• 약학회지
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• 제39권4호
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• pp.360-366
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• 1995

1-$\beta$-Methyl carbapenem-2-substituted pyrroudine derivatives. CRB 529 and CRB 550, were synthesized as investigational carbapenem derivatives. It has been reported that the in vitro antibacterial activities of the compounds against G(+) and G(-) bacteria were almost the same or more effective than those of imipenem (IPM) and meropenem (MEPM), and also showed better in vivo efficacy than MEPM and inlipeneni/cilastatin (IPM/CS) against representative G(-) organisms, P. aeruginosa and MRSA organisms, S. aureus. The antibacterial activities, pharmacokinetics and protective efficacy of IPM/CS and CRB 529 and CRB 550 wereconducted after subcutaneous or intravenous administration to mice and rats. The pharmacokinetic parameters of CRB 529 and CRB 550 in mice were as follows: the observed maximal serum concentrations (C$_{max}$) following I.V. administration were 87.5 and 101 $\mu\textrm{g}$/ml for CRB 529 and CRB 550, respectively, and 63.6 $\mu\textrm{g}$/ml for IPM/CS. The half-lives (t$_{1/2}$) were 14.0 and 12.0 n-dn for CRB 529 and CRB 550, respectively, and 14.8 min for IPM/CS. In rats, $C_{max}$ after I.V. administration were 74.0 and 91.8 $\mu\textrm{g}$/ml for CRB 529 and CRB 550, respectively, and 41.2 $\mu\textrm{g}$/ml for IPM/CS. The tissue levels of CRB 529 and CRB 550 and IPM/CS after I.V. administration at a dose of 20 mg/kg decreased by the following order: lung, heart, kindney, liver and spleen for CRB 529, lddney, liver. lung, heart and spleen for CRB 550 and kidney, lung, liver, heart, spleen and brain for IPM/CS. In systemic infection, CRB 529 and CRB 550 showed excellent efficacies against P. aeruginosa and S. aureus (MRSA) at a dose of 5 mg/kg. The PD$_{50s}$ were 0.80, 0.36 mg/kg for CRB 529 and CRB 550, respectively, and 3.22 mg/kg for IPM/CS against P. aeruginosa. The corresponding values against S. aureus (MRSA) were 76.0, 55.3 mg/kg for CRB 529 and CRB 550, respectively, and 146 mg/kg for IPM/CS. In local infection, the antibacterial activities of CRB 529 and CRB 550 were more effective than those of IPM/CS against intrarenal infection with E. coli and P. aeruginosa and also showed as effective as IPM/CS against respiratory tract infection with E. coli and P. aeruginosa at a dose of 5 mg/kg.

• 수산해양기술연구
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• 제57권1호
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• pp.34-44
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• 2021

In order to collect basic information of response behavior of red seabream (Pagrus major) during pilling, works for constructing wind power station in Byeonsan Peninsular, Korea were investigated. Four cultured red seabream CRB1 to CRB4 [total length (TL): 27.1 ± 1.0 cm; body weight: 359 ± 30 g] were tagged with an acoustic tag and used in experiment. CRB1 and CRB2 to CBR4 were released on the sea surface at same time around the constructing site of the wind power plant on September 22, 2017 and July 18, 2018, respectively. The tracking of the CRB1 to CRB2 and CRB3 to CRB4 were conducted for two hours, approximately, using VR100 receiver including a directional hydrophone and VR2W receivers array consisted of 19 presence/absence receivers (VR2W receivers), respectively. The underwater noise level before (no pile driving works) and during pile driving works was measured 116.0-118.0 dB (re 1��Pa) and a maximum of 160 dB (re 1��Pa), respectively. CRB1 moved about 6.0 km with average swimming speed of 80.2 ± 20.5 cm/s for 2.1 hours without pile driving work. The average water depth of the sea bed on the route of CRB1 was 9.1 ± 0.4 m. CRB2 moved about 7.3 km with the average swimming speed of 96.8 ± 27.1 cm/s for 2.1 hours with pile driving work. The water depth of the sea bed on the route of CRB2 was 11.9 ± 0.6 m. At results of the Rayleigh's z-test two fishes CRB1 and CRB2 showed significant directionality in the movement (p < 0.01). Movement mean angles of CRB1 and CRB2 were 92.7 and 251.8°, respectively. CRB2, CRB3 and CRB4 exhibited the escaping behavioral response from the noise of source during the pile driving work. The swimming speed of the CRB2 exposed on the heavy underwater noise stimuli due to the pile driving work was 1.21 times faster than that of the CRB1 exposed on the ambient underwater noise in the study site.

• 약학회지
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• 제39권3호
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• pp.215-222
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• 1995

The in vitro antibacterial activities of new carbapenem. CRB 529, 535, 538, 545 and 550 with meropenem and imipenem were compared. CRB 529. 535, 538, 545 and 550 proved to have a broad an tibacterial spectrum. Its in vitro activity against standard 20 strains was almost the same as that of imipenem and slightly higher than that of meropenem. However. against clinical isolated P. aeruginosa, CRB 529, 535, 538, 545 and 550 showed significantly higher activity than imipenem, and also CRB 529, 535, 538, 545 and 550 showed almost the same activity than imipenem and meropenem against 82 clinical isolated strains including S. aureus (MRSA), S. aureus (MSSA), E. faecalis, E. facium, E. coli, P. aeruginosa, K. pneumonia, P. mirabiris, P. stuartii, M. morganii, C. freundii, E. cloacae, S. marcescens and A. calcoaceticus var. anitratus. The stability of CRB 529, 535, 538, 545 and 550 against porcine renal dehydropeptidase-I(DHP-1) was 10 folds higher than that of imipenem and was 3 folds higher than that of meropenem.

• Asian-Australasian Journal of Animal Sciences
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• 제23권6호
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• pp.762-771
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• 2010

Two experiments were conducted to determine i) the fermentation characteristics of catfish by-product (C) ensiled with rice bran (RB) or sugarcane molasses (M) in different ratios, and ii) the digestibility of the silages in growing pigs. In the ensiling experiment, there were three ratios of C, ensiled with RB or M, of 8:2, 7:3 and 6:4 (wet basis for C and air-dry basis for RB and M). The six treatments were CRB8:2, CRB7:3, CRB6:4, CM8:2, CM7:3 and CM6:4, with 3 replications per treatment and seven sampling times. The pH of CRB7:3 and CRB6:4 decreased (p<0.05) from the first week and stayed stable until 8 weeks of ensiling, but the pH did not decrease in CRB8:2. The pH of CM8:2, CM7:3 and CM6:4 decreased rapidly from the first week until week 8. Dry matter (DM) and crude protein (CP) contents were slightly lower when catfish by-product was ensiled with RB than with M. Ammonia content in all treatments increased (p<0.05) during ensiling. Lactic acid content in silages with molasses increased from the first week, with the highest value at week 4. However, the lactic acid content in CRB8:2 did not increase with time and had the lowest value of all treatments. Acetic acid proportions of total volatile fatty acids were low at day 0, with the highest value at day 7, decreasing slowly until 8 weeks. The butyric acid proportion was highest at day 0 and decreased up to week 8. The proportion of propionic acid increased during ensiling. The digestibility experiment had a 4${\times}$4 Latin-square design and included 4 castrated crossbreed (Yorkshire${\times}$Landrace) male pigs fed four diets. The basal diet (BD) included rice bran, broken rice and maize meal, and the other three diets included fish meal (FMD) or catfish by-product ensiled with rice bran (CRBD) or sugarcane molasses (CMD). The silages chosen were those which gave the best results in the ensiling experiment for each additive. The coefficient of total tract apparent digestibility (CTTAD) of DM and organic matter (OM) was not significantly different among treatments. The CTTAD of CP was not different among the silage diets, but was lower in BD (p<0.01). The CTTAD of ether extract (EE) was higher in the catfish by-product silage diets than in FMD and BD. There was no significant difference in the digestibility of DM, OM, CP and EE between the fish meal and the by-product silages. In conclusion, catfish by-product can be successfully preserved by ensiling. Moreover, the total tract apparent digestibility of OM, CP and EE in ensiled catfish by-product was comparable with that of fish meal.

• 한국식품영양과학회지
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• 제36권12호
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• pp.1589-1595
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• 2007

취반시 chitosan 첨가가 쌀밥의 저장 중 품질특성에 미치는 효과를 조사하기 위해 먼저 취반시 밥물에 0.1%와 0.5%의 키토산을 첨가하여 밥을 제조하여 관능검사를 실시한 결과, 쌀밥의 종합적 기호도는 0.1% chitosan 처리구와 대조구와 유사하였으나 0.5% chitosan 첨가구의 기호성은 감소하였다. 0.1% chitosan을 첨가한 밥에 Bacillus 포자를 인위적으로 접종하여 $20^{\circ}C$와 $30^{\circ}C$에 3일 동안 저장하면서 품질변화를 조사하였다. Chitosan 첨가구의 생균수는 저장기간 동안 대조구에 비해 $20^{\circ}C$에서는 약 $1{\sim}1.5$ log cycle, $30^{\circ}C$에서는 약 $0.5{\sim}1$ log cycle정도 낮았다. 대조구와는 달리 chitosan 첨가구는 저장 2일째까지 pH의 뚜렷한 변화가 관찰되지 않았으며, $30^{\circ}C$에서는 대조구와 chitosan 첨가구 모두 pH가 점차 감소하였다. Hardness는 대조구와 chitosan 첨가구 사이에 뚜렷한 차이는 관찰되지 않았으며, 저장시간이 경과할수록 감소하였다. Cohesiveness는 chitosan 처리구와 대조구 모두 저장기간이 경과할수록 감소하였으며, chitosan 처리구의 cohesiveness가 대조구에 비해 저장 전 기간 동안 다소 높은 경향을 나타내었다. Chitosan첨가 쌀밥의 명도(L값)는 저장기간 동안 대조구에 비해 높았으며, b값은 낮게 나타났다.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2005년도 INTERNATIONAL SYMPOSIUM ON SOIL & GROUNDWATER ENVIRONMENT
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• pp.172-173
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• 2005

• 한국디지털건축인테리어학회논문집
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• 제12권1호
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• pp.35-43
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• 2012

This study aimed to seek a method capable of hedging a rising risk of housing rent price by introducing derivatives with the target of Korean housing rent markets. The research model used in this thesis progressed a research by applying a futures contract method with the target of the rent price of major apartments in Gangnam and Gangbuk Regions of Seoul. As an analysis result, the rent price of all complexes has risen during its analysis period, so it could be confirmed that the CRB future index was also risen according to this. Finally, it was confirmed that the rising risk of the rent price can be hedged through a purchase position of futures. But, as the difference between rent price variation and CRB future index variation occurs, it appeared that 100% of hedge is difficult. However, it is judged that if considering that a method capable of hedging the rising risk of the existing rent price was nonexistent, the hedge trading effect utilizing the CRB future index on the rent price will be meaningful.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 2002년도 Proceedings of the International Welding/Joining Conference-Korea
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• pp.545-550
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• 2002

In order to ensure the signal could be transported cocrrectly, the microwave devices made of Aluminmn alloys must be assembled and brazed flaw-freely. In this paper, a new approach of using contact reactive brazing (CRB) process to realize the compact brazing of Aluminum alloys was put forward. The reason for this is that CRB, which realizes bonding depending on the liquid alloy produced by metallurgy reaction between the materials to be joined, overcomes the limitation of traditional brazing that the macroscopically disorganized filling flow of liquid filler metal would result in defects in brazed seam. Joint ofLF21 (AA3003) with the compactness of over 95% was brazed by the method of CRB using Si powder as an interlayer. At last, the influence of the physical parameter related to the Si powder interlayer on the compactness of the joints was investigated in detail.

• 한국정보과학회논문지:시스템및이론
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• 제33권3호
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• pp.178-192
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• 2006

버퍼 오버플로우 공격은 Code Red나 SQL Stammer와 같은 최근의 웜의 발발에서 알 수 있는 것과 같이 가장 강력하고 치명적인 형태의 악성 코드 공격이다. 버퍼 오버플로우 공격은 일반적으로 시스템에 비정상적인 증상들을 유발한다. 버퍼 오버플로우 공격에 대한 기존의 대처방안들은 심각한 성능 저하를 초래하거나, 다양한 형태의 버퍼 오버플로우 공격을 모두 방지하지 못했으며, 특히 일반적으로 사용되는 소프트웨어 패치를 사용하는 방법은 버퍼 오버플로우 입의 확산을 효과적으로 차단하지 못한다. 이러한 문제를 해결하고자 본 논문에서는 적은 하드웨어 비용과 성능 저하만으로 거의 모든 악성 코드 공격을 탐지하고 피해를 복구할 수 있도록 하는 복귀 주소 포인터 스택 (Return Address Pointer Stack: RAPS) 과 변조 복구 버퍼 (Corruption Recovery Buffer: CRB)라는 마이크로 구조 기술들을 제안한다. 버퍼 오버플로우 공격으로 인한 비정상적인 증상들은 RAPS를 통해 프로세스 실행 중 메모리 참조의 안전성을 점검함으로써 쉽게 탐지될 수 있으며, 이는 그러한 공격들에 의한 잠재적인 데이타 흑은 제어 변조를 피하는 것을 가능하게 한다. 안전 점검 장치의 사용으로 인한 하드웨어 비용과 성능 손실은 거의 발생하지 않는다. 또한, RAPS에 비해 더욱 강도 높은 방법인 CRB를 이용하여 보안 수준을 더욱 향상시킬 수 있다. 변조 복구 버퍼는 안전 점검 장치와 결합되어 버퍼 오버플로우 공격에 의해 발생했을 가능성이 있는 의심스러운 쓰기들을 저장함으로써 공격이 탐지되는 경우 메모리의 상태를 공격 이전의 상태로 복구시킬 수 있다. SPEC CPU2000 벤치마크 중에서 선정한 프로그램들에 대해 상세한 시뮬레이션을 수행함으로써, 제안된 마이크로구조 기술들의 효율성을 평가할 수 있다. 실험 결과는 안전 점검 장치를 사용하여 공격으로 인한 복귀 주소 변조로부터 스택 영역을 방어하는 것이 시스템의 이상 증상들을 상당 부분 감소시킬 수 있다는 것을 보여준다. 또한, 1KB 크기의 작은 변조 복구 버퍼를 안전 점검 장치와 함께 사용할 경우 스택 스매싱 공격으로 인해 발생하는 추가적인 데이타 변조들까지 막아낼 수가 있는데, 이로 인한 성능 저하는 2% 미만에 불과하다.

• Journal of Communications and Networks
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• 제8권2호
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• pp.194-204
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• 2006

This contribution focuses on the maximum likelihood (ML) noncoherent synchronization of multi-antenna transceivers working in faded environments and employing ultra-wideband impulse radio (UWB-IR) transmit technology. In particular, the Cramer-Rao bound (CRB) is derived for the general case of multiple input multiple output (MIMO) UWB-IR systems and used to compare the ultimate performance of three basic transmit schemes, thereinafter referred to as single input multiple output (SIMO), MIMO equal signaling (MIMO-ES), and MIMO orthogonal signaling (MIMO-OS) ones. Thus, the noncoherent ML synchronizer is developed for the better performing transmit scheme (i.e., the SIMO one) and its performance is evaluated under both signal acquisition and tracking operating conditions. The performance gain in the synchronization of UWB- IR signals arising by the utilization of the multi-antenna technology is also evaluated.