• The Korean Journal of Applied Statistics
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• v.32 no.5
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• pp.741-752
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• 2019

The purpose of a Phase I Clinical Trial is to determine the maximum tolerated dose (MTD). MTD is important because it affects subsequent clinical trials; however, the existing method has a problem due to an inadequate dose allocated to patients. In this paper, an MTD estimation method is proposed to complement the problems of the existing MTD estimation method. The suggested method applies the initial acceleration step to the modified continual reassessment method. Monte Carlo Simulation Study is adapted to compare a suggested MTD estimation method with the standard design and the modified continual reassessment method.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3941-3944
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• 2013

Background: The use of preoperative chemoirradiation is the commonest treatment strategy employed in Malaysia for locally advanced rectal cancer. We need to determine the local control and survival rates for comparison with established rates in the literature. Materials and Methods: This retrospective study analyzed all newly diagnosed patients with rectal adenocarcinoma who underwent long course preoperative radiotherapy (RT) at the Department of Radiotherapy and Oncology, Kuala Lumpur Hospital (HKL) between $1^{st}$ January 2004 and $31^{st}$ December 2010. The aim of the study was to determine the radiological response post radiotherapy, pathological response including circumferential resection margin (CRM) status, 3 years local control, 3 years overall survival (OS) and 3 years disease free survival (DFS). Statistical analysis was performed using the SPSS software. Kaplan-Meier and log rank analysis were used to determine survival outcomes. Results: A total of 507 patients with rectal cancer underwent RT at HKL. Sixty seven who underwent long course preoperative RT were eligible for this study. The median age at diagnosis was 60 years old with a range of 26-78 years. The median tumour location was 6 cm from the anal verge. Most patients had suspicion of mesorectum involvement (95.5%) while 28.4% of patients had enlarged pelvic nodes on staging CT scan. All patients underwent preoperative chemo-irradiation except for five who had preoperative RT alone. Only 38 patients underwent definitive surgery (56.7%). Five patients were deemed to be inoperable radiologically and 3 patients were found to have unresectable disease intraoperatively. The remaining 21 patients defaulted surgery (31.3%). The median time from completion of RT to surgery was 8 weeks (range 5.6 to 29.4 weeks). Fifteen patients (39.5%) had surgery more than 8 weeks after completion of RT. Complete pathological response was noted in 4 patients (10.5%). The pathological CRM positive rate after RT was 18.4%. With a median follow-up of 38.8 months, the 3 year local control rate was 67%. The 3 years rate for CRM positive (<2 mm), CRM clear (>2 mm) and pCR groups were 0%, 88.1% and 100% respectively (p-value of 0.007). The 3 year OS and DFS were 57.3% and 44.8% respectively. Conclusions: In conclusion, the approach of long course preoperative chemoirradiation for rectal cancer needs to be re-examined in our local setting. The high rate of local recurrence is worrying and is mainly due to patient defaulting post-preoperative chemoirradiation or delayed definitive surgery.

• Journal of the Korean Society of Radiology
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• v.12 no.5
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• pp.557-563
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• 2018

Coincidence summing correction effects are known to be greater as the efficiency of the detector increases and as the distance between the source and the detector increases. A point source($^{60}Co$) was used to vary the distance in the direction of the detector's center axis and in the radial direction to obtain the P/T ratio for Coincidence summing correction calibration. In this study, values for coincidence summing corrected calibration of the values in the central and radial directions were applied to the mixed volume source(450 ml CRM source) to compare the overall peak efficiency change according to P/T with Geant4. In addition, the efficiency obtained from the mapping method is applied to the seaweed, a marine sample, and the compatibility of the P/T ratio with the detector and sample very dose together. The efficiency corrected to 1,836 keV was applied to the energy zone affected by the efficiency of 500 keV and the relative error of the measured and corrected values was well matcched by the 3.2 % peak efficiency correction. As with 450 mL CRM source, the larger the volume, the lower the P/T ratio was by ${\pm}5%$. This is due to the increased scattering of gamma-rays emitted as the source becomes farther away from the detector, and this change in P/T has been confirmed to affect the Coincidence summing corrected peak efficiency.

• Journal of the Korean Operations Research and Management Science Society
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• v.38 no.1
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• pp.15-27
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• 2013

Because consumers tend to have negative opinion about a company that neglects social issues like poverty or pollution while it focuses on its own profit, a lot of companies have invested their resources in Corporate Social Responsibility(CSR). CSR has merits of image improving and profit gaining, on the other hand, it has also many shortcomings. First, the cost of CSR may become a heavy financial burden. Specifically, CSR tends to be implemented by a company's unilateral backup, and then this may impose a heavy burden on the company. Second, one cannot expect effects of CSR in a short-term. Because of these shortcomings, the unilateral CSR has gone into alteration of the type of CSR since 1980's. Instead of unilaterality, Cause-Related Marketing(CRM) began to be used for mutual profits among company, consumers, and society. That is, CRM has become to be spotlighted as a new type of CSR. It focuses on partnership between a company and consumers based on cause and mutual profit pursuing through this partnership. So, many contemporary companies prefer CRM activities that derive their positive corporate image, that increase their sales, and that reduce their financial cost. The IBM Matching Grants Program, which is the largest of the IBM-Employee partnership programs, is a typical CRM. This program enables employees and retirees to increase the value of their donations to educational institutions, hospitals, hospices, nursing homes, and cultural & environmental organizations with a matching gift from IBM. Hundreds of educational institutions and thousands of nonprofit organizations have benefited from the contributions by IBM. There might be various types of matching grants. For example, an employee might choose a lump-sum expense or partitioning a lump-sum into a series of small ongoing expenses for his (or her) donation, and a firm might match the employee's total contribution with a lump-sum expense or might match the employee's total contribution with a series of small ongoing expenses. However, it is not easy to find an academic research on which type of matching grant is preferred by employees. This paper shows that an employee prefers the type of matching grants that consists of a lump-sum expense for his (or her) contribution and a series of small ongoing expenses for a firm's contribution [or the type of matching grants that consists of a series of small ongoing expenses for an employee's contribution and a lump-sum expense for a firm's contribution] to the other types of matching grants.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.21 no.2
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• pp.78-90
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• 2016

This report is to introduce detail processes during the restoration/revision project for the Korean Standard Methods for Marine Environment. The processes are composed of 3 steps: questionaries, QA/QC confirming step by CRM(Certified Reference Materials), and advisory council by specialists. The questionaries required four main topics to be included to the restoration/revision protocol: 1. the guidelines to sampling, transportation, storage, and pre-analytical procedures for the marine specimens, 2. the unified analytical method, especially for the organic compounds, 3. the QA/QC test requirement for CRM, 4. introduction of diverse analytical instruments, 5. the customer- friendly express of the protocol. Based on these new protocol, we expect two most important effects: 1, increased insurance of international credibility and equivalence by the QA/QC procedures, 2. increased conformability and representatively from wide-spread use of the protocol. Finally we suggested several residual topics remained to the inter-government cooperation.

• Journal of Service Research and Studies
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• v.6 no.3
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• pp.57-78
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• 2016

The purpose of this research is to study how service recovery activities influence customers' commodity churning in the media telecommunication industry(CATV industry). Put it differently, we tried to identify this change of commodity churning rates by the stages of service failures, by which we intend to emphasize the importance of service recoveries. Korean media telecommunication market has already been saturated; customers tend to move to bigger major companies with better customer care increasingly. As once customers gone never returns, CRM functions are being reinforced over the time. We were able to have the following results. First, turning rates, for those experienced service failure, who were dissatisfied with service recovery activities are 2~5 times (monthly average turning rates are 1.3%) higher than those satisfied. Secondly, active service recovery activities at the customer's service request after experiencing service failure lowered churning rates significantly. The most effective timing is service recovery activities pre-recovery stage. Thirdly, reward activities after service recovery activities at the immediate recovery stage is more effective than service recovery at the arranged recovery schedule and reward activities after customer's expressing churning intension. The implications of this study are that firms should engage in service recovery activities at the time of identifying service failures, prior to customer's expressing churning intention, which means relatively lower ROI for the service recovery activities than the times of customers' expressing churning intention.

• Proceedings of the Korea Database Society Conference
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• 2001.06a
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• pp.213-234
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• 2001

1. Brokat Server Technologies (Channel 통합 Messging Server) 복잡한 메시지 교환을 유연하게 제어함으로써 Front-End/Back-End각각에 존재하는 다양한 채널을 RealTime으로, 유연하게 통합관리하여 채널간의 Messaging을 Smart하게 컨트롤 2. Brokat Advisor (Rulebase Management System) 복잡한 비즈니스 룰의 적용과 Non-Programming/다이나믹한 관리를 동시에 가능하게 하는 Large E Business Engine (중략)

• CRM연구
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• v.4 no.1
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• pp.35-54
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• 2011

Organizing and maintaining customer-based online communities are becoming increasingly important in current business environment. Companies can utilize the member generated contents in developing their products and services and they can establish close relationships with their customers. This paper investigates how customer-based online communities increase individual members' contributive behaviors. Drawing on the social psychology literature, this study adopts the concept of self-discrepancy rooted in self-identity and derive an index for self-discrepancy by using the differences between actual and virtual self-identities. Furthermore, this study examines the relationship between the self-discrepancy and the anonymity-related psychological factors (autonomy, recovery, and catharsis), which in turn influence quality and quantity of contribution. Analysis of 114 respondents showed that self-discrepancy between actual and virtual selves has two different sub-dimensions (personal self-discrepancy and social sel f-discrepancy) and each dimension has different effect on the quality and quantity of contribution through the mediation of autonomy and recovery. Notably, catharsis negatively influenced quality of contribution. Theoretical and practical implications are discussed based on the major findings.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2003.11a
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• pp.51-54
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• 2003

We analyzed radiative properties of aerosols, $CO^{2}$ and clouds using Optical Properties of Aerosols and Clouds(OPAC) and the Column Radiation Model (CRM). From OPAC, if the soot component is disregarded, dust-like components depict the highest extinction values in the solar spectral range and the lowest. single scattering albedoes, which are attributable to the presence of large particles. In the dust aerosol, the high absorptivity in the infrared may induce a warming of the lower atmospheric layer in the nighttime. The radiative properties of aerosols, clouds and double $CO^{2}$ using the CRM model at Seoul (37N, 127.4 E) on 3 April 2003 were calculated. The solar zenith angle is 65˚ and the surface albedo is 0.1836 during the clear day. The aerosol optical depth change 0.14 to 1.7, which is derived during Asian dust days in Korea. At this time, abedo by aerosols is considered as 0.3. In cloudy condition, the short wave cloud forcing on both the TOA and the surface is -193.89 $Wm^{-2}$ and -195.03 $Wm^{-2}$, respectively, and the long wave cloud forcing is 19.58 $Wm^{-2}$ and 62.08 $Wm^{-2}$, respectively. As a result, the net radiative cloud forcing is -174.31 $Wm^{-2}$ and -132.95 $Wm^{-2}$, respectively. We calculate also radiative heating rates by double $CO^{2}$ during the clear day. The $CO^{2}$ volumn mixing ratio is 3.55E-4.

• CRM연구
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• v.1 no.1
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• pp.71-85
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• 2006

인터넷 웹사이트를 통한 개인정보의 대량 유통, 상품배송기관을 통한 개인정보의 유출, 명의도용, 신용정보유출 등의 정보프라이버시 침해의 사례가 많이 발표되면서, 개인정보의 적절한 이용과 정보 프라이버시(Information Privacy)의 보호에 대한 관심이 날로 높아져가고 있다. 이러한 사회 현상과 시민의 관심을 반영하여 개인정보 보호를 위한 다양한 법률과 제도가 최근에 검토되고 있다. 이 연구에서는 이름, 전화번호, 주소, 전자우편주소 등 비교적 민감하지 않은 개인정보를 기업의 마케팅이나 홍보에 이용하는 경우의 좁은 의미에서의 개인정보 보호에 초점을 맞추었다. 이러한 개인정보 및 개인정보서비스 와 관련된 법률, 정책 및 제도를 정보의 생성과 이용의 흐름 및 경제주체를 중심으로 적절한 정보의 이용이 보장 되면서 개인의 정보프라이버시가 보호될 수 있는 방안을 마련하는 방법을 체계적으로 검토하였다. 해외의 개인정보서비스 산업의 사례 조사를 통하여 향후 우리나라에서 개인정보서비스산업이 활성화되었을 때 개인의 만족증대, 실질적인 정보보호 수준의 향상, 고용창출, 기업활동의 효율화, 관련기업의 국제경쟁력 고양 등의 기대효과가 있음을 보였다. 또한, 개인정보의 적절한 이용과 보호, 그리고 정보서비스산업의 활성화를 위하여 관련 법률의 제정 및 개정, 정보보호 제도의 개발 및 효과적 운영, 장기적 정보서비스 산업 활성화 정책 수립과 단계적 추진, 활성화를 위한 정부 및 민간 재원 확보, 사회적 공감대 형성, 지속적인 연구 등을 제안한다.