• 동의신경정신과학회지
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• 제28권3호
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• pp.287-302
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• 2017

Objectives: To evaluate effects of Resina Dendropanacis Morbiferus (RDM) on stress and sleep hormones when administered to Chronic Mild Stressed (CMS) rats. Methods: Twenty-five healthy rats were randomly divided into 5 groups; Normal, CMS (Control), Resina Dendropanacis Mobiferus 50 mg/kg (RDM 50), 100 mg/kg (RDM 100), and 200 mg/kg (RDM 200). All rats except the normal group were exposed to unpredicted stress conditions such as water deprivation, empty bottles, forced thread mill, etc. according to timetable of CMS for 3 weeks. After a week starting experiments, rats in RDM 50, RDM 100, and RDM 200 groups were fed orally once a day for 2 weeks. Afterward, blood samples were taken from rats to analyze complete blood count, AST, ALT, and glucose. Noradrenalin, GABA and Melatonin were measured by ELISA kit. BDNF, CREB and TrkB were measured by RT-PCT. Results: 1. In Noradrenalin content, RDM 100 and RDM 200 groups revealed significant decrease compared to the control group. 2. In GABA content, RDM 50 and RDM 100 groups revealed significant decrease compared to the control group. 3. In Melatonin content, RDM 100 and 200 groups revealed significant decrease compared to the control group. 4. In Activity of BDNF, RDM 100 and 200 groups revealed significant increase compared to the control group. 5. In Activity of CREB and TrkB, RDM 100 group revealed significant increase compared to the control group. 6. In Erythrocyte and Thrombocyte changes, red blood cells and hematocrit significantly increased in RDM 50 and RDM 200 groups than the control group. Hemoglobin and platelet significantly increased in all experimental groups and the control group. 7. In Weight gain content, all RDM groups revealed insignificant increase compared to the control group. 8. In Glucose content, RDM 50, RDM 100, and RDM 200 groups revealed significant decrease compared to the control group. Conclusions: Results suggest that RDM have effects on stress and sleep hormones when administered to Chronic Mild Stressed (CMS) rats.

• 멤브레인
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• 제14권2호
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• pp.99-107
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• 2004

Carbon molecular sieve (CMS) membranes were prepared by pyrolysis of polyimides having carboxylic acid groups and applied to the hydrogen separation. The polymeric membranes having carboxylic acid groups showed different steric properties as compared with polymeric membranes having other side groups ($-CH_3$ and $-CF_3$) because of the hydrogen bond between the carboxylic acid groups. However, the microporous CMS membranes were significantly affected by the decomposable side groups evidenced from the wide angle X-rat diffraction, nitrogen adsorption isotherms, and single gas permeation measurement. Furthermore, the gas separation properties of the CMS membranes were essentially affected by the pyrolysis temperature. As a result, the CMS membranes Prepared by Pyrolysis of polyimide containing carboxylic acid froups at $700^{\circ}C$ showed the $H_2$ permeability of 3,809 Baller [$1{\times}10^{-10}$ H $\textrm{cm}^$(STP)cm/$\textrm{cm}^2$.s.cmHg], $H_2$/$N_2$, selectivity of 46 and $H_2$/$CH_4$ selectivity of 130 while the CMS membranes derived from polyimide showed the H$_2$ permeability of 3,272 Barrer, $H_2$/$N_2$ selectivity of 136 and $H_2$/$CH_4$ selectivity of 177.

• BMB Reports
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• 제53권10호
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• pp.545-550
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• 2020

Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-19. To elucidate the cardiotoxicity induced by CQ and AZM, we examined the effects of these drugs based on the electrophysiological properties of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) using multi-electrode arrays. CQ treatment significantly increased the field potential duration, which corresponds to prolongation of the QT interval, and decreased the spike amplitude, spike slope, and conduction velocity of hESC-CMs. AZM had no significant effect on the field potentials of hESC-CMs. However, CQ in combination with AZM greatly increased the field potential duration and decreased the beat period and spike slope of hESC-CMs when compared with CQ monotherapy. In support of the clinical data suggesting the cardiovascular side effects of the combination therapy of CQ and AZM, our results suggest that AZM reinforces the cardiotoxicity induced by CQ in hESC-CMs.

• 동의신경정신과학회지
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• 제13권2호
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• pp.121-147
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• 2002

This study was performed to evaluate the effects of Quibitang in the chronic mild stress(CMS) model of depression in rats. Chronic exposure to mild unpredictable stress was found to depress the consumption of sucrose solution in rats for 8 weeks. These CMS-treated rats were stratified into Quibitang gruop and saline group. And control rats were also stratified into Quibitang group and saline group. The change of the consumption of sucrose solution and the body weight were measured, and open field test, elevated startle response and plus maze test were performed, to investigate the anti-depression effect of Quibitang. The results were as follows: 1. The consumption of sucrose solution was significantly reversed in Quibitang-treated group at 9th, 11th, 12th week, but there was no significant change at 10th week 2. CMS schedule decreased body weight. CMS-treated groups showed decrease of body weight after 5 weeks. After 10 weeks, Quibitang group showed lower body weight than saline group in CMS-treated groups 3. In open field test, Quibitang group showed significant difference of locomotion, latency. 4. In elevated startIe test, Quibitang group showed no significant change of startle response. 5. In plus maze test, Quibitang group showed no significant change of plus maze-time and plus maze-error.

• 융합정보논문지
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• 제9권9호
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• pp.33-37
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• 2019

본 '클라우드컴퓨팅 발전 및 이용자 보호에 관한 법률'이 시행됨에 따라 이에 맞추어 국내 공공 및 민간기업에서 클라우드 컴퓨팅이라는 새로운 패러다임에 대한 관심이 고조되고 있다. 국내 클라우드 시장 선점을 위해서는 국내 통신사, SI 및 SW업체 등이 시장에 진출하고 있으나 글로벌 기업에 비해 경쟁력이 낮다. 따라서 국내기업은 국내시장에 특화된 SaaS 제품 개발을 하고 글로벌 기업에 앞선 IaaS 시장 선점을 위해 노력해야 할 것이다. 본 논문에서는 클라우드 컴퓨팅 개념과 G-클라우드의 클라우드관리시스템(G-CMS) 구축사례를 통해 향후 관련 산업의 발전방향 전망에 대해 알아본다. G-CMS는 이기종 Unix 가상화 시스템을 종합적으로 관리하는 최초의 시스템으로 볼 수 있습니다. 또한 G-CMS는 데이터 센터에서 이기종 가상화 시스템을 관리함으로써 비용을 절감할 수 있습니다.

• 한국정보통신학회논문지
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• 제26권6호
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• pp.872-880
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• 2022

본 논문은 패키지 투어에 참여하는 여행자들에게 관광 명소에 대한 정보를 디지털 게임 기반 학습(DGBL) 방식으로 제공하는 모바일 애플리케이션 개발의 핵심인 콘텐츠 관리 시스템(CMS)의 설계 및 구현 결과를 담고 있다. 설계 측면에서 이 CMS는 여행자 정보, 관광 명소 정보, 질문과 점수 구성 등 학습 게임 콘텐츠를 저장하는 데이터베이스, 저장 콘텐츠를 관리하기 위한 웹 애플리케이션, 그리고 모바일 학습 게임과의 연동을 위한 Rest API로 구성된다. CMS 구현을 위해 PHP 프로그래밍 언어와 MySQL 데이터베이스 관리 시스템을 사용하였으며, 성능 평가 결과 CMS와 데이터베이스 간에 0.77초에서 1.4초 사이의 평균 응답 시간을 보여줌을 확인하였다. 본 논문에서 개발한 CMS는 패키지 투어 여행자를 위한 모바일 학습 게임 구현에 실제 적용할 예정이며, 패키지 투어 그룹이 달라지더라도 게임을 재구성할 필요가 없는 융통성을 제공함을 알 수 있다.

• 공업화학
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• 제33권5호
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• pp.488-495
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• 2022

온실가스의 회수 및 분리를 위한 다공성 물질로 활성탄소와 탄소분자체가 주목을 받아왔다. 균일한 기공을 가지는 탄소분자체는 특정 가스를 선택적으로 흡착할 수 있기 때문에 가스의 포집 및 분리에 사용되고 있다. 탄소분자체의 성능은 세공의 크기 및 균일성에 따라 좌우되는데, 이러한 탄소분자체의 미세 기공 제어를 위하여 표면을 일정한 두께로 코팅할 수 있는 화학기상증착법이 널리 사용 되고 있다. 이 화학기상증착법은 탄소분자체 제조 시 기공의 크기를 제어하는데 사용될 수 있으나, 그 실험 변수가 다양하기 때문에 이에 대한 최적화가 필요하다. 따라서, 본 총설에서는 가스 흡착 및 분리공정용 활성탄소와 탄소분자체를 제조하기 위하여 여러 가지 활성화 공정, 화학기상증착법과 표면처리 등에 의한 기공 제어 기술들을 중심으로 다루고자 한다.

• 한국컴퓨터정보학회논문지
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• 제27권12호
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• pp.209-217
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• 2022

함정 전투관리체계는 다양한 센서, 무장 장비들이 연동 노드를 통해 연결되며 체계내 노드간 효율적인 통신을 위해 DDS(Data Distribution Service) 통신을 활용한다. DDS를 사용하기 위해 체계내 응용소프트웨어 사이에는 DDS토픽을 기본으로 하는 PUB/SUB(Publication/Subscribe)방식으로 통신한다. 이 PUB/SUB방식으로 통신하는 DDS 메시지 구조가 일치하지 않으면 송수신 응용소프트웨어에서 잘못된 명령처리 및 정보전달 등 문제가 발생한다. 이를 개선하기 위해 본 논문에서는 해시트리를 활용한 DDS 메시지 구조 무결성 검증 방법을 제안한다. 제안하는 방법의 전투관리체계에 적용가능성을 확인하기 위해, 제안하는 방법의 메시지 구조 무결성 검증률을 측정하고 전투관리체계의 운용과 개발과정에 미치는 영향을 확인하기 위해 전투관리체계 초기화 시간 비교, 메시지 해시트리의 생성시간 측정을 하였다. 이 시험을 통해 본 논문에서 제안하는 체계 안정성을 위한 메시지 구조 검증 방법이 함정 전투관리체계에 적용 가능함을 확인하였다.

• Archives of Pharmacal Research
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• 제27권10호
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• pp.1065-1072
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• 2004

Depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-HT) system. More recently, several lines of evidence suggest that an important factor in the development of depression may be a deficit in the function and expression of $5-HT_{1A}$ receptors. The present study assessed if Nelumbinis Semen (N. s.) had an anti-depression effect through reversing a decrease in $5-HT_{1A}$receptor binding in rats with depression-like symptoms induced by chronic mild stress. Using a $5-HT_{1A}$ receptor binding assay, with a specific $5-HT_{1A}$receptor agonist, 8- OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin), the mechanism of the anti-depression effect of N. s. on rats was investigated, and the effects compared with two well-known antidepressants, Hyperium Perforatum (St. Johns Wort) and fluoxetine (Prozac). Animals were divided into five groups: the normal (N) group without chronic mild stress (CMS), the control (C) group under CMS for 8 weeks, the Nelumbinis Semen (N. s.) treatment group under CMS for 8 weeks, the Hyperium Perforatum (H. p.) treatment group under CMS for 8 weeks and finally, the fluoxetine (F) treatment group under CMS for 8 weeks. Each treatment was administered to rats during the last 4 weeks of the 8-week CMS. A sucrose intake test was performed to test the anti-depression effect of N. s. The N. s. treatment significantly reversed the decreased sucrose intake under CMS (P<0.05 compared to control group under CMS). In the CA2 and CA3 regions of the hippocampus, both N. s. and H. p. reversed the CMS-induced decrease in $5-HT_{1A}$receptor binding. In the I to II regions of the frontal cortex, N. s. and H. p. also reversed the CMS-induced decrease in$5-HT_{1A}$receptor binding, and even showed a significant increase in $5-HT_{1A}$receptor binding compared to the F treatment group (N. s. vs. P, p<0.05, H. p. vs. P, p<0.05). However, in the hypothalamus, all treatments reversed the CMSinduced decrease in $5-HT_{1A}$receptor binding. This reversal effect of N. s. on the decrease in $5-HT_{1A}$receptor binding in the frontal cortex, hippocampus and hypothalamus of rat brains was very similar to that of H. p, but different from that of F. It is concluded that N. s. presents an anti-depression effect through enhancing $5-HT_{1A}$receptor binding.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 V
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• pp.2911-2914
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• 2003

Conventionally, biological manipulations have been performed manually with long training and pretty low success rates. To overcome this problem, a novel biological manipulation system has been developed to manipulate biological cells without any interference of a human operator, In this paper, we demonstrate a development of tole-autonomous Cell Manipulation System (CMS) using an image processing at a remote site. The CMS consists of two manipulators, a plane stage, and an optical microscope. We developed deformable template-model-matching algorithm for micro objects and pattern matching algorithm of end effect for these manipulators in order to control manipulators and the stage. Through manipulation of biological cells using these algorithms, the performance of the CMS is verified experimentally.