• Title/Summary/Keyword: CSA

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Allogeneic Hemopietic Stem Cell Transplants for the Treatment of B Cell Acute Lymphocytic Leukemia

  • Dong, Wei-Min;Cao, Xiang-Shan;Wang, Biao;Lin, Yun;Hua, Xiao-Ying;Qiu, Guo-Qiang;Gu, Wei-Ying;Xie, Xiao-Bao
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.15
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    • pp.6127-6130
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    • 2014
  • Objective: Explore the feasibility of allo-hemopietic stem cell transplants in treating patients with B cell acute lymphocytic leukemia. Methods: Between september 2006 and February 2011, fifteen patients with B cell acute lymphocytic leukemia (ALL) were treated by allo-hemopietic stem cell transplants (HSCT). Stem cell sources were peripheral blood. Six patients were conditioned by busulfan (BU) and cyclophosphamide (CY) and nine patients were conditioned with TBI and cyclophosphamide (CY). Graft versus host disease (GVHD) prophylaxis regimen consisted of cyclosporine A (CSA), methotrex ate (MTX) and mycophenolatemofetil (MMF). Results: Patients received a median of $7.98{\times}10^8{\cdot}kg^{-1}$ ($5.36-12.30{\times}10^8{\cdot}kg^{-1}$) mononuclear cells (MNC). The median time of ANC> $0.5{\times}10^9/L$ was day 12 (10-15), and PLT> $20.0{\times}10^9/L$ was day 13 (11-16). Extensive acute GVHD occurred in 6 (40.0%) patients, and extensive chronic GVHD was recorded in 6 (40.0%) patients. Nine patients were alive after 2.5-65 months follow-up. Conclusion: Allogeneic stem cell transplant could be effective in treating patients with B cell acute lymphocytic leukemia.

Effects of Godulbaegi Leaf Extracts on $CCl_4$-Induced Hepatotoxicity in Rats (고들빼기 잎추출물이 흰쥐의 사염화탄소에 의한 간손상에 미치는 영향)

  • 배송자;김남홍;하배진;정복미;노승배
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.26 no.1
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    • pp.137-143
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    • 1997
  • This study was carried out to investigate the effect of godulbaegi leaf extracts on detoxication of liver injury in $CCl_4$-treated rats. We divided normal group(5) and $CCl_4$-treated group and then $CCl_4$- treated group was divided into 6 groups; only $CCl_4$-treated group(CS), aqueous extract pretreated group (CSA), n-butanol extract pretreated group(CSB), Tween 80 pretreated group(CT), n-hexane extract pretreated group(CTH) and ethyl acetate extract pretreated group(CTE). The ratio of liver weight per body weight and the activity of GPT in hexane extract group(CTH) were lowest, similar to the results of S. Godulbaegi n-hexane extract(IS) groups intoxicated by $CCl_4$ had lower values of MDA than CS and CT which are control groups. Histological finding of liver tissue revealed less of necrosis in IS extracts groups than in control groups(CS, CT). From these results, IS extracts could predominently prevent hepat-otoxicity of rats. Especially, hexane extract was effective on the detoxication of liver injury among the other extracts.

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An Efficient Test Method for a Full-Custom Design of a High-Speed Binary Multiplier (풀커스텀 (full-custom) 고속 곱셈기 회로의 효율적인 테스트 방안)

  • Moon, San-Gook
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2007.10a
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    • pp.830-833
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    • 2007
  • In this paper, we implemented a $17{\times}17b$ binary digital multiplier using radix-4 Booth;s algorithmand proposed an efficient testing methodology for the full-custom design. A two-stage pipeline architecture was applied to achieve higher throughput and 4:2 adders were used for regular layout structure in the Wallace tree partition. Several chips were fabricated using LG Semicon 0.6-um 3-Metal N-well CMOS technology. We did fault simulations efficiently using the proposed test method resulting in the reduction of the number of faulty nodes by 88%. The chip contains 9115 transistors and the core area occupies $1135^*1545$ mm2. The functional tests using ATS-2 tester showed that it can operate with 24 MHz clock at 5.0 V at room temperature.

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Developement of Bamboo Strand Board Made from 3 Months Old Domesitic Bamboo Species (3개월생 국산 대나무를 이용한 대나무 스트랜드보드 개발)

  • 이화형;강석구;김관의
    • Journal of the Korea Furniture Society
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    • v.11 no.2
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    • pp.45-53
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    • 2000
  • This study was carried out to determine the suitability of 3 months old bamboo species of Phyllostachys bambusoides S. et Z., Phyllostachys Pubescens Mazel and Phyllostachys nigra var henonis Stapf as raw materials for the manufacture of strandboard. Total of 108 strandboards were made using urea-formaldehyde resin content level of 12% and one percent of liquid wax emulsion. The strandboard consisted of three layers the top and the bottom layer of which were oriented to the same direction and weighted 25% of the strandboard each. The middle core layer weighed 50% of the board and was perpendicular to the outer top and bottom layers. Analysis was performed to determine the effect of strand lengths and Uowing years of 3 months, 2 years and 3 years on strandboard properties. The physical and mechanical properties of bamboo species and boards were measured and compared to the standard requirements of strandboards. The results are as follows; 1. The more the growing years the higher the density of bamboo. Top part of bamboo indicated higher density value than that of bottom part. 2. Bamboo showed higher static bending strength compared to the main wood species. Longer growing years of bamboo generally inclosed the static tending strength out there were no statistical significancies for Phyllostachys bmbusoides S. et Z. and Phyllostachys pubescens Mazel. 3. Strand length indicated no difference on density and moisture content of strandboard. 5 cm of strand length gave the best static bending strength and internal bonding strength. Bamboo strandboard exhibited lesser extents of thickness swelling than that of CSA standard. 4. 3 months old bamboo gave higher static bending strength of strandboard than those of 2 years and 3 years old bamboo. In case of Phyllostachys nigra var henonis Stapf, 3 months old bamboo indicated higher internal bonding strength than those of 2 years and 3years old bamboo. but in Phyllostachys bambusoides S. et Z., Phyllostachys pubescens Mazel, there were no difference among growing years. Growing years showed no different physical properties of bamboo strandboard.

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Design of a Correlator and an Access-code Generator for Bluetooth Baseband (블루투스 기저대역을 위한 상관기와 액세스 코드 생성 모듈의 설계)

  • Hwang Sun-Won;Lee Sang-Hoon;Shin Wee-Jae
    • Journal of the Institute of Convergence Signal Processing
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    • v.6 no.4
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    • pp.206-211
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    • 2005
  • We describe the design for a correlator and an access code generator in bluetooth system. These are used for a connection setting, a packet decision and a clock synchronization between Bluetooth units. The correlator consists of two blocks; carry save adder based on Wallace tree and threshold-value decision block. It determines on an useful packet and clock-synchronization for input signal of 1.0Mbps through the sliding-window correlating. The access-code generator also consists of two blocks; BCH(Bose-Chadhuri-Hocquenghem) cyclic encoder and control block. It generates the access-codes according to four steps' generation process based on Bluetooth standard. In order to solve synchronization problem, we make use of any memory as a pseudo random sequence. The proposed correlator and access-code generator were coded with VHDL. An FPGA Implementation of these modules and the simulation results are proved by Xilinx chip. The critical delay and correlative margin based on synthesis show the 4.689ns and the allowable correlation-error up to 7-bit.

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New emerging surface treatment of GFRP Hybrid bar for stronger durability of concrete structures

  • Park, Cheolwoo;Park, Younghwan;Kim, Seungwon;Ju, Minkwan
    • Smart Structures and Systems
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    • v.17 no.4
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    • pp.593-610
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    • 2016
  • In this study, an innovative and smart glass fiber-reinforced polymer (GFRP) hybrid bar was developed for stronger durability of concrete structures. As comparing with the conventional GFRP bar, the smart GFRP Hybrid bar can promise to enhance the modulus of elasticity so that it makes the cracking reduced than the case when the conventional GFRP bar is used. Besides, the GFRP Hybrid bar can effectively resist the corrosion of conventional steel bar by the GFRP outer surface on the steel bar. In order to verify the bond performance of the GFRP hybrid bar for structural reinforcement, uniaxial pull-out test was conducted. The variables were the bar diameter and the number of strands and pitch of the fiber ribs. Tensile tests showed a excellent increase in the modulus of elasticity, 152.1 GPa, as compared to that of the pure GFRP bar (50 GPa). The stress-strain curve was bi-linear, so that the ductile performance could be obtained. For the bond test, the entire GFRP hybrid bar test specimens failed in concrete splitting due to higher shear strength resulting in concrete crushing as a function of bar deformation. Investigation revealed that an increase in the number of strands of fiber ribs enhanced the bond strength, and the pitch guaranteed the bond strength of 19.1 mm diameter hybrid bar with 15.9 mm diameter of core section of deformed steel the ACI 440 1R-15 equation is regarded as more suitable for predicting the bond strength of GFRP hybrid bars, whereas the CSA S806-12 prediction is considered too conservative and is largely influenced by the bar diameter. For further study, various geometrical and material properties such as concrete cover, cross-sectional ratio, and surface treatment should be considered.

Synthesis of Hyaluronic Acid Scaffold for Tissue Engineering and Evaluation of Its Drug Release Behaviors (히아루론산을 이용한 조직공학용 Scaffold의 제조와 약물 방출 거동에 관한 연구)

  • Nam, Hye-Sung;Kim, Ji-Heng;An, Jeong-Ho;Chung, Dong-June
    • Polymer(Korea)
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    • v.25 no.4
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    • pp.476-485
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    • 2001
  • In this study, we tried to design and synthesize using natural polymers (hyaluronic acid and sodium alginate) and also to make some kinds of scaffolds as sponge type for reducing the burst effect of loaded drug from them. Photo-dimerizable group was incorporated to hyaluronic acid and degradable hydrogel was prepared by the UV radiation of the polymer. The pore size and its distribution of scaffold were controlled by changing microsphere production conditions such as solution concentration and spraying pressure. It was found that drug release behavior from synthesized scaffolds was affected by hybridization of two naturally originated polymers (cinnamoylated tetrabutylammonium hyaluronate: CHT and cinnamolylated sodium alginate: CSA) and the obtained scaffolds were degraded in fairly long time (about 2 months) under in vitro environment. Therefore, we expect that obtained scaffolds can be applicable for the tissue regeneration scaffolds in the fields of orthopaedic surgery.

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A Scalable Word-based RSA Cryptoprocessor with PCI Interface Using Pseudo Carry Look-ahead Adder (가상 캐리 예측 덧셈기와 PCI 인터페이스를 갖는 분할형 워드 기반 RSA 암호 칩의 설계)

  • Gwon, Taek-Won;Choe, Jun-Rim
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.39 no.8
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    • pp.34-41
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    • 2002
  • This paper describes a scalable implementation method of a word-based RSA cryptoprocessor using pseudo carry look-ahead adder The basic organization of the modular multiplier consists of two layers of carry-save adders (CSA) and a reduced carry generation and Propagation scheme called the pseudo carry look-ahead adder for the high-speed final addition. The proposed modular multiplier does not need complicated shift and alignment blocks to generate the next word at each clock cycle. Therefore, the proposed architecture reduces the hardware resources and speeds up the modular computation. We implemented a single-chip 1024-bit RSA cryptoprocessor based on the word-based modular multiplier with 256 datapaths in 0.5${\mu}{\textrm}{m}$ SOG technology after verifying the proposed architectures using FPGA with PCI bus.

Thermal and Mechanical Properties of Alumina Cementitious Composite Materials (알루미나 시멘트에 기반한 복합재료의 열역학적 특성)

  • Yang, In-Hwan;Lee, Jung-Hwan;Choi, Young-Cheol
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.3 no.3
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    • pp.199-205
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    • 2015
  • The mechanical and thermal properties of high temperature aluminate cementitious thermal storage materials were investigated in this paper. Alumina cement was used as basic binder and the effect of the replacement of fly ash, silica fume, calcium sulfo-aluminate and graphite for alumina cement was investigated. Experiments were performed to measure mechanical properties including compressive strength before and after thermal cycling, and split tensile strength, and to measure thermal properties including thermal conductivity and specific heat. Test results show that the residual compressive strengths of mixtures with alumina cement only, or alumina cement and silica fume were greater than those of the others. Additionally, the specific heat of mixture with graphite was largest in all the mixtures used in the study. The results of this study could be used to provide realistic information for material properties in thermal energy storage concrete in the future.

An Empirical Study on Relationship between Environmental Management and Sustainable Development (기업의 환경경영이 지속가능한 발전에 미치는 실증분석)

  • Jang, Kee-Yoon
    • Journal of Environmental Policy
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    • v.8 no.3
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    • pp.81-113
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    • 2009
  • This study conducted a regulatory impact analysis regarding the introduction of the Korean version of REACH(Registration, Evaluation and Authorization of Chemicals). The direct cost of the Korean REACH is estimated at a total of 101 billion Korean won over the 11 year period. The cost includes pre-registration, testing, registration, Chemical Safety Assessment(CSA) and Chemical Safety Report(CSR), evaluation, and the authorization costs of 15,223 chemical substances produced and imported more than 1 ton per year in Korea in 2006. With regard to the benefit, the only public health benefit is included in the estimation. Based on the available foreign and domestic data, this study estimated that the economic values of public health benefits are in the range of 33.2~138.6 billion Korean won if only the savings of the National Health Expenditures are considered and it reaches 203.9~1,640.3 billion Korean won if the willingness to pay(WTP) for disease prevention is included. This study proved that the Korean REACH passed the cost/benefit criteria. The benefit-cost ratio of the Korean REACH, however, is estimated to be lower than its EU counterpart. Thus it is suggested that a rigorous study to reduce the costs to industry be required before the Korean government introduces the Korean REACH.

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