• The Transactions of The Korean Institute of Electrical Engineers
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• v.63 no.7
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• pp.1001-1007
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• 2014

This paper proposes a method to reduce operation time using discrete cosine transform and to improve image quality by the DC gain correction. Conventional filtered back projection (FBP) filtering in the frequency domain using Fourier transform, but the filtering process uses complex number operations. To simplify the filtering process, we propose a filtering process using discrete cosine transform. In addition, the image quality of reconstructed images are improved by correcting DC gain of sinograms. To correct the DC gain, we propose to find an optimum DC weight is defined as the ratio of sinogram DC and optimum DC. Experimental results show that the proposed method gets better performance than the conventional method for phantom and clinical CT images.

• Tuberculosis and Respiratory Diseases
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• v.57 no.2
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• pp.118-124
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• 2004

Lung cancer is the leading cause of cancer death for men and women in the industrialized world. It is desirable to detect disease at a stage when it is not causing symptoms and when control or cure is possible. If the screening test detects patients with the disease at an early stage, they can be examined to confirm the diagnosis and intervention can alter the natural history of the disease. The results of screening programs designed to detect early lung cancer using either conventional chest radiograph or sputum cytology are disappointing for a diagnostic screening test. Because of advances in helical CT imaging techniques, screening for lung cancer has been suggested as a possible method of improving outcome. Findings in recent publications suggest that substantial dose reduction is possible in chest CT. The advantages of low-dose CT are more sensitive than chest radiograph for detecting small pulmonary nodules that may be lung cancers, shorter scanning time than conventional chest CT scan without intravenous contrast injection, cheaper cost than standard CT, low radiation dose. However, the true clinical significance of the small tumors found by screening is still unknown, and their effect on mortality awaits future investigation. Furthermore, in addition to detecting an increased number of lung cancers, low-dose CT found at least one indeterminate nodule in many of all screened patients. The majority should be benign but evaluation of all these indeterminate nodules is not a trivial problem in routine practice. In conclusion, lung cancer screening with low-dose CT is a complex subject. The true effectiveness of lung cancer screening (a reduction in mortality from lung cancer) with low-dose CT can be determined through well-designed randomized control trials with enrolment of appropriate subjects.

• Journal of Technology Innovation
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• v.22 no.3
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• pp.261-286
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• 2014

Recently, project performance and management of government R&D program investing huge amount of budget is being focused. In this study, I built a model for estimating the performance creating paths of the government R&D program, then I analyzed the attributes of performances created by industries. I used simultaneous equations with FIML and examined the IT industry and CT industry of industrial technology innovation program using survey on R&D performance conducted by KEIT. On the analysis result, all the companies create the innovation performance through the government grants. However, the one who commercialize patents is SMEs in IT industry, and conglomerates in CT industry. SMEs in IT industry, which has characteristic of complex product, need extra self innovation activities even the government supports them. For improving the commercialization performance and technology development of SMEs in CT industry, it is effective when conducting cooperative research. These findings give us the implication that it is needed to consider different factors by industrial and enterprise characteristic when planning the public policy and government tasks.

• Journal of the Korean Geotechnical Society
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• v.27 no.11
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• pp.83-92
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• 2011

The random and heterogeneous pore structure is a significant factor that dominates physical and mechanical behaviors of soils such as fluid flow and geomechanical responses driven by loading. The characterization method using non-destructive testing such as micro X-ray CT technique which has a high resolution with micrometer unit allows to observe internal structure of soils. However, the application has been limited to qualitatively observe 2D and 3D CT images and to obtain the void ratio at macro-scale although the CT images contain enormous information of materials of interests. In this study, we constructed the 3D particle and pore structures based on sequentially taken 2D images of glass beads and quantitatively defined complex pore structure with void cell and void channel. This approach was enabled by implementing image processing techniques that include coordinate transformation, binarization, Delaunay Triangulation, and Euclidean Distance Transform. It was confirmed that the suggested algorithm allows to quantitatively evaluate the distribution of void cells and their connectivity of heterogeneous pore structures for glass beads.

• Advances in nano research
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• v.9 no.4
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• pp.277-294
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• 2020

In current paper, nonlocal (NLT), nonlocal strain gradient (NSGT) and Gurtin-Murdoch surface/interface (GMSIT) theories with classical theory (CT) are utilized to investigate vibration and stability analysis of Double Walled Piezoelectric Nanosensor (DWPENS) based on cylindrical nanoshell. DWPENS simultaneously subjected to direct electrostatic voltage DC and harmonic excitations, structural damping, two piezoelectric layers and also nonlinear van der Waals force. For this purpose, Hamilton's principle, Galerkin technique, complex averaging and with arc-length continuation methods are used to analyze nonlinear behavior of DWPENS. For this work, three nonclassical theories compared with classical theory CT to investigate Dimensionless Natural Frequency (DNF), pull-in voltage, nonlinear frequency response and stability analysis of the DWPENS considering the nonlocal, material length scale, surface/interface (S/I) effects, electrostatic and harmonic excitation.

• Analytical Science and Technology
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• v.16 no.3
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• pp.198-205
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• 2003

The ammonium salt of nitrosophenylhydroxylamine, called cupferron, has been used not only as the ligand but also as an oxidizing agent for adsorptive catalytic stripping voltammetry (AdCtSV). Cyclic voltammetry was used for elucidating the electrochemical behavior of Os-cupferron complex in 1 mM phosphate buffer. The optimal conditions for osmium analysis were found to be 1 mM phosphate buffer solution (pH 6.0) containing 0.1 mM cupferron at scan rate of 100 mV/s. By using the plot of reduction peak currents of linear scan voltammograms vs. osmium concentration, the detection limit was $1.0{\times}10^{-7}M$.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.40 no.4
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• pp.373-379
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• 2016

It is known that it is expedient to represent the distribution of the properties of a bone with complex heterogeneity as B-spline volume functions. For B-spline-based representation, the pixel values of CT images are interpolated by B-spline volume functions. However, the CT images of a bone are three-dimensional and very large, and hence a large amount of memory and long computation time for the interpolation are required. In this study, a method for resolving these problems is proposed. In the proposed method, the B-spline volume interpolation problem is simplified by using the uniformity of pixel spacing of the image and the properties of B-spline basis functions. This results in a reduction in computation time and the amount of memory used. The proposed method was implemented and it was verified that the computation time and the amount of memory used were reduced.

• Journal of the korean academy of Pediatric Dentistry
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• v.25 no.3
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• pp.493-498
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• 1998

Computed tomography(CT) has become more widely available in recent years and is recognized as an important diagnostic tool for complex disease and condition of the orofacial structure in adults. In pediatric patients, especially in the mixed dentition period, the number of superimposing dental structures in the jaw bone is much greater than in the permanant dentition period. Therefore, in spite of radiation risk, computed tomography should sometimes be used in pediatric patients in order to obtain a precise and valid diagnosis. This case study presents clinical application of computed tomography on patients visiting department of pediatric dentistry in Seoul National University Dental Hospital. The results obtained through these cases were summarized as follow : 1. Localization of impacted teeth using CT allows for efficient treatment planning leading to reduced postoperative complications. 2. In orthodontic traction of impacted permanent teeth, utilization of CT made exact localization of window site and determination of prognosis possible. 3. Use of CT made possible definite diagnosis of lesions in the jaw that were only suspected on plain film radiographs. 4. Careful selection is necessary when applying CT on children due to increased radiation dose and high cost.

• Imaging Science in Dentistry
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• v.53 no.1
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• pp.69-75
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• 2023

Purpose: Maxillofacial trauma predominantly affects young adults between 20 and 40 years of age. Although radioprotection is a legal requirement, the significant potential of dose reduction in computed tomography (CT) is still underused in the clinical routine. The objective of this study was to evaluate whether maxillofacial fractures can be reliably detected and classified using ultra-low-dose CT. Materials and Methods: CT images of 123 clinical cases with maxillofacial fractures were classified by two readers using the AOCOIAC software and compared with the corresponding results from post-treatment images. In group 1, consisting of 97 patients with isolated facial trauma, pre-treatment CT images at different dose levels (volumetric computed tomography dose index: ultra-low dose, 2.6 mGy; low dose, <10 mGy; and regular dose, <20 mGy) were compared with post-treatment cone-beam computed tomography (CBCT). In group 2, consisting of 31 patients with complex midface fractures, pre-treatment shock room CT images were compared with post-treatment CT at different dose levels or CBCT. All images were presented in random order and classified by 2 readers blinded to the clinical results. All cases with an unequal classification were re-evaluated. Results: In both groups, ultra-low-dose CT had no clinically relevant effect on fracture classification. Fourteen cases in group 2 showed minor differences in the classification code, which were no longer obvious after comparing the images directly to each other. Conclusion: Ultra-low-dose CT images allowed the correct diagnosis and classification of maxillofacial fractures. These results might lead to a substantial reconsideration of current reference dose levels.

• Macromolecular Research
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• v.14 no.1
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• pp.66-72
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• 2006

The purpose of this study is to develop novel nanoparticles based on polyion complex formation between low molecular weight water-soluble chitosan (LMWSC) and all-trans retinoic acid (atRA). LMWSC nanoparticles encapsulating atRA based on polyion complex were prepared by mixing of atRA into LMWSC aqueous solution using ultrasonication. In FTIR spectra, the carbonyl group of atRA at 1690 $cm^{-1}$ disappeared or decreased when ion complexes were formed between LMWSC and atRA. In ${1}^H$ NMR spectra, specific peaks of atRA disappeared when atRA-encapsulated LMWSC (RAC) nanoparticles were reconstituted into $D_{2}O$ while specific peaks both of atRA and LMWSC appeared in $D_{2}O$/DMSO (1/3, v/v) mixture. XRD patterns also showed that the crystal peaks of atRA were disappeared by encapsulation into LMWSC nanoparticles. LMWSC nanoparticles encapsulating atRA have spherical shapes with particle size below 200 nm. The mechanism of encapsulation of atRA into LMWSC nanoparticles was thought to be an ion complex formation between LMWSC and atRA. LMWSC nanoparticles showed high atRA loading efficiency over 90$\%$ (w/w). AtRA was continuously released from nanoparticles over 10 days. In in vitro cell cytotoxicity test, free atRA showed higher cytotoxic effect against CT 26 colon carcinoma cell line on 1 day. However, RAC nanoparticles showed similar cytotoxicity against CT 26 cells on 2 day. These results suggest the potential for the introduction of LMWSC nanoparticles into various biomedical fields such as drug delivery.