• YAKHAK HOEJI
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• v.38 no.2
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• pp.140-148
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• 1994

${\beta}-Lactamase$ stability, chemotherapeutic activity, and pharmacokinetics of 7-[(Z)-2-(2-aminothiazole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyridyl)piperazinyl]thiocarbonylthiomethyl-3-cephem-4-carboxylic acid(CEN1), 7-[(Z)-2-(2-aminothiazole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyrimidyl)piperazinyl]thiocarbonylthiomethyl-3-cephem-4-carboxylic acid(CEN2), pivaloyloxymethyl-7-[(Z)-2-(2-aminothizaole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyridyl)piperazinyl]thiocarbonyl-thiomethyl-3-cephem-4-carboxylate(CEN1P), and pivaloyloxymethyl-7-{(Z)--2-(2-aminothizaole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyridyl)piperazinyl]thiocarbonyl-thiomethyl-3-cephem-4-carboxylate(CEN2P) were examined. CEN1, CEN2, CEN1P, and CEN2P were very stable to the ${\beta}-lactamase$ obtained from three strains(Enterobacter cloacae P99, Escherichia coli TEM, and Citrobacter freundii). Chemotherapeutic activities$(ED_{50})$ of CEN2 and CEN2P against experimental systemic infections due to Streptococcus pyogenes 77A and Escherichia coli 078 were superior to those of CEN1 and CEN1P, respectively. The $ED_{50}$ values of CEN1, CEN2 were 5.82 mg/kg, 0.89 mg/kg(s.c., S. pyogenes 77A) while those of CEN1P, CEN2P were 14.56mg/kg, 6.40mg/kg(p.o., S. pyogenes 77A), respectively. The pharmacokinetics of CEN1, CEN2, CEN1P, and CEN2P were investigated in mice and rats. In mice, peak blood levels of $1.25\;{\mu}g/ml$ were recorded within 20 min after oral administration of a single dose equivalent to 40 mg/kg CEN1P. Cmax of CEN1P was much higher than that of CEN1 in mice and rats. Oral absorption of CEN2P was much higher than that of CEN2.

• YAKHAK HOEJI
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• v.38 no.2
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• pp.123-130
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• 1994

Physicochemical properties and hydrolysis kinetics of new some oral cephalosporins were examined in buttered solution and human plasma or rat liver homogenate. The test cephalosporins were 7-[(Z)-2-(2-aminothiazole-4-yl)-2- methoxyiminoacetamido]-3-[4-(2-pyridyl)piperazinyl] thiocarbonylthhiomethyl-3-cephem-4-carboxylic acid (CEN1), 7-[(Z)-2-(2-aminoth iazole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyrimidyl)piperazinyl]th iocarbonylthiomethyl-3-cephem-4-carboxylic acid (CEN2), pivaloyloxymethyl-7-[ (Z)-2-(2-aminothiazole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyridyl)piperazi nyl]thiocarbonylthiomethy1-3-cephem-4-carboxylate (CEN1P), and pivaloyloxymethyl-7-[(Z)-2-(2-aminothiazole-4-yl)-2-methoxyiminoacetamido]-3-[ 4-(2-pyrimidyl)piperazinyl]thiocarbonyl-thiomethyl-3-cephem-4-carboxylate (CEN2P). The partition coefficient(Ko/w) of CEN1P, CEN2P were higher than those of CEN1, CEN2. The calculated pKa values of CEN1, CEN2, CEN1P, and CEN2P were 7.09, 7.75, 4.92, and 5.39, respectively. The hydrolysis of CEN1P and CEN2P were not depend on the composition of pH of the test medium except weak alkaline buffered solution (pH 8.00). CEN1 and CEN2 were very stable in pH 6.80 and 8.00 buffer solutions. CEN1P and CEN2P were rapidly deesterified to CEN1 and CEN2 in human plasma and in rat liver homogenate. Half-lives$(t_{1/2})$ of CEN1 and CEN2 were 3.49 and 4.93 hr in human plasma, 1.47 and 1.26 hr in rat liver homogenate, respectively.

• YAKHAK HOEJI
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• v.37 no.3
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• pp.295-305
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• 1993

In order to develop oral cephalosporin having a new substituent at 3 position, the synthesis of cephalosporins modified at C-3 and the effect of the substituents on the oral absorption is studied. 7-[(Z)-2-(2-Aminothiazole- 4-yl)-2-methoxyiminoacetamidol-3-[4-(2-pyridyl )piperazinyl] thiocarbonylthiomethyl-3-cephem-4-carboxylic acid (CEN1) and 7-[(Z)-2-(2-aminothiazole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyrimid yl)piperazinylthiocarbonylthiomethyl-3-cephem-4-carboxylic acid (CEN2) were synthesized from 4-(2-piridyl)piperazinyl dithiocarbamate potassium salt or 4-(2-pirimidyl)piperazinyl dithiocarbamate potassium salt and cefotaxime. Also pivaloyloxymethyl esters of CEN1 and CEN2, pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyridyl )piperazinyllthiocarbonylthiomethyl-3-cephem-4-carboxylate (CENIP) and pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazole-4-yl)-2-methoxyiminoacetamidol-3- [4-(2-pyrimid yl)piperazinyllthiocarbonylthiomethyl-3-cephem-4-carboxylate (CEN2P) were synthesized. The in vitro activities of two new oral cephalosporins, CEN1 and CEN2, were compared with the in vitro activities of cefaclor and cefotaxime against a variety of bacterial species. CEN2 has a broad antibacterial spectrum covering Gram-positive and Gram-negative bacteria, similar to that exhibited by CEN1 and cefotaxime. CEN1 and CEN2 were more active in vitro than cefaclor against Streptococcus pyogenes, Klebsiella aerogenes and Enterobacter cloacae.

• Journal of the Korean Institute of Intelligent Systems
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• v.7 no.1
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• pp.34-44
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• 1997

The Belgian Nuclear Research Centre(SCK${\cdot}$CEN) has been a pioneer of the peaceful uses of nuclear energy after over forty years of existence. Recently, SCK${\cdot}$CEN's financial support of doctoral and postdoctoral research in close collaboration with universities has been a vital ingredient for securing a quality profile committed to the pursuit of execllence. FLINS, Fuzzy Logic and Intelligent technologies in Nuclear Science, was initially built within one of the postdoctoral research project at SCK${\cdot}$CEN. Among SCK${\cdot}$CEN's activities which will have an important impact on its scientific future, the application of fuzzy logic and intelligent technologies in nuclear science and engineering opens new domains in radiation protection, safety assessment, human reliability, nuclear reactor control, waste and disposal, etc. In this paper, we review the available literature on fuzzy logic in nuclear applications. We then present the initiative of R&D on fuzzy logic applications at SCK${\cdot}$CEN, namely, (1) safety control for a nuclear reactor, and (2) a safety evaluation model for nuclear transmission lines. By these two examples of nuclear applications, we illustrate the potential use of fuzzy logic in nuclear safety issues.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1993.06a
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• pp.1066-1069
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• 1993

The presence of older installations, in particular nuclear facilities, demands extra studies concerning the safety evaluation of those installations. One of the aspects to deal with is the safety of the several transmission lines in a nuclear installation, for instance the safety of control, safety against fire, etc.. . This paper investigates the use of fuzzy set theory in the inspection of transmission lines of nuclear installations at SCK/CEN, Belgium.

• The Bulletin of The Korean Astronomical Society
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• v.32 no.1
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• pp.92.2-92.2
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• 2007

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.1768-1773
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• 2010

CEN/TS 45545 is Europe consolidation standard for fire safety on railway behicles. This is based on the International Union of Railways(UIC) and different European countries. It is intended to protect passengers and staff in railway in the event of a fire on board. It will be prepared in 2012. Based on this consolidate standard, they are going to make single market, for raising technical competitiveness, technical innovation and globalization of that standard. For this reason, European academies, manufacturers, and sub-manufacturers confer and stady animated about CEN/TS 45545. In Korea, get out the safety assessment for ues incombustible interior material, the needs of quantitative analysis on fire protection, demand on recognition of fire protection scenario, and define about fire load analysis are becomin more and more important. Therefore, this paper will estimate and compare Flammability, Smoke Density, Toxicity Index( this is the key point for appraised fire safety performance of material) between CEN/TS45545 and fire standards on railway vehicle. Then suggest criteria for fire safety on railway vehicles.

• Electronics and Telecommunications Trends
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• v.11 no.4 s.42
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• pp.181-189
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• 1996

유럽은 역내 국가간의 정보통신 제품에 대한 기술장벽 제거를 통한 무역교류 확대를 위해, 유럽표준화위원회인 CEN(Comite European de Normalisation)과 유럽 정보통신 시험인증 위원회인 ECITC(European Committee for IT&T Testing and Certification)와의 협력관계하에 "CEN-ECITC Project Team 1"을 만들어 유럽의 체계적인 정보통신표준의 시험인증제도 정립을 위해 많은 노력을 해왔다. 본 고는 이 "CEN-ECITC Project Team 1"의 시험인증제도 정립에 대한 활동결과를 분석한 것이다.

• Nuclear industry
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• v.18 no.7 s.185
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• pp.55-59
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• 1998

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.54.2-54.2
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• 2010

The most massive galactic globular cluster, $\omega$ Cen has been observed using recently mounted WFC3/UVIS cameras of Hubble Space Telescope at both near-UV and optical bands. We present the photometry of stars in the central region of $\omega$ Cen in F225W, F275W and F336W bands. The near-UV color-magnitude diagrams and color-color diagrams of stars in $\omega$ Cen show multiple red giant branches and main sequences as already discovered in both ground-based and HST/ACS observations in the optical bands. We modelled the stellar populations of $\omega$ Cen using Yonsei Isochrone, where $\alpha$-particles and helium enhancement processes have been included properly. We compare the best-fit stellar populations obtained from the current near-UV observations to the suggested stellar population models based on optical band data. We also discuss the methodological issues arising when dealing with the near-UV observations; red-leak in near-UV filters and the huge interstellar extinction in near-UV bands compared to the optical bands and its non-linear effect in color-magnitude diagrams.