• Journal of the Korean Graphic Arts Communication Society
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• v.27 no.1
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• pp.107-118
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• 2009

The printing industry is getting more digitalized and integration. It has enabled the interactive information and networking from Pre-Press, Press, to the Post-Press. These are efficient management and the improved process and productivity are getting more important. Such trends improved in the functionality and automation. This paper tries to find out how technology for CIP3/4-based process may be applied and resolved. Such subject includes the domestic and international cases regarding each manufacturer's CIP3/4 technology types. Another purpose is to emphasize on the needs to establish the environment. Under this environment, it is possible to integrate network in exchangeable form through JDF standard format after CIP3/4. Based on the data from this study, it is expected to collect further substantial data which is related to the domestic printing company's CIP4 operation. It will be also possible to perform subsequent studies on the proper variables of the market segment. CIP4 stands for "International Cooperation for Integration of Prepress, Press and Post-press, it is an association of around forty international companies, mostly manufacturers of prepress, press and post-press, as well as suppliers and users. In this paper, we studied on the acting application of CIP4 workflow.

• Biomolecules & Therapeutics
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• v.15 no.4
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• pp.218-223
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• 2007

T cell proliferation is a pivotal to an effective immune response. Cyclin-dependent kinase (cdk) inhibitor, $p27^{kip1}$ is degraded to initiate T cell expansion. In this study, we show that although the expression of $p27^{kip1}$ protein was down-regulated, that of $p21^{cip1}$, another cdk inhibitor, was up-regulated in $CD8^+$ T cells following in vitro stimulation. Ex vivo gB antigen-stimulation following HSV immunization increased $p21^{cip1}$ positive cells that co-expressed IFN-$\gamma$. Moreover, $p21^{cip1}$ was co-expressed with IFN-${\gamma}$ in E7 antigen-stimulated $CD8^+$ T cells, whereas $p27^{kip1}$ was not. Our findings imply a role of $p21^{cip1}$ proteins in antigen-induced effector $CD8^+$ T cells differentiation in vivo.

• Journal of Ocean Engineering and Technology
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• v.27 no.2
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• pp.39-46
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• 2013

In this study, the impact loads on tank walls by sloshing phenomena and on a tall structure in a three-dimensional rectangular tank were predicted using multiphase flow simulations. The solver was based on the CIP/CCUP (Constraint interpolation CIP/CIP combined unified procedure) method, and the THINC-WLIC (Tangent hyperbola for interface capturing-weighted line interface calculation) scheme was used to capture the air-water interface. For the convection terms of the Navier-Stokes equations, the USCIP (Unsplit semi-lagrangian CIP) method was adopted. The results of simulations were compared with those of experiments. Overall, the comparisons were reasonably good.

• Molecules and Cells
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• v.28 no.5
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• pp.489-494
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• 2009

We have previously shown that the down-regulation of protein kinase CKII activity is tightly associated with cellular senescence of human fibroblast IMR-90 cells. Here, we examined the roles of p53 and $p21^{Cip1/WAF1}$ in senescence development induced by CKII inhibition using wild-type, isogenic p53-/- and isogenic p21-/- HCT116 human colon cancer cell lines. A senescent marker appeared after staining for senescence-associated ${\beta}$-galactosidase activity in wild-type HCT116 cells treated with CKII inhibitor or $CKII{\alpha}$ siRNA, but this response was almost abolished in p53- or $p21^{Cip1/WAF1}$-null cells. Increased cellular levels of p53 and $p21^{Cip1/WAF1}$ protein occurred with the inhibition of CKII. CKII inhibition upregulated p53 and $p21^{Cip1/WAF1}$ expression at post-transcriptional level and transcription level, respectively. RB phosphorylation significantly decreased in cells treated with CKII inhibitor. Taken together, this study shows that the activation of the $p53-p21^{Cip1/WAF1}$ pathway acts as a major mediator of cellular senescence induced by CKII inhibition.

• Journal of Korean Society of Environmental Engineers
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• v.34 no.7
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• pp.473-479
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• 2012

Water reuse has been highlighted as a representative alternative to solve the lacking water resource. This study carried out a study on the pipe corrosion and water quality change which can occur through the supply of reclaimed water, using a simulated reclaimed water distribution pipeline. Galvanized steel pipe (GSP), cast iron pipe (CIP), stainless steel pipe (STSP) and PVC pipe (PVCP) were used for the pipe materials. Reclaimed water(RW) and tap water(TW) were respectively supplied into simulated reclaimed water distribution pipelines. As a result of performing a loop test to supply reclaimed water to simulated reclaimed water distribution pipelines, the weight reduction of pipe coupons showed the sequence of CIP > GSP > STSP ${\approx}$ PVCP. In addition, reclaimed water showed a high corrosion rate comparing to that of tap water. In case of CIP, the initial corrosion rate showed 3.511 mdd(milligrams per square decimeter per day) for reclaimed water and 2.064 mdd for tap water and the corrosion rate for 90 days showed 0.833 mdd for reclaimed water and 0.294 mdd for tap water. Also in case of GSP, the initial corrosion rate showed 2.703 mdd for reclaimed water and 2.499 mdd for tap water and the corrosion rate for 90 days showed 0.349 mdd for reclaimed water and 0.248 mdd for tap water, which was a tendency similar to that appeared in CIP with a tendency to reduce the corrosion rate. As a result of water quality changes of reclaimed water at pipe materials to carry out the loop test, there was higher conversion ratio of ammonia into nitrate in CIP and GSP with higher corrosion rate than that in STSP and PVCP where no corrosion has occurred. The highest denitrification rate of nitrate could be observed from CIP with the most particles generated from corrosion. In CIP, it could be confirmed that there was MIC (Microbiologically Induced Corrosion) as a result of EDS (Energy Dispersive X-ray spectrometer System) analysis results.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.21 no.12
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• pp.1132-1137
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• 2011

MRE(magneto-rheological elastomers) is a material which shows reversible and various modulus in magnetic field. Comparing to conventional rubber vibration isolator, MREs are able to absorb vibration of broader frequency range. These characteristic phenomena result from the orientation of magnetic particles named carbonyl iron powder(CIP) in rubber matrix. In this paper, simulation on variation rate of shear modulus for anisotropic MRE due to volume fraction of CIP and an effective permeability model was applied to predict the field-induced shear modulus of MREs. Also, the variation rate of shear modulus for anisotropic MRE was derived using magneto-mechanical theory. Based on Maxwell-Garnett mixing rule, the increment of shear modulus was calculated to evaluate the shear modulus of MREs with column structure of CIP due to induced current. The simulation results on variation rate of shear modulus can be applied to the variable mechanical system of MRE such as tunable vibration absorber, stiffness variable bush and mount.

• Journal of the Korea Convergence Society
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• v.6 no.6
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• pp.163-169
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• 2015

This study was intended to suggest a new-concept construction method of permanent basement wall combined with earth retaining wall by using PHC piles to overcome the disadvantages of conventional CIP methods or the like which have been used just for earth retaining walls during field construction, and to determine its applicability. PHC piles are characterized by the reliable quality attributed to prefabrication (shop fabrication) as well as superior concrete strength and prestressing steel strength to that of CIP in the aspect of materials, and also higher bending moment than that of CIP in the aspect of structure.

• BMB Reports
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• v.41 no.4
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• pp.305-309
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• 2008

Cobalt is an essential microelements in many biological processes involving enzymatic activity. We found that $Zn^{2+}$ and $Mg^{2+}$, which are in the active site of native calf intestine alkaline phosphatase (CIP), can be replaced by $Co^{2+}$ directly in solution. The effect of $Co^{2+}$ concentration on the substitution reaction was examined at ratios of [$Co^{2+}$]/[CIP] from 0:1 to 8:1. The quantity of $Zn^{2+}$ in CIP decreased progressively as the ratio was increased, but the amount of $Mg^{2+}$ changed in irrregular fashion. A series of active site models of the reaction mechanism of CIP are proposed. Low pH was found to promote the replacement of $Mg^{2+}$ by $Co^{2+}$. To understand how the substitution affects the enzyme, we also solved the secondary structure of CIP after reaction with $Co^{2+}$ in different conditions.

• Journal of computational fluids engineering
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• v.10 no.2
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• pp.7-14
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• 2005

In this study, the shallow water equations on the sphere is simulated by the proposed method which has high spatial resolution and is based on the CIP(Cubic Interpolated Pseudoparticle) method. The governing equations are approximated on the longitude-latitudinal coordinate system. To avoid the problems resulting from the convergence of the meridians toward high-latitude and singularities on the poles, the semi-Lagrangian and finite volume method are employed. in addition, the CIP method is employed to solve the advection equations and is extended to apply on the equations in the polar coordinate system. The mathematical formulation and numerical results are also described. To verify of the efficiency, accuracy and capability of proposed algorithm, the standard test cases proposed bv Williamson et. al are simulated and the results are compared with other results. As a result, it is found that the present scheme gives a good properties in preserving shapes of solution and settles the pole problems in solving the shallow water equations on the sphere.

• International Journal of Ocean System Engineering
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• v.1 no.3
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• pp.136-143
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• 2011

In this paper, three-dimensional free-surface flows are simulated by using two different numerical methods, the constrained interpolation profile (CIP)-based and finite volume (FV)-based methods. In the CIP-based method, the governing equations are solved on stationary staggered Cartesian grids by a finite difference method, and an immersed boundary technique is applied to deal with wave-body interactions. In the FV-based method, the governing equations are solved by applying collocated finite volume discretization, and body-fitted meshes are used. A free-surface boundary is considered as the interface of the multi-phase flow with air and water, and a volumeof-fluid (VOF) approach is applied to trace the free surface. Among many variations of the VOF-type method, the tangent of hyperbola for interface capturing (THINC) and the compressive interface capturing scheme for arbitrary meshes (CICSAM) techniques are used in the CIP-based method and FV-based method, respectively. Numerical simulations have been carried out for dam-breaking and wave-body interaction problems. The computational results of the two methods are compared with experimental data and their differences are observed.