• Title/Summary/Keyword: CURA

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A Modified eCura System to Stratify the Risk of Lymph Node Metastasis in Undifferentiated-Type Early Gastric Cancer After Endoscopic Resection

  • Hyo-Joon Yang ;Hyuk Lee;Tae Jun Kim;Da Hyun Jung;Kee Don Choi;Ji Yong Ahn;Wan Sik Lee;Seong Woo Jeon;Jie-Hyun Kim;Gwang Ha Kim;Jae Myung Park;Sang Gyun Kim;Woon Geon Shin;Young-Il Kim;Il Ju Choi
    • Journal of Gastric Cancer
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    • v.24 no.2
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    • pp.172-184
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    • 2024
  • Purpose: The original eCura system was designed to stratify the risk of lymph node metastasis (LNM) after endoscopic resection (ER) in patients with early gastric cancer (EGC). We assessed the effectiveness of a modified eCura system for reflecting the characteristics of undifferentiated-type (UD)-EGC. Materials and Methods: Six hundred thirty-four patients who underwent non-curative ER for UD-EGC and received either additional surgery (radical surgery group; n=270) or no further treatment (no additional treatment group; n=364) from 18 institutions between 2005 and 2015 were retrospectively included in this study. The eCuraU system assigned 1 point each for tumors >20 mm in size, ulceration, positive vertical margin, and submucosal invasion <500 ㎛; 2 points for submucosal invasion ≥500 ㎛; and 3 points for lymphovascular invasion. Results: LNM rates in the radical surgery group were 1.1%, 5.4%, and 13.3% for the low-(0-1 point), intermediate- (2-3 points), and high-risk (4-8 points), respectively (P-fortrend<0.001). The eCuraU system showed a significantly higher probability of identifying patients with LNM as high-risk than the eCura system (66.7% vs. 22.2%; McNemar P<0.001). In the no additional treatment group, overall survival (93.4%, 87.2%, and 67.6% at 5 years) and cancer-specific survival (99.6%, 98.9%, and 92.9% at 5 years) differed significantly among the low-, intermediate-, and high-risk categories, respectively (both P<0.001). In the high-risk category, surgery outperformed no treatment in terms of overall mortality (hazard ratio, 3.26; P=0.015). Conclusions: The eCuraU system stratified the risk of LNM in patients with UD-EGC after ER. It is strongly recommended that high-risk patients undergo additional surgery.

PLC and Arduino CNC Control for Comparison of 2D Outputs (2D 출력물 비교를 위한 PLC와 아두이노 CNC 제어)

  • Cho, Hae-Jun;Kim, Kang-Ho;Jang, Hyun-Su;Jeon, Jong-Hwan;Lee, Seung-Dae
    • The Journal of the Korea institute of electronic communication sciences
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    • v.16 no.6
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    • pp.1295-1302
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    • 2021
  • As the market size of 3D printers increases, the precision of the printout and the speed of operation by the motor are very important issues. In this parer, G-code of each output was generated using a CURA program to compare whether the output of the PLC equipment is the same as that of the Arduino CNC. And after conversion to NC File, a pen was attached to each device to output a result to A4 paper. As a result, the output time was measured to be 1m 39s for PLC equipment and 2m 5s for Arduino CNC. In addition, it was confirmed that the 2D output was equally from the two equipments.

Development of a G-Code Generator for Color Gradation Generations in a Mixing Chamber FDM 3D Printers (Mixing chamber를 사용하여 그라데이션 색상을 구현하기 위한 G-code 생성기 개발)

  • Noh, Kyoung-Seok;Seo, Hae-Won;Kim, Tae-Young;Lee, Yong-Gu
    • Korean Journal of Computational Design and Engineering
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    • v.22 no.1
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    • pp.10-17
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    • 2017
  • The recent 3D printing industry has been focusing on developing 3D printers to fulfill the user's need to bring more colorful and realistic outcomes. Several 3D printers have deployed multiple extruders to print different colors. However, this method has a limit on its availability of colors. To solve this, recent research is focused on using mixing chambers to mix the possible colors to provide more color availability. In this paper, we discuss the environment and algorithm behind the development of G-code which allows a gradation effect of the mix of two filaments. The generation algorithm to make gradient G-code has been implemented in Cura using C ++ and Python.

Breast Cancer and Modifiable Lifestyle Factors in Argentinean Women: Addressing Missing Data in a Case-Control Study

  • Coquet, Julia Becaria;Tumas, Natalia;Osella, Alberto Ruben;Tanzi, Matteo;Franco, Isabella;Diaz, Maria Del Pilar
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.10
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    • pp.4567-4575
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    • 2016
  • A number of studies have evidenced the effect of modifiable lifestyle factors such as diet, breastfeeding and nutritional status on breast cancer risk. However, none have addressed the missing data problem in nutritional epidemiologic research in South America. Missing data is a frequent problem in breast cancer studies and epidemiological settings in general. Estimates of effect obtained from these studies may be biased, if no appropriate method for handling missing data is applied. We performed Multiple Imputation for missing values on covariates in a breast cancer case-control study of $C{\acute{o}}rdoba$ (Argentina) to optimize risk estimates. Data was obtained from a breast cancer case control study from 2008 to 2015 (318 cases, 526 controls). Complete case analysis and multiple imputation using chained equations were the methods applied to estimate the effects of a Traditional dietary pattern and other recognized factors associated with breast cancer. Physical activity and socioeconomic status were imputed. Logistic regression models were performed. When complete case analysis was performed only 31% of women were considered. Although a positive association of Traditional dietary pattern and breast cancer was observed from both approaches (complete case analysis OR=1.3, 95%CI=1.0-1.7; multiple imputation OR=1.4, 95%CI=1.2-1.7), effects of other covariates, like BMI and breastfeeding, were only identified when multiple imputation was considered. A Traditional dietary pattern, BMI and breastfeeding are associated with the occurrence of breast cancer in this Argentinean population when multiple imputation is appropriately performed. Multiple Imputation is suggested in Latin America's epidemiologic studies to optimize effect estimates in the future.

Strength Analysis of 3D Concrete Printed Mortar Prism Samples (3D 콘크리트 프린팅된 모르타르 프리즘 시편의 강도 분석)

  • Kim, Sung-Jo;Bang, Gun-Woong;Han, Tong-Seok
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.35 no.4
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    • pp.227-233
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    • 2022
  • The 3D-printing technique is used for manufacturing objects by adding multiple layers, and it is relatively easy to manufacture objects with complex shapes. The 3D concrete printing technique, which incorporates 3D printing into the construction industry, does not use a formwork when placing concrete, and it requires less workload and labor, so economical construction is possible. However, 3D-printed concrete is expected to have a lower strength than that of molded concrete. In this study, the properties of 3D-printed concrete were analyzed. To fabricate the 3D-printed concrete samples, the extrusion path and shape of the samples were designed with Ultimaker Cura. Based on this, G-codes were generated to control the 3D printer. The optimal concrete mixing proportion was selected considering such factors as extrudability and buildability. Molded samples with the same dimensions were also fabricated for comparative analysis. The properties of each sample were measured through a three-point bending test and uniaxial compression test, and a comparative analysis was performed.

3D Printing Orientation Optimization Based on Upright Orientation and Overhang (수직 방향과 오버행을 고려한 3D 프린팅 방향 최적화)

  • Park, Jiyoung;Shin, Hwa Seon
    • Proceedings of the Korea Information Processing Society Conference
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    • 2015.10a
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    • pp.1776-1777
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    • 2015
  • 본 연구에서는 3D 객체의 수직 방향(upright orientation)과 오버행(overhang) 면적을 고려하는 3D 프린팅 방향 최적화 방법을 제안한다. 모든 메시 법선들을 세 그룹으로 분류함으로써 객체의 수직방향을 계산한 후, 객체의 무게 중심과 3D convex hull을 사용하여 세 개의 후보 방향을 결정한다. 각 후보 방향에 대하여 오버행 메시 면적을 계산하고 최소 면적을 갖는 후보를 최종 프린팅 방향으로 결정한다. 후보 방향들을 적용하여 회전시킨 모델을 Cura에서 로드하여 프린팅 시간을 가측정한 결과, 제안 방법에 의해 최적화된 방향이 가장 짧은 시간이 소모되는 것으로 나타났다.

Community Structure of Macrobenthic Invertebrates of Fishing grounds in the coastal waters of Jeju Island (제주도 연안 마을어장의 저서무척추동물 군집구조)

  • Ko, Jun-Cheol;Koo, Jun-Ho;Lee, Seung-Jong;Chang, Dae-Su;Jo, Sung-Hwan
    • The Korean Journal of Malacology
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    • v.27 no.3
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    • pp.229-246
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    • 2011
  • This study was performed to know and compare the community structures of macrobenthic invertebrates of eight fishing grounds in the coastal waters of Jeju Island from September to October 2008. A total of 166 species was identified. Mollusks comprised 77 species (46.4%); Arthropods 24 (14.5%), Cnidarians 18 (10.8%); Poriferans 16 (9.6%); and the others including Echinoderms 33 (17.7%). Density and biomass were estimated to be 6,905 ind./$m^2$ and 113,100.7 gwwt/$m^2$, respectively. Gastropods was the most dominant taxon in terms of abundance (3,311 ind./$m^2$) and number of species as well, and Gastropods was predominant in biomass (55,789.2 gwwt/$m^2$). The dominant species were Omphalius pfeifferi, Astralium haematragum, Turbo cornutus, Ergalatax contraacta, Lithophaga cura, Anthocidaris crassispina, Herdmania monus in 5-15 m. Based on the cluster analysis, the study area could be divided into two station groups. The biodiversity, evenness and richness index appeared as follows: H' = 1.59-2.95, E' = 0.38-0.87, R = 3.3-10.4. The dominance index were highest in Daepo and lowest in Woljeong.

Making Aids of Magnetic Resonacnce Image Susing 3D Printing Technology (3D 프린트를 활용한 자기공명영상검사 보조기구 제작)

  • Choi, Woo jeon;Ye, Soo young;Kim, Dong hyun
    • Journal of the Korean Society of Radiology
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    • v.10 no.6
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    • pp.403-409
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    • 2016
  • MRI scan is a useful method in the diagnosis of musculoskeletal excellent contrast of the organization. Depending on the patient's musculoskeletal examinations state the type of aids provided the aid is used there is also challenging as well as the costs do not vary. This study was produced by the use of 3D printing technology, an MRI aids. Aids in the production process, then through 3D modeling and then convert stl files using (3D MAX.2014, Fusion360) slicing programs (Cubicreater 2.1ver., Cura 15.4ver) converted to G-code printed on the FDM scheme (Cubicon Style, output was MICRO MAKE). Output is, but in the FDM to evaluate the SNR on the MRI images were compared to the test is the case before use, and then to produce a Water Phantom case of a PLA, ABS, a TPU thickness 3mm, using aids before, It was evaluated in a clinical image after qualitatively. Obtaining an image of SNR Warter Phantom appeared to have been evaluated as T1 NON $123.778{\pm}28.492$, PLA $123.522{\pm}28.373$, ABS $124.461{\pm}25.716$, TPU $124.843{\pm}27.272$. T2 NON $127.421{\pm}26.949$, was rated as PLA $124.501{\pm}27.768$, ABS $128.663{\pm}26.549$, TPU $130.171{\pm}25.998$. The results did not show statistically significant differences. The use of assistive devices before and after images Clinical evaluation method palliative $3.20{\pm}0.88$, $3.95{\pm}0.76$ after using the aids used to aid improved the quality of the image. Production of the auxiliary mechanism using a future 3D printing is expected are thought to be used clinically, it can be an aid making safe and comfortable than the inspection of the patient is an alternative to improve the problems of the aids used in the conventional do.

The long-term prognostic impact of sentinel lymph node biopsy in patients with primary cutaneous melanoma: a prospective study with 10-year follow-up

  • Portinari, Mattia;Baldini, Gabriele;Guidoboni, Massimo;Borghi, Alessandro;Panareo, Stefano;Bonazza, Simona;Dionigi, Gianlorenzo;Carcoforo, Paolo
    • Annals of Surgical Treatment and Research
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    • v.95 no.5
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    • pp.286-296
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    • 2018
  • Purpose: Sentinel lymph node (SLN) biopsy (SLNB) is widely accepted for staging of melanoma patients. It has been shown that clinico-pathological features such as Breslow thickness, ulceration, age, and sex are better predictors of relapse and survival than SLN status alone. The aims of this study were to evaluate the long-term (10-year) prognostic impact of SLNB and to determine predictive factors associated with SLN metastasis, relapse, and melanoma specific mortality (MSM). Methods: This was a prospective observational study on 289 consecutive patients with primary cutaneous melanoma who underwent SLNB from January 2000 to December 2007, and followed until January 2014, at an Italian academic hospital. Results: SLN was positive in 64 patients (22.1%). The median follow-up was 116 months (79-147 months). Tenyear disease-free survival and melanoma specific survival were poor in patients with positive SLN (58.7% and 66.4%, respectively). Only the increasing Breslow thickness resulted independently associated to an increased risk of SLN metastasis. Cox regression analysis showed that a Breslow thickness >2 mm was an independent predictor of relapse, and male sex and Breslow thickness >2 mm was a predictor of MSM. At 10 years, SLN metastasis was not significantly associated to either relapse or MSM. Conclusion: After the fifth year of follow-up, SLN metastasis is not an independent predictive factor of relapse or mortality which are mainly influenced by the characteristics of the primary tumor and of the patient. Patients with a Breslow thickness >2 mm regardless of the SLN status should be considered at high risk for 10-year relapse and mortality.