• Journal of Ginseng Research
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• v.47 no.2
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• pp.183-192
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• 2023

Viral infections are known as one of the major factors causing death. Ginseng is a medicinal plant that demonstrated a wide range of antiviral potential, and saponins are the major bioactive ingredients in the genus Panax with vast therapeutic potential. Studies focusing on the antiviral activity of the genus Panax plant-derived agents (extracts and saponins) and their mechanisms were identified and summarized, including contributions mainly from January 2016 until January 2022. P. ginseng, P. notoginseng, and P. quinquefolius were included in the review as valuable medicinal herbs against infections with 14 types of viruses. Reports from 9 extracts and 12 bioactive saponins were included, with 6 types of protopanaxadiol (PPD) ginsenosides and 6 types of protopanaxatriol (PPT) ginsenosides. The mechanisms mainly involved the inhibition of viral attachment and replication, the modulation of immune response by regulating signaling pathways, including the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, cystathionine γ-lyase (CSE)/hydrogen sulfide (H₂S) pathway, phosphoinositide-dependent kinase-1 (PDK1)/ protein kinase B (Akt) signaling pathway, c-Jun N-terminal kinase (JNK)/activator protein-1 (AP-1) pathway, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. This review includes detailed information about the mentioned antiviral effects of the genus Panax extracts and saponins in vitro and in vivo, and in human clinical trials, which provides a scientific basis for ginseng as an adjunctive therapeutic drug or nutraceutical.

• Annual Conference on Human and Language Technology
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• 2022.10a
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• pp.360-365
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• 2022

문장 표현(sentence representation)은 자연어처리 분야 내의 다양한 문제 해결 및 응용 개발에 있어 유용하게 활용될 수 있는 주요한 도구 중 하나이다. 하지만 최근 널리 도입되고 있는 사전 학습 언어 모델(pre-trained language model)로부터 도출한 문장 표현은 이방성(anisotropy)이 뚜렷한 등 그 고유의 특성으로 인해 문장 유사도(Semantic Textual Similarity; STS) 측정과 같은 태스크에서 기대 이하의 성능을 보이는 것으로 알려져 있다. 이러한 문제를 해결하기 위해 대조 학습(contrastive learning)을 사전 학습 언어 모델에 적용하는 연구가 문헌에서 활발히 진행되어 왔으며, 그중에서도 레이블이 없는 데이터를 활용하는 비지도 대조 학습 방법이 주목을 받고 있다. 하지만 대다수의 기존 연구들은 주로 영어 문장 표현 개선에 집중하였으며, 이에 대응되는 한국어 문장 표현에 관한 연구는 상대적으로 부족한 실정이다. 이에 본 논문에서는 대표적인 비지도 대조 학습 방법(ConSERT, SimCSE)을 다양한 한국어 사전 학습 언어 모델(KoBERT, KR-BERT, KLUE-BERT)에 적용하여 문장 유사도 태스크(KorSTS, KLUE-STS)에 대해 평가하였다. 그 결과, 한국어의 경우에도 일반적으로 영어의 경우와 유사한 경향성을 보이는 것을 확인하였으며, 이에 더하여 다음과 같은 새로운 사실을 관측하였다. 첫째, 사용한 비지도 대조 학습 방법 모두에서 KLUE-BERT가 KoBERT, KR-BERT보다 더 안정적이고 나은 성능을 보였다. 둘째, ConSERT에서 소개하는 여러 데이터 증강 방법 중 token shuffling 방법이 전반적으로 높은 성능을 보였다. 셋째, 두 가지 비지도 대조 학습 방법 모두 검증 데이터로 활용한 KLUE-STS 학습 데이터에 대해 성능이 과적합되는 현상을 발견하였다. 결론적으로, 본 연구에서는 한국어 문장 표현 또한 영어의 경우와 마찬가지로 비지도 대조 학습의 적용을 통해 그 성능을 개선할 수 있음을 검증하였으며, 이와 같은 결과가 향후 한국어 문장 표현 연구 발전에 초석이 되기를 기대한다.

• Journal of Wetlands Research
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• v.18 no.4
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• pp.448-455
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• 2016

Diffuse pollution management in Korea initiated by the Ministry of Environment (MOE) resulted to the construction of pilot facilities termed Best Management Practices (BMPs). Twelve BMPs installed for the diffuse pollution management in the Kyung-An Stream were monitored since 2006. Data on the mass loading, removal efficiency, maintenance activities, etc. were gathered and utilized to conduct the evaluation of long-term performance of BMPs. The financial data such as actual construction, design and maintenance cost were also collected to evaluate the lifecycle cost (LCC) of BMPs. In this study, most of the maintenance activity was focused in the aesthetic maintenance that resulted to the annual maintenance cost of the four BMP types was closely similar ranging from 8,483 $/yr for retention pond to 8,888 $/yr infiltration system. The highest LCC were observed in constructed wetland ($418,324) while vegetated system had the lowest LCC ($210,418). LCC of BMPs was not so high as compared with the conventional treatment facility and sewage treatment plant. On the other hand, the relationship of removal efficiency on unit cost for TSS and TN was significant. This study will be used to design the cost effective BMP for diffuse pollution management and become models for LCC analysis.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.2
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• pp.83-89
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• 2010

In this study, we studied whether hydrogen sulfide ($H_2S$) has an effect on the pacemaker activity of interstitial cells of Cajal (ICC), in the small intestine of mice. The actions of $H_2S$ on pacemaker activity were investigated using whole-cell patch-clamp technique, intracellular $Ca^{2+}$ analysis at $30^{\circ}C$ and RT-PCR in cultured mouse intestinal ICC. Exogenously applied sodium hydrogen sulfide (NaHS), a donor of hydrogen sulfide, caused a slight tonic inward current on pacemaker activity in ICC at low concentrations (50 and $100{\mu}m$), but at high concentration ($500{\mu}m$ and 1 mM) it seemed to cause light tonic inward currents and then inhibited pacemaker amplitude and pacemaker frequency, and also an increase in the resting currents in the outward direction. Glibenclamide or other potassium channel blockers (TEA, $BaCl_2$, apamin or 4-aminopydirine) did not have an effect on NaHS-induced action in ICC. The exogenous application of carbonilcyanide p-triflouromethoxyphenylhydrazone (FCCP) and thapsigargin also inhibited the pacemaker activity of ICC as NaHS. Also, we found NaHS inhibited the spontaneous intracellular $Ca^{2+}$ ($[Ca^{2+}]_i$) oscillations in cultured ICC. In doing an RT-PCR experiment, we found that ICC enriched population lacked mRNA for both CSE and CBS, but was prominently detected in unsorted muscle. In conclusion, $H_2S$ inhibited the pacemaker activity of ICC by modulating intracellular $Ca^{2+}$. These results can serve as evidence of the physiological action of $H_2S$ as acting on the ICC in gastrointestinal (GI) motility.

• Journal of KIISE:Information Networking
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• v.31 no.4
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• pp.414-428
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• 2004

Many portable devices are coming to be commercially successful and provide useful services to mobile users. Mobile devices may request a variety of data types, including text and multimedia data, thanks to the rich content of the Internet. Different types of data and/or different classes of users may need to be treated with different qualities of service. The implementation of service differentiation in wireless networks is very difficult because of device mobility and wireless channel contention when the backoff algorithm is used to resolve contention. Modification of the t)mary exponential backoff algorithm is one possibility to allow the design of several classes of data traffic flows. We present a study of modifications to the backoff algorithm to support three classes of flows: sold, silver, and bronze. For example, the gold c]ass flows are the highest priority and should satisfy their required target bandwidth, whereas the silver class flows should receive reasonably high bandwidth compared to the bronze class flows. The mixture of the two different transport protocols, UDP and TCP, in ad hoc networks raises significant challenges when defining backoff algorithm modifications. Due to the different characteristics of UDP and TCP, different backoff algorithm modifications are applied to each class of packets from the two transport protocols. Nevertheless, we show by means of simulation that our approach of backoff algorithm modification clearly differentiates service between different flows of classes regardless of the type of transport protocol.

• The Journal of Society for e-Business Studies
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• v.14 no.4
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• pp.229-253
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• 2009

The effect of knowledge sharing and its importance have been reported in the information systems literature. However, little has been learned about the impact of knowledgeexchange web sites. This study explores relationships between individual characteristics such as personal innovativeness in the domain of information technology (PIIT), computer selfefficacy (CSE), and computer anxiety (CA), user involvement (UI), and knowledge sharing in a knowledge.exchange website. In order to examine our research model, we adopted a survey research design based on the Structural Equation Modeling method. By analyzing 241 samples collected, we conclude that UI and CA are valuable to discuss in terms of their theoretical and practical implications. This study not only extends the research on personal innovativeness and knowledge sharing, but also suggests a need for focused research efforts to investigate real practices on knowledge sharing. This study initiates this kind of efforts to make a relevant tie between design of knowledge sharing applications and the success case in the commercial field to encourage users to share their knowledge.

• The Korean Journal of Pain
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• v.19 no.2
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• pp.187-191
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• 2006

Background: Patient-controlled epidural analgesia (PCEA), using a local anesthetic-opioid mixture, has been effectively applied after total knee replacement (TKR) surgery, which is associated with intense postoperative pain that requires postoperative analgesia for both rehabilitation and the pain itself. However, adverse opioid-related effects, such as nausea, vomiting and pruritus, are commonly encountered. It was our hypothesis that the adverse opioid-related effects could be reduced by the addition of naloxone, an opioid antagonist, to a mixture of fentanyl-ropivacaine PCEA. Methods: In 120 patients undergoing elective TKR surgery, epidural or combined spinal-epidural (CSE) anesthesia was performed and PCEA applied. In the control group (n = 65), 0.16% ropivacaine and $3{\mu}g/ml$ fentanyl ($2.4{\mu}g/ml$ for those older than 65 yrs) were administered. In the naloxone group (n = 55), naloxone ($2{\mu}g/ml$) was coadministered with the above regimen. The incidence and severity of postoperative nausea and vomiting, and the frequency of pruritus, the visual analog score (VAS) and the PCEA volume used were assessed 6 and 24 hrs after surgery. Results: The incidence of nausea and vomiting during the early postoperative period, and those of pruritus during the late postoperative period were significantly lower in the naloxone group. The VAS pain scores, the PCEA volume used and amount of rescue IV meperidine were similar in the two groups. Conclusions: A small dose of naloxone mixed with an opioid significantly reduces the incidence and severity of adverse opioid-related effects in PCEA, without reducing the analgesic effect.

• Journal of KIISE:Software and Applications
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• v.34 no.1
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• pp.40-51
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• 2007

To improve academic achievement, the most students not only participate in regular classes but also take various extra programs such as private lessons, private institutes, and educational TV programs. In this paper, we propose a data mining approach to identify which studying methods or usual life patterns during a school vacation affect changes in the academic achievement. First, we derive various studying methods and life patterns that are thought to be affecting changes in the academic achievement during a school vacation. Second, we propose the method of transforming and analyzing data to apply them to decision trees and association rules, which are representative data mining techniques. Third, we construct decision trees and find association rules from the real survey data of middle school students. We have discovered four representative results from the decision trees. First, for students in the higher rank, there is a tendency that private institutes give a positive effect on the academic achievement. Second, for the most students, the Internet teaming sites nay give a negative effect on the achievement. Third, private lessons that have thought to be making a large impact to the achievement, however, do not make a positive effect on the achievement. Fourth, taking several studying methods in parallel nay give a negative effect on the achievement. In association rules, however, we cannot find any meaningful relationships between academic achievement and usual life patterns during a school vacation. We believe that our approach will be very helpful for teachers and parents to give a good direction both in preparing a studying plan and in selecting studying methods during a school vacation.

• The Korea Journal of Herbology
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• v.26 no.4
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• pp.39-47
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• 2011

Objective: The roots, leaves, flowers, stems and seeds of Cirsium japonicum var. ussuriense are often used in treatment of human diseases such as hemorrhage, blood congestion and inflammation. Focusing our attention on natural and bioavailable sources of antioxidants and anti-inflammation, we undertook to investigate the antioxidant and anti-inflammatory properties of Cirsium japonicum var. ussuriense used as a folk medicine in Korea. Methods: The extracts of the leaves, stems, flowers, seeds and roots from C. japonicum var. ussuriense were prepared by extracting with water or 80% ethanol. Total flavonoids and polyphenols were measured by a colorimetric assay. The free radical scavenging activity of the extract was analyzed by the DPPH (1,1-diphenyl-2-picryl hydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and Griess reagent assay. An oxidative product of nitric oxide (NO), was measured in the culture medium by the Griess reaction. The level of prostaglandin $E_2$ ($PGE_2$) was measured by enzyme-linked immunosorbent assay. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were measured by Western blot analysis. Results: Total flavonoid and polyphenol amounts of the leaves (CLE) and flowers (CFE) showed higher than those of the seed extract (CSE), stem extract (CSTE) and roots (CRE). CLE and CFE also showed the high antioxidant activities such as DPPH, NO-like and ABTS radical scavenging activity. An antioxidant activities of these water extracts showed higher than those of 80% ethanol extracts. We investigated the anti-inflammatory effects of CLE on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. CLE significantly suppressed the levels of the inflammatory mediators such as NO and prostaglandin $E_2$ ($PGE_2$) in dose dependant. Furthermore, the levels of iNOS and COX-2 protein expressions were markedly suppressed by the treatment with CLE extract in a dose dependent manner. Conclusions: These results suggest that CLE water extract has a higher anoxidant and anti-inflammatory activity, these properties may contribute to the oxidative and inflammatory related disease care.

• Journal of the Korean Institute of Gas
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• v.20 no.4
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• pp.50-57
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• 2016

According to the urban gas business legislation, cathodic protection systems should be applied for buried steel gas pipelines to prevent corrosion. In advanced countries including United States, the criteria for Cathodic Protection Potential is at least -850mV with respect to a saturated copper/copper sulfate electrode(CSE) when the CP applied, and the IR drops must be considered for valid interpretation. However, the IR drop through the pipe to soil boundary has been neglected in Korea. According to KGS code, a reference electrode must be placed in proximity to gas pipelines possible when measuring the CP potential. In this study, we have installed several solid reference electrodes around the buried pipeline(1.2m depth), lower surface(0.5m depth), and the surface individually in order to measure the CP potentials through the each reference electrode and find out the IR drops according to the location of each reference electrode. We have found the IR drop is the greatest when measuring the CP potential through the electrode placed on the ground and the IR drop is the smallest through the electrode installed near pipeline. Therefore, we have suggested the solid reference electrode should be installed as close as possible to buried pipeline in order to measure the correct CP potential without IR drop. We have also suggested the amendment of CP criteria considering IR drop.