• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.14 no.1
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• pp.16-25
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• 2003

Background and Objectives : Electroglottography(EGG) is a non-invasive method of monitoring the vocal cord vibration by measuring the variation of physiological impedance across the vocal folds through the neck skin. It reveals especially the vocal fold contact area and is widely used for basic laryngeal researches, voice analysis and synthesis. The purpose of this study is to investigate the effectiveness of EGG parameters in differential diagnosis of laryngeal cancer. Materials and Methods : The author investigated 10 laryngeal cancer and 25 benign laryngeal disease patients who visited at the Department of Otolaryngology, Pusan National University Hospital. The EGG equipment was devised in the author's Department. Among various parameters of EGG, closed quotient(CQ), speed quotient(SQ), speed index(SI), Jitter, Shimmer, Fo were determined by an analysis program made with MATLAB 6.5$^{\circledR}$(Mathwork, Inc.). In order to differentiate various laryngeal diseases from pathologic voice signals, the author has used the electroglottographic parameters using the neural network of multilayer perceptron structure. Results : SQ, SI, Jitter and Shimmer values except those of CQ and Fo showed remarkable differences between benign and malignant laryngeal disease groups. From the artificial neural network, the percentage of differentiating the laryngeal cancer was over 80% in SQ, SI, Jitter, Shimmer except for CQ and Fo. These results indicated that it is possible to discriminate the benign and malignant laryngeal diseases by EGG parameters using the artificial neural network. Conclusion : If parameters of EGG which can reveal for the pathology of laryngeal diseases are additionally developed and the current classification algorithm is improved, the discrimination of laryngeal cancer will become much more accurate.

• Journal of Biomedical Engineering Research
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• v.25 no.5
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• pp.343-349
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• 2004

Electroglottograph(EGG) is a signal recorded from the vocal cord vibration by measuring electrical impedance across the vocal folds through the neck skin. The purpose of this study was to develop EGG system and to evaluate possibility for the application on speech analysis and laryngeal disease diagnosis. EGG system was composed of two pairs of ring electrodes, tuned amplifier, phase sensitive detector, low pass filter, and auto-gain controller. It was designed to extract electric impedance after detecting by amplitude modulation method with 2.7MHz carrier signal. Extracted signals were transmitted through line-in of PC sound card, sampled and quantized. Closed Quotient(CQ), Speed Quotient(SQ), Speed Index(SI), fundamental frequency of vocal cord vibration(F0), pitch variability of vocal fold vibration (Jitter), and peak-to-peak amplitude variability of vocal fold vibration(Shimmer) were analyzed as EGG parameters. Experimental results were as follows: the faster vocal fold vibration, the higher values in CQ parameter and the lower values in SQ and SI parameters. EGG and speech signals had the same fundamental frequency. CQ, SQ, and SI were significantly different between normal subjects and patients with laryngeal cancer. These results suggest that it is possible to implement portable EGG system to monitor the function of vocal cord and to test functional changes of the glottis.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2011.10a
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• pp.19-19
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• 2011

예비실험 중 한국의 울릉도에 자생하고 취나물로 이용되고 있는 섬쑥부쟁이(Aster glehni Franchet et Sckmidt, Compositae)가 페놀성 화합물 함량이 높고 peroxynitrite 소거효과가 높았기 때문에 이를 이용한 추출물의 제조를 통한 건강기능식품을 창출하고자 하였다. 건강식품을 위한 추출물 제조를 위하여 물과 에탄올만을 이용하여 페놀성 화합물 고함유 추출물의 제조가 가능하고 높은 peroxynitrite 소거효과를 나타내는 추출물을 결정하고자 하였다. 즉, 추출용매로 Water-EtOH 비율을 조절하여 추출하여 추출물의 함량, HPLC를 이용한 caffeoylquinic acid(CQ) 화합물의 함량분석 및 peroxynitrite 소거효과를 비교하였다. Water-EtOH (7:3)으로 추출한 섬쑥부쟁이 추출물은 CQ 함량이 높고, 높은 peroxynitrite 소거효과, 항경련효과, 진정효과 및 항비만효과 등이 나타났다. 건강기능식품을 위한 추출물 제조시 한국에서는 물과 에탄올만이 허용되기 때문에 CQ 함량이 높은 추출물의 제조가 가능하고 높은 peroxynitrite 소거효과를 유지할 수 있는가에 관한 실험 이외에 마우스에서 선택된 추출물의 진정효과 및 항경련효과 실험을 수행하였다. 진정효과와 항경련효과를 위하여 마우스에서 각각 pentobarbital로 유도한 수면연장효과와 PTZ로 유도한 경련에 대한 효과를 측정하여 유의성있는 활성이 확인되었으므로 이 추출물을 이용한 건강기능식품으로의 이용이 가능하다고 생각된다.

• Parasites, Hosts and Diseases
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• v.47 no.2
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• pp.139-144
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• 2009

The aim of the present study was to investigate antimalarial drug pressure resulting from the clinical use of different antimalarials in Thailand. The phenotypic diversity of the susceptibility profiles of antimalarials, i.e., chloroquine (CQ), quinine (QN), mefloquine (MQ), and artesunate (ARS) in Plasmodium falciparum isolates collected during the period from 1988 to 2003 were studied. P. falciparum isolates from infected patients were collected from the Thai-Cambodian border area at different time periods (1988-1989, 1991-1992, and 2003), during which 3 different patterns of drug use had been implemented: MQ+sulphadoxine (S)+pyrimethamine (P), MQ alone and MQ+ARS, respectively. The in vitro drug susceptibilities were investigated using a method based on the incorporation of $[^3H]$ hypoxanthine. A total of 50 isolates were tested for susceptibilities to CQ, QN, MQ, and ARS. Of these isolates, 19, 16, and 15 were adapted during the periods 1988-1989, 1991-1993, and 2003, respectively. P. falciparum isolates collected during the 3 periods were resistant to CQ. Sensitivities to MQ declined from 1988 to 2003. In contrast, the parasite was sensitive to QN, and similar sensitivity profile patterns were observed during the 3 time periods. There was a significantly positive but weak correlation between the $IC_{50}$ values of CQ and QN, as well as between the $IC_{50}$, values of QN and MQ. Drug pressure has impact on sensitivity of P. falciparum to MQ. A combination therapy of MQ and ARS is being applied to reduce the parasite resistance, and also increasing the efficacy of the drug.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.40 no.8
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• pp.619-630
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• 2003

We present a method of runtime configuration scheduling in reconfigurable SoC design. As a model of computation, we use a popular formal model of computation, hierarchical FSM (HFSM) with synchronous dataflow (SDF) model, in short, HFSM-SDF model. In reconfigurable SoC design with HFSM-SDF model, the problem of configuration scheduling becomes challenging due to the dynamic behavior of the system such as concurrent execution of state transitions (by AND relation), complex control flow (HFSM), and complex schedules of SDF actor firing. This makes it hard to hide configuration latency efficiently with compile-time static configuration scheduling. To resolve the problem, it is necessary to know the exact order of required configurations during runtime and to perform runtime configuration scheduling. To obtain the exact order of configurations, we exploit the inherent property of HFSM-SDF that the execution order of SDF actors can be determined before executing the state transition of top FSM. After obtaining the order information and storing it in the ready configuration queue (ready CQ), we execute the state transition. During the execution, whenever there is FPGA resource available, a new configuration is selected from the ready CQ and fetched by the runtime configuration scheduler. We applied the method to an MPEG4 decoder and IS95 design and obtained up to 21.8% improvement in system runtime with a negligible overhead of memory usage.

• Journal of the Korean Society of Clothing and Textiles
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• v.15 no.1
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• pp.70-75
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• 1991

Contact angle measuring device was developed in this laboratory using laser beam projec-tion. The new method allows for rapid and direct determination of stationary, advancing, and receding contact angles on both planar and nonplanar solid surfaces, including fibers with very small diameters. A narrow laser beam impinges on an edge of an interface of liquid and solid. This makes two projected laser beam lines upon and radiating from the center of a protractor scale on a tangent screen. Contact angle is measured by determining the difference in angle on the protractor scale between the two projected laser beam lines. Contact angles measured on Perspex-CQ using this instrument were in agreement with the literature. it was shown that this instrument provides a novel method for the facile and accurate measurement of contact angles.

• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.438-438
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• 2015

기후변화 시나리오는 다양한 자연조건에 대한 불완전한 이해, 연산능력 등의 제한으로 매우 높은 불확실성이 내포되어 있으며, 국내의 다양한 연구에서도 제시되어 있듯이 매우 과소 추정되어 있는 문제점이 있다. 이러한 문제로 인하여 다양한 편의보정 기법을 통해 기후변화 시나리오의 불확실성을 줄이고자 하는 노력이 수행되었다. 그러나 편의보정 기법은 적용 방법이 서로 상이하기 때문에 보정에 따른 강우 특성이 다르게 나타나는 문제점이 있다. 이에 본 연구에서는 편의보정 기법에 따른 강우-유출 특성을 갑천유역을 대상으로 분석하였다. Change Factor(CF)와 Quantile Mapping(QM) 그리고 CF와 QM을 연계한 편의보정기법(CQ)에 따른 강우-유출 특성을 갑천유역을 대상으로 Change Factor(CF)에서 연평균(CF_Y)/월평균(CF_M) 교정계수를 이용하는 방법과 Quantile Mapping(QM)을 총 편의보정기간(QM_E)과 우기와 비우기(QM_P)를 구분하여 누적확률분포를 고려하는 방법, 그리고 CF와 QM을 연계한 편의보정기법(CQ) 총 5가지에 대해서 편의보정을 수행하고 유출특성을 SWAT모형을 이용하여 분석하였다. 과거 기간에 대해 CF_M과 QM_P는 첨두유량이 실측 첨두유량에 비해 2배 이상 크게 나타났으며, 특히 QM_P는 최대 강우 발생 월이 다른 편의보정 기법과는 다르게 나타나 월별 유출 분석시 큰 오류가 발생될 것으로 판단된다. 5가지의 편의보정 기법 중에 CQ가 과거 강수 크기, 발생 분포 및 빈도 재현을 가장 잘 반영하며, 미래기간에 대한 기간별(2030s, 2050s, 2070s, 2090s) 평균유량을 비교한 결과 본 연구에서 사용한 SRES A1B 시나리오의 이산화탄소 배출 시나리오의 특성을 유지한 미래 강우-유출해석이 이루어지는 것으로 나타났다. 기후변화 시나리오에 편의보정 기법 적용으로 자연적인 현상을 정확하게 모의하기에는 어려움이 많고 불확실성 역시 매우 크지만, 과거 강수발생 경향이나 편의보정의 특성을 알고 활용목적에 맞는 편의보정을 수행한다면 수자원 관리 계획 수립 등에 큰 도움이 될것으로 판단된다.

• Journal of KIISE:Databases
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• v.33 no.3
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• pp.310-326
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• 2006

In this paper, we deal with a method of efficiently processing continuous queries in a data stream environment. We classify previous query processing methods into two dual categories - data-initiative and query-initiative - depending on whether query processing is initiated by selecting a data element or a query. This classification stems from the fact that data and queries have been treated asymmetrically. For processing continuous queries, only data-initiative methods have traditionally been employed, and thus, the performance gain that could be obtained by query-initiative methods has been overlooked. To solve this problem, we focus on an observation that data and queries can be treated symmetrically. In this paper, we propose the duality model of data and queries and, based on this model, present a new viewpoint of transforming the continuous query processing problem to a multi-dimensional spatial join problem. We also present a continuous query processing algorithm based on spatial join, named Spatial Join CQ. Spatial Join CQ processes continuous queries by finding the pairs of overlapping regions from a set of data elements and a set of queries defined as regions in the multi-dimensional space. The algorithm achieves the effects of both of the two dual methods by using the spatial join, which is a symmetric operation. Experimental results show that the proposed algorithm outperforms earlier methods by up to 36 times for simple selection continuous queries and by up to 7 times for sliding window join continuous queries.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.10 no.1
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• pp.1-11
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• 2012

The equation of the step-drawdown test "$s_w=BQ+CQ^p$" written by Rorabaugh (1953) is suitable for drawdown increased non-linearly in the fractured rocks. It was found that value of root mean square error (RMSE) between observed and calculated drawdowns was very low. The calculated $C$ (well head loss coefficient) and $P$ (well head loss exponent) value of well head losses ($CQ^p$) ranged $3.689{\times}10^{-19}{\sim}5.825{\times}10^{-7}$ and 3.459~8.290, respectively. It appeared that the deeper depth in pumping well the larger drawdowns due to pumping rate increase. The well head loss in the fractured rocks, unlike that in porous media, is affected by properties of fractures (fractures of aperture, spacing, and connection) around pumping well. The $C$ and $P$ value in the well head loss is very important to interpret turbulence interval and properties of high or low permeability of fractured rock. As a result, regression analysis of $C$ and $P$ value in the well head losses identified the relationship of turbulence interval and hydraulic properties. The relationship between $C$ and $P$ value turned out very useful to interpret hydraulic properties of the fractured rocks.

• Journal of the Chungcheong Mathematical Society
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• v.21 no.3
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• pp.327-337
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• 2008

In this paper, we prove strong convergence theorems of Halpern iteration for relatively asymptotically nonexpansive mappings in the framework of Banach spaces. Our results extend and improve the recent ones announced by [C. Martinez-Yanes, H. K. Xu, Strong convergence of the CQ method for fixed point iteration processes, Nonlinear Anal. 64 (2006), 2400-2411], [X. Qin, Y. Su, Strong convergence theorem for relatively nonexpansive mappings in a Banach space, Nonlinear Anal. 67 (2007), 1958-1965] and many others.