1급의 가입자 정합 장치를 제공하며, 중계선 정합 장치로는 DS-3 및 STM-1 급을 지원한다. 이러한 구조에서 사용자 QOS 를 만족시키며 네트워크 비용을 최소화 시키는데 많은 어려움이 따른다. 즉 다양한 정합장치와 다단 스위치 구조하에서 다양한 트래픽 특성을 갖는 호/연결에 대한 효과적인 호 수락 제어 기능이 필수적으로 요구된다. 본 고에서는 다양한 정합 장치와 3단 스위치 구조를 갖는 HANbit ACE ATM 교환기를 살펴보고, 다양한 트래픽 수용을 위한 트래픽제어 요구사항을 알아보며, 이와 같은 특성을 해결하고자 실현된 호/연결 수락 제어 기능에 대해 고찰한다.

• Computers and Concrete
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• v.16 no.1
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• pp.37-48
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• 2015

Alkali aggregate reaction affects numerous civil engineering structures and causes irreversible expansion and cracking. This work aims at developing model to predict the potential expansion of concrete containing alkali-reactive aggregates. First, the paper presents the experimental results concerning the influence of particle size of an alkali-reactive aggregate on mortar expansion studied at 0.15-0.80 mm, 1.25-2.50 mm and 2.5-5.0 mm size fractions and gives data necessary for model development. Results show that no expansion was measured on the mortars using small particles (0.15-0.80 mm) while the particles (1.25-2.50 mm) gave the largest expansions. Finally, model is proposed to simulate the experimental results by studying correlations between the measured expansions and the size of aggregates and to calculate the thickness of the porous zone necessary to take again all the volume of the gel created by this chemical reaction.

• Computers and Concrete
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• v.1 no.1
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• pp.31-46
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• 2004

A methodology is presented for computing stresses in structural concrete members exposed to fire. Coupled heat and moisture migration simulations are used to establish temperature, pore pressure, and liquid-saturation state variables within near-surface zones of heated concrete members. Particular attention is placed on the use of coupled heat and multiphase fluid flow simulations to study phenomena such as moisture-clogging. Once the state variables are determined, a procedure for combining the effects of thermal dilation, mechanical loads, pore pressure, and boundary conditions is proposed and demonstrated. Combined stresses are computed for varying displacement boundary conditions using data obtained from coupled heat and moisture flow simulations. These stresses are then compared to stresses computed from thermal analyses in which moisture effects are omitted. The results demonstrate that moisture migration has a significant influence on the development of thermal stresses.

• Computers and Concrete
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• v.1 no.1
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• pp.61-76
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• 2004

The paper is devoted to present the Continuum Strong Discontinuity Approach (CSDA) and to examine its capabilities for modeling cracking of concrete. After introducing the main ingredients of the CSDA, an isotropic continuum damage model, which distinguishes tension and compression states, is used to implicitly induce a projected traction separation-law that rules the cracking phenomena. Criteria for onset and propagation of material failure and specific finite elements with embedded discontinuities are also briefly sketched. Finally, some representative numerical simulations of cracking, in plain and reinforced concrete specimens, using the CSDA are presented.

• Computers and Concrete
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• v.1 no.1
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• pp.77-98
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• 2004

This paper presents a numerical model for simulating the nonlinear response of reinforced concrete (RC) shear walls subject to cyclic loadings. The material behavior of cracked concrete is described by an orthotropic constitutive relation with tension-stiffening and compression softening effects defining equivalent uniaxial stress-strain relation in the axes of orthotropy. Especially in making analytical predictions for inelastic behaviors of RC walls under reversed cyclic loading, some influencing factors inducing the material nonlinearities have been considered. A simple hysteretic stress-strain relation of concrete, which crosses the tension-compression region, is defined. Modification of the hysteretic stress-strain relation of steel is also introduced to reflect a pinching effect depending on the shear span ratio and to represent an average stress distribution in a cracked RC element, respectively. To assess the applicability of the constitutive model for RC element, analytical results are compared with idealized shear panel and shear wall test results under monotonic and cyclic shear loadings.

• Computers and Concrete
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• v.1 no.1
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• pp.15-30
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• 2004

In this study, a design process for reinforced concrete structures using the nonlinear FEM analysis is developed. Instead of using the nonlinear analysis to evaluate the required performance after design process, the nonlinear analysis is applied before designing the reinforcement arrangement inside the RC structures. An automatic reinforcement generator for computer aided reinforcement agreement is developed for this purpose. Based on a nonlinear FEM program for analyzing the reinforced concrete structure, a smart fictitious material model of steel, is proposed which can self-adjust the reinforcement to the required amount at the cracking location according to the load increment. Using this tool, the reinforcement ratio required at design load level can be decided automatically. In this paper, an example of RC beam with opening is used to verify the proposed process. Finally, a trial design process for a real size underground RC LNG tank is introduced.

• Journal of Pharmaceutical Investigation
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• v.41 no.2
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• pp.95-102
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• 2011

An amphiphilic cationic branched methoxy poly (ethylene glycol)-branched polyethylenimine - poly(L-phenylalanine) (mPEG-bPEI-pPhe) block copolymer was successfully synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of L-phenylalanine (Phe-NCA) with mPEG-bPEI for the preparation of more stable polyelectrolyte complex (PEC) included a hydrophobic interaction. mPEG-bPEI was firstly prepared by the coupling of mPEG and bPEI using hexamethylene diisocyanate (HMDI). The structural properties of mPEG-bPEI-pPhe copolymers were confirmed by $^1H$ NMR. The copolymers exhibited a self-assemble behavior in water above critical aggregate concentration (CAC) in the range of 0.01-0.14 g/L. The CAC of copolymers obviously depended on the hydrophobic block content in the copolymers (the value decreased with the increase of the pPhe block content). The cationic copolymers have the ability to form multi-interaction complex (MIC) with bovine serum albumin (BSA) and plasmid DNA through multi-interaction (electrostatic and hydrophobic interaction). The physicochemical characterization of the complex was carried out by the measurement of zeta potential and particle size. Their zeta-potentials were positive (approximately +10 mV) and their sizes decreased with increasing pPhe contents in the copolymers (PPF/BSA wt% ratio = 2). The complex showed good stability at high ionic strength. Therefore, mPEG-bPEI-pPhe block copolymer was considered as a potential material to enhance the stability of complex including biotherapuetic drugs.

• Bulletin of the Korean Chemical Society
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• v.26 no.4
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• pp.523-528
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• 2005

Diblock copolymers with different poly($\varepsilon$-caprolactone) (PCL) block lengths were synthesized by ringopening polymerization of $\varepsilon$-caprolactone in the presence of monomethoxy poly(ethylene glycol) (mPEG-OH, MW 2000) as initiator. The self-aggregation behaviors of the diblock copolymer nanoparticle, prepared by the diafiltration method, were investigated by using $^1H$ NMR, dynamic light scattering (DLS), and fluorescence spectroscopy. The PEG-PCL block copolymers formed the nano-sized self-aggregate in an aqueous environment by intrsa- and/or intermolecular association between hydrophobic PCL chains. The critical aggregation concentrations (cac) of the block copolymer self-aggregate became lower with increasing hydrophobic PCL block length. On the other hand, reverse trends of mean hydrodynamic diameters were measured by DLS owing to the increasing bulkiness of the hydrophobic chains and hydrophobic interaction between the PCL microdomains. The hydrodynamic diameters of the block copolymer nanoparticles, measured by DLS, were in the range of 65-270 nm. Furthermore, the size of the nanoparticles was scarcely affected by the concentration of the block copolymers in the range of 0.125-5 mg/mL owing to the negligible interparticular aggregation between the self-aggregated nanoparticles. Considered with the fairly low cac and nanoparticle stability, the PEG-PCL nanoparticles can be considered a potential candidate for biomedical applications such as drug carrier or imaging agent.

• Tuberculosis and Respiratory Diseases
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• v.80 no.3
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• pp.270-276
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• 2017

Background: A disputed rpoB mutation is a specific type of rpoB mutation that can cause low-level resistances to rifampin (RIF). Here, we aimed to assess the frequency and types of disputed rpoB mutations in Mycobacterium tuberculosis isolates from South Korea. Methods: Between August 2009 and December 2015, 130 patients exhibited RIF resistance on the MTBDRplus assay at Asan Medical Center. Among these cases, we identified the strains with disputed rpoB mutation by rpoB sequencing analysis, as well as among the M. tuberculosis strains from the International Tuberculosis Research Center (ITRC). Results: Among our cases, disputed rpoB mutations led to RIF resistance in at least 6.9% (9/130) of the strains that also exhibited RIF resistance on the MTBDRplus assay. Moreover, at the ITRC, sequencing of the rpoB gene of 170 strains with the rpoB mutation indicated that 23 strains (13.5%) had the disputed mutations. By combining the findings from the 32 strains from our center and the ITRC, we identified the type of disputed rpoB mutation as follows: CTG511CCG (L511P, n=8), GAC516TAC (D516Y, n=8), CTG533CCG (L533P, n=8), CAC526CTC (H526L, n=4), CAC526AAC (H526N, n=3), and ATG515GTG (M515V, n=1). Conclusion: Disputed rpoB mutations do not seem to be rare among the strains exhibiting RIF resistance in South Korea.

• Biomedical Science Letters
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• v.4 no.2
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• pp.137-142
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• 1998

We examined mRNAs, isolated from the rat brain, to ascertain if there is any polymorphism for S-100 beta protein gene. As templates for polymerase chain reaction (PCR) the reverse-transcribed cDNA from the rat brain or phage DNAs isolated from the rat brain cDNA libraries were used. Although PCR products turned out to be exactly same as the expected size based on the previously reported mRNA sequence a single base substitution (CAT to CAC) was identified at nucleotide level. This change was considered as polymorphism since it did not cause any change of the primary structure for S-100 beta protein. This result should facilitate the understanding of the overall structure of the gene for S-100 beta protein.