• Asian Pacific Journal of Cancer Prevention
• /
• 제16권15호
• /
• pp.6423-6428
• /
• 2015

The present study was designed to evaluate in vitro anti-proliferative potential of extracts from four Indian medicinal plants, namely Anogeissus latifolia, Terminalia bellerica, Acacia catechu and Moringa oleiferna. Their cytotoxicity was tested in nine human cancer cell lines, including cancers of lung (A549), prostate (PC-3), breast (T47D and MCF-7), colon (HCT-16 and Colo-205) and leukemia (THP-1, HL-60 and K562) by using SRB and MTT assays. The findings showed that the selected plant extracts inhibited the cell proliferation of nine human cancer cell lines in a concentration dependent manner. The extracts inhibited cell viability of leukemia HL-60 and K562 cells by blocking G0/G1 phase of the cell cycle. Interestingly, A. catechu extract at $100{\mu}g/mL$ induced G2/M arrest in K562 cells. DNA fragmentation analysis displayed the appearance of a smear pattern of cell necrosis upon agarose gel electrophoresis after incubation of HL-60 cells with these extracts for 24h.

• Composites Research
• /
• 제31권6호
• /
• pp.311-316
• /
• 2018

In the present study, the effect of GO in damping capacity of CF/epoxy laminates was studied via free vibration analysis. The composite laminates were manufactured by using vacuum assisted resin transfer molding technique. The damping properties of the prepared hybrid composites were determined in terms of natural frequency and damping ratio in free vibration test. The foremost aspire of this investigation was to compare the vibration properties i.e. natural frequency and modal damping of the prepared composites with the numerical results. The numerical study was carried out via FEA using $ANSYS^{TM}$ workbench software. The parametric study of the numerical models was also studied considering the beam free length and the beam thickness. It was found that the incorporation of GO enhanced the damping capacity of the composite and the variation of natural frequencies in mode1varied by 2-5% compared to the experimental study.

• Computers and Concrete
• /
• 제31권3호
• /
• pp.241-252
• /
• 2023

Corrosion of rebar is one of the major deteriorating mechanisms that affect the durability of reinforced concrete (RC) structures. The increase in CO₂ concentration in the atmosphere leads to early carbonation and deterioration due to corrosion in RC structures. In the present study, an attempt has been made to modify the existing carbonation depth prediction empirical model. The modified empirical model is verified from the carbonation data collected from selected RC structures of CSIR-SERC campus, Chennai and carbonation data available from the reported literature on in-situ RC structures. Attempt also made to study the carbonation depth in the laboratory specimens using oxygen permeability index (OPI) test. The carbonation depth measured from RC structures and laboratory specimens are compared with estimated carbonation depth obtained from OPI test data. The modified empirical model shows good correlation with measured carbonation depth from the identified RC structures and the reported RC structures from the literature. The carbonation depth estimated from OPI values for both in-situ and laboratory specimens show lesser percentage of error compared to measured carbonation depth. From the present investigation it can be said that the OPI test is the suitable test method for both new and existing RC structures and laboratory RC specimens.

• 대한약침학회지
• /
• 제20권2호
• /
• pp.93-99
• /
• 2017

Objectives: Selaginella bryopteris L. (family: Selaginaceae), is often used in traditional Indian systems of medicine for the prevention and cure of several disorders and for the treatment of patient with spermatorrhoea, venereal disease, constipation, colitis, urinary tract infections, fever, epilepsy, leucorrhoea, beri-beri and cancer. It is also used as a strength tonic. This study aimed to evaluate the mechanisms underlying the anti-inflammatory effects of topically administered aqueous, polar and non-polar methanolic fractions ($10mg/20{\mu}L$) of Selaginella bryopteris. Methods: An acute oral toxicity study of Selaginella bryopteris at doses from 250 to 2,000 mg/kg body weight (bw) was performed. Aqueous, polar and non-polar methanolic extracts ($10mg/20{\mu}L$) applied topically for 5 days were evaluated for their anti-inflammatory effects against 12-tetra-O-decanoyl phorbol acetate (TPA)- induced inflammation by using the redness in the ear, the ear's weight (edema), oxidative stress parameters, such as lipid-peroxide (LPO) and nitric oxide (NO), and the pro-inflammatory cytokines involved in inflammation, such as tumour necrosis factor $(TNF)-{\alpha}$, interleukin $(IL)-1{\beta}$ and IL-6. Indomethacine ($0.5mg/20{\mu}L$) was used for the positive control. Results: Selaginella bryopteris produced no mortalities when administered orally at doses from 250 to 2,000 mg/kg bw. Topical treatment with the non-polar methanolic fraction ($10mg/20{\mu}L$) significantly suppressed redness ($2.4{\pm}0.5$) and edema ($30.4{\pm}1$) and effectively reduced the LPO level ($32.3{\pm}3.3$). The NO level was ($8.07{\pm}0.55$), and the $TNF-{\alpha}$, $IL-1{\beta}$, and IL-6 levels were decreased to $69.6{\pm}15.5$, $7.7{\pm}4.8$ and $82.6{\pm}5.9$, respectively. Conclusion: This study demonstrated for the first time the mechanisms underlying the anti-inflammatory effect of medicinal plants like Selaginella bryopteris and quantified the pharmacological interactions between them. The present study showed this herbal product to be a promising anti-inflammatory phytomedicine for the treatment of patients with inflammatory skin diseases.

• Advances in materials Research
• /
• 제2권1호
• /
• pp.51-64
• /
• 2013

Enantioselective macromer of trimesic acid was prepared using S(-) menthol with trimesoyl chloride on polyimide (PI) ultrafiltration membrane. The chemical composition of macromer as well as polyimide ultrafiltration membrane was determined by ATR-FTIR Spectroscopy. The optical resolution of chiral alcohols was performed in pressure driven process. The effect of monomer solutions concentration, effect of air-drying time of S(-) menthol solution, effect of reaction time, effect of operating pressure, effect of feed concentration of racemate on the performance of macromer was studied. The synthesised material exhibits separation of chiral alcohols (menthol ~23% and sobrelol ~21%).

• Mycobiology
• /
• 제43권2호
• /
• pp.118-121
• /
• 2015

Graphis yunnanensis is described here as a new species. It is taxonomically well characterized by entire labia, slit-like disc, lateral thalline margin, completely carbonized proper exciple, inspersed hymenium, 8-spored asci, muriform $25{\sim}45{\times}8{\sim}12{\mu}m$ ascospores, and the presence of norstictic and stictic acids. The separation of the new species from other somewhat similar Graphis species is discussed. In addition, the study includes Graphis tenoriensis and Phlyctis karnatakana reported for the first time from China.

• Structural Engineering and Mechanics
• /
• 제43권6호
• /
• pp.771-794
• /
• 2012

This paper presents a multi-objective evolutionary algorithm for combinatorial optimisation and applied for design optimisation of fiber reinforced composite structures. The proposed algorithm closely follows the implementation of Pareto Archive Evolutionary strategy (PAES) proposed in the literature. The modifications suggested include a customized neighbourhood search algorithm in place of mutation operator to improve intensification mechanism and a cross over operator to improve diversification mechanism. Further, an external archive is maintained to collect the historical Pareto optimal solutions. The design constraints are handled in this paper by treating them as additional objectives. Numerical studies have been carried out by solving a hybrid fiber reinforced laminate composite cylindrical shell, stiffened composite cylindrical shell and pressure vessel with varied number of design objectives. The studies presented in this paper clearly indicate that well spread Pareto optimal solutions can be obtained employing the proposed algorithm.

• Smart Structures and Systems
• /
• 제4권4호
• /
• pp.465-492
• /
• 2008

Proper pretest planning is a vital component of any successful vibration test on engineering structures. The most important issue in dynamic testing of many engineering structures is arriving at the number and optimal placement of sensors. The sensors must be placed on the structure in such a way that all the important dynamic behaviour of a structural system is captured during the course of the test with sufficient accuracy so that the information can be effectively utilised for structural parameter identification or health monitoring. Several optimal sensor placement (OSP) techniques are proposed in the literature and each of these methods have been evaluated with respect to a specific problem encountered in various engineering disciplines like aerospace, civil, mechanical engineering, etc. In the present work, we propose to perform a detailed characteristic evaluation of some selective popular OSP techniques with respect to their application to practical civil engineering problems. Numerical experiments carried out in the paper on various practical civil engineering structures indicate that effective independence (EFI) method is more consistent when compared to all other sensor placement techniques.

• Structural Engineering and Mechanics
• /
• 제26권1호
• /
• pp.31-42
• /
• 2007

The unsymmetric finite element formulation has been proposed recently to improve predictions from distorted finite elements. Studies have also shown that this special formulation using parametric functions for the test functions and metric functions for the trial functions works surprisingly well because the former satisfy the continuity conditions while the latter ensure that the stress representation during finite element computation can retrieve in a best-fit manner, the actual variation of stress in the metric space. However, a question that remained was whether the unsymmetric formulation was variationally correct. Here we determine that it is not, using the simplest possible element to amplify the principles.

• Advances in concrete construction
• /
• 제8권2호
• /
• pp.101-117
• /
• 2019

Structural strengthening of reinforced concrete (RC) beams is becoming essential to meet the up-gradation of existing structures due to the infrastructure development. Strengthening is also essential for damaged structural element due to the adverse environmental condition and other distressing factors. This article reviews the state of the field on repair, retrofitting and rehabilitation techniques for the strengthening of RC beams. Strengthening of RC beams using various promising techniques such as externally bonded steel plates, concrete jacketing, fibre reinforced laminates or sheets, external prestressing/external bar reinforcement technique and ultra-high performance concrete overlay have been extensively investigated for the past four decades. The primary objective of this article is to discuss investigations on various strengthening techniques over the years. Various parameters that have been discussed include the flexural capacity, shear strength, failure modes of various strengthening techniques and advances in techniques over the years. Firstly, background information on strengthening, including repair, retrofitting, and rehabilitation of RC beams is provided. Secondly, the existing strengthening techniques for reinforced concrete beams are discussed. Finally, the relative comparisons and limitations in the existing techniques are presented.