• Title/Summary/Keyword: CD81

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Pallidal Deep Brain Stimulation in Primary Cervical Dystonia with Phasic Type : Clinical Outcome and Postoperative Course

  • Jeong, Seong-Gyu;Lee, Myung-Ki;Kang, Ju-Young;Jun, Sung-Man;Lee, Won-Ho;Ghang, Chang-Ghu
    • Journal of Korean Neurosurgical Society
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    • v.46 no.4
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    • pp.346-350
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    • 2009
  • Objective : The purpose of this study was to analyze in detail the relationship between outcome and time course of effect in medically refractory primary cervical dystonia (CD) with phasic type that was treated by bilateral globus pallidus internus (Gpi) deep brain stimulation (DBS). Methods : Six patients underwent bilateral implantation of DBS into the Gpi under the guide of microelectrode recording and were followed for $18.7{\pm}11.1$ months. The mean duration of the CD was $5.8{\pm}3.4$ years. The mean age at time of surgery was $54.2{\pm}10.2$ years. Patients were evaluated with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and relief scale using patient self-reporting. Results : The TWSTRS total scores improved by 64.5%, 65.5%, 75.8%, and 76.0% at 3, 6, 12 months, and at the last available follow-up after surgery, respectively. Statistically significant improvements in the TWSTRS scores were observed 3 months after surgery (p=0.028) with gradual improvement up to 12 months after surgery, thereafter, the improvement was sustained. However, there was no statistically significant difference between the scores at 3 and 12 months. Subjective improvement reported averaged $81.7{\pm}6.8%$ at last follow-up. Mild dysarthria, the most frequent adverse event, occurred in 3 patients. Conclusions : Our results show that the bilateral Gpi-DBS can offer a significant therapeutic effect from 3 months postoperatively in patients with primary CD with phasic type, without significant side effects.

The Removal Rates of the Constituents of Litters in the Littoral Grassland Ecosystems in the Lake Paldangho Ⅶ.Cadmium and Lead (팔당호 연안대 초지생태계에서 낙엽 구성성분의 유실률 Ⅶ.카드뮴과 납)

  • 최선영;이인숙;장남기
    • Asian Journal of Turfgrass Science
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    • v.10 no.4
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    • pp.305-313
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    • 1996
  • This study was carried out to investigate the removal rates of Cd and Pb of the litters in the Phragmites communis. Miscanthus sacchariflorus, Typha angustata, Scirpus tabernaemontani grassland aquatic ecosystem in the lake Paldangho. The annual production of Cd and Pb were 0.005g /$m^2$ , 0.21g /$m^2$in P. commumis, 0.004g /$m^2$, O.08g /$m^2$ in M. sacchariflorus, 0.023g /$m^2$, 0.42g /$m^2$ in T. angustata and 0.020g /$m^2$, 0.23g /$m^2$ in S. tabernaemontani respectively. The removal rates of Cd and Pb of the litters were 0.83, 0.85 in P. communis. 0.36, 0.54 in M. sacchariflorus, 0.61, 0.51 in T. angustata and 0.76, 0.71 in S. tabernaemontani, respectively. The times required to decay 50, 95, 99 percent of the steady state level and turnover values of cadmium on the grassland floor were 0.83, 3,60, 6.00 years in P. communis. 1.90, 8.24, 13.74 years in M.sacchariflorus, 1.15, 4.96, 8.27 years in T. angustata and 0.91, 3.95, 6.58 years in S. tabernaemontani The times required to decay 50, 95, 99 percent of the steady state level and turnover values of lead on the grassland floor were 0.81, 3.51, 5.86 years in P. communis. 1.28, 5.56, 9.26 years in M. sacchariflorus, 1.37, 5.94, 9.90 years in T. angustata and 0.97, 4.21, 7.02 years in S. tabernaemontani. Key words: Removal rate, Accumulation, Paldangho, Cadmium, Lead, Phragmites communis Miseanthus sacchariflorus, Typha angustata, Scirpus tabernaemontani.

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Heavy Metal Uptake by Balloon Flower Together with Investigating Soil Properties and Heavy Metal Concentrations in the Cultivated Soils

  • Bae, Jun-Sik;Seo, Byoung-Hwan;Lee, Sin-Woo;Kim, Won-Il;Kim, Kwon-Rae
    • Korean Journal of Soil Science and Fertilizer
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    • v.47 no.3
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    • pp.172-178
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    • 2014
  • Soil properties and heavy metal (HM) concentrations in the field soils where balloon flowers (Platycodon grandiflorum, BF) were cultivated, were investigated together with HM (Cd, Cu, Pb, and Zn) accumulation by the BF roots. Basically, in most soils examined (51-97% among 65 samples), the chemical properties including soil pH, organic matter, available-P, and exchangeable cation contents appeared to be lower than the optimal ranges for balloon flower cultivation. There were no samples exceeding the standard limits for HM in soils. Instead, the total HM concentration levels in soils appeared to be maintained at around background levels for general soil in Korea. This implied that elevated HM accumulation in the soils caused by any possible input sources was unlikely. Even though the BF cultivated soils were not contaminated by HM, it was appeared that substantial amount of Cd was accumulated in BF roots with 1.5% and 35% roots samples exceeding the standard limits legislated for BF root ($0.81mg\;kg^{-1}DW$) and herbal plants ($0.3mg\;kg^{-1}DW$), respectively. This implied that the soil HM standard limits based on the total concentration does not reflect well the metal accumulation by plants and also it is likely that the Cd standard limits for BF and herbal plants is too restrict.

Effects of Lime, Fly Ash & Rice Straw Ash on Cadmium and head Translocation from Soil to Radish (석회, Fly Ash 및 볏짚재가 토양에서 무우로 이행 축적되는 카드뮴과 납의 함량 감소에 미치는 영향)

  • 한돈희
    • Journal of Environmental Science International
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    • v.1 no.1
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    • pp.97-126
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    • 1992
  • Greenhouse pot experiments were conducted to evaluate the effects of lime, fly ash and ash(from rice straw) on the cadmium and lead translocation from soil to radish. The soils with low metal contents(Cd 1.52 ppd and Pb 25.37ppm) were prepared and high metal contents (Cd 8.99 rpm and Pb 50.81ppm) were prepared and amended with 0.25%, 0.5%, 1.095, 2.055 each of lime, fly ash and ash. Radishes(Raphanus satiuus) were cultivated and cropped on the soils during 25, 50 and 75 days after sprout, and then cadmium and lead contents of radishes were analyzed by roots and tops. The results obtained are as follows. 1. Lime and ash were effective in raising the soil pH, but fly ash was not effective. 2. The growth of radishes were not impaired by the cadmium and lead contamination but, impaired by soil pH 7.5 or more. 3. Cadmium was accumulated very strongly in radishes and the greater concentration was found in tops than roots, but lead showed no evidence of accumulation in radishes. 4. In general, when the concentrations of lime and ash in soils increased, the uptake of cadmium and lead by radishes decreased, and lime was more effective than ash, while fly ash revealed no effect of reducing the translocation of cadmium and lead from soils to radishes. 5. The uptake of cadmium by radishes decreased more effectively than lead and the uptake of Cd or Pb by radishes grown in the soils with high metal contents decreased more effectively than low metal con tents. 6. Cadmium and lead contents of radishes were negatively correlated with soil pH values and the relationship in cadmium content was stronger than that in lead content.

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Development of an efficient method of radiation characteristic analysis using a portable simultaneous measurement system for neutron and gamma-ray

  • Jin, Dong-Sik;Hong, Yong-Ho;Kim, Hui-Gyeong;Kwak, Sang-Soo;Lee, Jae-Geun;Jung, Young-Suk
    • Analytical Science and Technology
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    • v.35 no.2
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    • pp.69-81
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    • 2022
  • The method of measuring and classifying the energy category of neutrons directly using raw data acquired through a CZT detector is not satisfactory, in terms of accuracy and efficiency, because of its poor energy resolution and low measurement efficiency. Moreover, this method of measuring and analyzing the characteristics of low-energy or low-activity gamma-ray sources might be not accurate and efficient in the case of neutrons because of various factors, such as the noise of the CZT detector itself and the influence of environmental radiation. We have therefore developed an efficient method of analyzing radiation characteristics using a neutron and gamma-ray analysis algorithm for the rapid and clear identification of the type, energy, and radioactivity of gamma-ray sources as well as the detection and classification of the energy category (fast or thermal neutrons) of neutron sources, employing raw data acquired through a CZT detector. The neutron analysis algorithm is based on the fact that in the energy-spectrum channel of 558.6 keV emitted in the nuclear reaction 113Cd + 1n → 114Cd + in the CZT detector, there is a notable difference in detection information between a CZT detector without a PE modulator and a CZT detector with a PE modulator, but there is no significant difference between the two detectors in other energy-spectrum channels. In addition, the gamma-ray analysis algorithm uses the difference in the detection information of the CZT detector between the unique characteristic energy-spectrum channel of a gamma-ray source and other channels. This efficient method of analyzing radiation characteristics is expected to be useful for the rapid radiation detection and accurate information collection on radiation sources, which are required to minimize radiation damage and manage accidents in national disaster situations, such as large-scale radioactivity leak accidents at nuclear power plants or nuclear material handling facilities.

3D Point Cloud Reconstruction Technique from 2D Image Using Efficient Feature Map Extraction Network (효율적인 feature map 추출 네트워크를 이용한 2D 이미지에서의 3D 포인트 클라우드 재구축 기법)

  • Kim, Jeong-Yoon;Lee, Seung-Ho
    • Journal of IKEEE
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    • v.26 no.3
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    • pp.408-415
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    • 2022
  • In this paper, we propose a 3D point cloud reconstruction technique from 2D images using efficient feature map extraction network. The originality of the method proposed in this paper is as follows. First, we use a new feature map extraction network that is about 27% efficient than existing techniques in terms of memory. The proposed network does not reduce the size to the middle of the deep learning network, so important information required for 3D point cloud reconstruction is not lost. We solved the memory increase problem caused by the non-reduced image size by reducing the number of channels and by efficiently configuring the deep learning network to be shallow. Second, by preserving the high-resolution features of the 2D image, the accuracy can be further improved than that of the conventional technique. The feature map extracted from the non-reduced image contains more detailed information than the existing method, which can further improve the reconstruction accuracy of the 3D point cloud. Third, we use a divergence loss that does not require shooting information. The fact that not only the 2D image but also the shooting angle is required for learning, the dataset must contain detailed information and it is a disadvantage that makes it difficult to construct the dataset. In this paper, the accuracy of the reconstruction of the 3D point cloud can be increased by increasing the diversity of information through randomness without additional shooting information. In order to objectively evaluate the performance of the proposed method, using the ShapeNet dataset and using the same method as in the comparative papers, the CD value of the method proposed in this paper is 5.87, the EMD value is 5.81, and the FLOPs value is 2.9G. It was calculated. On the other hand, the lower the CD and EMD values, the better the accuracy of the reconstructed 3D point cloud approaches the original. In addition, the lower the number of FLOPs, the less memory is required for the deep learning network. Therefore, the CD, EMD, and FLOPs performance evaluation results of the proposed method showed about 27% improvement in memory and 6.3% in terms of accuracy compared to the methods in other papers, demonstrating objective performance.

Quantifying the Interactive Inhibitory Effect of Heavy Metals on the Growth and Phosphorus Removal of Pseudomonas taeanensis

  • Yoo, Jin;Kim, Deok-Hyun;Oh, Eun-Ji;Chung, Keun-Yook
    • Korean Journal of Soil Science and Fertilizer
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    • v.51 no.1
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    • pp.35-49
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    • 2018
  • This study was initiated to quantitatively evaluate the effects of five heavy metals (Cd, Cu, Zn, Pb, and Ni) on growth and P removal efficiencies of Pseudomonastaeanensis, known as the phosphorus accumulating microorganism. The heavy metals were added individually and with the binary mixture to the batch culturing system of Pseudomonastaeanensis. $IC_{50}$ and $EC_{50}$ were used to quantitatively evaluate their effects on the growth and phosphorus removal efficiency of Pseudomonas taeanensis in those treatments. Additionally, additive index value method was used to evaluate the interactive effects of heavy metals for Pseudomonas taeanensis in this study. As those heavy metals were singly added to Pseudomonastaeanensis, the greatest inhibitory effect on its growth and P removal efficiency was observed in Cd, whereas, the smallest effect was found in Ni. As the concentrations of all heavy metals added were gradually increased, its growth and P removal efficiency was correspondingly decreased. Specifically, $IC_{50}$ of Pseudomonas taeanensis for Cd, Cu, Zn, Pb, and Ni were $0.44mg\;L^{-1}$, $5.12mg\;L^{-1}$, $7.46mg\;L^{-1}$, $8.37mg\;L^{-1}$ and $14.56mg\;L^{-1}$, respectively. The P removal efficiency of Pseudomonas taeanensis was 81.1%. $EC_{50}$ values of Pseudomonas taeanensis for Cd, Cu, Zn, Pb, and Ni were $0.44mg\;L^{-1}$, $4.08mg\;L^{-1}$, $7.17mg\;L^{-1}$, $8.90mg\;L^{-1}$ and $11.26mg\;L^{-1}$, respectively. In the binary treatments of heavy metals, the lowest $IC_{50}$ and $EC_{50}$ were found in the Cd + Cu treatment, whereas, the highest $IC_{50}$ and $EC_{50}$ were found in the Zn + Pb and Pb + Ni treatments, respectively. Most of the interactive effects for the binary mixture treatments of heavy metals were antagonistic. Based on the results obtained from this study, it appears that they could provide the basic information about the toxic effects of the respective individual and binary treatments of heavy metals on the growth and P removal efficiency of other phosphorus accumulating organisms.

Korean research project on the integrated exposure assessment of hazardous substances for food safety

  • Lim, Ji-Ae;Kwon, Ho-Jang;Ha, Mina;Kim, Ho;Oh, Se Young;Kim, Jeong Seon;Lee, Sang-Ah;Park, Jung-Duck;Hong, Young-Seoub;Sohn, Seok-Joon;Pyo, Heesoo;Park, Kyung Su;Lee, Kwang-Geun;Kim, Yong Dae;Jun, Sangil;Hwang, Myung Sil
    • Environmental Analysis Health and Toxicology
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    • v.30
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    • pp.4.1-4.11
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    • 2015
  • Objectives: This survey was designed to conduct the first nationwide dietary exposure assessment on hazardous substances including the intakes of functional food and herbal medicine. In this paper, we introduced the survey design and the results of the dietary exposure status and internal exposure levels of lead (Pb), cadmium (Cd), and mercury (Hg). Methods: We selected 4867 subjects of all ages throughout Korea. We conducted a food survey, dietary survey, biomonitoring, and health survey. Results: Pb and Cd were the highest (median value) in the seaweed ($94.2{\mu}g/kg$ for Pb; $594{\mu}g/kg$ for Cd), and Hg was the highest in the fish ($46.4{\mu}g/kg$). The dietary exposure level (median value) of Pb was $0.14{\mu}g/kg$ body weight (bw)/d, $0.18{\mu}g/kg$ bw/d for Cd, and $0.07{\mu}g/kg$ bw/d for Hg. Those with a blood Pb level of less than $5.00{\mu}g/dL$ (US Centers for Disease Control and Prevention, reference value for those 1 to 5 years of age) were 99.0% of all the subjects. Those with a blood Cd level with less than $0.30{\mu}g/L$ (German Federal Environmental Agency, reference value for non-smoking children) were 24.5%. For those with a blood Hg level with less than $5.00{\mu}g/L$ (human biomonitoring I, references value for children and adults, German Federal Environmental Agency) was 81.0 % of all the subjects. Conclusions: The main dietary exposure of heavy metals occurs through food consumed in a large quantity and high frequency. The blood Hg level and dietary exposure level of Hg were both higher than those in the European Union.

Effects of Saururus Chinensis Baill Extracts on Anticancer Activity and Cadmium Induced Cytotoxicity (삼백초 추출물의 항암활성과 카드뮴에 대한 독성억제효과)

  • Park Seung-Joung;Yoo Hyun-Ju;Choi Hee-Seok;Seo Byeong-Yun;Yang Seon-Ho;Kim Yeong-Hun;Jeong Jae-Yeal;Lee Ki-Nam
    • Journal of Society of Preventive Korean Medicine
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    • v.8 no.2
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    • pp.81-98
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    • 2004
  • 1. The cell viability was determined by MTT method. Their cytotoxic activities against three cancer cell lines such as A549, MDA-MB-231 and SNU-C4 cell line were tested. Among them, The methanol extract of Saururus chinensis Baill. showed the strongest cytotoxic effect against SNU-C4 cells. These results suggest that the methanol extract of Saururus Chinensis Baill. possessed a potential antitumorous agent. 2. In vitro the antitoxic activity of ethanol extract of Saururus Chinensis Bail on NIH 3T3 fibroblasts was evaluate by the MTT (3-(4,5-dimethyl- thiazol-2-yl)-2,5-diphenyl-2H-tetra캐lium bromide) and SRB (sulforhodamine B protein) assays. The number of NIH 3T3 fibroblasts were increased and tend to regenerate. These results suggest that Saururus Chinensis Bail extract retains a potential antitoxic activity. 3. Complexation of Cd (II) ion with ligands such as quercetin has been determined by UV-vis spectrophotometric method in tris buffer solution at various pH. It was found that only 1 : 1 Cd-complex is formed by the interaction between catechol moiety in ring B and cadmium [Cd(II)] in aqueous solution. The spectral parameters for Cd-complex were determined by Beer's law at various pH. It has shown that 1 : 1 Cd-complex has a maximum absorbance and red shift by the alkaline pH.

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Effect of Cassia tora L. Powder Added-Diets on the Accumulation of Cadmium in Rat (결명자 첨가식이가 흰쥐의 체내 카드뮴 축적에 미치는 영향)

  • 김성조;백승화;허종욱;김운성;이주돈;강경원;박성혜;한종현;정성윤
    • Journal of the East Asian Society of Dietary Life
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    • v.12 no.6
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    • pp.554-565
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    • 2002
  • The purpose of this study is to investigate the effect of raw Cassia tora L. powder added-diets on reducing cadmium accumulation in rats. The experimental animals were Sprague-Dawley family(♂, 4 weeks) which was classified into normal group CN, compared group CS, Cd-added group Cl and groups C2, C3, C4 in which 0.5, 1.0 and 1.5% of the Cassia tora L. powder are added, respectively. The growth rate and food efficiency ratio, and the amounts of accumulated cadmium in rats for S weeks were measured and analyzed. The results are as follows; 1. The rates of weight gain decreased in the order of C3>C2>C4>Cn>Cs>Cl groups, and Cl group to which only cadmium water had been fed was the lowest among them. The correlation between groups Cl and C3 was significantly different at the 1% level. 2. Food efficiency ratio(FER) decreased in the order of C3>C2>Cs>Cn>C4>Cl, and the FERs of C3, C2, CS, CN and C4 are greater than that of Cl by 22.87, 19.59, 18.54, 14.20 and 13.17%, respectively. 3. As for the Cassia tora L. powder-added groups, the amounts of cadmium accumulated in organs and tissues, that is, the brain, heart, spleen, liver, lungs, testicles. kidney, femoral muscle and leg bones were 0.45 $\pm$ 0.04 to 0.83$\pm$0.04, 1.68$\pm$0.02 to 2.16$\pm$0.02, 3.26$\pm$0.05 to 4.62$\pm$0.27, 37.52$\pm$0.09 to 47.71$\pm$0.73, 1.07$\pm$0.10 to 1.66$\pm$0.04, 1.04$\pm$0.06 to 1.24$\pm$0.08, 36.79$\pm$0.20 to 39.61 $\pm$0.53, 0.87$\pm$0.02 to 1.00$\pm$0.02 and 0.65$\pm$0.17 to 1.27 $\pm$ 0.06 $\mu\textrm{g}$/g, respectively. 4. The accumulated Cd content for C4 was the lowest among Cassia tora L. powder-added groups. When the results for C4 are compared with those for Cl, it is observed that each cadmium content accumulated in the brain, heart spleen, liver, lungs, testicles, kidney. femoral muscle and leg bones is dropped by 49.03, 22.56, 36.02, 35.75, 41.75, 36.20, 37.00, 22.77 and 56.67 %, respectively. On the other hand. the accumulated Cd content increased in the order of brain

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