• Natural Product Sciences
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• v.13 no.1
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• pp.61-67
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• 2007

The ethanolic extract of Bacopa monnieri Linn. aerial parts were studied far its hepatoprotective effect on $CCl_4-induced$ hepatotoxic rats. The extract was found to decrease significantly $CCl_4-induced$ elevation of SGOT, SGPT, ALP, bilirubin and total cholesterol. But, it increased HDL-cholesterol level and liver weight with respect to $CCl_4$ toxic rats. The extract was also found to decrease significantly the $CCl_4-induced$ elevation of lipid peroxidation and increase the activity of antioxidant enzymes (SOD and CAT) and GSH level in the liver of extract treated rats when compared with $CCl_4$ induced rats. Histopatholosical profiles showed that the extract had significant protective effect against $CCl_4-induced$ liver injury, which corroborates the above findings. Hence it may be possible that the mechanism of hepatoprotection of the extract is due to its antioxidant effect.

• Journal of the Korean Society of Food Science and Nutrition
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• v.19 no.4
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• pp.279-284
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• 1990

This experiment was conducted to study the effect of dietary vitamin E on the lipid composi-tion of rats treated with carbon tetrachloride. Rats were divided into five groups I. e. C(soybean oil with vitamin E(40mg/kg diet)) EF(CCl4 with vitamin E deficient diet) 40E(CCl4 with vitamin E(40mg/kg diet) 400E(CCl4 with vitamin E(400mg/kg diet) 800E(CCl4 with vitamin E(800mg/kg diet) Body weight gain and food efficient ratio were not observed significant differences. The liver weight was significantly increased in the CCl4 treated groups but the liver weight of 800E group was significantly lower than that of EF group. In EF and 40E groups kidney weights were significantly higher compared to that of C group. The content of total lipid in liver of 40E and 400E groups were significantly higher than that of control group but in 400E and 800E groups the contents were significantly lower compared with that of EF group. The content of triglyceride in liver was significantly higher in the CCl4 treated group and the content of cholesterol was significantly higher in the EF and 40E groups but those of 800E group were significantly lower compared with those of EF group. In CCl4 administration groups were significantly higher than those of control group and 400E and 800E groups were significantly lower than those of EF group.

• Biomolecules & Therapeutics
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• v.10 no.3
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• pp.202-207
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• 2002

The hepato-protective activity of the GODEX (Hepadif-s capsule) has been studied in the rats against $CCl_4$-ethanol induced liver toxicity. The rats were oral1y treated with $CCl_4$ (corn oil/ $CCl_4$ 1:1, 1 mg/kg). And one week passes, $CCl_4$(0.4 mg/kg) administered two times a week for 7 weeks. The drugs have been administered every two days for 4 weeks after $CCl_4$ injection. The experimental groups have consisted of the GODEX (250 mg/kg), Hepadif (200 mg/kg), DDB complex (DDB 50 mg/kg and garlic oil powder 50 mg/kg), DDB (50 mg/kg), and vehicle control respectively. There was a significant decrement on the serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin in all treated groups. Specially, ALT level of GODEX and Hepadif only treated groups was decreased c1early. Also, serum albumin level was significantly enhanced in GODEX treated group compared with control and DDB treated groups. In histological results, hepatocellular vacuolar degeneration, lobular restructure and necrosis of bile duct were severely showed in control. But other treated groups showed centerilobular degeneration and mild hyper-plasia. Hepadif or DDB has a effects of the recovery on serum parameters and structure ill liver injury. When it was compared GODEX to Hepadif alone or DDB complex or DDB, it suggested to have the best activity of the liver recovery.

• Herbal Formula Science
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• v.9 no.1
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• pp.375-385
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• 2001

Objectives : This study was carried out to research the protective effects of Sagunja-Tang(SA) through in vivo experiments, and tried to investigate the relation between oxidation of liver tissues and deficiency of Qi. Methods : Acute liver injury which initiated from free radical induced by $CCl_4$, were applied to mice and metabolic data were obtained. In order to measure the degree of liver injury, serum level of alanine aminotransferase(AST), aspartate aminotransferase(ALT), creatinine, blood urea nitrogen(BUN), total protein(TP) and glucose were measured. Lipid peroxidation of liver slice was examined by measuring malondialdehyde(MDA), a product of lipid peroxidation. Results : SA had protective effects on $CCl_4$ induced acute liver injury by decreasing serum level of ALT. Kidney injury was induced by injection of $CCl_4$ too, and SA protected kidney injury by decreasing serum level of creatinine and BUN. Conclusions : Through this study, we found that SA have healing effects on liver and kidney injury of $CCl_4$ induced oxidative stress that is similar to deficiency of Qi. And further studies have to be followed to certify the mechanisms.

• Journal of the East Asian Society of Dietary Life
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• v.4 no.1
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• pp.105-112
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• 1994

To evaluate the role of dietary earthworm flour in liver injury by CCl4 treatment, the rats were fed 5% earthworm flour supplemented diet for 53 days and control rats were fed standard diet without earthworm supplementation. Liver damage was induced both in earthworm flour supplemented diet and control groups by two intraperitoneal injections of CCl4 at the level of 0.1$m\ell$/100g body weight(50% in olive oil) at intervals of 16 hours the increasing rate of lover weight/body weight(%) and serum levels of alanine aminotransferase activity to the control group were higher in CCl4-treated rats fed earthworm flour supplemented diet than those fed standard diet. The decreasing rate of hepatic microsomal aniline hydroxylase activity was also higher in rats fed earthworm supplemented rats by the CCl4 treatment, Hepatic glutathione S-transferase activity was sinificantly higher in rats fed earthworm supplemented diet than those fed standard diet. It is concluded that a dietary earthworm flour argument the metabolic rate of CCl in rats.

• International Journal of Internet, Broadcasting and Communication
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• v.10 no.3
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• pp.109-114
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• 2018

In order to improve performance for the size of the BLPD, the CCL is used for the realization as the delay line. As realizing lower coupling coefficient and lower characteristic impedance, the CCL has good performance of the phase delay. The CCL is applied as the compact BLPD with optimized coupling factor and matched impedance because the lower coupling coefficient and lower characteristic impedance are increased the size and the loss, respectively. Designed BLPD using the CCL has the size of $0.13{\lambda}_g{\times}0.13{\lambda}_g$ and the size-reduction ratio of fabricated BLPD using the CCL has 58.5% ($21.08{\times}21.40mm^2$). Also, fabricated BLPD is measured the insertion loss of 3.16dB at the center frequency of 1.78GHz and the 20dB bandwidth is 9.58%. Differenced magnitude and phase between threw port and coupled port are measured 0.1dB and $89.9^{\circ}$, respectively. These performances are almost same compared with the conventional BLPD. Suggested application of the CCL can be used various devices and circuits for the size-reduction.

• Journal of the Institute of Convergence Signal Processing
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• v.16 no.1
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• pp.1-8
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• 2015

In many image processing tasks, connected component labeling (CCL) is performed to extract regions of interest. CCL was usually done in a sequential fashion when image resolution was relatively low and there are small number of input channels. As image resolution gets higher up to HD or Full HD and as the number of input channels increases, sequential CCL is too time-consuming to be used in real time applications. To cope with this situation, parallel CCL framework was introduced where multiple cores are utilized simultaneously. Several parallel CCL methods have been proposed in the literature. Among them are NSZ label equivalence (NSZ-LE) method[1], modified 8 directional label selection (M8DLS) method[2], and HYBRID1 method[3]. Soh [3] showed that HYBRID1 outperforms NSZ-LE and M8DLS, and argued that HYBRID1 is by far the best. In this paper we propose an improved hybrid parallel CCL algorithm termed as HYBRID2 that hybridizes M8DLS with label backtracking (LB) and show that it runs around 20% faster than HYBRID1 for various kinds of images.

• YAKHAK HOEJI
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• v.42 no.1
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• pp.108-113
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• 1998

G009, a polysaccharide isolated from the mycelia of Ganoderma lucidum IYO09, showed a hepatoprotective activity against $CCl_4$ induced cytotoxicity in primary cu ltured rat hepatocytes. Incubation of $CCl_4$-intoxicated hepatocytes with G009 significantly reduced the levels of glutamic pyruvic transaminase and sorbitol dehydrogenase released from hepatocytes in the medium. G009 showed antioxidative effect by elevating the activities of glutathione reductase and superoxide dismutase, and the content of glutathione in $CCl_4$-intoxidcated primary cultured rat hepatocytes. Furthermore, G009 significantly elevated glutathione-S-transferase activity in $CCl_4$-intoxicated primary cultured rat hepatocytes. G009 also reduced the production of malondialdehyde, a byproduct of lipid peroxidation. From these results, it could be concluded that G009 exerted hepatoprotective activity against $CCl_4$-induced cytotoxicity through antioxidation.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.11a
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• pp.917-920
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• 2010

Web 2.0 시대를 대표하는 핵심적인 컨텐츠는 단연 UCC이다. 사용자가 직접 만드는 컨텐츠를 의미하는 UCC는 유투브, 아프리카TV 등을 통하여 많은 수익을 거두며 관련 업계의 주목을 받고 있으나 복제와 수정, 전송이 쉬운 인터넷 환경에서 많은 저작권 문제를 내포하고 있다. 최근에는 웹을 중심으로 CCL을 통해 자신의 저작물에 대한 허용조건을 명시하여 다른 사용자에게 명시된 조건하에서 자유롭게 저작물을 이용할 수 있게 하는 방법이 널리 이용되고 있다. 그러나 CCL로 허용된 컨텐츠를 이용함에 있어서 CCL의 누락 및 위변조를 통해 저작물을 불법으로 이용하는 행위가 증가하고 있어 CCL 활성화의 장애물이 되고 있다. 또한 다양한 응용프로그램에 CCL을 적용하고 검증하기 위한 SW 플랫폼이 부재한 상태이다. 이에 본 논문에서는 효과적으로 컨텐츠에 CCL을 적용하고 CCL로 사용허가된 컨텐츠를 검증 할 수 있는 SW 플랫폼을 제안한다.

• Korean Journal of Clinical Laboratory Science
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• v.47 no.4
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• pp.251-258
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• 2015

Curcumin, a major polyphenolic compound of turmeric, is well known to prevent non-alcoholic steatohepatitis (NASH) related to obesity. The aim of the study was to investigate the effect of curcumin on hepatic fibrosis induced by carbon tetrachloride ($CCl_4$) in obese mice. $CCl_4$ was administrated in mice fed a normal diet (ND) or a high fat diet (HFD) for 7 weeks together with or without curcumin. It was conducted to examine for metabolic profiles, adipocyte size, and liver fibrosis by serum biochemistry, histology and immunohistochemistry. Also, Apoptosis of hepatic cells was determined by the TUNEL method. Treatment with curcumin significantly lowered the body weight, fasting glucose, serum AST and ALT, and decreased the adipocyte size, the number of macrophage and mast cells in adipose tissue, and collagen deposition in liver tissue in the HFD+$CCl_4$ group compared with the findings of the HFD+$CCl_4$ group. In contrast, treatment with curcumin on the ND+$CCl_4$ group did not show a significant difference except the body weight and mast cell number when compared with the ND+$CCl_4$ group. Furthermore, curcumin significantly reduced the number of parenchymal apoptotic cells, whereas it increased the number of non-parenchymal apoptotic cells, especially resembling an activated hepatic stellate cell in the liver. Taken together, this data suggests that curcumin might be an effective antifibrotic drug for the prevention of liver disease progression in obese mice. Thus, the development of curcumin as a therapy for obesity and liver fibrosis is supported.