• 한국어정보학회:학술대회논문집
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• 2016.10a
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• pp.14-19
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• 2016

본 논문은 문장에서의 어절 간 의존관계가 성립될 때 의존소와 지배소가 어떠한 관계를 가지는지 의존 관계명을 부착하는 모델을 제안한다. 국내에서 한국어 의존구문분석에 관한 연구가 활발히 진행되고 있지만 의존 관계만을 결과로 제시하고 의존 관계명을 제공하지 않는 경우가 많았다. 따라서 본 논문에서는 의존경로(Dependency Path)와 음절의 의존 관계명 분포를 반영하는 음절 임베딩를 이용한 의존 관계명 부착모델을 제안한다. 문장에서 나올 수 있는 최적의 입력 열인 의존 경로(Dependency Path)를 순차 레이블링에서 좋은 성능을 나타내고 있는 bidirectional LSTM-CRFs의 입력 값으로 사용하여 의존 관계명을 결정한다. 제안된 기법은 자질에 대한 많은 노력 없이 의존 경로에 따라 어절 및 음절 단어표상(word embedding)만을 사용하여 순차적으로 의존 관계명을 부착한다. 의존 경로를 사용하지 않고 전체 문장의 어절 순서를 바탕으로 자질을 추출하여 CRFs로 분석한 기존 모델보다 의존 경로를 사용했을 때 4.1%p의 성능향상을 얻었으며, 의존 관계명 분포를 반영하는 음절 임베딩을 사용한 bidirectional LSTM-CRFs는 의존 관계명 부착에 최고의 성능인 96.01%(5.21%p 개선)를 내었다.

• 한국어정보학회:학술대회논문집
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• 2017.10a
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• pp.143-146
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• 2017

심층학습 모델 중 LSTM-CRF는 개체명 인식, 품사 태깅과 같은 sequence labeling에서 우수한 성능을 보이고 있다. 한국어 개체명 인식에 대해서도 LSTM-CRF 모델을 기본 골격으로 단어, 형태소, 자모음, 품사, 기구축 사전 정보 등 다양한 정보와 외부 자원을 활용하여 성능을 높이는 연구가 진행되고 있다. 그러나 이런 방법은 언어 자원과 성능이 좋은 자연어 처리 모듈(형태소 세그먼트, 품사 태거 등)이 없으면 사용할 수 없다. 본 논문에서는 LSTM-CRF와 최소한의 언어 자원을 사용하여 다국어에 대한 개체명 인식에 대한 성능을 평가한다. LSTM-CRF의 입력은 문자 기반의 n-gram 표상으로, 성능 평가에는 unigram 표상과 bigram 표상을 사용했다. 한국어, 일본어, 중국어에 대해 개체명 인식 성능 평가를 한 결과 한국어의 경우 bigram을 사용했을 때 78.54%의 성능을, 일본어와 중국어는 unigram을 사용했을 때 각 63.2%, 26.65%의 성능을 보였다.

• The Korea Journal of Herbology
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• v.23 no.4
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• pp.59-70
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• 2008

Objectives: Investigation of the antidepressant effects of Citri Reticulatae Viride Pericarpium(CR) Methods: In order to investigate the antidepressant effects of Citri Reticulatae Viride Pericarpium(CR), we performed the forced swimming test. Also the expression of CRF, HSP70 and c-fos was measured with immunohistochemical method at PVN. Results: 1. The duration of immobility in the forced swimming test was significantly decreased in the CR 100mg/kg, 400mg/kg groups. 2. In the Control group, CRF expression was significantly increased in the PVN. Also, these CRF increase were significantly reduced in the CR 100mg/kg and 400mg/kg treated group. 3. HSP70 expression was significantly decreased at PVN in the CR 100mg/kg and 400mg/kg treated group. 4. C-fos expression was significantly decreased at PVN in the CR 100mg/kg and 400mg/kg treated group. Conclusions: According to the results, it can be considered that Citri Reticulatae Viride Pericarpium has antidepressant effect.

• Herbal Formula Science
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• v.17 no.2
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• pp.195-201
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• 2009

Objectives : To evaluate the efficacy of herbal medicine on CRF, clinical study on one case of 48 year old male patient of CRF was performed. The patient complained of general weakness and anorexia, dizziness and both lower limb edema. Methods : According to the Differentiation of Symptoms(變證), the patient was classified as weakness(虛勞) prescribed Sipjeondaebo-tang(十全大補湯) as well as acupuncture and moxibustion. treatment. Change of BUN, Creatinine, Hgb, Albumin, VAS of weakness and urine volume was compared before and after treatment for 3 months. Results : After such treatments, the level of BUN and creatinine was decreased and the volume of urine was increased. Conclusion : Herbal medicine Sipjeondaebo-tang with acupuncture and moxibustion treatment would be efficient to the patient of CRF.

• Annual Conference on Human and Language Technology
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• 2016.10a
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• pp.14-19
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• 2016

본 논문은 문장에서의 어절 간 의존관계가 성립될 때 의존소와 지배소가 어떠한 관계를 가지는지 의존 관계명을 부착하는 모델을 제안한다. 국내에서 한국어 의존구문분석에 관한 연구가 활발히 진행되고 있지만 의존 관계만을 결과로 제시하고 의존 관계명을 제공하지 않는 경우가 많았다. 따라서 본 논문에서는 의존 경로(Dependency Path)와 음절의 의존 관계명 분포를 반영하는 음절 임베딩를 이용한 의존 관계명 부착 모델을 제안한다. 문장에서 나올 수 있는 최적의 입력 열인 의존 경로(Dependency Path)를 순차 레이블링에서 좋은 성능을 나타내고 있는 bidirectional LSTM-CRFs의 입력 값으로 사용하여 의존 관계명을 결정한다. 제안된 기법은 자질에 대한 많은 노력 없이 의존 경로에 따라 어절 및 음절 단어표상(word embedding)만을 사용하여 순차적으로 의존 관계명을 부착한다. 의존 경로를 사용하지 않고 전체 문장의 어절 순서를 바탕으로 자질을 추출하여 CRFs로 분석한 기존 모델보다 의존 경로를 사용했을 때 4.1%p의 성능향상을 얻었으며, 의존 관계명 분포를 반영하는 음절 임베딩을 사용한 bidirectional LSTM-CRFs는 의존 관계명 부착에 최고의 성능인 96.01%(5.21%p 개선)를 내었다.

• Journal of Haehwa Medicine
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• v.16 no.2
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• pp.229-234
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• 2007

Objectives : Chronic renal failure(CRF) is a pathophysiologic process with multiple etiologies, resulting in the inexorable attrition of nephron number and function and frequently leading to end-stage renal disease. It causes various symptoms(edema, general body weakness, nausea, anorexia, uremia, osteodystrophy and so on) which impair quality of life and long term complications. The purpose of this case is to report the improvement of a patient with chronic renal failure. Methods : We treated the patient with herbal medication(Gyulpyjeonwon) and measured the creatinine, BUN, albumin, hemoglobin in the serum. Results : Gyulpyjeonwon decreased serum creatinine and BUN level and increased serum albumin and hemoglobin level. And the symptoms of CRF(edema, general body weakness, anorexia) was improved significantly. Conclusions : This case suggests the efficacy of herbal medication(Gyulpyjeonwon) to patient who was involved CRF.

• Smart Media Journal
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• v.8 no.2
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• pp.74-79
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• 2019

Traditional compound noun decomposition algorithms often face challenges of decomposing compound nouns into separated nouns when unregistered unit noun is included. It is very difficult for those traditional approach to handle such issues because it is impossible to register all existing unit nouns into the dictionary such as proper nouns, coined words, and foreign words in advance. In this paper, in order to solve this problem, compound noun decomposition problem is defined as tag sequence labeling problem and compound noun decomposition method to use syllable unit embedding and deep learning technique is proposed. To recognize unregistered unit nouns without constructing unit noun dictionary, compound nouns are decomposed into unit nouns by using LSTM and linear-chain CRF expressing each syllable that constitutes a compound noun in the continuous vector space.

• The Journal of Internal Korean Medicine
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• v.29 no.4
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• pp.1115-1122
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• 2008

Chronic renal failure (CRF) is defined as a permanent reduction in glomerular filtration rate (GFR) sufficient to produce detectable alterations in well-being and organ function. This usually occurs at GFR below 25 ml/min. In this report, is a 75-year-old woman who had back pain and diarrhea as chief complaints. She was diagnosed with CRF on March. 2008. is a 62-year-old man who had whole body weakness, anorexia and dyspepsia as chief complaints. He was diagnosed with CRF on 2008. We used herbal enteroclysis solution. which consists of Radix et Rhizoma Rhei. Concha Ostreae and Radix Glycyrrhizae or Radix Salviae Miltiorrhizae. Herbal enteroclysis was done for 15 min once a day. Enteroclysis solution was controlled at 37-39 $^{\circ}C$ and inserted 15-20cm depth for intubation. We found the patient's BUN, creatinine and GFR were improved through enteroclysis. In both and , the patient's BUN and creatinine decreased, and GFR increased favorably. This result suggests that herbal enteroclysis used for CRF is effective in clinical therapy.

• The Journal of Internal Korean Medicine
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• v.29 no.4
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• pp.871-886
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• 2008

Objective : Gypsum fibrosum has been traditionally used in treatment of febrile diseases and recently been shown to have anti-inflammatory effect. Chronic renal failure has a serious clinical symptoms including proteinuria, azotemia, anemia, and hyperlipidemia and has characteristic histopathological changes, glomerular hypertrophy, infiltration of inflammatory cells, and crescentic sclerosis, We investigated the effects of gypsum fibrosum on renal functional and histopathological disorder in chronic renal failure rat model induced 5/6 nephrectomy. Methods : Using Sprague-Dawley rats, CRF was induced by 5/6 nephrectomy. The rats were divided into 3 groups, normal, conrol, and gypsum administered orally with gypsum fibrosum 500mg/kg/day. Body weight, 24 hr proteinuria, hematologic analysis, and histological morphologic changes were followed up after 8 weeks. The glomerular macrophage/monocyte infiltration, $TGF-{\beta}_1$, type IV collagen, and angiotensin II type1 receptor($AT_1$) were evaluated by immunohistochemistry. Resuls : In the CRF control group, functional parameters and histopathologic changes clearly indicated the development of CRF. 24 hr proteinuria significantly increased in the CRF control group over the normal group, and serum creatinine level was lower in the gypsum group than in the control group, LDL-cholesterol was significantly lower in the gypsum group than in the control group. Morphological investigations showed a variety of characteristic features of CRF, glomerular hypertrophy, increasing cellular density of glomerulus, deposition of extra-cellular matrix, fibrotic change, and glomerular sclerosis in the control group, but in the gypsum group, these features diminished significantly. In observation of renal type IV collagen and $AT_1$ expression, positive area significantly increased in the control group over the normal group, and it significantly decreased in the gypsum group compared to the control group. Conclusions : Our findings suggest that gypsum fibrosum inhibits $AT_1$ and type IV collagen expression in renal tissues and attenuates progression of glomerulosclerosis and interstitial fibrosis in chronic renal failure rats, which lead to amelioration of renal function. From these results, we suggest that gypsum fibrosum may have renoprotective effects and could be a useful remedy agent for treating chronic renal failure.

• Korean Journal of Biological Psychiatry
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• v.2 no.2
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• pp.252-256
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• 1995

Corticotropin-releasing factor(CRF)를 분비하는 배양세포주는 CRF의 세포내 조절을 연구하는데 있어 훌륭한 체계가 된다. BE(2)-M17 및 BE(2)-C 세포주는 CRF를 생산하고 분비하며 forskolin 처치에 반응하는 것으로 알려져 있다. 저자들은 이들 세포주에 phorbol 에스테르, 즉 phorbol 12-myristate 13-acetate(TPA) 0.8, 4, 10, 20 nM, 및 nitric oxide(NO)의 신호전달 경로의 자극제(1-${\mu}M$ nitroprusside)와 차단제($1{\mu}M$ nitroprusside+$300{\mu}M$ $N^G$-methyl-D-arginine), 그리고 interleukin-$1{\alpha}$ (IL $1{\alpha}$ ; 4, 20, 100, 500 pM)를 처치하여 CRF를 의미있게 증가시켰으나 세포외 분비는 C 세포에서만 변화되었다. NOS계의 자극제와 차단제는 C 세포의 forskolin 효과를 의미있게 변화시켰다. IL$1{\alpha}$는 두 세포주에 대한 영향이 없었다. 상기 제제들에 대한 이들 세포의 반응이 중추신경계 CRF 신경들과 관련하여 논의되었다.