• Journal of Pharmaceutical Investigation
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• 제7권1_4호
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• pp.38-50
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• 1977

A study on the mechanism of biliary and urinary excretion of chloramphenicol has been performed in the dog. 1) Chloramphenicol administered intravenously to dogs with ligated renal pedicle, readily appeared in bile greater than in plasma. 6.9% of a 50mg /kg i. v. dose of chloramphenicol were excreted into bile within 100 minutes. During the same periods of above experiment, the bile/plasma concentration ratios(B/P ratios) were 46 to 87. 2) Chloramphenicol injected into the vein of dog was rapidly excreted into urine. 18% of the administered dose were excreted into urine within 70 minutes. In the same periods of this experiment, Ccm/Ccr ratios were greater than 1.0 in most cases. 3) In experiment of simultaneous measurement of biliary and urinary excretion of chloramphenicol, Ccm/Ccr ratios were less than 1.0 and B/P ratios were 50 to 52. 4) In experiment measured simultaneously biliary and urinary excretion both Ccm/Ccr and $C^Hcm$(hepatic clearance) were significantly declined by probenecid, but not affected by 2,4-DNP and aminophylline although 2,4-DNP increased only bile flow and aminophylline both bile and urine volume. 5) Ccm/Ccr and $C^Hcm$ were increased in proportion to increment of plasma concentration ranging from 3.3 to 30 mg% of chloramphenicol. But when plasma concentration were increased to 70mg %, Ccm/Ccr were not increased and $C_Hcm$ were reduced about 30% in comparison with values obtajned at 30mg% of chloramphenicol. 6) Free/Bound(free to bouid from) ratios ranging from 1.0 to 90.0mg% of chloramphenicol were 76.2+3.72% $(mean{\pm}S.E.)$ Above results suggest that chloramphenicol is excreted into bile by a process of active trasport, that excretion of chloramphenicol into urine was made up with dual process, reabsorption and secretion, and that renal secretion was attained by active trasport process although renal reabsorption process could not understand.

• Clinical and Experimental Pediatrics
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• 제62권3호
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• pp.95-101
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• 2019

Purpose: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by various insults including pressure overload, cardiac apoptosis appears to result from an exaggerated local production of angiotensin in adult SHRs. Altered expressions of Bcl associated X (Bax), Bcl-2, chemokine receptor (CCR)-2, monocyte chemoattractant protein (MCP)-1, transforming growth factor $(TGF)-{\beta}1$, phosphorylated extracellular signal-regulated kinases (PERK), and connexin 43 proteins, and kallikrein mRNA were investigated to explore the effects of losartan on the SHR model. Methods: Twelve-week-old male rats were grouped as follows: control (C), SHR (hypertension: H), and losartan (L; SHRs were treated with losartan [10 mg/kg/day] for 5 weeks). Western blot and reverse transcription polymerase chain reaction assays were performed. Results: Expression of Bax, CCR-2, MCP-1, $TGF-{\beta}1$, PERK, and connexin 43 proteins, and kallikrein mRNA was significantly increased in the H group compared to that in the C group at weeks 3 and 5. Expression of Bax, CCR-2, MCP-1, $TGF-{\beta}1$, and connexin 43 proteins and kallikrein mRNA was significantly decreased after losartan treatment at week 5. PERK protein expression was significantly decreased after losartan treatment at weeks 3 and 5. Bcl-2 protein expression was significantly decreased in the H group compared to that in the C group at weeks 3 and 5. Conclusion: Losartan treatment reduced expression of Bax, CCR-2, MCP-1, $TGF-{\beta}1$, PERK, and connexin 43 proteins, and kallikrein mRNA in SHRs, along with decreased inflammation and apoptosis.

• 한국항만경제학회지
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• 제29권2호
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• pp.159-171
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• 2013

본 연구는 DEA기법을 이용하여 물류시설을 공항터미널, 물류단지, 컨테이너터미널, 화물자동차터미널로 나누어 상대적 효율성을 분석하고 물류시설의 개발 및 운영 활성화를 위한 정책적 방안을 제시하는 것을 목적으로 하였다. 분석결과 첫째, 공항터미널의 경우 CCR기준으로 대구국제공항터미널이 가장 효율적이며, 인천국제공항 미군사우편시설이 가장 비효율적인 것으로 나타났다. 인천, 충북, 대전, 부산은 규모의 비효율이 크며, 전남은 운영상의 비효율이 큼을 나타내고 있다. 둘째, 물류단지의 경우 CCR기준으로 군포 복합물류터미널이 가장 효율적이며, 인천국제공항 공항물류단지가 가장 비효율적인 것으로 나타났다. 경기와 경북은 각각 현재 투입물보다 3.5%와 44.3% 증가시켜도 효율성을 유지할 수 있음을 보여주고 있다. 셋째, 항만터미널의 경우 CCR기준으로 한진해운부산신항터미널이 가장 효율적이며, 대한통운부산컨테이너터미널이 가장 비효율적인 것으로 나타났다. 넷째, 화물자동차터미널의 경우 CCR기준으로 울산화물자동차터미널이 가장 효율적이며, 풍암화물자동차터미널이 가장 비효율적인 것으로 나타났다. 서울과 울산은 각각 현재 투입물보다 26.3%와 14.0% 증가시켜도 효율성을 유지할 수 있음을 보여주고 있다. 결론적으로 물류단지의 효율성이 가장 낮고 화물자동차터미널의 효율성이 가장 큼을 알 수 있으며, 규모의 비효율성보다는 운영상의 비효율성이 더 크게 나타났다.

• 대한의생명과학회지
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• 제17권1호
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• pp.89-93
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• 2011

Asthma is an inflammatory airway disease and is characterized by the releases of inflammatory mediators including chemokines. They are mainly associated with the recruitment, activation and dysregulation of specific inflammatory cells, especially neutrophils in neutrophilic asthma. CC chemokines bind to CC chemokine receptors (CCRs) in the surface of their target cells. The aims of this study are to examine the CCR expression in neutrophils of bronchoalveolar lavage fluid (BALF) of asthmatic patients and to determine the alternation of migration and apoptosis of neutrophils by the BALF. We demonstrate that CCR3 strongly expresses in BALF neutrophils of asthmatic patients as compared to other CCRs and increases during apoptosis of the BALF neutrophils. The migration of asthmatic blood neutrophils increases in response to asthmatic BALF as compared to BALF of normal volunteer. In addition, asthmatic BALF includes the higher levels of IL-8 protein than normal BALF and it has no effect on apoptosis of asthmatic blood neutrophils. Taken together, our results indicate that CCR3 expression may be associated with unknown function of asthmatic BALF neutrophils and BALF may be involved in the recruitment of neutrophils into the airway, but not in the neutrophils apoptosis.

• 한국콘텐츠학회논문지
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• 제13권1호
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• pp.366-375
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• 2013

최근 매스미디어 중 신문사의 경영은 인터넷뉴스, 방송 등의 확산으로 인해 신문사간의 경쟁뿐만 아니라 타 매체와의 경쟁도 심화되고 있는 현실이다. 따라서 본 연구에서는 자료포괄분석기법을 이용한 분석을 통해 국내 매스미디어인 신문발행업의 운영 효율성을 평가하여 운영성과 제고를 위한 벤치마킹 대상 신문사와 신문사가 개선해야할 투사값을 제시함으로써 효율적인 신문사 운영에 도움이 될 수 있는 근거를 제시하고자 한다. 분석을 위해 30개 신문발행사을 선정하였으며 평가항목으로는 CCR-O, BCC-O 효율성과 규모효율성(SE), 규모수익성(RTS)을 중심으로 평가하였으며 각각의 분석결과를 살펴보면 30개 신문발행사 중 CCR-O효율성이 1로 나타난 신문사가 10개, BCC-O효율성이 1로 나타난 신문사가 14개, 규모수익성분석을 위해 3가지 측면에서 분석 해 본 결과로는 규모의 보수증가가 1개 업체, 규모의 보수감소가 16업체, 규모의 보수불변이 13업체로 나타났다. 이와 같은 결과를 바탕으로 신문발행업체들이 효율적으로 프론티어에 도달하기 위한 투사값을 투입변수와 산출변수를 가지고 분석함으로써 신문발행업의 효율성에 영향을 주는 변수에 대한 정확한 이해와 기업경영 개선과 관련한 효율성 및 성과에 대해 분석하고자 한다.

• Journal of Electrical Engineering and Technology
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• 제5권2호
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• pp.337-341
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• 2010

In this paper, an extremely low voltage operated micro corner cube retroreflector (CCR) was fabricated for free-space optical communication applications by using bulk silicon micromachining technologies. The CCR was comprised of an orthogonal vertical mirror and a horizontal actuated mirror. For low voltage operation, the horizontal actuated mirror was designed with two PZT cantilever actuators, torsional bars, hinges, and a mirror plate with a size of $400{\mu}m{\times}400{\mu}m$. In particular, the torsional bars and hinges were carefully simulated and designed to secure the flatness of the mirror plate by using a finite element method (FEM) simulator. The measured tilting angle was approximately $2^{\circ}$ at the applied voltage of 5 V. An orthogonal vertical mirror with an extremely smooth surface texture was fabricated using KOH wet etching and a double-SOI (silicon-on-insulator) wafer with a (110) silicon wafer. The fabricated orthogonal vertical mirror was comprised of four pairs of two mutually orthogonal flat mirrors with $400{\mu}m4 (length) $\times400{\mu}m$ (height) $\times30{\mu}m$ (thickness). The cross angles and surface roughness of the orthogonal vertical mirror were orthogonal, almost $90^{\circ}$ and 3.523 nm rms, respectively. The proposed CCR was completed by combining the orthogonal vertical and horizontal actuated mirrors. Data transmission and modulation at a frequency of 10 Hz was successfully demonstrated using the fabricated CCR at a distance of approximately 50 cm.

• Journal of Trauma and Injury
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• 제21권1호
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• pp.15-21
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• 2008

Purpose: National Emergency X-Radiography Utilization Study (NEXUS) criteria and the Canadian Cervical Spine rule (CCR) are commonly used in cervical trauma patients to determine whether a plain cervical X-ray should be performed. However, plain cervical X-rays are so inaccurate that cervical spine computed tomography (CT) is often considered as a screening test. We studied the usefulness of the NEXUS criteria and the CCR for determining the need for a CT evaluation in the emergency department (ED). Methods: This prospective observational study was conducted from January 2007 to March 2008. Plain X-ray and CT scans of the cervical spine were performed on blunt trauma patients with neck pain. The relevancy of CT was examined using the NEXUS criteria and the CCR. Sensitivity, specificity, positive predicted value, and negative predicted value analyses were performed to diagnose the cervical spine injury. Results: During the study period, 284 patients were enrolled in this study. The sensitivity, specificity, positive predicted value, and negative predicted value of the NEXUS criteria were 87.5%, 1.1%, 5.0%, and 60.0% respectively, while those of the CCR were 87.5%, 8.2%, 5.3%, and 91.6%. There were two missed fracture cases when the NEXUS criteria and the CCR were applied independently, however, no cases were missed when both were applied. Conclusion: This study suggests the NEXUS and the CCR in combination can be used as a guide to CT evaluation for cervical spine injury in the ED.

• 한국콘텐츠학회논문지
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• 제11권6호
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• pp.397-406
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• 2011

본 연구에서는 국내 금융투자기관의 효율성 분석을 위해 코참비즈에서 제공하는 재무데이터를 이용하여 2009년도 영업이익순위 30위이하의 금융투자기관을 중심으로 DEA분석방법을 적용한 CCR-I, BCC-I 효율성과 규모수익성(RTS)평가를 통해 금융투자기관의 효율성을 분석함으로써 벤치마킹의 대상이 될 수 있는 국내 금융투자기관을 확인하고, 비효율적인 기업을 위한 각 기업이 개선시켜야하는 투사 값을 제시함으로써 기업의 효율성을 위한 수치를 제공함과 동시에 분석된 자료를 바탕으로 벤치마킹의 대상이 될 수 있는 금융투자기관을 제시하고자 한다.

• 한국항만경제학회지
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• 제33권4호
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• pp.135-148
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• 2017

본 연구는 다음과 같은 문제를 제기한다. 체선이 항만의 운영 효율성에 어느 정도 영향을 미치는가? 이 연구 문제에 대한 답하기 위해 본 연구에서는 SBM-DEA 모형을 이용하여 체선을 고려한 항만의 효율성을 분석하고 DEA-CCR BCC 모형의 연구 결과와 비교하였다. 먼저 DEA-CCR BCC 분석 결과, 부산(2011), 울산(2011)이 효율적인 DMU로 나타났으며 DEA-BCC 모형 분석 결과, 부산(2011), 울산(2011), 울산(2012), 부산(2012), 여수 광양(2012)이 효율적인 DMU로 나타났다. 체선을 고려한 SBM-DEA 모형 분석 결과, 울산(2012), 부산(2011), 부산(2012), 인천(2011), 울산(2011)이 효율적인 DMU로 나타났다. DEA-CCR BCC 결과와 SBM-DEA 결과 간 불일치를 보여 체선이 항만의 운영 효율성에 미치는 영향이 크지 않은 것으로 나타났으며 체선선박척수의 잔여물을 제거한다면 인천항은 3년간 총 11.9억 원, 여수 광양항은 3년 간 총 65.52억 원의 비용 보존이 가능한 것으로 나타났다.

• Restorative Dentistry and Endodontics
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• 제48권2호
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• pp.15.1-15.7
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• 2023

Objectives: This study evaluated the efficiency of WaveOne Primary files (Dentsply Sirona) for removing root canal fillings with 2 types of movement: reciprocating (RCP) and continuous counterclockwise rotation (CCR). Materials and Methods: Twenty mandibular incisors were prepared with a RCP instrument (25.08) and filled using the Tagger hybrid obturation technique. The teeth were retreated with a WaveOne Primary file and randomly allocated to 2 experimental retreatment groups (n = 10) according to movement type: RCP and CCR. The root canals were emptied of filling material in the first 3 steps of insertion, until reaching the working length. The timing of retreatment and procedure errors were recorded for all samples. The specimens were scanned before and after the retreatment procedure with micro-computed tomography to calculate the percentage and volume (mm³) of the residual filling material. The results were statistically evaluated using paired and independent t-tests, with a significance level set at 5%. Results: No significant difference was found in the timing of filling removal between the groups, with a mean of 322 seconds (RCP) and 327 seconds (CCR) (p < 0.05). There were 6 instrument fractures: 1 in a RCP motion file and 5 in continuous rotation files. The volumes of residual filling material were similar (9.94% for RCP and 15.94% for CCR; p > 0.05). Conclusions: The WaveOne Primary files used in retreatment performed similarly in both RCP and CCR movements. Neither movement type completely removed the obturation material, but the RCP movement provided greater safety.