• 생명과학회지
• /
• 제9권6호
• /
• pp.639-645
• /
• 1999

This research was for investigating the physiological effect caused by genetic disorder and others. Serum protein, serum LDH, and serum CPK were analyzed on Fragile X syndrome patients, carriers, unclassified mental retardees, and Down's syndrome patients by cellulose acetate plate electrophoresis. Also enzyme activity of LDH and CPK were measured. Significant differences were observed between normal group and mental retardees in compositions of serum protein, serum LDH, serum CPK, and enzyme activities. Mean percentages of albumin were 53.70$\pm$7.73% for Fragile X syndrome patients, 57.09$\pm$7.73% for carriers, 47.33$\pm$6.06% for unclassified mental retardees, 50.19$\pm$ 15.72% for Down's syndrome patients. Mean percentages of ${\gamma}$-globulin were 19.64$\pm$6.71% for Fragile X syndrome patients, 19.24$\pm$3.38% for carries, 25.66$\pm$4.74 for unclassified mental retardees, 23.41$\pm$6.08% for Down's syndrome patients. Mean percentages of LDH3 were 27.76$\pm$2.72% for Fragile X syndrome patients, 22.70$\pm$2.76% for carriers, 25.42$\pm$1.26% for unclassified mental retardees, 27.72$\pm$2.58% for Down's syndrome patients. Mean percentages of LDH4 were 2.70$\pm$2.04 for Fragile X syndrome patients, 3.79$\pm$2.74% for carriers, so both of them were significantly lower than normal(P<0.05). Mean percentages of CK-MB were 3.96$\pm$5.56% for Fragile X syndrome patients, 8.80$\pm$7.92%. Mean percentages of CK-MM were 95.81$\pm$5.50% for Fragile X syndrome patients, 91.20$\pm$7.92% for carriers. These results showed that significant abnormal compositions of blood proteins might be caused by genetic disorder. However, further analysis of many patients will be needed for clear conclusion.

• Preventive Nutrition and Food Science
• /
• 제15권2호
• /
• pp.88-91
• /
• 2010

This study examined the effects of Korean red ginseng (RG) on muscle injury induced by eccentric exercise. Eighteen college male students were randomly assigned to either the RG group or the placebo group (P). The RG group ingested RG extract at 20 g/day (mixed with 200 mL of water) for 7 days prior to performing a downhill treadmill exercise and for 3 days after performing the downhill treadmill exercise, while the P group ingested 200 mL of water containing Agastachis Herba for 7 days prior to and 3 days following a downhill treadmill exercise. All subjects performed 2 bouts of a downhill treadmill exercise (6 km, -14 degree slope, 12 km/hr speed) with a 5 minute resting interval between bouts. Blood samples were drawn immediately before and after exercise, and at 1 hr, 24 hr, 48 hr, and 72 hr. Two-way repeated ANOVA documented that creatine kinase (CK) levels in the RG group were significantly reduced at 48 hr after exercise, as compared with P group, and remained constant until 72 hr after exercise. Lactate levels in the RG group were also significantly lower at 24 hr and 72 hr after exercise as compared to the P group. We conclude that supplementation of RGreduces CK levels and may prevent muscle injury induced by eccentric exercise.

• 대한세포병리학회지
• /
• 제17권1호
• /
• pp.51-55
• /
• 2006

The plasmacytoid variant is an extremely rare form of urothelial carcinoma in which the malignant cells resemble those of plasmacytoma. We report the cytologic features of 3 cases of this disorder. All 3 patients were male and presented with painless macroscopic hematuria. The voided urine cytology revealed a few scattered clusters of tumor cells in a bloody background. Each tumor cell had an abundant amount of cytoplasm that was clear or densely stained and characterized by eccentrically located nuclei. A histological examination of tissue obtained from a radical cystectomy confirmed the cytologic diagnosis in each 3 case, revealing a diffusely infiltrating tumor composed of round, noncohesive tumor cells demonstrating a high nuclear grade. These cells had infiltrated the tunica propria in 2 cases, but were limited to the submucosa in 1 case. The tumor cells were plasmacytoid in appearance, each demonstrating an eccentric nucleus and dense cytoplasm, as seen in the cytologic findings. All of the tumors were immunoreactive for pancytokeratin, CK7, CK20; negative for epithelial membrane antigen (EMA), leukocyte common antigen (LCA), kappa, lambda, and CD79a. Thus, it is important to consider the plasmacytoid variant of urothelial carcinoma in addition to plasmacytoma or lymphoma as a diagnosis when encountering plasmacytoid tumor cells in a voided urine sample.

• Journal of Ginseng Research
• /
• 제47권2호
• /
• pp.255-264
• /
• 2023

Background: Red ginseng (RG) alleviates psychiatric disorders. Fermented red ginseng (fRG) alleviates stress-induced gut inflammation. Gut dysbiosis causes psychiatric disorders with gut inflammation. To understand the gut microbiota-mediated action mechanism of RG and fRG against anxiety/depression (AD), we investigated the effects of RG, fRG, ginsenoside Rd, and 20(S)-β-D-glucopyranosyl protopanaxadiol (CK) on gut microbiota dysbiosis-induced AD and colitis in mice. Methods: Mice with AD and colitis were prepared by exposing to immobilization stress (IS) or transplanting the feces of patients with ulcerative colitis and depression (UCDF). AD-like behaviors were measured in the elevated plus maze, light/dark transition, forced swimming, and tail suspension tests. Results: Oral gavage of UCDF increased AD-like behaviors and induced neuroinflammation, gastrointestinal inflammation, and gut microbiota fluctuation in mice. Oral administration of fRG or RG treatment reduced UCDF-induced AD-like behaviors, hippocampal and hypothalamic IL-6 expression, and blood corticosterone level, whereas UCDF-suppressed hippocampal BDNF⁺NeuN⁺ cell population and dopamine and hypothalamic serotonin levels increased. Furthermore, their treatments suppressed UCDF-induced colonic inflammation and partially restored UCDF-induced gut microbiota fluctuation. Oral administration of fRG, RG, Rd, or CK also decreased IS-induced AD-like behaviors, blood IL-6 and corticosterone and colonic IL-6 and TNF-α levels, and gut dysbiosis, while IS-suppressed hypothalamic dopamine and serotonin levels increased. Conclusion: Oral gavage of UCDF caused AD, neuroinflammation, and gastrointestinal inflammation in mice. fRG mitigated AD and colitis in UCDF-exposed mice by the regulation of the microbiota-gut-brain axis and IS-exposed mice by the regulation of the hypothalamic-pituitary-adrenal axis.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 2004년도 춘계 학술발표회 제16권1호
• /
• pp.204-207
• /
• 2004

In this paper, mechanical properties of the high strength lightweight self-compacting concrete with simple mixed design method was investigated. Experimental tests were performed as such compressive strength, splitting tensile strength, modulus of elasticity and density of high strength lightweight self-compacting concrete. The 28 days compressive strength of high strength lightweight self-compacting concrete with the LC replacement ratio of $100\%$ reduces about $31\%$ but LF replacement ratio of $100\%$ increase about $20\%$ compared that of the control concrete. The structural efficiency of high strength lightweight self-compacting concrete increase with proportional to the replacement into of LF. The relationship between the splitting tensile strength and 28 days compressive strength can be represented by the equation $f_s=0.076f_{ck}+0.5582$. The modulus of elasticity was found to be lower than that of normal weight concrete, ranging form 24 to 33 GPa.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 2003년도 가을 학술발표회 논문집
• /
• pp.613-616
• /
• 2003

Steel-concrete composite columns are used extensively in modern buildings. Extensive research on composite columns in which structural steel are in concrete have been carried out. In-filled composite columns, however have received limited attention compared to encased columns. In this paper, interrelationship of parameters is examined into analyzing and comparing with data through ABAQUS program and experiment on concrete filled tubular column under axial load and propriety of model is checked out by FEM analysis. The main variations of this paper are width-thickness ratio of the section(B/t =33.3, 38.9, 44.4), concrete strength($f_{ck}$=240, 360kgf/$\textrm{cm}^2$), and width-length ratio($L_o$/B=8.0, 10.0, 12.0, 15.0, 20.0). The ultimate value obtained through analysis is compared with test value and calculated by design code of other countries and previous studies.

• 한국멀티미디어학회논문지
• /
• 제20권8호
• /
• pp.1175-1186
• /
• 2017

Human emotion recognition is one of the promising applications in the era of artificial super intelligence. Thus far, facial expression traits are considered to be the most widely used information cues for realizing automated emotion recognition. This paper proposes a novel facial expression recognition (FER) method that works well for recognizing emotion from image sequences. To this end, we develop the so-called weighted soft voting classification (WSVC) algorithm. In the proposed WSVC, a number of classifiers are first constructed using different and multiple feature representations. In next, multiple classifiers are used for generating the recognition result (namely, soft voting) of each face image within a face sequence, yielding multiple soft voting outputs. Finally, these soft voting outputs are combined through using a weighted combination to decide the emotion class (e.g., anger) of a given face sequence. The weights for combination are effectively determined by measuring the quality of each face image, namely "peak expression intensity" and "frontal-pose degree". To test the proposed WSVC, CK+ FER database was used to perform extensive and comparative experimentations. The feasibility of our WSVC algorithm has been successfully demonstrated by comparing recently developed FER algorithms.

• 한국농업기계학회:학술대회논문집
• /
• 한국농업기계학회 2017년도 춘계공동학술대회
• /
• pp.55-55
• /
• 2017

본 연구는 파프리카를 자동 수확하기 위한 시스템 개발의 일환으로 수확작업기의 절단장치를 설계하고자 파프리카 과병의 절단특성을 분석하고자 하였다. 파프리카 과병의 절단특성을 분석하기 위하여 사용한 파프리카는 경기도 평택시에서 재배된 파프리카를 사용하였다. 적색 품종인 Nagano RZ와 황색 품종인 Helsinki, 주황색 품종인 Boogie를 사용하였다. 파프리카 과병의 절단 특성을 분석하기 위하여 상기 세 가지 품종의 파프리카 30개씩 총 90개의 파프리카를 사용하여 과병의 중앙 지점을 절단하였다. 절단 특성을 측정하기 위하여 push-pull gauge인 digitect dtg-20을 사용하였으며, 파프리카의 과병의 절단 특성을 측정하기 위하여 일반 농가에서 사용하는 접도 OLFA CK2의 접도의 칼날을 digitect dtg-20에 장착하여 측정하였다. 파프리카 과병의 절단 특성의 시험 항목은 절단강도를 측정하였다. 파프리카의 과병의 절단 특성 측정은 수확작업기의 파프리카 과병의 절단을 위한 절단장치의 설계를 위하여 진행하였다. 파프리카 과병의 절단 특성은 파프리카의 훼손을 최소화한 수확작업을 위한 중요한 요소이다. 파프리카의 과병의 중앙을 절단하여 절단강도와 절단력을 측정하였다. 그 결과 파프리카 과병의 절단강도는 $4.18{\pm}1.18kgf$로 나타났으며, 최대값은 6.91kgf, 최소값은 2.26kgf로 나타났다. 파프리카 과병은 측정된 절단강도의 최대값인 6.91kgf보다 큰 힘을 이용하여 절단하여야 하므로 그에 맞게 수확작업기의 절단장치의 모터를 선정하고 설계가 이루어져야 한다고 판단한다.

• 한국지리정보학회지
• /
• 제20권3호
• /
• pp.125-140
• /
• 2017

지금까지 지가나 주택가격을 추정하는데 회귀모형 기반 공간내삽법과 크리깅(Krging) 기반 공간내삽법이 많이 사용되었지만, 이들 공간내삽법의 성능을 서로 비교한 연구는 거의 없는 실정이다. 따라서 본 연구는 대구시 달서구를 사례로 지가를 추정하는데 회귀모형 기반 공간내삽법과 크리깅 기반 공간내삽법을 적용해 보고 그 정확성을 평가하였다. 회귀모형 기반 공간내삽을 위해 최소자승모형(OLS), 공간지체모형(SLM), 공간오차모형(SEM), 지리가중회귀모형(GWR)을 사용하였고, 크리깅 기반 공간내삽을 위해 단순 크리깅(SK), 정규 크리깅(OK), 일반 크리깅(UK), 공동 크리깅(CK)을 이용하였다. 먼저, 전역적 정확성 지수인 평균 제곱근 오차(RMSE), 수정된 평균 제곱근 오차(adjusted RMSE), 분산지수(COD)를 이용하여 그 정확성을 통계적으로 평가하였다. 다음으로, 3차원 잔차도와 산점도를 이용하여 그 정확성을 시각적으로 서로 비교하였다. 통계적 및 시각적 분석결과에 의하면, 공간적 의존성을 반영할 수 있는 공간회귀모형(SAR)과 크리깅 기법들 보다 공간적 이질성을 고려할 수 있는 GWR이 사례지역에서 지가를 추정하는데 상대적으로 정확한 공간내삽방법인 것으로 나타났다. 본 연구의 결과는 지가를 통해 도시의 공간구조를 분석하는 이차적 연구에 기여할 것이다.

• 한국식품과학회지
• /
• 제49권2호
• /
• pp.209-214
• /
• 2017

본 연구에서는 잉여 농산물인 오이를 이용하여 제조한 식초음료의 항피로 효과를 검증하기 위하여 고강도 운동을 실시한 흰쥐에 오이식초음료를 매일 섭취시켜 지구력, 혈청 피로물질, 간과 근육 조직 내 글리코겐 함량, 근육 내 LDH 및 CK 등의 변화를 살펴보았다. 실험동물은 4주령의 수컷 SD계 흰쥐 15마리를 1주간 고형식이로 적응시킨 후 난괴법에 의하여 비운동군(SC), 운동군(EC), 오이식초 섭취군(CV)으로 나누었다(n=5). CV는 사람의 하루 섭취량을 기준으로 체중 kg당 7 mL씩 매일 일정시각에 경구투여 하였고 나머지 그룹은 동량의 증류수를 투여하였다. EC와 CV는 매일 일정한 시각에 트레드밀을 이용하여 분당 15 m로 20분, 분당 20 m로 30분, 분당 25 m로 60분씩 운동을 일주일에 5회 실시하였다. 식이섭취량과 식이효율에서는 그룹 간의 별다른 차이가 나타나지 않았으며 CV군의 신장 무게가 SC군보다 낮았다. 지구력 측정에서 CV가 EC보다 55.96% 더 높은 지구력을 가진 것으로 측정되었고 혈청 피로물질은 CV가 EC보다 현저히 낮은 경향을 보였다. 간과 근육의 글리코겐 함량은 CV가 다른 두 군보다 높은 수치를 나타내어 오이식초음료의 섭취에 따라 간과 근육에서의 글리코겐 재합성이 증가된 것을 확인하였으며 근조직의 LDH와 CK 측정 결과 CV와 EC를 비교하였을 때 CV에서 증가된 수치를 보였다. 이와 같이 고강도 운동으로 훈련을 실시한 흰쥐는 오이식초음료의 섭취에 의해 지구력 증진과 혈중피로물질의 감소, 간과 근육에서의 글리코겐 재합성, ATP 수치의 유지 및 젖산 대사 촉진과 같은 항피로 효과를 나타내었으므로 본 연구의 결과가 오이식초를 이용한 스포츠드링크 개발에 도움이 될 수 있을 것으로 사료된다.