• 디지털산업정보학회논문지
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• 제9권1호
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• pp.151-163
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• 2013

Recently the attention on digital hologram that is regarded as to be the final goal of the 3-dimensional video technology has been increased. Digital hologram is calculated by modeling the interference phenomenon between an object wave and a reference wave. The modeling for digital holograms is called by computer generated hologram (CGH) Generally, CGH requires a very large amount of calculation. So if holograms are generated in real time, high-speed method should be needed. In this paper, we analyzed CGH equation, optimized it for mapping general purpose graphic processing unit (GPGPU), and proposed a optimized CGH calculation technique for GPGPU by resource allocation and various experiments which include block size changing, memory selection, and hologram tiling. The implemented results showed that a digital hologram that has $1,024{\times}1,024$ resolution can be generated during approximately 24ms, using 1K point clouds. In the experiment, we used two GTX 580 GPGPU of nVidia Inc.

• 국제물리치료학회지
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• 제9권3호
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• pp.1564-1570
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• 2018

The International Headache Society (IHS) has validated cervicogenic headache (CGH) as a secondary headache type that is hypothesized to originate due to nociception in the cervical area. CGH is a common form of headache and accounts for 15% to 20% of all chronic and recurrent headaches. CGH is commonly treated with manual and exercise therapy. To date, no studies have isolated only one manual intervention in an attempt to determine its effectiveness. In this case study we present a 28-year-old patient with right upper cervical (UC) and occipital pain who responded well to a single manual intervention technique. This technique was applied in isolation for the first three visits and two therapeutic exercises prescribed on the fourth and fifth visit. In total, manual and exercise intervention occurred over 8 visits at which point in time the patient was discharged with no UC motion impairments, an NPRS rating of 0, a NDI and HDI demonstrating a 100% improvement and a 37% improvement in FOTO score. The traction based manual intervention and two therapeutic exercises prescribed for this patient were successful in relieving UC pain and CGH. At six months follow up, the patient was still symptom free.

• ETRI Journal
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• 제44권1호
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• pp.85-93
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• 2022

We propose an efficient method for synthesizing mesh-based realistic computer-generated hologram (CGH). In a previous nonanalytic mesh-based CGH synthesis, the angular spectrum of the two-dimensional (2D) plane is calculated using the fast Fourier transform (FFT) with the same size as the resolution of the final hologram. Because FFT increases the computation time as the size of the input matrix increases, the previous method has a problem: The higher the resolution of the hologram, the greater the computational load, thereby delaying synthesis time. In this study, when calculating the angular spectrum of the 2D plane in mesh-based CGH synthesis, we propose a method to calculate the angular spectrum by defining the 2D plane with an arbitrary size smaller than the resolution of the final hologram. The resolution adjustment method reduces the computation time and can be applied to occlusion culling and texturing for the realistic effect of mesh-based CGH. We describe the principle, error analysis, application of realistic effect, and experimental results of the proposed method.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송∙미디어공학회 2020년도 하계학술대회
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• pp.311-313
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• 2020

컴퓨터 생성 홀로그램(CGH)에서 시야각은 매우 중요한 특성이다. 시야각에 따라 홀로그램을 볼 수 있는 영역이 결정되며 시야각을 넘어가게 되면 재구성된 오브젝트가 잘려 보이게 된다. CGH의 최대 시야각은 회절 격자 방정식에 의해 결정이 되며, 해당 수식에 따르면 홀로그램 재생 장치인 공간 광 변조기(SLM)의 픽셀 피치에 반비례한다. SLM의 픽셀 피치를 줄이는 것은 어렵고 비용이 많이 들기 때문에 본 논문에서는 고해상도 랜덤 바이너리 위상 마스크를 SLM에 부착하여 CGH의 시야각을 확장하는 방법을 제안한다. CGH를 계산하는데 자주 사용되는 반복 푸리에 변환 알고리즘(IFTA)에 위상 평균화 단계를 도입하여 SLM과 위상 마스크간의 픽셀 크기 및 개수의 차이를 극복하였다. 또한 스칼라 회절 이론을 바탕으로 한 홀로그램 시뮬레이션에 제안한 방법을 적용 후 가상 눈 모델을 도입하여 두 개의 물체로 이루어진 홀로그램을 재구성하고 여러 각도에서 관찰하여 시야각이 향상되는것을 검증하였다.

• 한국미생물·생명공학회지
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• 제36권2호
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• pp.128-134
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• 2008

Erro-prone PCR에 의해서 열안정성이 향상된 Streptomyces coelicolor A(3) 유래의 L-threonine aldolase를 Corynebacterium glutamicum R에서 과잉발현시키기 위하여 Corynebacterium용 vector plasmid인 pCRB1의 SD배열과 개시코든사이의 1염기를 제거한 고발현용 vector plasmid인 pCG-H44(2)를 구축하였다. pCG-H (2)에 의해서 형질전환된 C. glutamicum R 균주(CGH44-2)에서 L-TA를 발현시킨 결과, 기존의 Corynebacterium용 vector plasmid인 pCRB1(CGH44-1)보다 L-TA의 발현량이 높았다. L-threo-DOPS의 합성을 위한 최적조건은 $30^{\circ}C$, 0.1 M cirtric acid buffer(pH 7.0)이었으며, 0.1% TritonX-100를 첨가하였을 경우 보다 높은 활성을 보였다. 최적조건하에서 CGH44-2를 whole cell biocatalyst로 이용한 반복회분식반응에서 재조합대장균을 숙주로 이용한 경우보다 재조합Corynebacterium을 이용하였을 경우, 목적하는 L-threo-DOPS의 합성이 안정적으로 이루어졌다.

• Preventive Nutrition and Food Science
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• 제17권3호
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• pp.223-227
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• 2012

This study examined the effects of corn gluten (CG), wheat gluten (WG), and soybean protein isolate (SPI), as well as their hydrolysates, on weight reduction in rats fed a high-fat diet. Eight-month-old male Sprague-Dawley rats (n=70) were fed a high-fat diet (40% of the calories were fat) for 4 weeks. Rats were then randomly divided into seven groups and were fed isocaloric diets with different protein sources for 8 weeks. The protein sources were casein (control group), intact CG (CG group), CG hydrolysate (CGH group), intact WG (WG group), WG hydrolysate (WGH group), intact SPI (SPI group), and SPI hydrolysate (SPIH group). Body weight gain, adipose tissue weights, lipid profiles in plasma and liver; and hepatic activities of carnitine palmitoyl transferase, fatty acid synthase (FAS), malic enzyme, and glucose-6-phosphate dehydrogenase were assessed. The CGH group showed significant weight reduction compared with the other groups. Epididymal fat pad and plasma triglycerides in the CGH group were the lowest and were significantly different than those in the control group. FAS activity in the CGH group was significantly lower than that in the other groups. In conclusion, the CGH diet of these experimental animals demonstrated a weight-reducing effect by lowering the adipose tissue weight and by affecting the activities of hepatic lipogenic enzymes.

• Journal of Genetic Medicine
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• 제2권2호
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• pp.71-77
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• 1998

Comparative genomic hybridization (CGH) can now be applied to detect the origin of extra or missing chromosomal material in cases with common unbalanced aberrations and in prenatal investigations. This method has been used in 13 cases of fetal samples for this study; 3 for amniocytes, 2 for cord blood and 8 for abortus tissues. These samples were previously subjected to GTG-banding. Our study showed aneuploidy in 8 cases, and partial monosomy, partial trisomy or marker chromosome in the remaining 5. The CGH disclosed further small genetic imbalances in 4 of all 13 cases: a prenatal sample showing del(20)(q13) by GTG confirmed a loss of the segment 20p13-pter by CGH; a marker chromosome manifested normal CGH profile; chromosome der(?)(?;15) found in an abortus sample by GTG turned out to be a loss of 15pter-q14 (partial monosomy) and a gain of 10pter-q22 (partial trisomy); the der(15) shown by GTG represented partial trisomy of 3q24-qter. These findings show that CGH is very useful and efficient for cytogenetic investigations of clinical cases.

• 방송공학회논문지
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• 제16권3호
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• pp.403-415
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• 2011

본 논문에서는 고속으로 디지털 홀로그램을 생성할 수 있는 하드웨어구조를 제안하였다. 수정된 컴퓨터 생성 홀로그램(computer-generated hologram, CGH) 알고리즘을 이용하고, 기존의 한 화소에 대한 홀로그램 전체 화소를 연산하는 방법이 아니라 객체 전체 화소에서 홀로그램의 한 화소씩 연산하는 방법을 선택하여 홀로그램 한 화소씩 계산하고 바로 출력 하여 메모리 병목 현상을 제거하기 위한 파이프라인 기반의 하드웨어 구조를 제안하였다. CGH 알고리즘을 바탕으로 입력부, 연산부, 및 정규화부로 구성된 디지털 홀로그램 생성기의 구조를 제안하였고, 이를 효율적인 하드웨어로 구현하였다. 객체의 화소만 저장하여 반복 사용하기 때문에 메모리의 사용량을 줄일 수 있었다. 제안한 하드웨어는 세로 방향으로 확장을 하여 동작을 병렬화시킬 수 있다. 제안한 하드웨어는 1K의 광원에 대해 HD급 홀로그램을 초당 약 87장을 생성할 수 있었다.

• Journal of Chest Surgery
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• 제44권2호
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• pp.123-130
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• 2011

Background: The aim of the present study was to identify chromosomal loci that contribute to the pathogenesis of aortic dissection (AD) in a Korean population using array comparative genomic hybridization (CGH) and to confirm the results using real-time polymerase chain reaction (PCR). Materials and Methods: Eighteen patients with ADs were enrolled in this study. Genomic DNA was extracted from individual blood samples, and array CGH analyses were performed. Four corresponding genes with obvious genomic changes were analyzed using real-time PCR in order to assess the level of genomic imbalance identified by array CGH. Results: Genomic gains were most frequently detected at 8q24.3 (56%), followed by regions 7q35, 11q12.2, and 15q25.2 (50%). Genomic losses were most frequently observed at 4q35.2 (56%). Real-time PCR confirmed the results of the array CGH studies of the COL6A2, DGCR14, PCSK6, and SDHA genes. Conclusion: This is the first study to identify candidate regions by array CGH in patients with ADs. The identification of genes that may predispose an individual to AD may lead to a better understanding of the mechanism of AD formation. Further multicenter studies comparing cohorts of patients of different ethnicities are warranted.

• 대한두경부종양학회지
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• 제24권2호
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• pp.155-161
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• 2008

Head and neck squamous cell carcinoma(HNSCC) still has poor outcome, and laryngeal cancer is the most frequent subtype of HNSCC. Therefore, there is a need to develop novel treatments to improve the outcome of patients with HNSCC. It is critical to gain further understanding on the molecular and chromosomal alteration of HNSCC to identify novel therapeutic targets but genetic etiology of squamous cell carcinoma of the larynx is so complex that target genes have not yet been clearly identified. Array based CGH(array-CGH) allows investigation of general changes in target oncogenes and tumor suppressor genes, which should, in turn, lead to a better understanding of the cancer process. In this study, We used genomic wide array-CGH in tissue specimens to map genomic alterations found in laryngeal squamous cell carcinomas. As results, gains of MAP2, EPHA3, EVI1, LOC389174, NAALADL2, USP47, CTDP1, MASP1, AHRR, and KCNQ5, with losses of SRRM1L, ANKRD19, FLJ39303, ZNF141, DSCAM, GPR27, PROK2, ARPP-21, and B3GAT1 were observed frequently in laryngeal squamous cell carcinoma tissue specimens. These data about the patterns of genomic alterations could be a basic step for understanding more detailed genetic events in the carcinogenesis and also provide information for diagnosis and treatment in laryngeal squamous cell carcinoma. The high resolution of array-CGH combined with human genome database would give a chance to find out possible target genes which were gained or lost clones.