• Bulletin of the Korean Chemical Society
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• v.31 no.10
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• pp.2761-2770
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• 2010

In this study, we have developed QSAR models for a series of 38 piperidine-4-carboxamide CCR5 antagonists using CoMFA, CoMSIA and HQSAR methods. Developed models showed good statistics in terms of $q^2$ and $r^2$ values. Best predictions obtained with standard CoMFA model ($r^2$ = 0.888, $q^2$ = 0.651) and combined CoMSIA model ($r^2$ = 0.892, $q^2$ = 0.665) with electrostatics and H-bond acceptor parameter. The validity of developed models was assessed by test set of 9 compounds, which showed good predictive correlation coefficient for CoMFA (0.804) and CoMSIA (0.844). Bootstrapped analysis showed statistically significant and robust CoMFA (0.968) and CoMSIA (0.936) models. Best HQSAR model was obtained with a $q^2$ of 0.662 and $r^2$ of 0.936 using atom, connection, hydrogen, donor and acceptor as parameters and fragment size (7-10) with optimum number of 6 components. Predictive power of developed HQSAR model was proved by test set and it was found to be 0.728.

• Journal of the Korean Society of Tobacco Science
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• v.4 no.2
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• pp.41-50
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• 1982

To investigate tile effects of growth characteristics on the yield, price per Kg, chemical contents and physical properties in Burley tobacco, ten varieties including Burley 21 were tested in this study. The results obtained are summarized as follows. 1 Forty to fifty days after transplanting, CCR (Crop Growth Rate) was the highest. RCR (Relative Growth Rate) increased up to 40 days, but decreased 50 days when maturation began. High- yielding varieties showed high CCR and RCR till 60 days. 2. Total alkaloid content of cured leaf increased about three times than that of topping stage, but the increased rates were some what different among varieties. 3. Leaf area, stalk diameter, stalk height and days to flower showed positive correlations to yield, whereas leaf thickness and weight per unit leaf area showed negative. 4 Varieties which are high in cured leaf weight ratio and weight per unit leaf thickeners showed relatively poor quality. 5 Nitrogen content was high in leafy and larger stalk diameter variety. 6. There are positive correlation between weight per unit leaf thickness and filling power. The time of combustion was positively correlated to leaf thickness and weight Per unit leaf. 7. It can be concluded that many characteristics are related to the yield, but not quality. It is, there fore, easy to Predict tile yield, but difficult to forecast the qualiffy.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.16 no.10
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• pp.923-930
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• 2003

We jointed Bi(Pb)-Sr-Ca-Cu-O multifilament tapes and evaluated their electrical and mechanical properties. In order to improve connectivity of multifilaments, one or two single-filament tape was inserted between two multifilament tapes. The critical current ratio(CCR) and n-value of the jointed tapes were evaluated as a function of uniaxial pressure. It was observed that critical current ratio and n-value were 24.8-29.0% and 2.5-2.8 for MM lap-jointed tape. On the other hand, the corresponding values were improved to 24.7-53.9% and 3.1-4.2 for MSM jointed tape, and 63.4-76.0% and 3.4-5.1 for double MS:vr lap-jointed tape, respectively. The highest electrical properties of double MSM lap-jointed tape are considered to be owing to the presence of single core, causing better interconnections of multifilaments between the two tapes. The mechanical property of jointed tape was evaluated and correlated to the microstructural evolution. The strength of jointed tapes was 44-64% less than that of the unjoined tape. The strain tolerance of jointed tape was also reduced compared to that of the unjoined tape. These lower mechanical properties of jointed tape are probably due to the induced nonuniform microstructure such as the existence of cracks and Ag-intrusion in the joined region.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.3
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• pp.677-683
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• 2009

This study measures the relative efficiency and productivity change of IT firms received policy fund using DEA model and Malmquist Index for 2006-2007. The main results of this study can by summarized as follows. First, in case of efficiency of CCR for 2006-2007, the number of efficient firms(CCR value is one) are six firms, six firms, respectively. Second, in case of efficiency of BCC for 2006-2007, the number of efficient firms(BCC value is one) are eleven firms, thirteen firms respectively. Third, In case of return to scale for 2006-2007, DRS are fifteen firms and fourteen firms respectively. IRS are two firms and one firm respectively. DRS firms can improve efficiency by the reduction of scale and IRS Firms can improve efficiency by the increase of scale. Fourth, Mean value of Malmquist Index representing productivity change for 2006-2007 are bigger than 1.00. This imply that productivity increase was achieved.

• Journal of Digital Convergence
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• v.11 no.5
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• pp.119-133
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• 2013

This study aims to provide power generating plants with eco-efficiency information. To implement the purposes, of study, both DEA(Data, Envelopment Analysis) model and interview were incorporated in terms of methodologies. To analyze the managerial efficiency, total labor cost and number of employees were considered as input factors. CO2, NOx, and water also were considered as input factors to analyze eco-efficiency. Both annual total power product and annual total revenue were used as output factors. CRS(Constant Return to Scale) and VRS(Variable Return to) model were facilitated in this analysis. According to the findings, most of the power plants were evaluated as 'Efficient'' taking into consideration of average value, both 0.928 from CCR model and 0.969 from VRS model. 7 DMUs including DMU3 and DMU12 are efficient out of 35 DMUs relatively, other DMUs are inefficient. For results of inefficient output factors distribution, it was found that inefficiency for NOx was marked relatively higher than CO2. In order to improve the eco-efficiency in the power plants in the long term, the target amount of Co2 as well as NOx reduction needs to be properly proposed in consideration of particularity of power plants. In the long run, renewable energy, alternative fuels should be adapted to reduce the eco-inefficient.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.517-524
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• 2020

In line with the recent wave of the 4th Industrial Revolution, the environment for defense R&D is transforming into a center of high-tech military technology. In particular, developed countries are strengthening control of technology exports and technology transfer to protect advanced defense science and technology. For this reason, the budget demand for securing the ability to develop independently high-tech weapons and core technologies suitable for the future battlefield environment is increasing, and increasing efficiency in R&D investment has been highlighted for efficient distribution of limited budgets. This study examined the efficiency of the defense basic R&D project using the non-parametric approach, DEA. The R&D budget, R&D researcher, and R&D period were selected as the input variables, and the number of papers and patents were used as output variables. The efficiency of basic R&D projects was analyzed through CCR, BCC models, and SE. Lastly, based on the efficiency measurements, the cause of the inefficiency of R&D projects was suggested, and ways to improve efficiency were suggested. This study is expected to be used as useful information that can be applied to project performance management through efficiency analysis of basic defense R&D projects and be reflected in the project planning stage through feedback.

• Korean Journal of Poultry Science
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• v.47 no.1
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• pp.49-59
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• 2020

The present study determined the effect of dietary cultivated microalgae (Parachlorella sp.) on the growth and immune responses of pre-starter broilers. A total of 320 one-day-old birds (Ross 308) were allocated to 4 treatments with 8 blocks in a randomized complete block design. The four experimental diets consisted of a corn-soybean meal-based control diet, and three diets contained 0.5%, 1.0%, and 1.5% microalgae powder at the expense of cornstarch in the control diet. After feeding the experimental diets for 7 days, the body weight and feed intake of all birds were measured, and 8 birds were randomly selected from each treatment. Peripheral blood mononuclear cells (PBMCs) and serum were harvested for immune profile assessment, including cytokines and cell migration receptors. No differences in growth performance were observed among the treatments. The birds that were fed diets containing graded levels of microalga showed a linear increase in the mRNA expression of cytokine genes in PBMCs, including that of IL2, IL1β, and IL18 (P<0.05). With respect to the chemokine receptor genes in PBMCs, mRNA expression of CCR2, CCR9, and ITGA4 changed quadratically (P<0.05), but that of CCR7 increased linearly (P<0.01). Cytokine protein secretion in blood, including that of IL-1β and IL-6, increased linearly (P<0.01) with an increase in the microalgal content. Overall, the present results show that the indigenous microalgae powder used in this study could stimulate immunity with no detrimental effects on the growth performance of pre-starter broiler chickens.

• Journal of Korea Port Economic Association
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• v.30 no.4
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• pp.151-168
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• 2014

The purpose of this paper is to show the brief efficiency and clustering measurement way by using the game cross-efficiency model which is newly introduced in this paper for 13 container ports during 3 years(2009, 2010, and 2013) with 3 input variables(depth, total area, and number of crane) and 1 output variable(container TEU). The main empirical results are as follows. First, the average rankings of game cross-efficiency model are Ningbo, Hongkong, Shanghai, Dubai, Singapore, Qingdao, Kaosiung, Busan, Tokyo, Incheon, Nagoya, Manila, Gwangyang ports in order. Second, according to ANOVA analysis, three models show the similar results in terms of the efficiency rankings. Third, in the clustering analysis using dendrogram, group A(Shangahi and Busan), group B(Ningbo and Nagoya), and group C(Incheon and Manila) show the common clustering ports during 3 or 2 years. The policy implication of this paper is that Korean port policy planner should introduce the game cross-efficiency method when measuring the individual port efficiency. Also port authority should consider the merits of the clustering ports for improving the port management and operations.

• The Journal of shipping and logistics
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• v.27 no.3
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• pp.457-474
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• 2011

The aim of this study is to analyze the efficiency of major ports in Northeast Asia such as Korea, China and Japan. For the empirical analysis, we tried to apply the data envelopment analysis (DEA), which is an efficiency evaluation model based on mathematical programming theory, and we also established a model to Northeast Asian ports. In our opinion, DEA analysis which involves multiple inputs as well as multiple outputs in its efficiency valuation makes analysis more suitable for port efficiency measurement because ports produce a number of different outputs. In this paper, we attempted to analyze the relative efficiency of 27 ports (5 Korean ports, 13 Chinese ports, 9 Japanese ports) through DEA-CCR, DEA-BCC models. According to the result, Chinese ports are relatively efficient than Korean and Japanese ports. The result of the analysis shows that 7 Chinese ports are efficient in DEA-CCR model in 2009, but in DEA-BCC model 8 Chinese ports and 1 Koran port are efficient. Most of inefficient ports have a value closed to 1 in efficiency for scale, it means that the reason of inefficiency is caused from the technical aspect. Furthermore, we also verified that there exists excess of input in Korean and Japanese ports than Chinese ports.

• Molecules and Cells
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• v.38 no.1
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• pp.89-94
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• 2015

The shape and activity of mitochondria are tightly regulated by fusion and fission processes that are essential for maintaining normal cellular function. However, little is known about the involvement of mitochondrial dynamics in the development of the immune system. In this study, we demonstrate that mitochondrial dynamics play a role in the differentiation and migration of immature dendritic cells (imDCs). We show that mitochondrial elongation is induced during GM-CSF-stimulated differentiation of bone marrow progenitors to imDCs accompanied by upregulation of mitochondrial fusion proteins. These processes precede the changes in mitochondrial morphology and connectivity that occur during differentiation. Mfn2 and OPA1, but not Mfn1, are transcriptionally upregulated during differentiation; however, knockdown of Mfn2 and OPA1 does not induce any change in expression of CD11c, CDC80, or CD86. Notably, knockdown of Mfn2 or OPA1 by siRNA in imDCs significantly reduces CCR7 expression and CCL19-mediated migration. These results suggest that the mitochondrial fusion-related proteins Mfn2 and OPA1 are upregulated during bone marrow progenitor differentiation and promote the migration of imDCs by regulating the expression of CCR7.