• The Korean Journal of Food And Nutrition
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• v.25 no.1
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• pp.123-131
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• 2012

The objective of the present study was to evaluate the potential antidiabetic and antioxidant effect of the ethanol extract from Chrysanthemum cornarium L. var. spatiosum(CSE) against alloxan-induced oxidative stress in pancreatic ${\beta}$-cells, HIT-T15. In this study, the antidiabetic effect of CSE was examined using the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazoliu bromide(MTT) cell proliferation assay, lactate dehydrogenase(LDH) release assay, $NAD^+$/NADH ratio and insulin secretion. To further investigate whether CSE is involved in the antioxidant activity of alloxan-damaged HIT-T15 cells, its antioxidant effect against alloxan-induced oxidative stress was measured in HIT-T15 cells by determining the levels of antioxidant enzymes including superoxide dismutase(SOD), glutathione S-transferase(GST), glutathione reductase(GR) and glutathione peroxidase(GPx). The results of this analysis showed that alloxan significantly decreased cell viability, increased LDH leakage, and lowered $NAD^+$/NADH ratio and insulin secretion in HIT-T15 cells. However, CSE significantly increased the viability of alloxan-treated cells and lowered LDH leakage. The intracellular NAD+/NADH ratio and insulin secretion were also significantly increased by 1.7-fold and 1.3-fold, respectively, after treatment with 100 ${\mu}g/m{\ell}$ CSE. The HIT-T15 cells treated with alloxan showed significant decreases in the activities of antioxidant enzymes, while CSE significantly elevated the levels of antioxidant enzymes. These findings suggest that CSE could have a protective effect against cytotoxicity and dysfunction of pancreatic cells in the presence of alloxan-induced oxidative stress.

• Food Science and Preservation
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• v.17 no.5
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• pp.644-651
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• 2010

We prepared sikhe (CSE/BR-SH) using corn silk extract and black rice. The pH decreased during saccharification, from pH $5.88{\pm}0.03$ to pH $5.67{\pm}0.02$ after 6 h. However, the brix and reducing sugar contents increased during saccharification of CSE/BR-SH, with the highest levels ($7.6{\pm}0.05$ brix and $4.012{\pm}0.05$ g/l, respectively) being attained at 6 h. Amylase activity increased to 116.12% of control values 1 h after saccharification of CSE/BR-SH, and decreased thereafter. CSE/BR-SH was light purple in color. Soluble phenolic concentration increased markedly from an initial 8.43 g/l to 23.09 g/l at the end of saccharification (6 h), as did DPPH radical-scavenging activity (from an initial 17.3% to 70.98%), Increases were noted in all of ABTS radical-scavenging activity (from 40.25% to 75.32%), reducing power (from 0.241 to 0.682), and ferric reducing antioxidant power (FRAP) (from 0.288 to 1.071).

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.86-94
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• 2003

Electronically available biological literature has been accumulated exponentially in the course of time. So, researches on automatically acquiring knowledge from these tremendous data by text mining technology become more and more prosperous. However, most of the previous researches are technology oriented and are not well focused in practical extraction target, hence result in low performance and inconvenience for the bio-researchers to actually use. In this paper, we propose a more biology oriented target domain specific text mining system, that is, POSTECH bio-text mining system (POSBIOTM), for signal transduction pathway extraction, especially for G protein-coupled receptor (GPCR) pathway. To reflect more domain knowledge, we specify the concrete target for pathway extraction and define the minimal pathway domain ontology. Under this conceptual model, POSBIOTM extracts interactions and entities of pathways from the full biological articles using a machine learning oriented extraction method and visualizes the pathways using JDesigner module provided in the system biology workbench (SBW) [14]

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.25 no.2
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• pp.1-10
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• 2019

Background: The purpose of this study was to determine the effects of cervical extension-traction exercise on cervical alignment, pain, and neck disability in patients with mild turtle syndrome. Methods: Thirty two outpatients with mild turtle neck syndrome were recruited and randomly divided into two groups. Participants in the experimental group was applied cervical extension-traction exercise (CETE, n=16) and in the control group applied cervical stabilization exercise (CSE, n=16) for three times a week for 4 weeks. Results: Cobb angle and Jochumsen depth were CETE showed significant difference within the group post test (p<.05). And the CETE was significantly higher than the CSE. In the pressure pain threshold, both CETE and CSE showed significant differences within post test (p<.05). And the CETE was significantly higher than the CSE. Neck disability index were significant (p<.05) in the CETE post test. There was no significant difference between the two groups. Conclusion: Our results of this study showed that applying cervical extension-traction exercise to patients with mild turtle syndrome improved cervical alignment, pain and neck dysfunction.

• Korean Journal of Pharmacognosy
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• v.46 no.4
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• pp.327-333
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• 2015

Alzheimer's disease (AD) is a progressive neurodegenerative disorder symptomatically characterized by impairment in memory and cognitive abilities. AD is characterized pathologically by the deposition of ${\beta}$-amyloid ($A{\beta}$) peptides of 40-42 residues, which are generated by processing of amyloid precursor protein (APP). $A{\beta}$ has been believed to be neurotoxic and now is also considered to have a role on the mechanism of memory dysfunction. In this study, we tested that EtOH extract of the fruits of Chaenomeles sinensis Koehne (CSE) affects on the processing of APP from the APPswe over-expressing Neuro2a cell line. We found that CSE increased over 2 folds of the $sAPP{\alpha}$ secretion level, a metabolite of ${\alpha}$-secretase. We showed that CSE reduced the secretion level of $A{\beta}42$ and $A{\beta}40$ by down regulation of ${\beta}$-secretase (BACE) without cytotoxicity. Furthermore, we found that CSE inhibited BACE and acetylcholinesterase activity in vitro. We suggest that Chaenomelis Fructus may be an useful source to develop a herbal medicine for AD.

• Journal of the Korea Safety Management & Science
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• v.14 no.3
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• pp.229-236
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• 2012

소프트웨어 기반의 시스템 설계과정에서 설계자가 고려해야 하는 요소들이 다양해지면서 시스템 설계가 점점 어려워지고 있다. 다양한 설계 요소들이 존재하지만 사용자의 특성 및 직무, 사용가능한 정보기술의 특성 등이 핵심적인 요소로 간주된다. 또한 정보기술이 발달하면서 인간과 시스템의 상호작용이 점점 인지적인 특징을 지니게 되었다. 따라서 사용성 높고, 효율적이면서 안전한 소프트웨어 기반의 시스템을 개발하기 위해서는 시스템 설계자가 사용자의 인지적인 요구사항 및 그들의 직무를 시스템 설계과정에서 체계적으로 다룰 수 있어야 한다. 그러나 소프트웨어 공학, 시스템 공학 및 인간-컴퓨터 상호작용 등에서의 전통적인 시스템 설계 방법은 이러한 설계자의 설계활동을 효과적으로 지원하는데 한계가 있었다. 그 대안으로 인지시스템공학(cognitive systems engineering; CSE)은 인간중심의 설계철학을 바탕으로 소프트웨어 기반의 복잡한 시스템 설계과정에서 설계자의 활동을 체계적으로 도와줄 수 있는 유용한 개념과 방법을 제공해주고 있다. CSE는 원래 사람이 실시간으로 감시 및 제어해야 하는 복잡한 사회기술적 시스템(예: 원자력발전소 및 공항관제소)의 분석, 설계 및 평가를 위해 태동한 학문이다. 그러나 CSE에서 제공하는 이론적 및 방법론적 프레임워크는 소프트웨어 기반의 시스템을 설계하는 데에도 유용하게 활용할 수 있는 충분한 가능성을 갖고 있다. 이 논문은 CSE의 근간을 이루는 핵심 개념 및 원칙을 고찰하고 소프트웨어 기반 시스템 설계에의 활용가능성 및 그 방안을 논의한다.

• Food Science and Biotechnology
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• v.16 no.1
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• pp.150-153
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• 2007

Hydrocarbons have been successfully used as a chemical marker in order to identify irradiated from non-irradiated foods. The method for determining hydrocarbons consists of extraction of fats, followed by separation of hydrocarbons by florisil column chromatography, and then identification of hydrocarbons by GC/MS. Currently, solvent extraction method for fats has certain limitations with regard to extraction time and solvent consumption. Commercial hams and sausage were irradiated at 0 and 5 kGy, and the efficiency of microwave-assisted extraction (MAE) and conventional solvent extraction (CSE) methods on the extraction of radiation-induced hydrocarbons from the meat products was compared. Significant levels of hydrocarbons, mainly composed of 1,7-hexadecadien, 1,7,10-hexadecatriene, and 6,9-heptadecadiene, were detected in the extracts from irradiated hams and sausages by both CSE and MAE methods. Both methods were acceptable in extracting hydrocarbons from samples, but MAE method required apparently reduced amounts of solvent from 150 (CSE) to 50 mL and reduced extraction time from 23 (CSE) to 5 min.

• Journal of Power Electronics
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• v.18 no.1
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• pp.147-159
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• 2018

In this paper, the voltage tracking control of a conventional DC-DC boost converter affected by unknown, time-varying circuit parameter perturbations is investigated. Based on the fundamental property of incremental passivity, a passivity based control law is designed. Then, to obtain a better disturbance rejection property, two generalized proportional integral (GPI) observers are employed to estimate the time-varying uncertainties in the output voltage and inductor current channels, and the estimated values are applied as feedforward compensation. Moreover, the global trajectory tracking performance of a system with disturbances is ensured under the composite controller. Finally, simulation and experiment studies are provided to demonstrate the feasibility and effectiveness of the proposed method. The results show that the proposed controller delivers a promising disturbance rejection capability as well as a good nominal tracking performance.

• Proceedings of the Korea Information Processing Society Conference
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• 2019.05a
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• pp.342-345
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• 2019

드론의 동작 검증을 위한 테스트는 최종적으로 드론이 운용될 환경에서 이루어진다. 그러나 테스트 비용이 크고 테스트 비행 중 파손의 위험이 있기 때문에 시뮬레이션을 통한 사전 검증을 수행하는 것이 중요하다. 시뮬레이션은 SIL 방식이나 HIL 방식으로 이루어지는데 추가적인 외부 센서를 활용하는 경우 검증하기가 어렵다. SIL에서는 검증을 위해 가상의 외부 센서 구현이 필요하다. HIL 에서는 실제 센서를 사용하므로 가상의 외부 센서 구현은 필요 없다. 그러나 테스트 환경이기 때문에 실제 환경과 비슷한 데이터나 동작 검증에 적합한 데이터를 얻기 어렵다. 이러한 HIL에서의 문제를 해결하기 위해 외부 센서를 실제 환경에서 사용한 로그나 테스트 환경에서 센서 검증에 사용한 로그를 이용할 수 있다. 본 논문에서 제안하는 외부 센서의 로그를 활용한 HIL 시뮬레이션 기법 확장 내용은 외부 센서 데이터 입력기가 로그로부터 얻은 센서 데이터를 비행 컨트롤러로 보내 검증을 수행하기 때문에 데이터를 재사용할 수 있고 테스트 비용을 줄일 수 있다. 또 외부 센서 데이터 입력기는 로그 파서, 뷰어, 슬라이서, 데이터 전송기로 구성되어 로그로부터 검증에 적합한 데이터를 쉽게 얻어 활용할 수 있다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2019.07a
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• pp.1-4
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• 2019

드론은 여러 센서를 사용할 수 있고 자율적으로 비행 가능하다는 이점 때문에 다양한 분야에 활용할 수 있다. 그러나 단일 드론으로는 수행할 수 있는 작업이나 미션이 제한적이기 때문에 최근에는 다중 드론을 활용한 군집 비행 기술 연구가 활발하게 이루어지고 있다. 드론은 테스트를 통해 동작 검증이 이루어지는데 테스트 비용이 크고 파손의 위험이 있기 때문에 시뮬레이션을 이용한 사전 검증이 먼저 이루어진다. 그런데 다중 드론을 이용한 군집 비행 시뮬레이션의 경우 드론들이 밀집해 있기 때문에 시뮬레이션 중 드론의 충돌사고가 발생할 수 있다. 동기화가 제대로 이루어지지 않은 시뮬레이션은 각 드론 소프트웨어의 정확한 동작을 보장할 수 없기 때문이다. 이러한 문제를 해결하기 위해서 본 논문에서는 순서 기반의 동기화 기법을 제안한다. 제안하는 기법은 기존 동기화 기법과는 달리 순서 기반의 동기화로 시뮬레이션 오버헤드를 줄이며 다중 드론의 군집 비행 시뮬레이션에서 예상하지 못한 드론의 동작을 최소화 할 수 있다.