• Journal of Pharmaceutical Investigation
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• v.7 no.1_4
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• pp.38-50
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• 1977

A study on the mechanism of biliary and urinary excretion of chloramphenicol has been performed in the dog. 1) Chloramphenicol administered intravenously to dogs with ligated renal pedicle, readily appeared in bile greater than in plasma. 6.9% of a 50mg /kg i. v. dose of chloramphenicol were excreted into bile within 100 minutes. During the same periods of above experiment, the bile/plasma concentration ratios(B/P ratios) were 46 to 87. 2) Chloramphenicol injected into the vein of dog was rapidly excreted into urine. 18% of the administered dose were excreted into urine within 70 minutes. In the same periods of this experiment, Ccm/Ccr ratios were greater than 1.0 in most cases. 3) In experiment of simultaneous measurement of biliary and urinary excretion of chloramphenicol, Ccm/Ccr ratios were less than 1.0 and B/P ratios were 50 to 52. 4) In experiment measured simultaneously biliary and urinary excretion both Ccm/Ccr and $C^Hcm$(hepatic clearance) were significantly declined by probenecid, but not affected by 2,4-DNP and aminophylline although 2,4-DNP increased only bile flow and aminophylline both bile and urine volume. 5) Ccm/Ccr and $C^Hcm$ were increased in proportion to increment of plasma concentration ranging from 3.3 to 30 mg% of chloramphenicol. But when plasma concentration were increased to 70mg %, Ccm/Ccr were not increased and $C_Hcm$ were reduced about 30% in comparison with values obtajned at 30mg% of chloramphenicol. 6) Free/Bound(free to bouid from) ratios ranging from 1.0 to 90.0mg% of chloramphenicol were 76.2+3.72% $(mean{\pm}S.E.)$ Above results suggest that chloramphenicol is excreted into bile by a process of active trasport, that excretion of chloramphenicol into urine was made up with dual process, reabsorption and secretion, and that renal secretion was attained by active trasport process although renal reabsorption process could not understand.

• Restorative Dentistry and Endodontics
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• v.48 no.2
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• pp.15.1-15.7
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• 2023

Objectives: This study evaluated the efficiency of WaveOne Primary files (Dentsply Sirona) for removing root canal fillings with 2 types of movement: reciprocating (RCP) and continuous counterclockwise rotation (CCR). Materials and Methods: Twenty mandibular incisors were prepared with a RCP instrument (25.08) and filled using the Tagger hybrid obturation technique. The teeth were retreated with a WaveOne Primary file and randomly allocated to 2 experimental retreatment groups (n = 10) according to movement type: RCP and CCR. The root canals were emptied of filling material in the first 3 steps of insertion, until reaching the working length. The timing of retreatment and procedure errors were recorded for all samples. The specimens were scanned before and after the retreatment procedure with micro-computed tomography to calculate the percentage and volume (mm³) of the residual filling material. The results were statistically evaluated using paired and independent t-tests, with a significance level set at 5%. Results: No significant difference was found in the timing of filling removal between the groups, with a mean of 322 seconds (RCP) and 327 seconds (CCR) (p < 0.05). There were 6 instrument fractures: 1 in a RCP motion file and 5 in continuous rotation files. The volumes of residual filling material were similar (9.94% for RCP and 15.94% for CCR; p > 0.05). Conclusions: The WaveOne Primary files used in retreatment performed similarly in both RCP and CCR movements. Neither movement type completely removed the obturation material, but the RCP movement provided greater safety.

• The Journal of the Korea Contents Association
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• v.11 no.6
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• pp.302-310
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• 2011

Recently, many construction firms fall on hard times because construction business continues to stagnate. In this paper, we analyze the efficiency of the listed construction firms using a combined AHP and DEA model. In order to determine the input and output factors of DEA, the AHP model is applied to evaluate the importance of input and output factors. The benchmarking companies and efficiency value for the construction firms with inefficiency are also provided to improve the their efficiency. We analyzed the 57 listed companies consisted of 36 listed on KOSPI and 21 listed on KOSDAQ at the end of 2009. The analysis results show that eleven companies whose values of CCR are 1, and fourteen enterprises whose values of BCC efficiency are 1. In additions, the eleven firms have the scalability efficiency. Finally, we test the correlation between efficiency and the stock price and the correlation coefficient of efficiency group is 0.7 in the CCR model.

• Journal of Korea Port Economic Association
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• v.28 no.4
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• pp.59-77
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• 2012

Inland transportation system has been improving inefficiencies and structural problems due to excess of supply. Therefore, inland transportation market needs to reform its regional logistics structure in order to increase its competitiveness. To improve the solution, the research studied efficiencies and productivity of inland transportation systems in regions. In order to obtain specific facts, each cities' five years of (2005-2009) balanced panel data on inland transportation system has been studied. According to CCR and BCC analysis, Ul-San has been evaluated as the most efficient DMU during 2005-2008. In addition, in 2009, Seoul was the most efficient DMU. Also, according to Window analysis, Gwan-Ju and Gwangwon-do scored 0.062. Therefore, they were estimated as stable DMUs. According to Malmquist productivity analysis, average productivity indexes of four terms of Chungcheongnam-do and Chungcheongbuk-do haves been increased to 6.6% and 7.3%. I hope this study contributes to the improvement of regional inland transportation system.

• Journal of Korea Society of Industrial Information Systems
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• v.14 no.1
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• pp.32-42
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• 2009

Information and communication industry, which has been growing rapidly, is now leading the global economic growth, contributing a ripple effect on general business and economic structure. It is said that information and communication industry enables swift economic growth taking a role as a basic industry of information-oriented society. Especially, rapid technical innovation promotes mutual growth of other related industries and it is technology-intensive. The purpose of this research is to analyze the management efficiency of information and communication industry using DEA method, and finally suggests numerical value for inefficient organizations to improve their efficiency. CCR-I, BCC-I efficiency and RTS(Returns to scale) of 29 companies engaged in information and communication industry was evaluated. With the results, we suggested the model companies for benchmarking in information and communication industry. To summarize, 7 companies were selected with CCR-I efficiency rate 1, and 12 companies with BCC-I efficiency rate 1. RTS was finalized with 8 IRS companies, 10 DRS companies, and 11 CRS companies.

• Archives of Pharmacal Research
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• v.21 no.6
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• pp.634-639
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• 1998

Seven transmembrane segment (7TMS) receptors for chemokines and related molecules have been demonstrated to be essential, in addition to CD4, for HIV and SIV infection. The beta-chemokine receptor CCR5 is the primary, perhaps sole, coreceptor for HIV-1 during the early and chronic phases of infection, and supports infection by most primary HIV-1 and many SIV isolates. Late-stage primary and laboratory-adapted HIV-1, HIV-2, and SIV isolates can use other 7TMS receptors. CXCR4 appears especially important in late-stage HIV infection; several related receptors can also be used. The specificity of SIV viruses is similar. Commonalities among these receptors, combined with analyses of mutated molecules, indicate that discrete, conformationally-depenclent sites on the chemokine receptors determine their association with the third variable and conserved regions of viral envelope glycoproteins. These studies are useful for elucidating the mechanism and molecular determinants of HIV-1 entry, and of inhibitors to that entry.

• Journal of Navigation and Port Research
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• v.46 no.2
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• pp.110-120
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• 2022

Spain is Europe's second-largest country with total throughput reaching 16.7 million twenty-foot equivalent units (TEU) by 2020. The purpose of this study was to measure and compare the efficiency of 17 container terminals. As a study method, the DEA-CCR model, undesirable variable, and Malmquist Index (MI) were used for data envelopment analysis (DEA). The study results are as follow: (1) DEA-CCR is used to evaluate basic efficiency. The most efficient terminals are decision-making units DMU 1 (APM Terminals (Algeciras Port)), DMU 2 (Total Terminal International Algeciras (Algeciras Port)) and DMU 5 (Barcelona Europe South Terminal (Barcelona Port)). (2) Undesirable DEA was conducted to suggest inefficiency from the undesirable output. Overall, the efficiency scores were reduced. However, DMU 1, DMU 2, and DMU 5 maintained efficiency scores regardless of the finish factor. (3) Malmquist Index was used to observe technology and efficiency changes dynamically. The changes in TCI affected Spanish container terminals more than the Technical Efficiency Change Index (TECI) in 2018-2019. However, in 2019-2020, the TECI was 2.706, higher than the TCI value, indicating that the change in TECI had more influence on the increase in productivity. This study offers a broader understanding of Spanish container terminals.

• Journal of Digital Convergence
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• v.15 no.10
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• pp.31-43
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• 2017

This study was aimed at analyzing the operational efficiency of DPAs(the delivery and pickup agents), which serve as sub-terminals in parcel delivery services, using CCR/BCC models in DEA. The input variables included the number of employees, and the amount of equipment and the operating expenses. The output variable was revenue value. The efficiency for the period from 2014 to 2016 was analyzed. The results revealed that the operational efficiency improved in 2016, compared with 2014, in both CCR and BCC models. According to the benchmarking analysis, DMU 1 and DMU 7 showed higher efficiency in 2016. The inefficiency analysis based on the BCC model showed increased efficiency of all factors in 2016 when compared with 2014. The Malmquist productivity index (MPI) dropped slightly as a result of technical changes and indicated a declining technical efficiency in all DMUs. This study suggests the need for government-led systematic improvement and support for DPAs by providing current insight into the parcel delivery industry and analyzing DPAs' operational efficiency in Korea for the first time. This research performed efficiency analysis of DPAs located in new town of paju and gimpo cities. In future research, comparative study on efficiency analysis including new town, old town area, and other cities are needed.

• The Journal of the Korea Contents Association
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• v.11 no.1
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• pp.317-328
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• 2011

Logistic system and methods of the transportation have been changed rapidly by the variety of the logistics environment. It is necessary to analyze the efficiency of Korean trucking companies for enhancing the competitive power and operating. This paper will describe the analysis of the efficiency of the trucking companies with DEA models. By the CCR and the BCC models, which are in parts of DEA model, the efficiency and RTS(Return To Scale) of forty two selected trucking companies were studied. It was also analyzed how the study the input-output variables were effected. And then, some of the forty two trucking companies were shown as the benchmark. As the result of analysis on the two models, seven companies won the score '1' on CCR model and seventeen companies on BCC model. Moreover, this study showed that reducing the total asset out of input variables, and raising the sales profit out of the output variables played a main role to increase the efficiency of the trucking companies highly.

• The Journal of the Korea Contents Association
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• v.10 no.12
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• pp.328-341
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• 2010

Korea Trucking Transport Business is one of principal national logistics sector, though, so many issues and problems came to arises, which brought cargo transport system crisis over the country such as logistics enormous jam and traffic. This paper analyzes the efficiency of korean trucking transport business firms using DEA model. We evaluate the CCR, BCC efficiency and RTS of 30 trucking transport firms. We also suggest the trucking transport firms which can be benchmarked based on analyzed information. The result shows that seven enterprises whose values of CCR efficiency are 1, and fifteen enterprises whose values of BCC efficiency are 1. RTS indicates IRS of 16 firms, DRS of 5 firms and CRS of 9 firms.