• IMMUNE NETWORK
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• v.20 no.5
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• pp.42.1-42.10
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• 2020

Long-lasting post-switched plasma cells (PCs) arise mainly from germinal center (GC) reactions, but little is known about the mechanism by which GC B cells differentiate into PCs. Based on our observation that the expression of the transcription factor CCAAT/enhancer binding protein β (C/EPBβ) is associated with the emergence of post-switched PCs, we enquired whether a cell-autonomous function of C/EPBβ is involved in the program for PC development. To address this, we generated C/EPBβ-deficient mice in which the Cebpb locus was specifically deleted in B cells after transcription of the Ig γ1 constant gene segment (Cγ1). In response to in vitro stimulation, B cells from these Cebpb^fl/flCγ1^Cre/+ mice had defects in the induction of B lymphocyte-induced maturation protein 1 (Blimp1) and the formation of IgG1⁺ PCs, but not in proliferation and survival. At steady state, the Cebpb^fl/flCγ1^Cre/+ mice had reduced serum IgG1 titers but normal IgG2c and IgM titers. Moreover, upon immunization with T-dependent Ag, the mice produced reduced levels of Ag-specific IgG1 Ab, and were defective in the production of Ag-specific IgG1 Ab-secreting cells. These results suggest that a cell-autonomous function of C/EPBβ is crucial for differentiation of post-switched GC B cells into PCs through a Blimp1-dependent pathway.

• Proceedings of the Korean Society of Computer Information Conference
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• 2016.07a
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• pp.99-100
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• 2016

본 논문에서는 근골격계 질환 중에서 가장 흔히 나타나는 어깨의 질환에 대하여 살펴보도록 한다. 특히 어깨를 옆으로 반드시 폈다가 안으로 오므리는 수평 벌림과 수평 모음에 대한 측정 방법을 살펴본다. 여기서 일정한 임계값보다 크게 나타나는 값인 통증 유발에는 반드시 도수 치료가 필요하다고 본다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2016.07a
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• pp.97-98
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• 2016

본 논문에서는 흔히 나타나는 어깨 질환의 치료에서 팔 부분에 대하여 알아본다. 특히 팔을 반듯이 위로 올렸을 때 통증이 발생하는 어깨 질환에 대한 도수치료법(Manual Therapy)을 제시한다. 실험에서는 도수진단(Manual Diagnosis)을 위하여 팔을 반듯이 위로 올릴 때 팔의 각도를 입력하고, 이상이 발생할 시 진단 및 치료법까지 시스템에서 제시하도록 한다.

• Biomolecules & Therapeutics
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• v.13 no.4
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• pp.232-239
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• 2005

An aqueous extract of oriental herbal composition named Onchengyeum and curcumin, an antioxidant isolated from turmeric (Curcuma Zonga L.) reduced hepatotoxicity induced by carbon tetrachloride ($CCI_4$). Improved liver function was observed by measuring the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), blood urea nitrogen (BUN), creatinine (CRE), total cholesterol (T-CHO), triglyceride (TG), low density lipoprotein cholesterol (LDL-CHO), high density lipoprotein cholesterol (HDL-CHO), total protein (TP), albumin (ALB) and total bilirubin (BIL) in serum. Hepatic parameters monitored were levels of cholesterol (CHO), triglyceride (TG), and malondialdehyde (MDA) and activities of cytochrome P450 (CYP), NADPH-CYP reductase, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx). The histopathological examination showed that the treatment of Onchengyeum and curcumin relieved the ballooning degeneration of hepatocytes which had been generated by $CCI_4$. The results suggested that hepatoprotective effects of Onchengyeum and curcumin possibly are due to their promising antioxidative activity.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2001.01a
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• pp.448-455
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• 2001

Recently, many enterprises have attempted to capitalize knowledge assets on data warehouse (DW). It has been recognized as strategic core process to create corporate competitive advantage and implement enterprise e-biz strategies. However, most approaches to represent knowledge and decision process have limits in considering various knowledge types, their relationships and continuity in knowledge formulation. In addition, they are so inclined to one side such as concept-oriented frameworks or technology-oriented ones. They lack universal and wide-ranging features. This paper presents a comprehensive methodology to accumulate knowledge capital on DW via a properly grained hypermedia model. The methodology consists of three phases: knowledge requirement elicitation, hypermedia modeling, and system implementation. A real-life case for medical DW development is presented to demonstrate the usefulness of the proposed methodology. This methodology is effective when an organization accumulates knowledge assets to put the corporate e-biz or cre-biz strategy into practice.

• Journal of information and communication convergence engineering
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• v.12 no.1
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• pp.26-32
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• 2014

Vehicular-to-anything (V2X) technology is attractive for wireless vehicular ad-hoc networks (VANETs) because it allows for opportunistic choice of a vehicular protocol between vehicular-to-vehicular (V2V) and vehicular-to-infrastructure (V2I) communications. In particular, achieving seamless connectivity in a VANET with nearby network infrastructure is challenging. In this paper, we propose a density-based opportunistic broadcasting (DOB) protocol, in which opportunistic connectivity is carried out by using the nearby infrastructure and opposite vehicles for solving the problems of disconnection and long end-to-end delay times. The performance evaluation results indicate that the proposed DOB protocol outperforms the considered comparative conventional schemes, i.e., the shortest path protocol and standard mobile WiMAX, in terms of the average end-to-end delay, packet delivery ratio, handover latency, and number of lost packets.

• Archives of Pharmacal Research
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• v.13 no.1
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• pp.69-73
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• 1990

As a part of the study to elucidate the mechanism by which transcription of LDH A-gene is regulated by cAMP, we aimed to isolated rat LDH A gene and characterize cAMP-reponsive element (CRE). We have screened $1.2{\times}10^6$ recombinant phages of rat Charon 4A genomic library and isolated 33 positive clones among which we identified 12 different LDH A gene-related clones. By the results of restriction enzyme mapping, Southern blotting, and nucleotide sequence analyses, we concluded that the 12 LDH A gene-related clones were intronless and frequently mutated LDH A-pseudogenes. In this report, we present the characteristic features of the 12 rat liver LDH A-pseudogenes.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 1998.11a
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• pp.93-96
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• 1998

NAPL이 다핵방향족화합물의 하나인 phenanthrene 의 생분해에 미치는 영향을 알아보았다. Pseudomonas putida CRE7 을 이용한 실험에서 NAPL 의 첨가로 인한 가장 큰 차이는 미생물의 소수성의 변화였다. 소수성이 증대됨으로써 phenanthrene 의 가용성이 증대되었으며, 이로 인해 더 많은 양의 오염물 분해가 이루어졌다. 생물학적 분해의 관찰은 발생되어지는 $^{14}$ $CO_2$의 radioactivity 측정을 통해 이루어졌으며, 미생물의 소수성 측정은 bacterial adhesion to hydrocarbon (BATH) assay 를 이용하였다.

• Journal of Environmental Science International
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• v.14 no.1
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• pp.9-14
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• 2005

This study evaluated the hazard caused by $NO_{2}$, an oxidant generated in the process of welding. We com­pared hematological and biochemical parameters in workers who chronically inhale $NO_{2}$ and office workers not exposed to $NO_{2}$. $NO_{2}$ exposure affected the hematological and biochemical parameters. Increasing $NO_{2}$ concen­trationincreased the number of leukocytes, while decreasing the number of erythrocytes. Blood urea nitrogen, cre­atinine, uric acid, and lactate dehydrogenase were increased, while total protein and triglycerides were decreased. The mean concentration of $NO_{x}(NO_{2}^{-}/NO_{3}^{-})$ in the serum of welders and the control group was $35.97{\pm}2.85\;and\;55.40{\pm}5.81\;{\mu}mol/L,$ respectively. The difference was significant (p < 0.05), although $NO_{2}^{-}$ was not detected in the serum.

• Proceedings of the Korean Society of Computer Information Conference
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• 2017.01a
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• pp.205-206
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• 2017

본 논문에서는 주차 시설 이용 현황 중에서 차량 번호판 조사를 통하여 평균주차시간과 주차 회전율을 구하도록 한다. 관찰하는 사람이 없이 카메라를 활용하고, 조사 시간에 일정한 간격을 주어 조사하도록 한다. 일정한 조사 시간 간격을 주차된 차량에 나눠주어 평균 주차 지속 시간을 구하도록 한다. 그리고 이렇게 하여 주차면 1개당 1시간당 주차 차량 대수인 주차 회전율을 구하도록 한다.