• 한국콘텐츠학회논문지
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• 제17권1호
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• pp.201-212
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• 2017

본 연구에서는 변동계수를 이용하여 DEA 모형의 변별력 평가에 적용할 수 있는 새로운 평가기준을 제시하였다. 변별력 평가를 위해 기존 연구에서 제시한 중요도와 본 연구에서 제안한 변동계수를 이용하여 변별력을 분석하였다. 다양한 DEA 모형들 중 변별력 평가를 위해 CCR-DEA, BCC-DEA, entropy, bootstrap, super efficiency, cross efficiency DEA 모형을 선정하고 실증분석을 실시하였다. 모형들의 순위상관관계를 파악하기 위해서 CCR 모형과 BCC 모형의 효율성 값과 entropy, bootstrap, super efficiency, cross efficiency 모형의 효율성 값들 간에 순위상관분석을 실시하였다. 본 연구를 통해 도출된 연구결과를 요약하면 다음과 같다. 첫째, 중요도와 변동계수를 이용한 모형들의 변별력 순위가 동일한 것으로 분석되어 변동계수를 DEA 모형의 변별력 평가기준으로 이용할 수 있다는 것이다. 둘째, 본 연구의 실증분석 결과에 따르면 4개 모형 중 super efficiency 모형이 변별력이 가장 높은 것으로 분석되었다. 셋째, CCR 모형과 순위상관관계가 가장 높은 모형은 super efficiency 모형으로 나타났고, BCC 모형과 순위상관관계가 가장 높은 모형도 super efficiency 모형으로 분석되었다.

• 수산경영론집
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• 제46권2호
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• pp.111-125
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• 2015

This study is to analyze the efficiency of Korean sea food manufacturing using Data Envelopment Analysis. Firstly, based on an output oriented traditional CCR, BCC model, the study estimated the efficiency scores. The average estimates of technical, pure technical, and scale efficiency turned out 0.6517, 0.7184, 0.9074 respectively, which are separated for 50 marine corporations. The 10 DMUs were efficient under CCR model while the 17 DMUs under BCC model. Also, the study suggested that the operating profit of the two output factors should be more increased relatively and averagely from the viewpoint of efficiency improvement. Secondly, super efficiency scores are estimated under super efficiency and SBM model. As a result, it came to be possible to distinguish and rank the efficiency of the efficient DMUs. The highest score was 4.2975 under Super-CCR, was 2.4947 under Super-BCC, was 2.7160 under SBM-Super-CCR, and was 1.5319 under SBM-Super-BCC model. The average estimates of super efficiency were 0.76 and 0.82 under Super-CCR and Super-BCC model respectively, and were 0.61 and 0.67 under SBM-Super-CCR and SBM-Super-BCC model. Finally, the study conducted a rank-sum test, Wilcoxon-Mann-Whitney test, to find a statistical significance of heterogeneity existing in efficiencies among the sample corporations. The result showed that there was a significant difference in average efficiency between Dried, Salted product manufacturing and Frozen product manufacturing under BCC-Super efficiency model at 10% level of significance. Furthermore, TOBIT model was applied to find out the potential factors that might influence the efficiency, Wilcoxonand the results showed debt and sales cost influenced all of the technical, pure technical, and scale efficiency, while net profit influenced only the technical efficiency.

• 한국항해항만학회지
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• 제34권7호
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• pp.577-585
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• 2010

This paper analyzes the efficiency of Korean Ship Component Part Manufacturer firms using DEA model. We evaluated the CCR, BCC efficiency and RTS of 30 Korea Ship Component Part Manufacturer firms. We also suggested the Korean Ship Component Part Manufacturer firms that can be benchmarked based on analyzed information. The result showed five enterprises whose values of CCR efficiency are 1, and eleven enterprises whose values of BCC efficiency are 1. RTS indicated IRS of 1 firms, DRS of 24 firms and CRS of 5 firms.

• 통합자연과학논문집
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• 제7권4호
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• pp.234-240
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• 2014

C-C chemokine receptor type 4 (CCR4) is a chemokine receptor with seven transmembrane helices and it belongs to the GPCR family. It plays an important role in asthma, lung disease, atopic dermatitis, allergic bronchopulmonary aspergillosis, cancer, inflammatory bowel disease, the mosquito-borne tropical diseases, such as dengue fever and allergic rhinitis. Because of its role in wide spectrum of disease processes, CCR4 is considered to be an important drug target. Three dimensional structure of the protein is essential to determine the functions. In the present study homology modeling of human CCR4 was performed based on crystal structure of CCR5 chemokine receptor. The generated models were validated using various parameters. Among the generated homology models the best one is selected based on validation result. The model can be used for performing further docking studies to identifying the critical interacting residues.

• 한국항만경제학회지
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• 제33권4호
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• pp.135-148
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• 2017

본 연구는 다음과 같은 문제를 제기한다. 체선이 항만의 운영 효율성에 어느 정도 영향을 미치는가? 이 연구 문제에 대한 답하기 위해 본 연구에서는 SBM-DEA 모형을 이용하여 체선을 고려한 항만의 효율성을 분석하고 DEA-CCR BCC 모형의 연구 결과와 비교하였다. 먼저 DEA-CCR BCC 분석 결과, 부산(2011), 울산(2011)이 효율적인 DMU로 나타났으며 DEA-BCC 모형 분석 결과, 부산(2011), 울산(2011), 울산(2012), 부산(2012), 여수 광양(2012)이 효율적인 DMU로 나타났다. 체선을 고려한 SBM-DEA 모형 분석 결과, 울산(2012), 부산(2011), 부산(2012), 인천(2011), 울산(2011)이 효율적인 DMU로 나타났다. DEA-CCR BCC 결과와 SBM-DEA 결과 간 불일치를 보여 체선이 항만의 운영 효율성에 미치는 영향이 크지 않은 것으로 나타났으며 체선선박척수의 잔여물을 제거한다면 인천항은 3년간 총 11.9억 원, 여수 광양항은 3년 간 총 65.52억 원의 비용 보존이 가능한 것으로 나타났다.

• 한국콘텐츠학회논문지
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• 제12권7호
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• pp.284-294
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• 2012

본 연구는 전국지방의료원연합회에서 발간하고 있는 경영평가통계편람에서 2005년부터 2009년까지 지방의료원의 운영실적자료를 이용하여 DEA의 CCR 모형, AP모형, superSBM 모형의 각 효율성을 측정하여 비교 분석하였다. 그리고 환경요인(지역, 종별형태, 운영형태, 교육수련여부, 수요와 공급여건, 의료급여 환자비율)별 superSBM 모형의 효율성의 차이를 확인하기 위하여 Willcoxon- Mann- Whitney 통계량을 이용하여 분석하였다. 분석결과, 첫째, SuperSBM 모형에서 15%~17.1%, CCR 모형에서 13%~15.5%, AP 모형에서 7%~12.6%의 비효율을 보여 주고 있다. 둘째, 지역, 병원종별 형태, 병원운영형태, 수요와 공급여건, 저소득층의 진료비 비중 등 환경적 요인에 따라 효율성의 차이가 발생하였다. 셋째, 환경요인에 의해 발생되는 비효율을 해소하기 위해서는 병원내부의 독자적인 노력만으로 한계가 있으며 정부와 지방자치단체의 정책과 제도의 개선이 뒷받침되어야 한다.

• 통합자연과학논문집
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• 제6권3호
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• pp.163-169
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• 2013

The chemokine receptor CCR1 a GPCR super family protein contains seven transmembrane domains. It plays an important role in rheumatoid arthritis, organ transplant rejection, Alzheimer's disease and also causes inflammation. Because of its role in disease processes, antagonism of CCR1 became an attractive therapeutic target. In the current study, we have taken a novel series of recently reported CCR1 antagonist of 1-(4-Phenylpiperazin-1-yl_-2-(1H-Pyrazol-1-yl) ethanone derivatives and performed a HQSAR analysis. The model was developed with Atom (A) and bond (B) parameters and with different set of atom counts to improve the model. The results of HQSAR showed good predictive ability in terms of $r^2$ (0.904) and $q^2$ (0.590) with 0.710 as standard error of prediction and 0.344 as standard error of estimate. The contribution map depicted the atom contribution in inhibitory effect. Compound-14 which was reported to be a highly active compound showed positive atom contribution in three R groups ($R^3$. $R^{5a}$ and $R^{2b}$) in inhibitory effect, which could be the reason why this compound is highly active compound whereas, the lowest active compound-6 showed negative contribution to inhibitory effect.

• 한국콘텐츠학회논문지
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• 제13권1호
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• pp.366-375
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• 2013

최근 매스미디어 중 신문사의 경영은 인터넷뉴스, 방송 등의 확산으로 인해 신문사간의 경쟁뿐만 아니라 타 매체와의 경쟁도 심화되고 있는 현실이다. 따라서 본 연구에서는 자료포괄분석기법을 이용한 분석을 통해 국내 매스미디어인 신문발행업의 운영 효율성을 평가하여 운영성과 제고를 위한 벤치마킹 대상 신문사와 신문사가 개선해야할 투사값을 제시함으로써 효율적인 신문사 운영에 도움이 될 수 있는 근거를 제시하고자 한다. 분석을 위해 30개 신문발행사을 선정하였으며 평가항목으로는 CCR-O, BCC-O 효율성과 규모효율성(SE), 규모수익성(RTS)을 중심으로 평가하였으며 각각의 분석결과를 살펴보면 30개 신문발행사 중 CCR-O효율성이 1로 나타난 신문사가 10개, BCC-O효율성이 1로 나타난 신문사가 14개, 규모수익성분석을 위해 3가지 측면에서 분석 해 본 결과로는 규모의 보수증가가 1개 업체, 규모의 보수감소가 16업체, 규모의 보수불변이 13업체로 나타났다. 이와 같은 결과를 바탕으로 신문발행업체들이 효율적으로 프론티어에 도달하기 위한 투사값을 투입변수와 산출변수를 가지고 분석함으로써 신문발행업의 효율성에 영향을 주는 변수에 대한 정확한 이해와 기업경영 개선과 관련한 효율성 및 성과에 대해 분석하고자 한다.

• 품질경영학회지
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• 제35권3호
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• pp.21-36
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• 2007

This article is to analyze the service efficiency of public sector using Data Envelopment Analysis(DEA). We tried to measure the public service quality and overall satisfaction by using several DEA models, degree of combination and top2box which is a little bit different methodology from traditional ones. We used CCR, Super-efficiency and Slack based measure(SBM) model in DEA to measure public service efficiency of the 16 public institutions(7 City Halls and 9 Provincial offices). Since the traditional method based on the measurement model(CCR, BCC) has the fundamental problems without taking account of the existence of slacks inputs and outputs in several efficient units, we suggest to measure the exact amount of efficiency and inefficiency of the public sector and rank analysis many efficient units exactly through the slacks-based measure model(SBM)

• Bulletin of the Korean Chemical Society
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• 제34권11호
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• pp.3429-3443
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• 2013

Chemokine receptor (CCR2) is a G protein-coupled receptor that contains seven transmembrane helices. Recent pharmaceutical research has focused on the antagonism of CCR2 and candidate drugs are currently undergoing clinical studies for the treatment of diseases like arthritis, multiple sclerosis, and type 2 diabetes. In this study, we analyzed the time dependent behavior of CCR2 docked with a potent 4-azetidinyl-1-aryl-cyclohexane (4AAC) derivative using molecular dynamics simulations (MDS) for 20 nanoseconds (ns). Homology modeling of CCR2 was performed and the 4AAC derivative was docked into this binding site. The docked model of selected conformations was then utilized to study the dynamic behavior of the 4AAC enzyme complexes inside lipid membrane. MDS of CCR2-16b of 4AAC complexes allowed us to refine the system since binding of an inhibitor to a receptor is a dynamic process and identify stable structures and better binding modes. Structure activity relationships (SAR) for 4AAC derivatives were investigated and reasons for the activities were determined. Probable binding pose for some CCR2 antagonists were determined from the perspectives of binding site. Initial modeling showed that Tyr49, Trp98, Ser101, Glu291, and additional residues are crucial for 4AAC binding, but MDS analysis showed that Ser101 may not be vital. 4AAC moved away from Ser101 and the hydrogen bonding between 4AAC and Ser101 vanished. The results of this study provide useful information regarding the structure-based drug design of CCR2 antagonists and additionally suggest key residues for further study by mutagenesis.