• Journal of Yeungnam Medical Science
• /
• v.5 no.1
• /
• pp.93-100
• /
• 1988

In clinical practice, creatinine clearance(Ccr) remains the most commonly used laboratory assessment of glomerular function despite methodological and technical problems of urine collection. Schwartz et al. in 1976, reported that an accurate estimate of glomerular filtration rate(GFR) could be obtained from the simple determinations of plasma creatinine(Pcr) and body length(L) : GFR($m{\ell}/min/1.73m^2$=k L(cm)/Pcr(mg/$100m{\ell}$), (k=constant). The subject of this study were ill children admitted to our pediatric department from July, 1985 to June, 1987 and they were divided into three groups; group I, from 1 to 5 years old, group II, from 6 to 10 years old, group III. from 11 to 15 years old. The results were as following ; 1) Measured creatinine clearance($Ccr_M$, $m{\ell}/min/1.73m^2$) were $109.73{\pm}9.97$ in group I, $108.26{\pm}9.02$ in group II, $96.20{\pm}4.72$ in group III and $105.48{\pm}5.23$ in all age group. 2) Measured k($k_M$) obtained from $Ccr_M=k$ Ht/Pcr were $0.49{\pm}0.03$ in group I, $0.48{\pm}0.02$ in group II, $0.43{\pm}0.02$ in group III, and $0.47{\pm}0.02$ in all age group.(Ht ; height) 3) Linear equations and correlation coefficients between Ht/Pcr(x) and Ccr(y) were y=0.822x-65.63(r=0.99) in group I, y=0.61x-23.46(r=0.72) in group II, y=0.18x+54.44(r=0.54) in group III and y=0.58x-22.13(r=0.81) in all age group. 4) $Ccr_E$ was again estiamted from linear equations between Ht/Pcr and $Ccr_M$ and $k_E$ was calculated with Ht/Pcr and $Ccr_E$ were $0.48{\pm}0.01$ in group I, $0.49{\pm}0.01$in group II, $0.43{\pm}0.01$ in group III and $0.47{\pm}0.00$ in all age group. 5) Consistant values of $k_E$ and $k_M$ were highly significant as 95~97.5% in group I and II, 90~95% in group III and 97.5~99% in all age group. In summary, we could estimate GFR with height, plasma creatinine and measured k($k_M$) according to the age in easy and rapid way.

• The Journal of the Korea Contents Association
• /
• v.9 no.4
• /
• pp.323-330
• /
• 2009

This study measures the relative efficiency and productivity change of the Korean Life Insurance Firms using DEA model and Malmquist Index for 2004-2007. The main results of this study can by summarized as follows. First, in case of efficiency of CCR for 2004-2007, the number of efficient firms(CCR value is one) are six firms, five firms, four firms, seven firms respectively. Second, in case of efficiency of BCC for 2004-2007, the number of efficient firms(BCC value is one) are eight firms, nine firms, ten firms, twelve firms respectively. Third, In case of return to scale for 2004-2007, DRS are nine firms and IRS are two firms, DRS are five firms and IRS are five firms, DRS are five firms and IRS are four firms, DRS are five firms and IRS are two firms respectively, Fourth, Malmquist Index representing productivity change for 2004-2007 are 1.12 in 2004-2005, 0.97 in 2005-2006, 1.05 in 2006-2007.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.13 no.3
• /
• pp.247-253
• /
• 2000

We evaluated the electric properties of Bi-2223 jointed tapes processed by both resistive-and superconducting-joint methods. For resistive-joint. filler materials of wood metal Pb/Sn. In and silver paste were used whereas for superconductive-joint lap joint method was used. In the resistive joint tape. critical transport property(CCR) n-value and contact resistance were observed to be in the range of 10-85% 1-8,9. and 0.71x10$\^$-6/-0.13x10$\^$-6/Ω, respectively. depending on their filler materials. Specifically it is believed that the electrical properties of resistive joint tape are significantly related to the resistivity of filler materials. On the other hand the CCR of superconductin joint type was varied 55 to 85% with uniaxial pressure probably due to the irregular microstructure in the transition region.

• The Journal of the Korea Contents Association
• /
• v.10 no.10
• /
• pp.456-463
• /
• 2010

This study measured the relative efficiency and productivity change of the Korean professional sport teams using DEA model and Malmquist Index for 2006-2009. The main results of this study can be summarized as follows. First, in case of efficiency of CCR for 2006-2009, the number of efficient professional sport teams(CCR value is one) are two(Daejeon Citizen, Incheon United), three(Daejeon Citizen, Incheon United, FC Seoul), two(Daejeon Citizen, Incheon United), three(Kyungnam FC, Incheon United, FC Seoul) respectively. Second, Malmquist Index representing productivity change for 2006-2009 are 1.035, 0.9658, 1.5331 for Kyungnam FC, 1.2514, 0.8948, 0.9056 for Daegu FC, 1.1768, 0.8620, 0.9722 for Daejeon Citizen, 0.9368, 1.2609, 0.7714 for Incheon United, 1.0000, 1.0000, 1.0000 for FC Seoul, respectively. This result will be used by inefficient professional sport teams to improve inefficiency.

• Genomics & Informatics
• /
• v.18 no.4
• /
• pp.39.1-39.8
• /
• 2020

Alzheimer's disease (AD) is a chronic, progressive brain disorder that slowly destroys affected individuals' memory and reasoning faculties, and consequently, their ability to perform the simplest tasks. This study investigated the hub genes of AD. Proteins interact with other proteins and non-protein molecules, and these interactions play an important role in understanding protein function. Computational methods are useful for understanding biological problems, in particular, network analyses of protein-protein interactions. Through a protein network analysis, we identified the following top 10 hub genes associated with AD: PTGER3, C3AR1, NPY, ADCY2, CXCL12, CCR5, MTNR1A, CNR2, GRM2, and CXCL8. Through gene enrichment, it was identified that most gene functions could be classified as integral to the plasma membrane, G-protein coupled receptor activity, and cell communication under gene ontology, as well as involvement in signal transduction pathways. Based on the convergent functional genomics ranking, the prioritized genes were NPY, CXCL12, CCR5, and CNR2.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.17
• /
• pp.7201-7205
• /
• 2014

Chemokine and chemokine receptor expression by tumor cells contributes to tumor growth and angiogenesis and thus these factors may be considered as tumor markers. Here we aimed to characterize cells directly extracted from glioma, meningioma, and secondary brain tumors as well as non-tumoral cells in vitro. Cells were isolated from brain tissues using 0.2% collagenase and characterized by flow cytometry. Expression of SDF-1, CXCR4, CXCR7, RANTES, CCR5, MCP-1 and IP-10 was defined using flow cytometry and qRT-PCR methods. Brain tissue isolated cells were observed as spindle-shaped cell populations. No significant differences were observed for expression of SDF-1, CXCR4, CXCR7, RANTES, CCR5, and IP-10 transcripts. However, the expression of CXCR4 was approximately 13-fold and 110-fold higher than its counterpart, CXCR7, in meningioma and glioma cells, respectively. CXCR7 was not detectable in secondary tumors but CXCR4 was expressed. In non tumoral cells, CXCR7 had 1.3-fold higher mRNA expression than CXCR4. Flow cytometry analyses of RANTES, MCP-1, IP-10, CCR5 and CXCR4 expression showed no significant difference between low and high grade gliomas. Differential expression of CXCR4 and CXCR7 in brain tumors derived cells compared to non-tumoral samples may have crucial impacts on therapeutic interventions targeting the SDF-1/CXCR4/CXCR7 axis.

• Bulletin of the Korean Chemical Society
• /
• v.31 no.10
• /
• pp.2761-2770
• /
• 2010

In this study, we have developed QSAR models for a series of 38 piperidine-4-carboxamide CCR5 antagonists using CoMFA, CoMSIA and HQSAR methods. Developed models showed good statistics in terms of $q^2$ and $r^2$ values. Best predictions obtained with standard CoMFA model ($r^2$ = 0.888, $q^2$ = 0.651) and combined CoMSIA model ($r^2$ = 0.892, $q^2$ = 0.665) with electrostatics and H-bond acceptor parameter. The validity of developed models was assessed by test set of 9 compounds, which showed good predictive correlation coefficient for CoMFA (0.804) and CoMSIA (0.844). Bootstrapped analysis showed statistically significant and robust CoMFA (0.968) and CoMSIA (0.936) models. Best HQSAR model was obtained with a $q^2$ of 0.662 and $r^2$ of 0.936 using atom, connection, hydrogen, donor and acceptor as parameters and fragment size (7-10) with optimum number of 6 components. Predictive power of developed HQSAR model was proved by test set and it was found to be 0.728.

• The Journal of the Korea Contents Association
• /
• v.17 no.2
• /
• pp.316-326
• /
• 2017

In this research, in order to analyze the efficiency of vocational education and training public services, we analyzed 27 projects conducted in Chungcheongnamdo province in 2014 using DEA. Also we compared the efficiency of 2014 projects with 2013 projects, and verified 3 representative DMU's inefficiency to suggest how to improve the efficiency. The DEA examined the efficiency using CCR model, BCC model and SE(CCR / BCC). As a result of this analysis, the total project costs and the number of projects were increased in 2014 from 2013, but it turned out that the number of inefficient projects were increased and the overall efficiency is decreased. Therefore, in order to improve efficiency, we proposed to allocate labor costs and direct project costs appropriately. In the case of large-scale projects, it was confirmed that reducing the scale of the project is important to increase the overall efficiency. Based on this research, we are presenting a research model that analyzes the efficiency of vocational education and training, and expanding the research area of performance management into the area of various public services.

• Journal of Navigation and Port Research
• /
• v.41 no.3
• /
• pp.127-136
• /
• 2017

The aim of this study is using DEA-CCR, BCC, and Malmquist analysis to determine the efficiency and productivity of Korean automobile ports. We analyzed eight Korean automobile port terminals, using the number of workers and size of ports as input variables and the number of processed car as output variables. An efficiency analysis of the eight automobile port terminals for the four-year span from 2013 to 2016 revealed efficiency levels of 1 for the CCR, BCC, and the scales for Ulsan port and the Gwangyang port terminal, indicating efficient operation of the terminals. As a result of benchmarking analysis, Gunsan port 1, 2 terminal, Incheon port, Pyeongtaek Dangjin 2 terminal should benchmark Busan Port and Ulsan Port. Conversely, Malmquist analysis showed a slight increase in the production volume from 2013 to 2015, but a decline to 1 or less from 2015 to 2016. In the case of TECI the technology was confirmed as effective at 1 or more from 2014 to 2015. The TCI value was 0.87 for the period from 2015 to 2016. During this period, the TCI index of all terminals was less than 1.

• The Journal of the Korea Contents Association
• /
• v.11 no.1
• /
• pp.317-328
• /
• 2011

Logistic system and methods of the transportation have been changed rapidly by the variety of the logistics environment. It is necessary to analyze the efficiency of Korean trucking companies for enhancing the competitive power and operating. This paper will describe the analysis of the efficiency of the trucking companies with DEA models. By the CCR and the BCC models, which are in parts of DEA model, the efficiency and RTS(Return To Scale) of forty two selected trucking companies were studied. It was also analyzed how the study the input-output variables were effected. And then, some of the forty two trucking companies were shown as the benchmark. As the result of analysis on the two models, seven companies won the score '1' on CCR model and seventeen companies on BCC model. Moreover, this study showed that reducing the total asset out of input variables, and raising the sales profit out of the output variables played a main role to increase the efficiency of the trucking companies highly.