• Journal of the Korean Institute of Intelligent Systems
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• v.8 no.2
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• pp.70-81
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• 1998

This paper proposes an accurate and cost-effective COA defuzzifier of fuzzy logic controller (FLC). The accuracy of the proposed COA defuzzifier is obtained by involving both membership values and spans of membership functions in calculating a crisp value. The cost-effectiveness of the proposed COA defuzzifier is obtained by replacing the division in the COA defuzzifier by finding an equilibrium point of both the left and right moments. The proposed COA defuzzifier has two disadvantages that it ncreases the hardware complexity due to the additional multipliers and it takes a lot of computation time to find the moment equilibrium point. The first disadvantage is overcome by replacing the multipliers with the stochastic AND operations. The second disadvantage is alleviated by using a coarse-to-fine searching algorithm that accelerates the finding of moment equilibrium point. Application of the proposed COA defuzzifier to the truck backer-upper control problem is performed in the VHDL simulation and the control accuracy of the proposed COA defuzzifier is compared with that of the conventional COA defuzzifier in terms of average tracing distance.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.33B no.10
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• pp.80-89
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• 1996

This paper proposes a new COA (center of area) defuzzifier that is working in the accurate and fast manner. The proposed COA defuzzifier involves both membership values and the spans of membership functions in clauclating a crisp value. In additon, it avoid division by replacing the COA calculation with the searching of the momentum equilibrium point. The moment equilibrium point is searched in the coarse-to-fine manner such that the moment computing points during the coarse searching are moved in the interval of fuzzy terms until they are reached at two adjacent fuzzy terms searching method accerlates the finding of the moment equilibrium point by O(M) mazimally when compared iwth the equal interval searching method of ruitz. In order to verify the accuracy of the proposed COA defuzzifier, the crisp values obtained form the proposed coarse-to-fine searching are compared with the precise crisp values from the arithmetic calculation. Application to the truck backer-upper control problem of the proposed COA defuzzifier is presented. The control performance is compared with that of the conventional COA defuzzifier in tems of the average tracing distance.

• Proceedings of the Korea Society for Simulation Conference
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• 2003.11a
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• pp.3-10
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• 2003

Developments in science and technology based on computer technology influenced military fields and created up-to-date weapons and equipment, and as a result, which is changing the war accomplishing methods of the future warfare. Due to these changes in the war accomplishing methods, the army command centers are requested to make changes in their decision-making process. In other words, they need to apply more scientific methods rather than just build a scheme by the mere analysis of commanders and the staffs as in the past. Consequently, we propose a model, Vision 21 we developed as a war game model for division-size unit analysis use, in the COA development process, which is the most important part in establishing the OPLAN for mission accomplishment. Vision 21, with a comparative analysis of the other COA built in the COA development process, can be applied to making the best COA. Model employment concept can let us choose the best COA, operating war games on condition that the COA of the opposite forces is fixed and ours sequentially opposed against, and with a comparative analysis also. Moreover, if the time available is limited, before establishing several courses, we can apply the COA to the process for making the best decision, analysing in stages or by main phases and not establishing several courses for a special purpose.

• Journal of the Korean Institute of Intelligent Systems
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• v.6 no.4
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• pp.81-91
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• 1996

This paper proposes an optimal COA(Center Of Area) defuzzification method that improves the contr~lp erformance of a fuzzy logic controller. The defuzzification method incorporates both the membership values and the effective span of membership function6 in calculating a crisp value. An optimal effective span is determined automatically by the genetic algorithm thrqugh the training of some typical examples. Simulation of the proposed COA defuzzifier to the truck backer-upper control problem is presented and the control performance of the praposed COA defuzzifier outperforms that of the conventional COA defuzzifier by more than 20% in terms of ayerage tracing distance.

• Journal of Families and Better Life
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• v.25 no.2 s.86
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• pp.1-12
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• 2007

This is an investigative study to consider children's COA by parent's problem drinking and their psychological-social character by the COA. According to the results of this study, almost half of the children's COA, among those who have problem drinking parents, demonstrated high dangerous lever in the lower factors, such as emotional character, personnel relative character, and co-dependent character. Results of the inspection into the differences between the psyrhological-social characters, according to the danger lever of the children's COA, suggested the children's danger lever is higher, the self-efficiency and adaptable flexibility, which are the psychological-social characters, are lower, and there are no special differences in the social-support.

• Journal of Microbiology and Biotechnology
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• v.24 no.9
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• pp.1238-1244
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• 2014

Dephosphocoenzyme A (CoaE) catalyzes the last step in the biosynthesis of the cofactor coenzyme A. In this study, we report the identification and application of CoaE from Stretomyces peucetius ATCC27952. After expression of coaE, the protein was found to have a molecular mass of 28.6 kDa. Purification of the His-tagged fused CoaE protein was done by immobilized metal-affinity chromatography, and then in vitro enzymatic coupling assay was performed. The increasing NADH consumption with time shed light on the phosphorylating activity of CoaE. Furthermore, the overexpression of coaA and coaE independently under the $ermE^*$ promoter in the doxorubicin -producing wild type strain, resulted in 1.4- and 1.5-fold enhancements in doxorubicin production, respectively. In addition, the overexpression of both genes together showed a 2.1-fold increase in doxorubicin production. These results established a positive role for secondary metabolite production from Streptomyces peucetius.

• The Journal of Information Systems
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• v.18 no.1
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• pp.25-46
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• 2009

According to adaptive structuration theory, faithfulness of appropriation(FOA), and consensus on appropriation(COA) are variables for measuring appropriation in use of IT. FOA is the level of interpreting and using the intentions of the IT designers objectively and COA is the level of agreement on ways of using IT among or with user group independently of designers' intention. In traditional theories of IT adoption, computer self-efficacy(CSE), self evaluation on abilities of using computer, has been considered as one of the important individual differences. which would influence on beliefs of using IT. Therefore, considering the relationship among CSE, FOA, COA and attitude, we can hypothesize that CSE would play a moderation varaible among appropriation related variables relationships, FOA-attitude and COA-attitude. The objective of this study is an analysis of CSE's moderation effects in causality relationship among appropriation measuring variables. For this purpose, we propose a research model where there are four hypotheses for moderation effects of CSE on the relationships between appropriation variables. We test these hypotheses by sampling ERP and groupware users. In result, our proposed hypotheses except moderation effect of COA-usefulness are accepted. Main contribution of this study is to identify the relationship between CSE and AST. This study implies that very careful consideration of users' CSE is necessary in order to perform managerial activities based on FOA and COA in IT management department.

• Korean Journal of Microbiology
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• v.41 no.1
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• pp.24-37
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• 2005

This study was conducted to analyze the molecular epidemiological properties and to select the most efficient and reliable PCR method on 116 of Staphylococcus aureus (S. aureus) isolates from Korean cattle, black goat, pig, dog, chicken, mouse and also human clinical cases from hospital. The distribution patterns of SSG [species specific genes; coagulase (coa), protein A (spa), nuclease (nuc) and aroA (RsaI) gene] were analyzed by PCR method. Among the SSGs, the nuc-gene was found in all strains $(100\%)$ tested and followed by coa-gene $(87.9\%)$, spa-gene $(91.4\%)$ and aroA-gene $(26.7\%)$, in order. The genetic subtyping by RFLP method was performed on the coa [AluI] and aroA-gene [RsaI] PCR products. The mecA-gene PCR and PCR-RFLP techniques were chosen to detect and verify of MRSA strains. Only the human strains $(12.1\%)$ were detected the positive mecA-gene products (533 bp), which were divided into two specific bands [201 & 332 bp] by HhaI enzyme digestion. On coa-gene and spa-gene typing, coa-gene was typed with ten kinds of genotype and coa-3 type were determined as the most predominant genotype, while spa-gene was divided into eleven kinds of genotype and also spa-7 type were selected the most prevalent genotype based on their genetic variations. On the aroA and coa-gene subtyping by PCR-RFLP, aroA-gene products were discriminated with only seven types of genotype, while coa-gene products were further divided into an eleven genotype, respectively. In comparison of SID values of five PCR based typing methods, the coa-PCR-RFLP (SID0.894) was evaluated the most efficient and reliable tools and followed by coa-PCR (SID0.883) and aroA-PCR-RFLP (SID0.462), in order. In conclusion, we could determined that the coa-PCR-RFLP method was the most suitable genetic analysis tool for S. aureus and MRSA strains from domestic animals and humans.

• Journal of Microbiology and Biotechnology
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• v.31 no.10
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• pp.1350-1357
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• 2021

Staphylococcus aureus (S. aureus) is a major pathogen that causes human pneumonia, leading to significant morbidity and mortality. S. aureus coagulase (Coa) triggers the polymerization of fibrin by activating host prothrombin, which then converts fibrinogen to fibrin and contributes to S. aureus pathogenesis and persistent infection. In our research, we demonstrate that isovitexin, an active traditional Chinese medicine component, can inhibit the coagulase activity of Coa but does not interfere with the growth of S. aureus. Furthermore, we show through thermal shift and fluorescence quenching assays that isovitexin directly binds to Coa. Dynamic simulation and structure-activity relationship analyses suggest that V191 and P268 are key amino acid residues responsible for the binding of isovitexin to Coa. Taken together, these data indicate that isovitexin is a direct Coa inhibitor and a promising candidate for drug development against S. aureus infection.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.6 no.10
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• pp.2601-2619
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• 2012

A differencing multiuser detection (MUD) method is proposed for multiple-input multiple-output (MIMO) direct sequence (DS) ultra-wideband (UWB) system to cope with the multiple access interference (MAI) and the computational efficiency in Nakagami fading channel. The method, which combines a multiuser-interference-cancellation-based decision feedback equalizer using error feedback filter (MIC DFE-EFF), a coefficient optimization algorithm (COA) and a differencing algorithm (DA), is termed as MIC DFE-EFF (COA) with DA for short. In the paper, the proposed MUD method is illuminated from the rudimental MIC DFE-EFF to the advanced MIC DFE-EFF (COA) with DA step by step. Firstly, the MIC DFE-EFF system performance is analyzed by minimum mean square error criterion. Secondly, the COA is investigated for optimization of each filter coefficient. Finally, the DA is introduced to reduce the computational complexity while sacrificing little performance. Simulations show a significant performance gain can be achieved by using the MIC DFE-EFF (COA) with DA detector. The proposed MIC DFE-EFF (COA) with DA improves both bit error rate performance and computational efficiency relative to DFE, DFE-EFF, parallel interference cancellation (PIC), MIC DFE-EFF and MIC DFE-EFF with DA, though it sacrifices little system performance, compared with MIC DFE-EFF (COA) without DA.