• International Journal of High-Rise Buildings
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• v.10 no.4
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• pp.311-321
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• 2021

Perception of the public to structural fires is very important because there are only a number of tall timber buildings constructed in the world. People are hesitating to accept tall timber buildings, so it is essential to ensure the first generation of tall timber buildings to a very high standard, especially fire safety. Right now, there are no specific design standards or regulations for fire design of tall timber buildings in Europe. Even though heavy timber members have better fire resistance than steel components, many conditions still need to be verified before considering the use of timber materials, e.g. fire spread, post-fire collapse, etc. This research numerically explores the structural behaviours of a tall Glulam building when one of its internal Glulam (Glued laminated timber) columns fails after sustaining a full 120-min standard fire and is removed from the established finite element building model created in SAP2000. The numerical results demonstrate that the failure and removal of the selected internal Glulam column may lead to the local failure of the adjacent CLT (Cross laminated timber) floor slabs, but will not lead to large disproportionate damage and collapse of the whole building. Here, the building is assumed to be located in Glasgow, Scotland, UK.

• Korean Journal of Veterinary Research
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• v.40 no.3
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• pp.471-478
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• 2000

The pharmacokinetic properties of KR-V compounds, recently developed as new anti-HIV agents, were studied after i.v. and p.o. administration in rats. The concentrations of the KR-V series were determined in rat plasma using an high-performance liquid chromatography (HPLC)-UV detection system. Of the 19 KR-V compounds investigated in the present study, only KR-V 3, 10, 14, 16 and 18-1 showed oral bioavailability. The plasma concentration-time data could be adequately described by an one-compartment open model. In the i.v. kinetic study (10mg/kg), the CLt of KR-V 3, 10, 14 and 16 (>4L/hr/kg) were significantly higher than that of KR-V 18-1 (1.1 L/hr/kg). The AUC of KR-V 18-1 was greater ($8.97{\mu}g{\cdot}hr/ml$) than that of the other compounds, but the Vd (0.58 L/kg) was lower. In the p.o. kinetic study (50mg/kg), although the t-1/2 of KR-V 18-1 was shorter than that of the other compounds, the AUC ($3.659{\mu}g{\cdot}hr/ml)$ and $C_{max}(1.891{\mu}g/ml$) were markedly higher. In a seperated in vitro experiment, only KR-V 18-1, of the 5 compounds with bioavailibility, exhibits potent activity against HIV-1 mutant strains. Therefore, KR-V 18-1 is expected to become a new potent anti-AIDS drug candidate/lead compound.

• Journal of the Korean Wood Science and Technology
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• v.41 no.6
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• pp.535-543
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• 2013

The objective of this study was to analyse the residual stress in Larix kaempferi board during and after kiln-drying. The boards were primarily intended for using as laminar of cross laminated timber (CLT). In this study, the equivalence of moisture content by equalizing treatment was proved and reduction of residual stress by conditioning treatment was quantified. Prong test and slice test were carried out to analyse the residual stress in wood during drying. Transverse casehardening was measured immediately after making prong sample. Residual stress of four parts in wood from surface to center was analyzed quantitatively based on elastic deformation after just cutting slices from board. Tensile stress and compressive stress on the surface of board during drying did not exceed 2.2 MPa when boards were dried by kiln-drying schedule of T10-C4 and T12-D5. Because the tensile strength and compressive strength of transverse direction of Larix kaempferi lumber are 2.65 MPa and 4.60 MPa, application of more severe drying schedule can be recommended. Cup and twist were reduced by about 40% by equalizing and conditioning treatments after drying.

• Journal of Hospice and Palliative Care
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• v.12 no.1
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• pp.27-31
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• 2009

Purpose: Lymphedemas are tissue fluid swellings, usually on the arms or legs, and occur as a result of impaired lymphatic drainage. Presently, the most effective treatment available is complete decongestive physiotherapy (CDP). However, this therapy is ineffective in some patients and surgery may be indicated. Herein, we examined the efficacy of minimally invasive needle aspiration of the most enlarged areas in hypodermic adipose tissues, of patients who had failed CDP. Methods: We included 21 patients who were diagnosed with lymphedema stage II-III in the upper or lower extremities and visited the lymphedema clinic at a university hospital from September 1, 2003 to February 28, 2004. All patients had been treated with CDP at least once, but had failed to respond to the therapy for more than one year. Nine patients had breast cancer and 12 had cervical cancer. We identified the area with the most severe edema by using MRI and performed a 16-gauge angio-needle aspiration on the area. The patients were followed up for 3 months. Effectiveness of the treatment was evaluated by comparing the volume of edema before and after the treatment using Wilcoxon signed rank-test. Results: The mean reduction ratio of the volume of edema comparison normal volume was 41.1${\pm}$35.3% (P=0.001). There were no major or minor operative complications except localized hemorrhage. Conclusion: We conclude that a needle aspiration prior to other surgical treatments is relatively safe and effective for those patients who are unresponsive to CDP.